Spermine and spermidine induce intestinal maturation in the rat
Abstract
In the present study, we aimed to induce precocious intestinal maturation in neonatal rats by the oral administration of polyamines. Groups of 5 rats received either saline, spermidine (10 mumol daily), or spermine (6 mumol daily) orally on the 12th, 13th, and 14th postnatal days. The rats were killed on the 15th postnatal day. After the small bowel was removed, a 1-cm distal ileal segment was removed for histologic examination and the remaining small bowel tissue was homogenized for further biochemical analysis. Polyamine administration was shown to induce structural and biochemical mucosal changes characteristic of postnatal maturation. Lactase, sucrase, and maltase specific activities (micromoles of substrate hydrolyzed per minute per gram of protein) were 80 +/- 10, 10 +/- 3, and 116 +/- 19 for the saline-treated rats; 51 +/- 7, 34 +/- 2, and 315 +/- 37 for the spermidine-treated rats; and 25 +/- 2, 46 +/- 5, and 419 +/- 63 for the spermine-treated rats, respectively. Similar results were obtained with rats, first treated with spermine (6 mumol) on the 7th postnatal day, receiving spermine (6 mumol) daily as described above and killed on the 10th postnatal day. Dose-response experiments performed as reported above in rats whose treatment began on the 12th postnatal day showed that the maturational effects of orally administered spermine are dose-dependent.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oral administration of polyamines enhances development and maintenance of the intestinal mucosa and resident immune cells.
“Oral administration of polyamines enhances the development and maintenance of the intestinal mucosa and resident immune cells (Buts et al., 1993; Dufour et al., 1988; Löser et al., 1999; Pérez-Cano et al., 2010).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Dufour et al., 1988
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
[99] Determination of nucleic acids in tissues by pentose analysis
Schneider, W. (1957) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(57)03442-4 · Cited by 1,890 · see citing works
Polyamines in rapid growth and cancer
Jänne, J. (1978) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(78)90015-x · Cited by 1,346 · see citing works
Assay of intestinal disaccharidases
Dahlqvist, A. (1968) · Analytical Biochemistry · doi:10.1016/0003-2697(68)90263-7 · Cited by 1,208 · see citing works
Russell, D., & Snyder, S. H. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.60.4.1420 · Cited by 747 · see citing works
Lux, G. D., Marton, L. J., & Baylin, S. B. (1980) · Science · doi:10.1126/science.6774420 · Cited by 346 · see citing works
Influence of Epidermal Growth Factor on the Development of Suckling Mouse Intestinal Mucosa
Malo, C., & Ménard, D. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80280-1 · Cited by 194 · see citing works
Klein, R. M., & McKenzie, J. C. (1983) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198302010-00004 · Cited by 72 · see citing works
Klein, R. M., & McKenzie, J. C. (1983) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198302020-00002 · Cited by 54 · see citing works
Malo, C., & Ménard, D. (2009) · Biology of the Neonate · doi:10.1159/000241712 · Cited by 49 · see citing works
Bontemps, J., Laschet, J. J., Dandrifosse, G., Cutsem, J. L. V., & Forget, P. (1984) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)84691-5 · Cited by 44 · see citing works
Developmental physiology: Hard-wired local triggering of intestinal enzyme expression
Diamond, J. M. (1986) · Nature · doi:10.1038/324408a0 · Cited by 23 · see citing works
Role of Milk-Borne Factors in Weaning and Intestinal Development
Henning, S. (2009) · Biology of the Neonate · doi:10.1159/000241561 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 14 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works
“Dufour et al., 1988; Levy et al., 2015; Pérez-Cano et al., 2010; Wang et al., 1997; Zhang et al., 1999 Gut Bacteria ty bile l Inhibit NF-kB-dependent transcription of proinflammatory genes in monocytes, macrophages, dendritic cells.”
BackgroundToxicological effects of dietary biogenic amines.
Ladero, V., Calles-Enriquez, M., Fernandez, M., & A. Alvarez, M. (2010) · Current Nutrition & Food Science · doi:10.2174/157340110791233256 · Cited by 538 · see citing works
Biological significance of dietary polyamines
Larqué, E., Molina, M. S., & Zamora, S. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.006 · Cited by 306 · see citing works
Tovar‐Ramírez, D., Zambonino‐Infante, J., Cahu, C. L., Gatesoupe, F.-J., Vázquez‐Juárez, R., & Lésel, R. (2002) · Aquaculture · doi:10.1016/s0044-8486(01)00650-0 · Cited by 277 · see citing works
Polyamines in food—implications for growth and health
Bardócz, S., Grant, G., Brown, D. S., Ralph, A., & Pusztai, A. J. (1993) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(93)90001-d · Cited by 234 · see citing works
Zhang, Y., Chen, R., Zhang, D., Qi, S., & Liu, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114295 · Cited by 210 · see citing works
Influence of dietary live yeast on European sea bass (Dicentrarchus labrax) larval development
Tovar‐Ramírez, D., Zambonino‐Infante, J., Cahu, C. L., Gatesoupe, F.-J., & Vázquez‐Juárez, R. (2004) · Aquaculture · doi:10.1016/j.aquaculture.2004.01.028 · Cited by 191 · see citing works
Immunonutrition: role of sulfur amino acids, related amino acids, and polyamines
Grimble, R. F., & GRIMBLE, G. K. (1998) · Nutrition · doi:10.1016/s0899-9007(98)80041-5 · Cited by 185 · see citing works
Goulet, O., Révillon, Y., Jan, D., Potter, S. D., Maurage, C., Lortat‐Jacob, S., Martelli, H., Nihoul‐Feketé, C., & Ricour, C. (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81032-7 · Cited by 175 · see citing works
Buts, J., Keyser, N. D., & Raedemaeker, L. D. (1994) · Pediatric Research · doi:10.1203/00006450-199410000-00019 · Cited by 175 · see citing works
Formation, Degradation, and Detoxification of Putrescine by Foodborne Bacteria: A Review
Wunderlichová, L., Buňková, L., Koutný, M., Jančová, P., & Buňka, F. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12099 · Cited by 166 · see citing works
Polyamines in foods: development of a food database
Ali, M. A., Poortvliet, E., Strömberg, R., & Yngve, A. (2011) · Food & Nutrition Research · doi:10.3402/fnr.v55i0.5572 · Cited by 163 · see citing works
Löser, C., Eisel, A., Harms, D., & Fölsch, U. R. (1999) · Gut · doi:10.1136/gut.44.1.12 · Cited by 155 · see citing works
Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract
Hébert, S., Cheng, S. X., & Geibel, J. P. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.10.015 · Cited by 140 · see citing works
Maturation of villus and crypt cell functions in rat small intestine: Role of dietary polyamines
Buts, J.-P., De Keyser, N., Kolanowski, J., Sokal, E., & Van Hoof, F. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01295726 · Cited by 137 · see citing works
Immunomodulation by food: impact on gut immunity and immune cell function
Hachimura, S., Totsuka, M., & Hosono, A. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1433017 · Cited by 131 · see citing works
The gut ecosystem and immune tolerance
Shao, T., Hsu, R., Rafizadeh, D. L., Wang, L., Bowlus, C. L., Kumar, N., Mishra, J., Timilsina, S., Ridgway, W. M., Gershwin, M. E., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103114 · Cited by 136 · see citing works
Matsumoto, M., & Benno, Y. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb03887.x · Cited by 129 · see citing works
The Functions and Roles of the Extracellular Ca2+–Sensing Receptor along the Gastrointestinal Tract
Geibel, J. P., & Hébert, S. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163128 · Cited by 125 · see citing works
Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets
Wu, G., Flynn, N. E., & Knabe, D. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.2.e395 · Cited by 115 · see citing works
Microbiota–Host Transgenomic Metabolism, Bioactive Molecules from the Inside
Turroni, S., Brigidi, P., Cavalli, A., & Candela, M. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00244 · Cited by 107 · see citing works
Polyamines in human and rat milk and in infant formulas
Pollack, P., Koldovska, O., & Nishioka, K. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.2.371 · Cited by 107 · see citing works
Cheng, S. X., Geibel, J. P., & Hébert, S. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.064 · Cited by 106 · see citing works
Effects of Saccharomyces boulardii on Intestinal Mucosa
Buts, J., & Keyser, N. D. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-9016-x · Cited by 104 · see citing works
Matsumoto, M., Aranami, A., Ishige, A., Watanabe, K., & Benno, Y. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02642.x · Cited by 98 · see citing works
Polyamines in human and animal milk
Löser, C. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002257 · Cited by 96 · see citing works
Polyamines and the Intestinal Tract
Seiler, N., & Raul, F. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701250016 · Cited by 93 · see citing works
Seiler, N. (1991) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-7139-6_3 · Cited by 87 · see citing works
Use of Yeasts as Probiotics in Fish Aquaculture
Navarrete, P., & Tovar‐Ramírez, D. (2014) · InTech eBooks · doi:10.5772/57196 · Cited by 81 · see citing works
Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats
Buts, J.-P., Keyser, N. D., Marandi, S., Hermans, D., Sokal, E. M., Chae, Y.-H. E., Lambotte, L., Chanteux, H., & Tulkens, P. M. (1999) · Gut · doi:10.1136/gut.45.1.89 · Cited by 79 · see citing works
Are milk polyamines preventive agents against food allergy?
Dandrifosse, G., Peulen, O., Khefif, N. E. E., Deloyer, P., Dandrifosse, A.-C., & Grandfils, C. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000100 · Cited by 78 · see citing works
Gut-microbiota derived bioactive metabolites and their functions in host physiology
Debnath, N., Kumar, R., Kumar, A., Mehta, P. K., & Yadav, A. K. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1989847 · Cited by 77 · see citing works
Tang, L., Cheng, C. Y., Sun, X., Pedicone, A. J., Mahamadzadeh, M., & Cheng, S. X. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00245 · Cited by 79 · see citing works
Homeostasis in the Gut Microbiota in Chronic Kidney Disease
Bhargava, S., Merckelbach, E., Noels, H., Vohra, A., & Jankowski, J. (2022) · Toxins · doi:10.3390/toxins14100648 · Cited by 77 · see citing works
Health promoting activities of probiotics
Tang, C., & Lu, Z. (2019) · Journal of Food Biochemistry · doi:10.1111/jfbc.12944 · Cited by 66 · see citing works
Intracellular Polyamine Levels of Intestinal Epithelial Cells in Inflammatory Bowel Disease
Weiß, T. S., Herfarth, H. H., Obermeier, F., Ouart, J., Vogl, D., Schölmerich, J., Jauch, K. ‐., & Rogler, G. (2004) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200409000-00006 · Cited by 66 · see citing works
Gut Microbiome Modulates Response to Cancer Immunotherapy
Khan, M. A. W., Ologun, G. O., Arora, R., McQuade, J. L., & Wargo, J. A. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06111-x · Cited by 66 · see citing works
Trophic Factors for the Gastrointestinal Tract
Carver, J. D., & Barness, L. A. (1996) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30242-2 · Cited by 65 · see citing works
Probiotics: The Scientific Evidence in the Context of Inflammatory Bowel Disease
Celiberto, L. S., Bedani, R., Rossi, E. A., & Cavallini, D. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.941457 · Cited by 64 · see citing works
Biogenic Amines Formation Mechanism and Determination Strategies: Future Challenges and Limitations
Ahmad, W., Mohammed, G. I., Al‐Eryani, D. A., Saigl, Z. M., Al-Youbi, A. O., Alwael, H., Bashammakh, A. S., O’Sullivan, C. K., & El-Shahawi, M. S. (2019) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2019.1657793 · Cited by 62 · see citing works
The role of the calcium-sensing receptor in gastrointestinal inflammation
Owen, J. L., Cheng, S. X., Ge, Y., Sahay, B., & Mohamadzadeh, M. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.10.040 · Cited by 61 · see citing works
Spermine Induces Maturation of the Immature Intestinal Immune System in Neonatal Mice
ter Steege, J. C. A., Buurman, W. A., & Forget, P. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199709000-00017 · Cited by 59 · see citing works
Gao, Y., He, L., Katsumi, H., Sakane, T., Fujita, T., & Yamamoto, A. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.061 · Cited by 57 · see citing works
Matsumoto, M., & Benno, Y. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.50464 · Cited by 56 · see citing works
Probiotic and nutritional effects of Debaryomyces hansenii on animals
Angulo, M., Reyes‐Becerril, M., Medina-Córdova, N., Tovar‐Ramírez, D., & Angulo, C. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10780-z · Cited by 56 · see citing works
Gastrointestinal immune and microbiome changes during parenteral nutrition
Pierre, J. F. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00321.2016 · Cited by 56 · see citing works
Dietary polyamines and non-neoplastic growth and disease
Deloyer, P., Peulen, O., & Dandrifosse, G. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200109000-00005 · Cited by 53 · see citing works
The Application of Metabolomics to Probiotic and Prebiotic Interventions in Human Clinical Studies
O’Connell, T. M. (2020) · Metabolites · doi:10.3390/metabo10030120 · Cited by 54 · see citing works
Biol, M.-C., & Louisot, P. (2003) · Biochimie · doi:10.1016/s0300-9084(03)00039-7 · Cited by 52 · see citing works
Polyamines in cow's and sow's milk
Motyl, T., Płoszaj, T., Wojtasik, A., Kukulska, W., & Podgurniak, M. (1995) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)00010-6 · Cited by 50 · see citing works
Péres, A., Cahu, C. L., & Zambonino‐Infante, J. (1997) · Fish Physiology and Biochemistry · doi:10.1023/a:1007786128254 · Cited by 50 · see citing works
Matsumoto, M., Kakizoe, K., & Benno, Y. (2007) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2007.tb03888.x · Cited by 49 · see citing works
Effects of dietary polyamines at physiologic doses in early-weaned piglets
Molina, M. S., Larqué, E., Torrella, F., Zamora, J. P., Lozano, T., Muñoz, A., & Zamora, S. (2009) · Nutrition · doi:10.1016/j.nut.2009.01.017 · Cited by 49 · see citing works
Role of calcium and other trace elements in the gastrointestinal physiology
Kirchhoff, P. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i20.3229 · Cited by 47 · see citing works
Boobis, A. R., Watelet, J., Whomsley, R., Benedetti, M. S., Demoly, P. M., & Tipton, K. F. (2009) · Drug Metabolism Reviews · doi:10.1080/10837450902891550 · Cited by 46 · see citing works
Health Benefits of Bovine Colostrum in Children and Adults
Buttar, H. S., Bagwe, S. M., Bhullar, S. K., & Kaur, G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809868-4.00001-7 · Cited by 44 · see citing works
Molecular aspects of the interaction of spermidine and α-chymotrypsin
Farhadian, S., Shareghi, B., Saboury, A. A., Babaheydari, A. K., Raisi, F., & Heidari, E. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.07.069 · Cited by 40 · see citing works
Ali, M. A., Poortvliet, E., Strömberg, R., & Yngve, A. (2011) · Food & Nutrition Research · doi:10.3402/fnr.v55i0.5455 · Cited by 40 · see citing works
Novel regulatory aspects of the extracellular Ca2+-sensing receptor, CaR
Riccardi, D., Finney, B. A., Wilkinson, W. J., & Kemp, P. J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0681-z · Cited by 38 · see citing works
Structural change of myoglobin structure after binding with spermidine
Eslami-Farsani, R., Farhadian, S., Shareghi, B., & Asgharzadeh, S. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.118691 · Cited by 37 · see citing works
Estimation of 24-Hour Polyamine Intake From Mature Human Milk
Dorhout, B., van Beusekom, C. M., Huisman, M., Kingma, A. W., de Hoog, E., Boersma, E. R., & Muskiet, F. A. J. (1996) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199610000-00015 · Cited by 36 · see citing works
Biol, M.-C., Gréco, S., George, P., Hugueny, I., & Louisot, P. (2002) · Pediatric Research · doi:10.1203/00006450-200205000-00014 · Cited by 35 · see citing works
Yao, Z., Cao, Y.-N., Peng, L., Yan, Z., & Zhao, G. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c05691 · Cited by 35 · see citing works
Enhancement of intestinal absorption of macromolecules by spermine in rats
Sugita, Y., Takao, K., Toyama, Y., & Shirahata, A. (2007) · Amino Acids · doi:10.1007/s00726-007-0532-1 · Cited by 33 · see citing works
Polyamines in Human and Rat Milk Influence Intestinal Cell Growth In Vitro
Capano, G., Bloch, K. J., Carter, E. A., Dascoli, J. A., Schoenfeld, D., & Harmatz, P. (1998) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.1998.tb01255.x · Cited by 31 · see citing works
Harada, E., Hashimoto, Y., & Syuto, B. (1994) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(94)90208-9 · Cited by 31 · see citing works
Peulen, O., Dewé, W., Dandrifosse, G., Henrotay, I., & Romain, N. (1998) · Public Health Nutrition · doi:10.1079/phn19980028 · Cited by 30 · see citing works
Kaouass, M., Deloyer, P., Gouders, I., Peulen, O., & Dandrifosse, G. (1997) · Endocrine · doi:10.1007/bf02738963 · Cited by 30 · see citing works
Kaouass, M., Deloyer, P., Wéry, I., & Dandrifosse, G. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02088570 · Cited by 29 · see citing works
Buts, J., Keyser, N. D., Romain, N., Dandrifosse, G., Sokal, E. M., & Nsengiyumva, T. (1994) · Gastroenterology · doi:10.1016/s0016-5085(94)94279-x · Cited by 28 · see citing works
Huber, M., & Poulin, R. (1995) · PubMed · Cited by 27 · see citing works
Putrescine is involved in the vitamin D action in chick intestine
Shinki, T., Tanaka, H., Takito, J., Yamaguchi, A., Nakamura, Y., Yoshiki, S., & Suda, T. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90590-h · Cited by 27 · see citing works
Spermine affects intestinal in vitro permeability to different-sized molecules in rats
Osman, N., Weström, B. R., Wang, Q., Persson, L., & Karlsson, B. W. (1998) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)00042-5 · Cited by 27 · see citing works
Peulen, O., Pirlet, C., Klimek, M., Goffinet, G., & Dandrifosse, G. (1998) · Archives of Physiology and Biochemistry · doi:10.1076/apab.106.1.46.4392 · Cited by 27 · see citing works
Gréco, S., Niepceron, E., Hugueny, I., George, P., Louisot, P., & Biol, M.-C. (2001) · Journal of Nutrition · doi:10.1093/jn/131.7.1890 · Cited by 27 · see citing works
Polysaccharides to postbiotics: Nurturing bone health via modulating “gut-immune axis”
Yadav, S., Sapra, L., & Srivastava, R. K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134655 · Cited by 27 · see citing works
Polyamines in Goat's Colostrum and Milk
Płoszaj, T., Ryniewicz, Z., & Motyl, T. (1997) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(97)00018-7 · Cited by 26 · see citing works
Cellular Energy Metabolism and Regulation
Kelly, J. M., Summers, M., Park, H. S., Milligan, L. P., & McBride, B. W. (1991) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(91)78215-5 · Cited by 24 · see citing works
Reversibility of spermine-induced intestinal maturation in the rat
Georges, P., Dandrifosse, G., Vermesse, F., Forget, P. P., Deloyer, P., & Romain, N. (1990) · Digestive Diseases and Sciences · doi:10.1007/bf01540571 · Cited by 24 · see citing works
Liu, G., Fang, T., Yan, T., Jia, G., Zhao, H. Y., Huang, Z., Chen, X., Wang, J., & Bai, X. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500882t · Cited by 23 · see citing works
Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract
Mukonowenzou, N. C., Adeshina, K. A., Donaldson, J., Ibrahim, K. G., Usman, D., & Erlwanger, K. H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.684464 · Cited by 22 · see citing works
Effect of spermine administration on pancreatic maturation in unweaned rats
Romain, N., Gesell, M. S., Leroy, O., Forget, P. P., Dandrifosse, G., & Luk, G. D. (1998) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/s1095-6433(98)10040-5 · Cited by 22 · see citing works
Intestinal maturation induced by spermine in young animals
Peulen, O., Deloyer, P., Grandfils, C., Loret, S., & Dandrifosse, G. (2000) · Livestock Production Science · doi:10.1016/s0301-6226(00)00218-9 · Cited by 22 · see citing works
Dorhout, B., Faassen, A. V., van Beusekom, C. M., Kingma, A. W., de Hoog, E., Nagel, G. T., Karrenbeld, A., Boersma, E. R., & Muskiet, F. A. J. (1997) · British Journal Of Nutrition · doi:10.1079/bjn19970180 · Cited by 22 · see citing works
Amines protect in vitro the celiac small intestine from the damaging activity of gliadin peptides
Auricchio, S., de Ritis, G., Vincenzi, M. D., Gentile, V., Maiuri, L., Mancini, E., Porta, R., & Raia, V. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90473-e · Cited by 22 · see citing works
Buts, J., Duranton, B., Keyser, N. D., Sokal, E. M., Maernhout, A.-S., Raul, F., & Marandi, S. (1998) · Pediatric Research · doi:10.1203/00006450-199805000-00005 · Cited by 22 · see citing works
Intestinal effects of long‐lasting spermine ingestion by suckling rats
Deloyer, P., Peulen, O., & Dandrifosse, G. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.031583 · Cited by 21 · see citing works
Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling
Kelly, D., King, T. P., Brown, D., & McFadyen, M. C. E. (1991) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19910107 · Cited by 21 · see citing works
Liu, G., Yan, T., Fang, T., Jia, G., Chen, X., Zhao, H. Y., Wang, J., & Wu, C. (2015) · RSC Advances · doi:10.1039/c5ra01507c · Cited by 20 · see citing works
Matsumoto, M., & Kurihara, S. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.06.011 · Cited by 20 · see citing works
Moderate Folate Deficiency Influences Polyamine Synthesis in Rats
Sun, D., Stephen, A. M., & Wollin, A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2632 · Cited by 20 · see citing works
Oral administration of spermine advances intestinal maturation in sucking piglets
Cheng, Z., Li, D. F., Xing, J. J., Guo, X. Y., & Li, Z. J. (2006) · Animal Science · doi:10.1079/asc200690 · Cited by 19 · see citing works
Exogenous Spermine Induces Maturation of the Liver in Suckling Rats
Wéry, I., Kaouass, M., Deloyer, P., Buts, J., Barbason, H., & Dandrifosse, G. (1996) · Hepatology · doi:10.1002/hep.510240537 · Cited by 19 · see citing works
Fecal Polyamine Concentration in Children with and without Nutrient Malabsorption
Forget, P., Sinaasappel, M., Bouquet, J., Deutz, N. E. P., & Smeets, C. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199703000-00010 · Cited by 19 · see citing works
Polyamine metabolism of enterocyte-like Caco-2 cells after exposure to Phaseolus vulgaris lectin.
Koninkx, J. F. J. G., Brown, D. S., Kok, W., Hendriks, H., Pusztai, A. J., & Bardócz, S. (1996) · Gut · doi:10.1136/gut.38.1.47 · Cited by 19 · see citing works
Microbiota Signals during the Neonatal Period Forge Life-Long Immune Responses
Phillips-Farfán, B. V., Gómez‐Chávez, F., Medina-Torres, E. A., Vargas-Villavicencio, J. A., Carvajal, K., & Camacho, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158162 · Cited by 19 · see citing works
The effects of polyamines on human colonic mucosal function
Rogers, A. C., McDermott, F. D., Mohan, H. M., O’Connell, P. R., Winter, D. C., & Baird, A. W. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.07.006 · Cited by 18 · see citing works
Postnatal intestinal development
Kelly, D., Begbie, R., & King, T. P. (1992) · BSAP Occasional Publication · doi:10.1017/s0263967x00004092 · Cited by 18 · see citing works
Wéry, I., Deloyer, P., & Dandrifosse, G. (1996) · Archives of Physiology and Biochemistry · doi:10.1076/apab.104.2.163.12886 · Cited by 18 · see citing works
- Authors
- Dufour, C., Dandrifosse, G., Forget, P., Vermesse, F., Romain, N., & Lepoint, P.
- Affiliations
- University of Liège (BE)
- ORCID
- Romain, N.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1988-07
- Volume
- 95
- Issue
- 1
- Pages
- 112-116
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2171807112
- Cited by
- 158
- References
- 14
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- spermine, spermidine, polyamines, intestinal maturation, postnatal development, ileum, lactase, sucrase, maltase, brush border enzymes, neonatal rats, dose-response relationship
- MeSH terms
- Age Factors, Animals, Disaccharidases, DNA, Dose-Response Relationship, Drug, Intestinal Mucosa, Intestines, Proteins, Putrescine, Rats, Inbred Strains, Spermidine, Spermine, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
