The Effect of Stimulus Parameters on the Recruitment Characteristics of Direct Nerve Stimulation
Abstract
The effect of stimulus parameters on the recruitment characteristics of motor nerve was studied for regulated current monophasic and balanced charge biphasic stimuli. Results of a nerve model investigation indicated that the threshold difference between different diameter nerve fibers would be dependent on pulse width, the choice between monophasic and biphasic stimuli, and the delay between the primary cathodic and secondary anodic pulses. Threshold difference increased with decreasing pulse width, the greatest effects evident for pulses less than 100 μs. Biphasic stimulation with no delay between pulses provided greater threshold separation than monophasic stimulation or biphasic stimulation with delay. Animal experiments, in which recruitment in a nerve trunk composed of mixed diameter nerve fibers was examined, showed a decrease in recruitment slope with a decrease in pulse width and with the use of a biphasic, zero delay pulse. These results were examined through muscle force measurements using both a metal loop electrode encircling the nerve trunk and a nerve cuff electrode, i. e., a loop electrode in an insulating tube.
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Modification of pulse duration can allow for spatial selectivity and steeper recruitment curves.
“Modification of the pulse duration can allow for spatial selectivity and steeper recruitment curves [75].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [75]
Safety of acute and chronic peripheral nerve stimulation has been demonstrated in animals and humans for pulse durations from 1 to 300 μs for motor function and sensory feedback.
“The safety of acute and chronic peripheral nerve stimulation has been demonstrated in animals and humans for pulse durations from 1 to 300 μs for the purpose of motor function and sensory feedback [43, 44, 75]”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [75]
Gorman and Mortimer confirmed these results, observing steeper recruitment curves and lower threshold currents with increasing interphase delay.
“Gorman and Mortimer confirmed these results, observing steeper recruitment curves (stimulus current vs normalized force) and lower threshold currents with increasing interphase delay [75].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [75]
A large part of the literature and of our knowledge about neural stimulation is based on animal studies mostly conducted in the 1980s and 1990s.
“Consequently, a large part of the literature and of our knowledge about neural stimulation is based on animal studies mostly conducted in the 1980s and 1990s [43–45, 62–64, 75, 92, 94, 96, 99, 100].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [75]
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- Authors
- Gorman, P. H., & Mortimer, J. T.
- Affiliations
- Case Western Reserve University (US)
- Venue
- IEEE Transactions on Biomedical Engineering
- Published
- 1983-07
- Volume
- BME-30
- Issue
- 7
- Pages
- 407-414
- ISSN
- 0018-9294 (ISSN-L)
- 1558-2531
- OpenAlex
- W2068982338
- Cited by
- 313
- References
- 19
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 14 · 2022: 23 · 2021: 15 · 2020: 13 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 6 · 2015: 11 · 2014: 12 · 2013: 5 · 2012: 8
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- stimulus parameters, pulse duration, biphasic stimulation, cuff electrodes, muscle force measurement, nerve trunks
- MeSH terms
- Animals, Cats, Electric Stimulation, Electric Stimulation Therapy, Muscles, Nerve Fibers, Neural Conduction, Paralysis, Recruitment, Neurophysiological
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