Effect of nicotine, mecamylamine, and hexamethonium on shock-induced fighting, pain reactivity, and locomotor behaviour in rats
Abstract
Three series of experiments were performed to evaluate possible nicotinic cholinergic influences on fighting behaviour in rats. Each series consisted of three tests (naive animals in each test); shock-induced fighting, pain threshold estimation and locomotor activity. In the first series, nicotine (0.25 -- 1.00 mg/kg) was found to produce a dose-dependent inhibition of fighting without altering shock thresholds. However, the highest dose used also significantly reduced rearing in the activity test. In the second series, mecamylamine (a centrally active antinicotinic) produced a facilitation of fighting at low doses (2.5 mg/kg) and an inhibition at higher doses (10 mg/kg). Whilst these effects were unrelated to changes in shock thresholds, the high dose resulted in a reduction in both horizontal activity and rearing. Finally, as a control for possible peripheral effects of nicotinic blockage, a third series examined the behavioural effects of hexamethonium. Low doses of this compound (2.25 -- 4.5 mg/kg) had little effect on fighting whilst higher doses (9 -- 18 mg/kg) attenuated these responses. Interestingly, although hexamethonium had no effect on shock thresholds, the highest dose (18 mg/kg) produced a facilitation of horizontal activity. Results are discussed in relation to the hypothesis of central nicotinic cholinergic inhibition of agonistic behaviour.
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Nicotine reduces aggression in rats in many different paradigms, including shock-induced fighting, frustrative non-reward, and a muricide model.
“Nicotine reduces aggression in rats in many different paradigms, including shock-induced fighting (Driscoll and Baettig, 1981; Rodgers, 1979; Waldbillig, 1980), frustrative non-reward (reaction to the inability to obtain rewards following repeated efforts; (Schechter, 1974), and a muricide model (Waldbillig, 1980).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Rodgers, 1979
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- Authors
- Rodgers, R. J.
- Affiliations
- University of Bradford (GB)
- Corresponding author
- Rodgers, R. J.
- Venue
- Psychopharmacology
- Published
- 1979-11
- Volume
- 66
- Issue
- 1
- Pages
- 93-98
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2070075734
- Cited by
- 54
- References
- 32
- Citations by year
- 2021: 1 · 2019: 1 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nicotine, mecamylamine, hexamethonium, agonistic behavior, pain threshold, locomotor activity, rearing behavior
- MeSH terms
- Aggression, Animals, Electroshock, Hexamethonium Compounds, Humans, Male, Mecamylamine, Motor Activity, Nicotine, Pain, Rats
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