The morphological response of Kc-H cells to ecdysteroids: Hormonal specificity

Cherbas, Lucy; Yonge, Christopher D.; Cherbas, Peter; Williams, Carroll M.

doi:10.1007/bf00848562

Cited by 122Neurobiology and Insect Physiology ResearchDevelopmental Biology and Gene RegulationEstrogen and related hormone effects

The morphological response of Kc-H cells to ecdysteroids: Hormonal specificity

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Cherbas, Lucy, Yonge, Christopher D., Cherbas, Peter, Williams, Carroll M.·1980·Wilhelm Roux's Archives of Developmental Biology

DOI 10.1007/bf00848562

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Abstract

Cells of the line Kc, derived fromDrosophila melanogaster embryos, extend long processes when exposed to ecdysteroid hormones. We have devised a quantitative assay for this morphological response, using the subline Kc-H. The assay was used to characterize the conditions required for the response. A halfmaximal response is elicited by approximately 10-8 M 20-hydroxyecdysone; the response is saturated by 10-7 M 20-hydroxyecdysone, which causes detectable elongation within a few hours, and a maximal response after 2-3 days. The response occurs substantially normally in the absence of serum, during growth in suspension, and in over-crowded cultures. It is not elicited by cyclic nucleotides, vertebrate growth factors, or a variety of other non-ecdysteroid reagents. Of 60 ecdysteroid compounds tested, only those which were active in other insect test systems elicited the response, and the concentrations required were approximately proportional to the concentrations active in other in vitro systems. We conclude that the response of Kc cells to 20-hydroxyecdysone retains basic features of the ecdysteroid response of intact tissues and therefore that Kc cells are a useful model system for studying ecdysteroid action.

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The Drosophila melanogaster Kc cell line assay had advantages of much greater reproducibility and no ecdysteroid metabolism but was still time-consuming.
“The next major development was to use the response of the Drosophila melanogaster Kc cell line to quantify the potency of ecdysteroid analogues [162], which had the advantages of much greater reproducibility and no ecdysteroid metabolism but was still time-consuming as it required the measurement of neurone-like cellular projections that were part of the response.”
From Ecdysteroids (2021) · cites this paper as [162]

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The Effect of 20-Hydroxyecdysone on the Synthesis of Fibroin mRNA in the Cultured Posterior Silk Gland of Bombyx mori
Maekawa, H., SAISHU-TAKADA, N., & Miyajima, N. (1984) · Applied Entomology and Zoology · doi:10.1303/aez.19.341 · Cited by 6 · see citing works

Pleiotropic Specific Responses Induced by Ecdysterone in the Cultured Kc Cells of Drosophila melanogaster
Couderc, J. L., Sobrier, M., Giraud, G., Micard, D., Dastugue, B., Ropp, M., Becker, J.-L., Maisonhaute, C., Peronnet, F., Courgeon, A., et al. (1984) · Proceedings in life sciences · doi:10.1007/978-3-642-69922-1_28 · Cited by 11 · see citing works
Ecdysteroid Effects on the Cell Cycle of Drosophila melanogaster Cells
O’Connor, J. D., & Stevens, B. A. (1983) · Springer eBooks · doi:10.1007/978-1-4612-5482-9_5
An ecdysteroid-induced alteration in the cell cycle of cultured Drosophila cells
Stevens, B. A., Alvarez, C. M., Bohman, R., & O’Connor, J. D. (1980) · Cell · doi:10.1016/0092-8674(80)90543-7 · Cited by 79 · see citing works
Effects of juvenile hormone on the ecdysone response of Drosophila Kc cells
Cherbas, L., Koehler, M., & Cherbas, P. T. (1989) · Developmental Genetics · doi:10.1002/dvg.1020100307 · Cited by 65 · see citing works
Self-citation
The Effects of 20-hydroxyecdysone in Drosophila Kc Cells on the Ecdysteroidosis
Hwang, S.-H., & Kim, P. (2002) · Korean Journal of Environmental Health Sciences

Authors: Cherbas, L., Yonge, C. D., Cherbas, P., & Williams, C. M.
Affiliations: Harvard University (US)
Venue: Wilhelm Roux's Archives of Developmental Biology
Publisher: Springer Science and Business Media LLC
Published: 1980
Volume: 189
Issue: 1
Pages: 1-15
ISSN: 0043-5546 (ISSN-L)
0340-0794
1432-041X
DOI: 10.1007/bf00848562
OpenAlex: W2020477872
Cited by: 122
References: 91
Citations by year: 2025: 2 · 2021: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2013: 1 · 2012: 3
FWCI: 2.35
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Development Genes and Evolution (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
Harvard University
National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: ecdysteroids, 20-hydroxyecdysone, Drosophila melanogaster, cell elongation, quantitative assay, serum independence, suspension culture, crowding, cyclic nucleotides, growth factors

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The morphological response of Kc-H cells to ecdysteroids: Hormonal specificity

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