Pharmacokinetics of fluconazole in pediatric patients
Abstract
The pharmacokinetic properties of fluconazole were studied in more than 100 pediatric patients, including 12 premature neonates. The volume of distribution and the rate of elimination differed significantly from the values reported for adults. The volume of distribution varied with age, being greatest during the neonatal period (1.18 to 2.25 l/kg) and decreasing by young adulthood to a value similar to that reported for adults (0.7 l/kg). With the exception of neonates, fluconazole clearance was generally more rapid in children than in adults, with a mean plasma elimination half-life of just over 20 h for all pediatric age groups. In neonates, fluconazole was eliminated slowly, with a mean elimination half-life of 88.6 h at birth, 67.5 h approximately one week later and 55.2 approximately two weeks after birth. Fluconazole appeared to be well absorbed from the gastrointestinal tract. These pharmacokinetic results, taken in conjunction with the corresponding data for adults, provide a sound basis for establishing appropriate fluconazole dosage recommendations for pediatric patients.
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The pharmacokinetics of fluconazole vary with age.
“The pharmacokinetics of fluconazole vary with age [89][90][91][92].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [90]
The pharmacological properties of fluconazole vary with neonatal age.
“the pharmacological properties of fluconazole vary with neonatal age, making the choice of dosage somewhat difficult [86,90,91].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [90]
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- Authors
- Brammer, K. W., & Coates, P. E.
- Affiliations
- Pfizer (United Kingdom) (GB)
- Venue
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 1994-04
- Volume
- 13
- Issue
- 4
- Pages
- 325-329
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W2074334239
- Cited by
- 139
- References
- 12
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 9 · 2012: 9
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Keywords
- fluconazole, pharmacokinetics, pediatric patients, neonates, preterm infants, volume of distribution, drug clearance, elimination half-life, age differences, gastrointestinal absorption, dosage recommendations, antifungal agents
- MeSH terms
- Administration, Oral, Adolescent, Aging, Body Weight, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Injections, Intravenous, Intestinal Absorption, Risk Factors, Fluconazole, Immunocompromised Host
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