Maturation of villus and crypt cell functions in rat small intestine: Role of dietary polyamines
Abstract
To evaluate the role of dietary polyamines in maturation of the rat small intestine, spermine was given orally twice daily to suckling pups from day 10 to day 14 postpartum at different doses: 0, 0.2, 0.5, 1, 2.5, and 5 mumol/dose. Compared to saline treated controls, spermine (5 mumol) produced significant increases in mucosal mass parameters (+12 to +57%, P < 0.05), induced prematurely an adult pattern of microvillous enzymes, and enhanced, respectively, by 19- and 3.5-fold (P < 0.01 vs controls) the concentration of the secretory component of p-immunoglobulins in villous and crypt cells. The response of microvillous enzymes (lactase, sucrase, maltase, and aminopeptidase) to spermine was dose-dependent and -specific since oral administration of arginine (5 mumol) or ornithine (5 mumol) was without effect. Intestinal changes were found to be significant (P < 0.05) for doses of spermine exceeding 1 mumol/day, which is in the range of the amount of polyamines provided by solid pellets at weaning (0.4 mumol/g). However, intestinal changes were undetectable at the physiological amounts of polyamines consumed by pups from rat milk during the suckling period (less than 0.3 mumol/day). Consistent with a direct effect of spermine on the intestinal cell, the cytosolic activity of ornithine decarboxylase was depressed by 27-fold (P < 0.005 vs controls) in the jejunum, while inhibition of ornithine decarboxylase by alpha-difluoromethylornithine did markedly decrease but did not suppress the cell response to spermine. Alternately, plasma corticosteronemia, which was virtually absent by day 14 in controls, ranged between 1.4 and 4.6 micrograms/dl in 60% (N = 9) of the spermine-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oral administration of polyamines enhances development and maintenance of the intestinal mucosa and resident immune cells.
“Oral administration of polyamines enhances the development and maintenance of the intestinal mucosa and resident immune cells (Buts et al., 1993; Dufour et al., 1988; Löser et al., 1999; Pérez-Cano et al., 2010).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Buts et al., 1993
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090 · see citing works
An Improved Diphenylamine Method for the Estimation of Deoxyribonucleic Acid
Giles, K. W., & MYERS, A. (1965) · Nature · doi:10.1038/206093a0 · Cited by 1,959 · see citing works
Polyamine metabolism and function
Pegg, A. E., & McCann, P. P. (1982) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1982.243.5.c212 · Cited by 1,661 · see citing works
Intestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis
Weiser, M. M. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44141-0 · Cited by 1,101 · see citing works
Purification of the human intestinal brush border membrane
Schmitz, J., Preiser, H., Maestracci, D., Ghosh, B. K., Cerda, J. J., & Crane, R. K. (1973) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(73)90434-3 · Cited by 790 · see citing works
The aminopeptidase from hog intestinal brush border
MAROUX, S., Louvard, D., & Barath, J. (1973) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(73)90083-1 · Cited by 543 · see citing works
Molecular genetics of polyamine synthesis in eukaryotic cells
Heby, O., & Persson, L. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90216-x · Cited by 523 · see citing works
A one-step ultramicro method for the assay of intestinal disaccharidases
Messer, M., & Dahlqvist, A. (1966) · Analytical Biochemistry · doi:10.1016/0003-2697(66)90280-6 · Cited by 413 · see citing works
Lux, G. D., Marton, L. J., & Baylin, S. B. (1980) · Science · doi:10.1126/science.6774420 · Cited by 346 · see citing works
Biosynthesis of putrescine in the prostate gland of the rat
Pegg, A. E., & Williams-Ashman, H. G. (1968) · Biochemical Journal · doi:10.1042/bj1080533 · Cited by 324 · see citing works
Determination of diamine oxidase activity by liquid scintillation counting
Okuyama, T., & Kobayashi, Y. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90141-2 · Cited by 284 · see citing works
Spermine and spermidine induce intestinal maturation in the rat
Dufour, C., Dandrifosse, G., Forget, P., Vermesse, F., Romain, N., & Lepoint, P. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90298-3 · Cited by 158 · see citing works
Polyamine biogenesis in the rat mammary gland during pregnancy and lactation
Russell, D. H., & McVicker, T. A. (1972) · Biochemical Journal · doi:10.1042/bj1300071 · Cited by 109 · see citing works
Raul, F., Simon, P., Kédinger, M., & HAFFEN, K. (1977) · Cell and Tissue Research · doi:10.1007/bf00229460 · Cited by 101 · see citing works
Bardócz, S., Brown, D. S., Grant, G., & Pusztai, A. J. (1990) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(90)90151-l · Cited by 86 · see citing works
Delineation of the Glucocorticoid-Sensitive Period of Intestinal Development in the Rat*
Henning, S., & SIMS, J. M. (1979) · Endocrinology · doi:10.1210/endo-104-4-1158 · Cited by 60 · see citing works
Bicarbonate modulation of glucose-9nduced biphasic insulin release by rat islets
Jc, H., & Lambert, A. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.231.3.713 · Cited by 50 · see citing works
Buts, J., Keyser, N. D., Kolanowski, J., & HOOF, F. V. (1990) · Pediatric Research · doi:10.1203/00006450-199002000-00015 · Cited by 40 · see citing works
Self-citationMechanism of induction of mucosal ornithine decarboxylase by food
Tabata, K., & Johnson, L. R. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.3.g370 · Cited by 40 · see citing works
Buts, J., & Delacroix, D. L. (1985) · PubMed · Cited by 37 · see citing works
Self-citationFogel, W. A., Biegański, T., Woźniak, J., & Maśliński, C. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90445-8 · Cited by 35 · see citing works
Kolanowski, J. (1974) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(74)90028-4 · Cited by 34 · see citing works
Self-citationSpermine uptake by rat intestinal brush-border membrane vesicles
Iseki, K., Kobayashi, M., & Miyazaki, K. (1991) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(91)90067-i · Cited by 34 · see citing works
Role of Diet in the Determination of Jejunal Sucrase Activity in the Weanling Rat
Henning, S., & Guerin, D. M. (1981) · Pediatric Research · doi:10.1203/00006450-198107000-00019 · Cited by 32 · see citing works
[Recent progress in polyamine research].
Ohsawa, N. (1990) · PubMed · Cited by 32 · see citing works
Reversibility of spermine-induced intestinal maturation in the rat
Georges, P., Dandrifosse, G., Vermesse, F., Forget, P. P., Deloyer, P., & Romain, N. (1990) · Digestive Diseases and Sciences · doi:10.1007/bf01540571 · Cited by 24 · see citing works
Effect of difluoromethyl ornithine (DFMO) on small intestine of adult and weanling rats
Alarcon, P., Lebenthal, E., & Lee, P. C. (1987) · Digestive Diseases and Sciences · doi:10.1007/bf01296713 · Cited by 23 · see citing works
Buts, J., & Meyer, R. D. (1984) · Pediatric Research · doi:10.1203/00006450-198402000-00006 · Cited by 21 · see citing works
Self-citationPolyamide profiles of porcine milk and of intestinal tissue of pigs during suckling
Kelly, D., King, T. P., Brown, D., & McFadyen, M. C. E. (1991) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19910107 · Cited by 21 · see citing works
Role of dietary iron in maturation of rat small intestine at weaning
Buts, J., Delacroix, D. L., Dekeyser, N., Paquet, S., Horsmans, Y., Boelens, M., Craynest, M. P. V., & Meyer, R. D. (1984) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1984.246.6.g725 · Cited by 18 · see citing works
Self-citationRole of Dietary Protein Adaptation at Weaning in the Development of the Rat Gastrointestinal Tract
Buts, J. P., & Nyakabasa, M. (1985) · Pediatric Research · doi:10.1203/00006450-198508000-00017 · Cited by 13 · see citing works
Self-citationCharacteristics of putrescine uptake by human brush border membrane vesicles.
Stein, J. M., Milović, V., Lembcke, B., & Caspary, W. F. (1992) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Oliphant, K., & Allen-Vercoe, E. (2019) · Microbiome · doi:10.1186/s40168-019-0704-8 · Cited by 1,327 · see citing works
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“Oral administration of polyamines enhances the development and maintenance of the intestinal mucosa and resident immune cells (Buts et al., 1993; Dufour et al., 1988; Löser et al., 1999; Pérez-Cano et al., 2010).”
BackgroundDevelopment of Intestinal Transport Function in Mammals
Pácha, J. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1633 · Cited by 397 · see citing works
Tovar‐Ramírez, D., Zambonino‐Infante, J., Cahu, C. L., Gatesoupe, F.-J., Vázquez‐Juárez, R., & Lésel, R. (2002) · Aquaculture · doi:10.1016/s0044-8486(01)00650-0 · Cited by 277 · see citing works
Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep04548 · Cited by 271 · see citing works
Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut
Fan, P. F., Li, L., Rezaei, A., Eslamfam, S., Che, D., & Ma, X. (2015) · Current Protein and Peptide Science · doi:10.2174/1389203716666150630133657 · Cited by 233 · see citing works
Zhang, Y., Chen, R., Zhang, D., Qi, S., & Liu, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114295 · Cited by 210 · see citing works
Buts, J., Keyser, N. D., & Raedemaeker, L. D. (1994) · Pediatric Research · doi:10.1203/00006450-199410000-00019 · Cited by 175 · see citing works
Self-citationArginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease
Kan, M. J., Lee, J. E., Wilson, J. G., Everhart, A. L., Brown, C. M., Hoofnagle, A. N., Jansen, M., Vitek, M. P., Gunn, M. D., & Colton, C. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4668-14.2015 · Cited by 174 · see citing works
Goat Milk‐Chemistry and Nutrition
Park, Y. W. (2006) · Wiley eBooks · doi:10.1002/9780470999738.ch3 · Cited by 166 · see citing works
Löser, C., Eisel, A., Harms, D., & Fölsch, U. R. (1999) · Gut · doi:10.1136/gut.44.1.12 · Cited by 155 · see citing works
Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract
Hébert, S., Cheng, S. X., & Geibel, J. P. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.10.015 · Cited by 140 · see citing works
Inulin, oligofructose and mineral metabolism — experimental data and mechanism
Scholz-Ahrens, K. E., & Schrezenmeir, J. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn/2002535 · Cited by 134 · see citing works
Buts, J., Dekeyser, N., Stilmant, C., Delem, E., Smets, F. N., & Sokal, E. M. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000220322.31940.29 · Cited by 130 · see citing works
Self-citationMatsumoto, M., & Benno, Y. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb03887.x · Cited by 129 · see citing works
The Functions and Roles of the Extracellular Ca2+–Sensing Receptor along the Gastrointestinal Tract
Geibel, J. P., & Hébert, S. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163128 · Cited by 125 · see citing works
Inulin, oligofructose and mineral metabolism — experimental data and mechanism
Scholz-Ahrens, K. E., & Schrezenmeir, J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002535 · Cited by 122 · see citing works
Factors influencing nutritional and health profile of milk and milk products
Michaelidou, A.-M. (2008) · Small Ruminant Research · doi:10.1016/j.smallrumres.2008.07.007 · Cited by 116 · see citing works
Cheng, S. X., Geibel, J. P., & Hébert, S. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.064 · Cited by 106 · see citing works
Effects of Saccharomyces boulardii on Intestinal Mucosa
Buts, J., & Keyser, N. D. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-9016-x · Cited by 104 · see citing works
Self-citationImmunoglobulin Transport and the Polymeric Immunoglobulin Receptor
Kaetzel, C. S., & Mostov, K. E. (2005) · Elsevier eBooks · doi:10.1016/b978-012491543-5/50016-4 · Cited by 102 · see citing works
Asquith, M. J., Davin, S., Stauffer, P., Michell, C., Janowitz, C., Lin, P., Ensign‐Lewis, J., Kinchen, J. M., Koop, D. R., & Rosenbaum, J. T. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40183 · Cited by 98 · see citing works
Matsumoto, M., Aranami, A., Ishige, A., Watanabe, K., & Benno, Y. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02642.x · Cited by 98 · see citing works
Polyamines in human and animal milk
Löser, C. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002257 · Cited by 96 · see citing works
Polyamines and the Intestinal Tract
Seiler, N., & Raul, F. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701250016 · Cited by 93 · see citing works
Immunometabolism: An Overview and Therapeutic Prospects in Autoimmune Diseases
Stathopoulou, C., Nikoleri, D., & Bertsias, G. K. (2019) · Immunotherapy · doi:10.2217/imt-2019-0002 · Cited by 87 · see citing works
Twenty-Five Years of Research on Saccharomyces boulardii Trophic Effects: Updates and Perspectives
Buts, J. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0322-y · Cited by 83 · see citing works
Self-citationInfluence of breast milk polyamines on suckling rat immune system maturation
Pérez-Cano, F. J., González-Castro, A. M., Castellote, C., Franch, À., & Castell, M. (2009) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2009.10.001 · Cited by 82 · see citing works
Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats
Buts, J.-P., Keyser, N. D., Marandi, S., Hermans, D., Sokal, E. M., Chae, Y.-H. E., Lambotte, L., Chanteux, H., & Tulkens, P. M. (1999) · Gut · doi:10.1136/gut.45.1.89 · Cited by 79 · see citing works
Self-citationAre milk polyamines preventive agents against food allergy?
Dandrifosse, G., Peulen, O., Khefif, N. E. E., Deloyer, P., Dandrifosse, A.-C., & Grandfils, C. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000100 · Cited by 78 · see citing works
Gut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77 · see citing works
Tang, L., Cheng, C. Y., Sun, X., Pedicone, A. J., Mahamadzadeh, M., & Cheng, S. X. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00245 · Cited by 79 · see citing works
Impact of LKM512 yogurt on improvement of intestinal environment of the elderly
Matsumoto, M., Ohishi, H., & Benno, Y. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00518.x · Cited by 66 · see citing works
Intracellular Polyamine Levels of Intestinal Epithelial Cells in Inflammatory Bowel Disease
Weiß, T. S., Herfarth, H. H., Obermeier, F., Ouart, J., Vogl, D., Schölmerich, J., Jauch, K. ‐., & Rogler, G. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200409000-00006 · Cited by 66 · see citing works
Goat Milk – Chemistry and Nutrition
Park, Y. W. (2017) · Wiley eBooks · doi:10.1002/9781119110316.ch2.2 · Cited by 65 · see citing works
Gut Microbiome Modulates Response to Cancer Immunotherapy
Khan, M. A. W., Ologun, G. O., Arora, R., McQuade, J. L., & Wargo, J. A. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06111-x · Cited by 66 · see citing works
The role of the calcium-sensing receptor in gastrointestinal inflammation
Owen, J. L., Cheng, S. X., Ge, Y., Sahay, B., & Mohamadzadeh, M. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.040 · Cited by 61 · see citing works
Spermine Induces Maturation of the Immature Intestinal Immune System in Neonatal Mice
ter Steege, J. C. A., Buurman, W. A., & Forget, P. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199709000-00017 · Cited by 59 · see citing works
Matsumoto, M., & Benno, Y. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.50464 · Cited by 56 · see citing works
The Application of Metabolomics to Probiotic and Prebiotic Interventions in Human Clinical Studies
O’Connell, T. M. (2020) · Metabolites · doi:10.3390/metabo10030120 · Cited by 54 · see citing works
Wu, X., Cao, W., Jia, G., Zhao, H. Y., Chen, X., Wu, C., Tang, J., Wang, J., & Liu, G. (2016) · Animal nutrition · doi:10.1016/j.aninu.2016.11.005 · Cited by 54 · see citing works
Dietary polyamines and non-neoplastic growth and disease
Deloyer, P., Peulen, O., & Dandrifosse, G. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200109000-00005 · Cited by 53 · see citing works
Biol, M.-C., & Louisot, P. (2003) · Biochimie · doi:10.1016/s0300-9084(03)00039-7 · Cited by 52 · see citing works
Polyamines in cow's and sow's milk
Motyl, T., Płoszaj, T., Wojtasik, A., Kukulska, W., & Podgurniak, M. (1995) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)00010-6 · Cited by 50 · see citing works
Péres, A., Cahu, C. L., & Zambonino‐Infante, J. (1997) · Fish Physiology and Biochemistry · doi:10.1023/a:1007786128254 · Cited by 50 · see citing works
Matsumoto, M., Kakizoe, K., & Benno, Y. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb03888.x · Cited by 49 · see citing works
Effects of dietary polyamines at physiologic doses in early-weaned piglets
Molina, M. S., Larqué, E., Torrella, F., Zamora, J. P., Lozano, T., Muñoz, A., & Zamora, S. (2009) · Nutrition · doi:10.1016/j.nut.2009.01.017 · Cited by 49 · see citing works
Role of calcium and other trace elements in the gastrointestinal physiology
Kirchhoff, P. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i20.3229 · Cited by 47 · see citing works
Les facteurs trophiques du lait
Buts, J. (1998) · Archives de Pédiatrie · doi:10.1016/s0929-693x(97)89374-8 · Cited by 46 · see citing works
Self-citationAli, M. A., Strandvik, B., SABEL, K. ‐., Kilander, C. P., Strömberg, R., & Yngve, A. (2013) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12156 · Cited by 44 · see citing works
Health Benefits of Bovine Colostrum in Children and Adults
Buttar, H. S., Bagwe, S. M., Bhullar, S. K., & Kaur, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809868-4.00001-7 · Cited by 44 · see citing works
Ewtushik, A. L., Bertolo, R. F. P., & Ball, R. O. (2000) · Canadian Journal of Animal Science · doi:10.4141/a99-134 · Cited by 43 · see citing works
Effects of vegetarian diet-associated nutrients on gut microbiota and intestinal physiology
Xiao, W., Zhang, Q., Yu, L., Tian, F., Chen, W., & Zhai, Q. (2021) · Food Science and Human Wellness · doi:10.1016/j.fshw.2021.11.002 · Cited by 46 · see citing works
Development and Renewal of Intestinal Villi in Pigs
Yang, H., Xiong, X., & Yin, Y. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1328-8_3 · Cited by 40 · see citing works
Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR
Riccardi, D., Finney, B. A., Wilkinson, W. J., & Kemp, P. J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0681-z · Cited by 38 · see citing works
Estimation of 24-Hour Polyamine Intake From Mature Human Milk
Dorhout, B., van Beusekom, C. M., Huisman, M., Kingma, A. W., de Hoog, E., Boersma, E. R., & Muskiet, F. A. J. (1996) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199610000-00015 · Cited by 36 · see citing works
Biol, M.-C., Gréco, S., George, P., Hugueny, I., & Louisot, P. (2002) · Pediatric Research · doi:10.1203/00006450-200205000-00014 · Cited by 35 · see citing works
Arnolds, K. L., & Lozupone, C. (2016) · PubMed Central · Cited by 33 · see citing works
Fang, T., Liu, G., Cao, W., Wu, X., Jia, G., Zhao, H. Y., Chen, X., Wu, C., & Wang, J. (2016) · RSC Advances · doi:10.1039/c6ra05361k · Cited by 32 · see citing works
Polyamines in Human and Rat Milk Influence Intestinal Cell Growth In Vitro
Capano, G., Bloch, K. J., Carter, E. A., Dascoli, J. A., Schoenfeld, D., & Harmatz, P. (1998) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1998.tb01255.x · Cited by 31 · see citing works
Harada, E., Hashimoto, Y., & Syuto, B. (1994) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(94)90208-9 · Cited by 31 · see citing works
Kaouass, M., Deloyer, P., Gouders, I., Peulen, O., & Dandrifosse, G. (1997) · Endocrine · doi:10.1007/bf02738963 · Cited by 30 · see citing works
Kaouass, M., Deloyer, P., Wéry, I., & Dandrifosse, G. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02088570 · Cited by 29 · see citing works
Buts, J., Keyser, N. D., Romain, N., Dandrifosse, G., Sokal, E. M., & Nsengiyumva, T. (1994) · Gastroenterology · doi:10.1016/s0016-5085(94)94279-x · Cited by 28 · see citing works
Self-citationButs, J., Stilmant, C., Bernasconi, P., Neirinck, C., & Keyser, N. D. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802308862 · Cited by 27 · see citing works
Self-citationPeulen, O., Pirlet, C., Klimek, M., Goffinet, G., & Dandrifosse, G. (1998) · Archives of Physiology and Biochemistry · doi:10.1076/apab.106.1.46.4392 · Cited by 27 · see citing works
Gréco, S., Niepceron, E., Hugueny, I., George, P., Louisot, P., & Biol, M.-C. (2001) · Journal of Nutrition · doi:10.1093/jn/131.7.1890 · Cited by 27 · see citing works
Christophersen, O. A. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.14787 · Cited by 26 · see citing works
Polyamines in Goat's Colostrum and Milk
Płoszaj, T., Ryniewicz, Z., & Motyl, T. (1997) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(97)00018-7 · Cited by 26 · see citing works
Effect of spermine administration on pancreatic maturation in unweaned rats
Romain, N., Gesell, M. S., Leroy, O., Forget, P. P., Dandrifosse, G., & Luk, G. D. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(98)10040-5 · Cited by 22 · see citing works
Intestinal maturation induced by spermine in young animals
Peulen, O., Deloyer, P., Grandfils, C., Loret, S., & Dandrifosse, G. (2000) · Livestock Production Science · doi:10.1016/s0301-6226(00)00218-9 · Cited by 22 · see citing works
Immunoglobulin Transport and Immunoglobulin Receptors
Baker, K., Blumberg, R. S., & Kaetzel, C. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00019-7 · Cited by 22 · see citing works
Dorhout, B., Faassen, A. V., van Beusekom, C. M., Kingma, A. W., de Hoog, E., Nagel, G. T., Karrenbeld, A., Boersma, E. R., & Muskiet, F. A. J. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970180 · Cited by 22 · see citing works
Buts, J., Duranton, B., Keyser, N. D., Sokal, E. M., Maernhout, A.-S., Raul, F., & Marandi, S. (1998) · Pediatric Research · doi:10.1203/00006450-199805000-00005 · Cited by 22 · see citing works
Self-citationIntestinal effects of long‐lasting spermine ingestion by suckling rats
Deloyer, P., Peulen, O., & Dandrifosse, G. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031583 · Cited by 21 · see citing works
Up-to-date clinical and experimental basis for the use of probiotics
Penna, F. J., Filho, L. A. P., Calçado, A. C., Junior, H. R., & Nicoli, J. R. (2000) · Jornal de Pediatria · doi:10.2223/jped.155 · Cited by 21 · see citing works
Bacteria and yeasts in the treatment of acute and chronic infectious diarrhea. Part I. Bacteria
Vandenplas, Y. (1999) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1999.tb00148.x · Cited by 21 · see citing works
Intestinal Microbial Metabolites in Ankylosing Spondylitis
Scalise, G., Ciancio, A., Mauro, D., & Ciccia, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153354 · Cited by 23 · see citing works
Matsumoto, M., & Kurihara, S. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.011 · Cited by 20 · see citing works
Oral administration of spermine advances intestinal maturation in sucking piglets
Cheng, Z., Li, D. F., Xing, J. J., Guo, X. Y., & Li, Z. J. (2006) · Animal Science · doi:10.1079/asc200690 · Cited by 19 · see citing works
Exogenous Spermine Induces Maturation of the Liver in Suckling Rats
Wéry, I., Kaouass, M., Deloyer, P., Buts, J., Barbason, H., & Dandrifosse, G. (1996) · Hepatology · doi:10.1002/hep.510240537 · Cited by 19 · see citing works
Self-citationCorrelation between methotrexate-induced intestinal damage and decrease in polyamine content
Gao, F., Tomitori, H., Igarashi, K., & Horie, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02241-5 · Cited by 19 · see citing works
Fecal Polyamine Concentration in Children with and without Nutrient Malabsorption
Forget, P., Sinaasappel, M., Bouquet, J., Deutz, N. E. P., & Smeets, C. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199703000-00010 · Cited by 19 · see citing works
Enhancement of lysozyme stability and activity by polyamines
Powroznik, B., Gharbi, M., Dandrifosse, G., & Peulen, O. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.009 · Cited by 17 · see citing works
Properties of Evidence-Based Probiotics for Human Health
McFarland, L. V., & Elmer, G. W. (2005) · CRC Press eBooks · doi:10.1201/9781420027570.ch5 · Cited by 17 · see citing works
Spermine-Induced Maturation in Wistar Rat Intestine: A Cytokine-Dependent Mechanism
Peulen, O., & Dandrifosse, G. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2004.tb12214.x · Cited by 17 · see citing works
Molecular Genetics and Probiotic Mechanisms of Saccharomyces cerevisiae var. boulardii
Ting, T., Lee, W.-J., & Goh, H. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10634-y · Cited by 16 · see citing works
Abril, A. G., Villa, T., Sánchez-Pérez, Á., Notario, V., & Carrera, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214333 · Cited by 16 · see citing works
Hong, L., Huang, Y., Han, J., Li, S., Zhang, L., Jiang, S., Zhou, Q., Cao, X., Yu, W., Yang, Y., et al. (2023) · Nutrients · doi:10.3390/nu15224849 · Cited by 15 · see citing works
Slezak, K., Hanske, L., Loh, G., & Blaut, M. (2013) · Beneficial Microbes · doi:10.3920/bm2012.0047 · Cited by 15 · see citing works
Implicaciones de las poliaminas en la salud infantil
Ruiz‐Cano, D. (2012) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2012.244 · Cited by 14 · see citing works
Peulen, O., Gharbi, M., Powroznik, B., & Dandrifosse, G. (2004) · Biochimie · doi:10.1016/j.biochi.2004.06.002 · Cited by 14 · see citing works
Gréco, S., Hugueny, I., GEORGE, P., PERRIN, P., Louisot, P., & Biol, M.-C. (1999) · Biochemical Journal · doi:10.1042/bj3450069 · Cited by 14 · see citing works
Mechanisms of Action of Biotherapeutic Agents
Buts, J. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-711-6_2 · Cited by 13 · see citing works
Self-citationFasting Gastric Fluid and Fecal Polyamine Concentrations in Premature Infants
Forget, P. P., Degraeuwe, P. L. J., Smeets, C., & Deutz, N. E. P. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1997.tb00448.x · Cited by 13 · see citing works
Peulen, O., & Dandrifosse, G. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005451928488 · Cited by 12 · see citing works
Wild, G., Searles, L. E., Koski, K. G., Drozdowski, L. A., Begum-Hasan, J., & Thomson, A. B. R. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00077.2006 · Cited by 11 · see citing works
Study and characterization of intestinal yeasts of mullet (Mugil spp.) for potential probiotic use
Laconi, S., & Pompei, R. (2007) · UNICA IRIS Institutional Research Information System (University of Cagliari) · Cited by 11 · see citing works
Chen, X., Yang, Z., Hu, H., Duan, W., Wang, A., Dong, Y., Gao, W., Deng, S., Cheng, B., Li, J., et al. (2019) · Current Protein and Peptide Science · doi:10.2174/1389203720666190125101834 · Cited by 10 · see citing works
- Authors
- Buts, J.-P., De Keyser, N., Kolanowski, J., Sokal, E., & Van Hoof, F.
- Affiliations
- UCLouvain (BE)
- ORCID
- Sokal, Etienne
- Venue
- Digestive Diseases and Sciences
- Published
- 1993-06
- Volume
- 38
- Issue
- 6
- Pages
- 1091-1098
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W2026258399
- Cited by
- 137
- References
- 32
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 5 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 2
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- intestinal maturation, small intestine, polyamines, spermine, villus cells, crypt cells, lactase, sucrase, maltase, aminopeptidase, secretory IgA, ornithine decarboxylase, difluoromethylornithine, suckling rats, weaning, dietary polyamines
- MeSH terms
- Animals, Animals, Suckling, Diet, Dose-Response Relationship, Drug, Intestinal Mucosa, Intestine, Small, Microvilli, Ornithine Decarboxylase, Polyamines, Secretory Component, Sodium Chloride, Spermine, Weaning, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
