Steroid signaling in plants and insects—common themes, different pathways

Thummel, Carl S.; Chory, Joanne

doi:10.1101/gad.1042102

PreprintCited by 161Plant Molecular Biology ResearchPlant biochemistry and biosynthesisEstrogen and related hormone effects

Steroid signaling in plants and insects—common themes, different pathways

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Thummel, Carl S., Chory, Joanne·2002·Genes & Development

DOI 10.1101/gad.1042102

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Abstract

Outside of mammals, two model systems have been the focus of intensive genetic studies aimed at defining the molecular mechanisms of steroid hormone action—the flowering plant, Arabidopsis thaliana, and the fruit fly, Drosophila melanogaster. Studies in Arabidopsis have benefited from a detailed description of the brassinosteroid (BR) biosynthetic pathway, allowing the effects of mutations to be linked to specific enzymatic steps. More recently, the signaling cascade that functions downstream from BR production has been defined, revealing for the first time how the hormone can exert its effects on gene expression through a cell surface receptor and phosphorylation cascade. In contrast, studies of steroid hormone action in Drosophila began in the nucleus, with a detailed description of the transcription puffs activated by the steroid hormone 20-hydroxyecdysone (20E) in the giant polytene chromosomes. Subsequent genetic studies have revealed that these effects are exerted through nuclear receptors, much like mammalian hormone signaling. Most recently, genetic studies have begun to elucidate the ecdysteroid biosynthetic pathway which, until recently, remained largely undefined. Our current understanding of steroid hormone signaling in Arabidopsis and Drosophila provides a number of intriguing parallels as well as distinct differences. At least some of these differences, however, appear to be due to deficiencies in our understanding of these pathways. Below we discuss recent breakthroughs in defining the molecular mechanisms of BR biosynthesis and signaling in plants, and we compare and contrast this pathway with what is known about the mechanisms of ecdysteroid action in Drosophila. We raise some current questions in these fields, the answers to which may reveal other similarities in steroid signaling in plants and animals.

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20E, which is produced in both insects and plants, such as Cyanotis vaga, can be used to disrupt the development of insect pests.
“20E, which is produced in both insects and plants, such as Cyanotis vaga, can be used to disrupt the development of insect pests [86].”
From G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone (2020) · cites this paper as [86]

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Authors: Thummel, C. S., & Chory, J.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Thummel, Carl S.
Chory, Joanne
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2002-12-15
Volume: 16
Issue: 24
Pages: 3113-3129
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1042102
OpenAlex: W2018830921
Cited by: 161
References: 162
Citations by year: 2026: 6 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 9 · 2013: 2 · 2012: 8
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: steroid hormone signaling, brassinosteroids, ecdysteroids, 20-hydroxyecdysone, brassinosteroid biosynthesis, ecdysteroid biosynthesis, nuclear receptors, cell surface receptors, phosphorylation cascade, polytene chromosomes, Arabidopsis thaliana, Drosophila melanogaster
MeSH terms: Animals, Gene Expression Regulation, Insecta, Steroids, Signal Transduction, Plant Physiological Phenomena

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Steroid signaling in plants and insects—common themes, different pathways

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