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Cited by 96Memory Processes and InfluencesMemory and Neural MechanismsCognitive Functions and Memory

Lorazepam and diazepam effects on memory acquisition in priming tasks

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Vidailhet, Pierre, Danion, Jean-Marie, Kauffmann-Muller, Françoise, Grangé, Danielle, Giersch, Anne, Van Der Linden, Martial, Imbs, Jean-Louis·1994·Psychopharmacology
DOI 10.1007/bf02245083
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Abstract

Unlike diazepam, lorazepam has repeatedly been shown to impair perceptual priming as well as explicit memory. To determine whether this deleterious effect was due to an impairment in acquisition of information, 60 healthy volunteers were randomly assigned to five treatment groups (placebo, lorazepam 0.026 or 0.038 mg/kg, diazepam 0.2 or 0.3 mg/kg) and successively performed perceptual priming tasks and a free-recall task. Priming performance on information learned before or 2 h after drug administration, i.e. at the peak concentration of lorazepam, was assessed under the influence of the drugs, using a picture-fragment and a word-stem completion task. Free-recall performance was altered by both drugs. Lorazepam decreased priming performance when information was acquired after, but not before, drug administration, indicating that the drug alters the acquisition of information. Lorazepam also impaired the ability to identify fragmented pictures, but there was no evidence that this perceptual effect accounts for the priming impairment. Surprisingly, diazepam also decreased priming when information was acquired after drug administration, suggesting that, at least in certain circumstances, the two benzodiazepines may exert similar effects on priming measures.

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  • Although benzodiazepines generally affect memory, some studies show that effects differ depending on the benzodiazepine used.

    “Additionally, although BZDs are generally known to affect memory, some studies have shown that effects differ depending on the BZD used.”

    From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [178]

  • Lorazepam appears to impair both explicit and implicit memory.

    “Lorazepam appears to impair both explicit memory and implicit memory”

    From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [178]

  • Diazepam impairs explicit memory, but results regarding impairment of implicit memory by diazepam are mixed.

    “and although diazepam impairs explicit memory, results regarding impairment of implicit memory by diazepam are mixed (176-179).”

    From Benzodiazepines in epilepsy: Pharmacology and pharmacokinetics (2008) · cites this paper as [178]

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Research works printed but not linked: 2

  1. Bonebakker AE, Wolters G (1992) Implicit memory in Korsakoff patients after varying delays. Internat J Psychol 27:122 (Ab- stract)
  2. Cochran WG, Cox GM (1957) Experimental designs, 2nd edn. Wiley, New York Content A, Mousty R Radeau M (1990) Brulex une base de donn~es lexicales informatis6e pour le frangais 6crit et parl6. L'Ann~e Psychol 90:551-566

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Authors
Vidailhet, P., Danion, J.-M., Kauffmann-Muller, F., Grangé, D., Giersch, A., Van Der Linden, M., & Imbs, J.-L.
Affiliations
  • Hôpitaux Universitaires de Strasbourg (FR)
  • Centre National de la Recherche Scientifique (FR)
  • Université de Strasbourg (FR)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1994-07
Volume
115
Issue
3
Pages
397-406
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02245083
OpenAlex
W2064262645
Cited by
96
References
56
Citations by year
2024: 22 · 2019: 1 · 2015: 1
FWCI
2.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Funders
Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
lorazepam, diazepam, benzodiazepines, perceptual priming, memory acquisition, free recall, declarative memory, drug effects on learning, word stem completion
MeSH terms
Adult, Amnesia, Cognition, Diazepam, Double-Blind Method, Female, Humans, Hypnotics and Sedatives, Learning, Lorazepam, Male, Mental Processes, Mental Recall, Wechsler Scales

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