Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development
Open accessAbstract
BACKGROUND: Polyamines are essential for cell growth. Dietary and probably gut bacterial derived polyamines contribute significantly to the polyamine body pool. AIMS: To evaluate the influence of dietary, luminal polyamines on growth and development of different gastrointestinal organs in normally growing rats. METHODS: Male suckling Wistar rats were randomly allocated to four treatment groups: polyamine deficient diet (PDD); PDD plus antibiotics (neomycin 2 g/kg and metronidazole 34 mg/kg); PDD plus polyamine supplementation at normal concentrations; or normal standard laboratory chow. After a six month feeding period 7-10 animals/group were sacrificed. RESULTS: No differences in body weight gain, food consumption, or general behaviour could be observed between the four groups of animals. Feeding of PDD alone or PDD plus antibiotics resulted in a highly significant decrease in organ weight, protein content, and DNA content in small intestinal and colonic mucosa whereas no alterations were found in the liver. CONCLUSIONS: Long term feeding of polyamine deficient diets resulted in a significant hypoplasia of small intestinal and colonic mucosa. Dietary, luminal polyamines are important local factors for growth and the development of small intestinal and colonic mucosa.
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Oral administration of polyamines enhances development and maintenance of the intestinal mucosa and resident immune cells.
“Oral administration of polyamines enhances the development and maintenance of the intestinal mucosa and resident immune cells (Buts et al., 1993; Dufour et al., 1988; Löser et al., 1999; Pérez-Cano et al., 2010).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Löser et al., 1999
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- Authors
- Löser, C., Eisel, A., Harms, D., & Fölsch, U. R.
- Affiliations
- aI Medical Department, Christian-Albrechts University, Schittenhelmstrasse 12, D-24105 Kiel, Germany, bInstitute of Pathology, Christian-Albrechts- University, Kiel, Germany
- Christian-Albrechts-Universität zu Kiel (DE)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1999-01-01
- Volume
- 44
- Issue
- 1
- Pages
- 12-16
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1760068
- OpenAlex
- W2164451296
- Cited by
- 155
- References
- 35
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 1 · 2023: 11 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- dietary polyamines, polyamine deficiency, small intestinal mucosa, colonic mucosa, mucosal growth, intestinal development, antibiotics, neomycin, metronidazole, gut microbiota, suckling rats
- MeSH terms
- Animals, Animal Nutritional Physiological Phenomena, Anti-Bacterial Agents, Body Weight, Colon, Diet, DNA, Intestinal Mucosa, Intestine, Small, Male, Polyamines, Rats, Wistar, Rats
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