Relationship between stimulus amplitude, stimulus frequency and neural damage during electrical stimulation of sciatic nerve of cat
Abstract
The relation is investigated between stimulus frequency, stimulus pulse amplitude and the neural damage induced by continuous stimulation of the cat's sciatic nerve. The chronically implanted electrodes were pulsed continuously and the effects of the electrical stimulation were quantified as the amount of early axonal degeneration (EAD) present in the nerves seven days after the continuous stimulation. The primary effect of stimulating at 100 Hz rather than 50 Hz was to cause an increase in the slope of the plot of the amount of EAD versus stimulus amplitude, but the threshold stimulus for the induction of EAD also was slightly lower. There was a small amount of EAD in three of the nerves stimulated at 20 Hz, but there was no detectable correlation between the amount of EAD and the stimulus amplitude. This suggests that continuous electrical stimulation of peripheral nerves at a low frequency induce little or no neural damage, even if the stimulus amplitude is very high. A preliminary presentation of the results has been made elsewhere (Agnew et al., 1993).
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McCreery et al. found that for all tested degrees of fiber recruitment, a frequency of 20 Hz proved to be safe, whereas with increasing frequency (50 and 100 Hz) even pulses with smaller currents, and therefore only partial fiber recruitment, resulted in neural damage in cat sciatic nerve.
“For all tested degrees of fiber recruitment, a frequency of 20 Hz proved to be safe, whereas with increasing frequency (50 and 100 Hz) even pulses with smaller currents, and therefore only partial fiber recruitment, resulted in neural damage.”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [92]
A large part of the literature and of our knowledge about neural stimulation is based on animal studies mostly conducted in the 1980s and 1990s.
“Consequently, a large part of the literature and of our knowledge about neural stimulation is based on animal studies mostly conducted in the 1980s and 1990s [43–45, 62–64, 75, 92, 94, 96, 99, 100].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [92]
Maximal tolerated stimulation pulse frequencies vary for different neural structures as demonstrated in a number of publications including the relatively low stimulus frequency tolerance of motor nerves when compared to examples in the central nervous system.
“Maximal tolerated stimulation pulse frequencies vary for different neural structures as demonstrated in a number of publications including the relatively low stimulus frequency tolerance of motor nerves when compared to examples in the central nervous system [44, 65, 92].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [92]
The only available study about the allowable stimulation frequency in chronic peripheral nerve stimulation suggests that 50 Hz is a maximal limit.
“The only available study about the allowable stimulation frequency in chronic peripheral nerve stimulation suggests that 50 Hz is a maximal limit.”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [92]
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Self-citationThe Effect of Stimulus Parameters on the Recruitment Characteristics of Direct Nerve Stimulation
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Self-citationThe response of the myelinated nerve fiber to short duration biphasic stimulating currents
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Tissue damage thresholds during therapeutic electrical stimulation
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- Authors
- McCreery, D. B., Agnew, W. F., Yuen, T. G. H., & Bullara, L. A.
- Affiliations
- Huntington Medical Research Institutes (US)
- ORCID
- McCreery, D. B.
- Venue
- Medical & Biological Engineering & Computing
- Published
- 1995-05
- Volume
- 33
- Issue
- 3
- Pages
- 426-429
- ISSN
- 0140-0118 (ISSN-L)
- 1741-0444
- OpenAlex
- W2015457931
- Cited by
- 95
- References
- 7
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 9 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Medical & Biological Engineering & Computing (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (N01-NS-2-2323)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- electrical stimulation, sciatic nerve, axonal degeneration, stimulation frequency, stimulus amplitude, peripheral nerve injury, chronic stimulation, nerve regeneration, cats
- MeSH terms
- Animals, Cats, Electric Stimulation, Electricity, Sciatic Nerve
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