Autophagic response to strenuous exercise in mouse skeletal muscle fibers

Salminen, A.; Vihko, V.

doi:10.1007/bf02889856

Cited by 100Exercise and Physiological ResponsesMuscle Physiology and DisordersAutophagy in Disease and Therapy

Autophagic response to strenuous exercise in mouse skeletal muscle fibers

Salminen, A., Vihko, V.·1984·Virchows Archiv B Cell Pathology Including Molecular Pathology

DOI 10.1007/bf02889856

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Abstract

Strenuous physical exercise induces necrosis of skeletal muscle fibers and increases lysosomal enzyme activities in surviving muscle fibers. This study examines the ultrastructural basis of the stimulation of the lysosomal system in mouse vastus medialis muscle during the appearance and repair of exercise-induced (9 h of running) injuries. Necrotic fibers appeared the day after exercise and an inflammatory response with the replacement of necrotic fibers by phagocytes was highest 2-3 days after exertion. Ultrastructural study of surviving muscle fibers revealed numerous autophagic vacuoles, residual bodies, and spheromembranous structures at the periphery of myofibers, especially in fibers adjacent to necrotic fibers. The autophagic response was most prominent between 2 and 7 days after exertion. Autophagic vacuoles with double or single limiting membranes contained mitochondria at various stages of degradation. Vacuolar and multilamellar structures were also observed in regenerating muscle fibers. The structure of injured skeletal muscle fibers returned to normal within 2 weeks. It is proposed that increased autophagic activity could be related to the breakdown of cellular constituents of surviving muscle fibers to provide structural elements for regenerating muscle fibers.

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The positive effect of exercise on autophagy was first noted in 1984, with the observation of autophagosome accumulation after exercise in rat skeletal muscle.
“The positive effect of exercise on autophagy was first noted in 1984, with the observation of autophagosome accumulation after exercise in rat skeletal muscle [482].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [482]
Similar effects have been seen in humans and mice after strenuous exercise, interpreted as a response to exercise-related muscle breakdown.
“Similar effects have been seen in humans and mice after strenuous exercise, interpreted as a response to exercise-related muscle breakdown [482,483].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [482]

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Authors: Salminen, A., & Vihko, V.
Affiliations: University of Jyväskylä (FI)
ORCID: Salminen, A.
Venue: Virchows Archiv B Cell Pathology Including Molecular Pathology
Publisher: Springer Science and Business Media LLC
Published: 1984-01
Volume: 45
Issue: 1
Pages: 97-106
ISSN: 0340-6075 (ISSN-L)
0042-6431
DOI: 10.1007/bf02889856
OpenAlex: W2045927301
Cited by: 100
References: 29
Citations by year: 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 12 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 2 · 2013: 4 · 2012: 1
FWCI: 10.05
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Virchows Archiv B Cell Pathology Including Molecular Pathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: autophagy, exercise-induced muscle damage, lysosomal system, autophagosomes, vastus medialis, muscle regeneration, muscle ultrastructure, mitochondrial degradation, phagocytes, muscle inflammation, running
MeSH terms: Animals, Autophagy, Physical Exertion, Glucuronidase, Lysosomes, Male, Microscopy, Electron, Muscles, Necrosis, Phagocytosis, Regeneration, Time Factors, Mice

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Autophagic response to strenuous exercise in mouse skeletal muscle fibers

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