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Cited by 22Diabetes Management and ResearchPancreatic function and diabetesDiabetes Treatment and Management

The effects of KATP channel modulators on counterregulatory responses and cognitive function during acute controlled hypoglycaemia in healthy men: a pilot study

Bingham, E., Hopkins, D., Pernet, A., Reid, H., Macdonald, I. A., Amiel, S. A.·2003·Diabetic Medicine
DOI 10.1046/j.1464-5491.2003.00922.x
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Abstract

Aims To examine the effects of agents that alter potassium adenosine triphosphate (KATP) channel activity in β‐cells on cognitive function and counterregulatory hormone responses during acute hypoglycaemia, given the physiological similarities between the pancreatic β‐cell and the hypothalamic glucose‐sensitive neurones (GSN) and the widespread distribution of sulphonylurea receptors in neuronal cells throughout the brain. Methods Ten healthy males were studied on four occasions and in random order underwent three stepped hypoglycaemic (plasma glucose aims: 3.4, 2.8, 2.4 mmol/l) and one euglycaemic (plasma glucose aim: 5 mmol/l) insulin clamps. Prior to each hypoglycaemic study, volunteers received either 10 mg glibenclamide, or 5 mg/kg diazoxide or placebo orally. Cognitive function, symptom scores and counterregulatory hormone responses were measured at each glycaemic level. Results There was no statistically significant effect of either drug on the symptoms generated or the counterregulatory hormonal response during hypoglycaemia. However, cognitive function was better preserved during hypoglycaemia in the glibenclamide‐treated arm, particularly four‐choice reaction time which deteriorated at a plasma glucose 2.5 mmol/l compared with 3.0 mmol/l with diazoxide (P = 0.015) and 2.9 mmol/l with placebo (P = 0.114). Conclusions Single doses of pharmacological agents which alter membrane KATP channel activity do not affect the counterregulatory response to hypoglycaemia but may modify cognitive function during cerebral glucopenia. The unexpected effects of glibenclamide on cortical function suggest a novel action of sulphonylureas that warrants further investigation. Diabet. Med. 20, 231–237 (2003)

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Authors
Bingham, E., Hopkins, D., Pernet, A., Reid, H., Macdonald, I. A., & Amiel, S. A.
Affiliations
Queen's Medical Centre (GB)
Corresponding author
Bingham, E.
ORCID
Venue
Diabetic Medicine
Publisher
Wiley
Published
2003-03
Volume
20
Issue
3
Pages
231-237
ISSN
  • 0742-3071 (ISSN-L)
  • 1464-5491
DOI
10.1046/j.1464-5491.2003.00922.x
OpenAlex
W2023861970
Cited by
22
References
34
Citations by year
2022: 1 · 2019: 1 · 2017: 1 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 9 d)
Locations
  • Diabetic Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
ATP-sensitive potassium channels, sulfonylurea receptor, hypoglycemia, counterregulatory hormones, cognitive function, glibenclamide, diazoxide, pancreatic beta cells, insulin clamp, reaction time
MeSH terms
Adenosine Triphosphate, Adult, Blood Glucose, Cognition, Diabetes Mellitus, Diazoxide, Glyburide, Hormones, Humans, Hypoglycemic Agents, Male, Pilot Projects, Vasodilator Agents, Potassium Channels, Glucose Clamp Technique, Insulin-Secreting Cells

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