CoChat
Sign Up
Cited by 31Pituitary Gland Disorders and TreatmentsTraumatic Brain Injury and Neurovascular DisturbancesGrowth Hormone and Insulin-like Growth Factors

Prospective investigation of anterior pituitary function in the acute phase and 12 months after pediatric traumatic brain injury

Ulutabanca, Halil, Hatipoglu, Nihal, Tanriverdi, Fatih, Gökoglu, Abdülkerim, Keskin, Mehmet, Selcuklu, Ahmet, Kurtoglu, Selim, Kelestimur, Fahrettin·2014·Child s Nervous System
DOI 10.1007/s00381-013-2334-y
Open this paper in CoChat — free account

Abstract

Purpose Although head trauma is common in childhood, there is no enough prospective study investigating both acute phase and 12 months after injury. Therefore, a prospective clinical trial was planned to evaluate the pituitary function in childhood in the acute and chronic phase after traumatic brain injury (TBI).Methods Forty-one children (27 boys and 14 girls, mean age 7 ± 4.3), who were admitted to neurosurgery intensive care unit due to head trauma, were included. Twenty-one (51.2 %) patients had mild, 10 (24.4 %) had moderate, and 10 (24.4 %) had severe TBI. Twenty-two of them were reevaluated 12 months after TBI. Basal pituitary hormone levels were measured during acute (first 24 h) and chronic phase of TBI. Additionally, in the chronic phase, GHRH-arginine test was used for the diagnosis of growth hormone (GH) deficiency.Results In the acute phase, 10 patients (24.4 %) had ACTH deficiency, and the overall 44.3 % of patients had at least one pituitary hormone dysfunction. All the pituitary hormone deficiencies during the acute phase were recovered after 12 months. Two patients (9.1 %) had new-onset GH deficiency in the chronic phase, and in one of them, ACTH deficiency was also present.Conclusions Present prospective data clearly demonstrated that most of the hormonal changes in the early acute phase were transient, suggesting an adaptive response, and these changes did not predict the hormone deficiencies after 1 year. In the chronic phase, although GH deficiency was present, the frequency of TBI-induced hypopituitarism was clearly lower than the adult patients.

Integrity signals

Registry

Crossref · 10.1007/s00381-013-2334-y

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Ulutabanca et al. reported pituitary hormone disturbances in 44% out of 41 pediatric patients during the acute phase following TBI, with deficiencies in ACTH in 24% of cases.

    “Ulutabanca et al. reported pituitary hormone disturbances in 44% out of 41 pediatric patients during the acute phase following TBI, with deficiencies in ACTH in 24% of cases [52].”

    From Endocrine Dysfunctions After Pediatric Traumatic Brain Injury: Present Insights and Future Directions (2025) · cites this paper as [52]

  • Acute AI after TBI does not correlate with chronic AI in adults or children.

    “Notably, acute AI after TBI does not correlate with chronic AI in adults [3, 4, 9, 10] or children [11].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [11]

  • Deficiencies termed 'chronic' after 3 months do not always persist and may improve over time.

    “While deficiencies are often termed 'chronic' after 3 months, they do not always persist [17]. Deficiencies, even those diagnosed in the chronic post-TBI period, may improve over time [11, 18-21].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [11]

  • Acute pituitary dysfunction does not correlate with chronic pituitary deficiencies.

    “Even acute pituitary dysfunction-abnormal findings in the first months after injury-has been shown not to correlate with chronic pituitary deficiencies [3, 4, 9-11].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [11]

  • Patients with normal IGF-1 levels can be diagnosed as having GHD on provocative testing.

    “Evaluation for growth hormone deficiency often requires GH stimulation; while IGF-1 was used as a screening test for years, it is now clear that patients with normal IGF-1 levels can be diagnosed as having GHD on provocative testing [11, 69, 70].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [11]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ulutabanca, H., Hatipoglu, N., Tanriverdi, F., Gökoglu, A., Keskin, M., Selcuklu, A., Kurtoglu, S., & Kelestimur, F.
Affiliations
Erciyes University (TR)
ORCID
Ulutabanca, Halil
Venue
Child s Nervous System
Publisher
Springer Science and Business Media LLC
Published
2013-12-10
Volume
30
Issue
6
Pages
1021-1028
ISSN
  • 0256-7040 (ISSN-L)
  • 1433-0350
DOI
10.1007/s00381-013-2334-y
OpenAlex
W2039414841
Cited by
31
References
69
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 4 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Child s Nervous System (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
pediatric traumatic brain injury, anterior pituitary function, hypopituitarism, ACTH deficiency, growth hormone deficiency, GHRH-arginine test, acute phase, chronic phase
MeSH terms
Acute Disease, Adrenocorticotropic Hormone, Anthropometry, Brain Injuries, Child, Child, Preschool, Female, Humans, Male, Pituitary Diseases, Pituitary Hormones, Anterior, Prospective Studies, Immunoradiometric Assay, Statistics, Nonparametric

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review