Lorazepam impairs perceptual integration of visual forms: A central effect
Abstract
Previous studies have shown a lorazepam effect on visual perception. We tested whether this impairment resulted from a peripheral effect induced by benzodiazepines. A first experiment showed that a single dose of lorazepam induces an oculomotor imbalance without impairing visual acuity or accommodation. In a second experiment, we tested whether the impairment induced by lorazepam on visual perception still occurred in monocular vision. Subjects matched incomplete forms controlled on the spacing and alignment of their local contour elements. A reference object was first displayed and followed by two laterally displayed objects, a target and a distractor. The distractor was the mirror-reversed version of the target. Performance was impaired in the lorazepam group when the reference was an incomplete form with a spacing of 10.8' or 22.2' of arc. These results were not correlated with sedation. They confirm that lorazepam has a central deleterious effect on visual perception. A post-hoc analysis also suggested that lorazepam-treated subjects used asymmetry in the stimuli as a compensatory strategy. This result is discussed in relation to previous hypotheses about the physiological mechanisms that determine the effects of lorazepam on visual perception.
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Giersch et al. have demonstrated effects of lorazepam and other benzodiazepines on GABA inhibitory activity on a visual closure task.
“Giersch et al. (85) have demonstrated effects of lorazepam and other benzodiazepines on GABA inhibitory activity on a visual closure task”
From Visual perception and its impairment in schizophrenia (2008) · cites this paper as [85]
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- Authors
- Giersch, A., Boucart, M., Speeg-Schatz, C., Muller-Kauffmann, F., & Danion, J. M.
- Affiliations
- Inserm (FR)
- Venue
- Psychopharmacology
- Published
- 1996-08
- Volume
- 126
- Issue
- 3
- Pages
- 260-270
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1967829416
- Cited by
- 28
- References
- 44
- Citations by year
- 2022: 1 · 2012: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- lorazepam, benzodiazepines, visual perception, perceptual integration, monocular vision, compensatory strategies, sedation
- MeSH terms
- Accommodation, Ocular, Adult, Double-Blind Method, Female, Form Perception, Humans, Lorazepam, Male, Anti-Anxiety Agents
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