Echocardiography in the evaluation of patients with syncope
Abstract
Objective Echocardiography is frequently used as a screening test for cardiac disease in patients with syncope despite the lack of published data describing its utility in this regard. The goal of the study was to examine the frequency with which echocardiography was used in the evaluation of patients admitted to one medical center because of syncope and to examine the diagnostic information, over and above that provided by the initial history, physical examination, and electrocardiography, contributed by the echocardiogram.Design A retrospective review was performed of all patients admitted to the study institution because of syncope over a seven-month period.Setting University teaching hospital in an urban setting of 2.5 million population.Patients/participants One hundred twenty-eight patients were identified: 47 men and 81 women (average age 67 +/- 17 years). Patients for whom syncope was of a known cause, those with near-syncope or vertigo, those with clinically obvious seizure, or those referred for electrophysiologic testing were excluded, leaving 128 patients for analysis. Details from the admission history, physical examination, and electrocardiography for each patient were recorded. The results of all other diagnostic tests ordered to evaluate syncope were recorded along with any consultations obtained. The cause of syncope was assigned by examining all physicians' notes and test results and with the use of previously published diagnostic criteria as guidelines.Measurements and main results Ninety percent of the patients underwent cardiac testing other than routine electrocardiography and continuous telemetry monitoring while in the hospital. An echocardiogram was obtained for 64% of the patients and did not reveal an unsuspected cause for syncope in any case. The echocardiogram was normal for 52% of the patients undergoing the test. Echocardiograms of patients with syncope and no clinical evidence of heart disease by history, physical examination, or electrocardiography either were normal (63%) or provided no useful additional information for arriving at a diagnosis (37%). Nearly half (46%) of the patients undergoing echocardiography fit this clinical profile. Among the patients for whom cardiac disease was suspected after history, physical examination, or electrocardiography, the echocardiogram confirmed the suspected diagnosis for 48% and served to rule out a suspected diagnosis for the remaining 52%. In no instance did echocardiography provide an unsuspected cause for syncope. The history, physical examination, and initial electrocardiography provided sufficient information to permit a diagnosis to be made for 37 of the 48 patients (77%) for whom a cause of syncope was ultimately determined.Conclusion Echocardiography was frequently used in the evaluation of patients admitted to the hospital because of syncope of unclear cause. For patients without suspected cardiac disease after history, physical examination, and electrocardiography, the echocardiogram did not appear to provide additional useful information, suggesting that syncope alone may not be an indication for echocardiography. For patients with suspected heart disease, echocardiography served to confirm or refute the suspicious in equal proportions. These data provide an objective basis to prospectively define the optimal role of echocardiography in the evaluation of patients with syncope.
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For patients with suspected heart disease, echocardiography plays an important role in risk stratification.
“and plays an important role in risk stratification. 235,236”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [235]
For patients with suspected heart disease, echocardiography serves to confirm or refute the suspicions in equal proportions.
“For patients with suspected heart disease, echocardiography serves to confirm or refute the suspicions in equal proportions”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [235]
Cites
ACC/AHA Guidelines for the Clinical Application of Echocardiography
Cheitlin, M. D., Alpert, J. S., Armstrong, W. F., Aurigemma, G. P., Beller, G., Bierman, F. Z., Davidson, T. W., Davis, J. L., Douglas, P. S., Gillam, L. D., et al. (1997) · Circulation · doi:10.1161/01.cir.95.6.1686 · Cited by 843 · see citing works
A Prospective Evaluation and Follow-up of Patients with Syncope
Kapoor, W. N., Karpf, M., Wieand, S., Peterson, J. R., & Levey, G. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307283090401 · Cited by 779 · see citing works
Evaluation and outcome of emergency room patients with transient loss of consciousness
Day, S. C., Cook, E. F., Funkenstein, H., & Goldman, L. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90913-5 · Cited by 587 · see citing works
Evaluation and Outcome of Patients with Syncope
KAPOOR, W. N. (1990) · Medicine · doi:10.1097/00005792-199005000-00004 · Cited by 539 · see citing works
Epidemiologic features of isolated syncope: the Framingham Study.
Savage, D. D., Corwin, L., McGee, D., Kannel, W. B., & Wolf, P. A. (1985) · Stroke · doi:10.1161/01.str.16.4.626 · Cited by 361 · see citing works
Patients With Syncope Admitted to Medical Intensive Care Units
Silverstein, M. D. (1982) · JAMA · doi:10.1001/jama.1982.03330100023024 · Cited by 251 · see citing works
Prospective evaluation of syncope
Martin, G. J., Adams, S. L., Martin, H. G., Mathews, J., Zull, D., & Scanlon, P. J. (1984) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(84)80511-9 · Cited by 239 · see citing works
Syncope in an Elderly, Institutionalised Population: Prevalence, Incidence, and Associated Risk
LIPSITZ, L. A., WEI, J. Y., & ROWE, J. W. (1985) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a067852 · Cited by 218 · see citing works
Kapoor, W. N., Snustad, D. G., Peterson, J. R., Wieand, H. S., Cha, R., & Karpf, M. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90716-3 · Cited by 202 · see citing works
Diagnostic evaluation of syncope
Kapoor, W. N. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90511-u · Cited by 175 · see citing works
Evaluation of prognostic classifications for patients with syncope
Eagle, K. A., Black, H. R., Cook, E. F., & Goldman, L. (1985) · The American Journal of Medicine · doi:10.1016/0002-9343(85)90032-4 · Cited by 134 · see citing works
Lipsitz, L. A., Pluchino, F. C., Wei, J. Y., & Rowe, J. W. (1986) · Journal of Chronic Diseases · doi:10.1016/0021-9681(86)90187-6 · Cited by 133 · see citing works
The economic burden of unrecognized vasodepressor syncope
Calkins, H. G., Byrne, M., El-Atassi, R., Kalbfleisch, S., Langberg, J. J., & Morady, F. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90329-n · Cited by 100 · see citing works
Clinical utility of transthoracic two-dimensional and Doppler echocardiography
Krumholz, H. M., Douglas, P. S., Goldman, L., et al. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90552-5 · Cited by 68 · see citing works
Bachinsky, W., Linzer, M., Weld, L. H., & Estes, N. A. M. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90861-r · Cited by 65 · see citing works
Prospective evaluation of syncope in patients presenting to the emergency department
Martin, G., Adams, S., Martin, H., Mathews, J., Zull, D. N., & Pj, S. (1984) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(84)80185-7 · Cited by 59 · see citing works
Gendelman, H. E., Linzer, M., Gabelman, M., Smoller, S., & Scheuer, J. (1983) · PubMed · Cited by 55 · see citing works
Syncope: a retrospective study of 101 hospitalized patients.
Ben‐Chetrit, E., Flugelman, M. Y., & ELIAKIM, M. (1985) · PubMed · Cited by 35 · see citing works
REDUCTION OF REDUNDANT HOSPITAL STAY THROUGH CONTROLLED INTERVENTION
Mozes, B., Katz, A., Halkin, H., et al. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90306-0 · Cited by 34 · see citing works
President's page: Does it really make a difference?
Frye, R. L. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90507-j · Cited by 29 · see citing works
Cost-effectiveness of in-hospital evaluation of patients with syncope.
Mozes, B., Confino‐Cohen, R., & Halkin, H. (1988) · PubMed · Cited by 28 · see citing works
Swallowing syncope: Observations in the absence of conduction system or esophageal disease
Kadish, A. H., Wechsler, L., & Marchlinski, F. E. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90418-3 · Cited by 26 · see citing works
(1990) · Circulation · doi:10.1161/01.cir.82.6.2323 · Cited by 24 · see citing works
Schaal, S. F., Nelson, S. D., Boudoulas, H. K., et al. (1992) · Current Problems in Cardiology · doi:10.1016/0146-2806(92)90002-6 · Cited by 8 · see citing works
D'Costa, D. F. (1993) · Age and Ageing · doi:10.1093/ageing/22.5.391 · Cited by 2 · see citing works
Syncope in the elderly. Report of 3 cases with sick sinus syndrome.
Maartens, G., Am, H., Ja, B., et al. (1986) · PubMed · Cited by 1 · see citing works
Je, S., & Jl, S. (1988) · PubMed · Cited by 1 · see citing works
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2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951 · see citing works
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.044 · Cited by 1,008 · see citing works
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000628 · Cited by 603 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.10.043 · Cited by 337 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
CLINICAL GUIDELINE: Diagnosing Syncope: Part 2: Unexplained Syncope
Linzer, M., Yang, E. H., Estes, N. A. M., Wang, P., Vorperian, V. R., & Kapoor, W. N. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-1-199707010-00014 · Cited by 313 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.002 · Cited by 155 · see citing works
Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., et al. (2019) · Heart Rhythm · doi:10.1016/j.hrthm.2018.10.037 · Cited by 131 · see citing works
Role of echocardiography in the evaluation of syncope: a prospective study
Sarasin, F. P., Junod, A.-F., Carballo, D., Slama, S., Unger, P.-F., & Louis-Simonet, M. (2002) · Heart · doi:10.1136/heart.88.4.363 · Cited by 120 · see citing works
Priorities for Emergency Department Syncope Research
Sun, B. C., Costantino, G., Barbic, F., Bossi, I., Casazza, G., Dipaola, F., McDermott, D., Quinn, J., Reed, M., Sheldon, R. S., et al. (2014) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2014.04.014 · Cited by 86 · see citing works
- Authors
- Recchia, D., & Barzilai, B.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Barzilai, Benico
- Venue
- Journal of General Internal Medicine
- Published
- 1995-12
- Volume
- 10
- Issue
- 12
- Pages
- 649-655
- ISSN
- 0884-8734 (ISSN-L)
- 1525-1497
- OpenAlex
- W1967506798
- Cited by
- 81
- References
- 27
- Citations by year
- 2026: 2 · 2024: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 7 · 2018: 11 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 1 · 2012: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of General Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- syncope, echocardiography, cardiac screening, diagnostic yield, electrocardiogram, clinical history and physical examination, heart disease diagnosis, diagnostic testing utilization, hospitalization
- MeSH terms
- Adult, Aged, Aged, 80 and over, Echocardiography, Electrocardiography, Female, Humans, Male, Medical History Taking, Middle Aged, Physical Examination, Retrospective Studies, Syncope
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