Cited by 128Exercise and Physiological ResponsesCardiovascular and exercise physiologyMuscle Physiology and Disorders

Exercise-induced skeletal muscle signaling pathways and human athletic performance

Camera, Donny M., Smiles, William J., Hawley, John A.·2016·Free Radical Biology and Medicine

Abstract

Skeletal muscle is a highly malleable tissue capable of altering its phenotype in response to external stimuli including exercise. This response is determined by the mode, (endurance- versus resistance-based), volume, intensity and frequency of exercise performed with the magnitude of this response-adaptation the basis for enhanced physical work capacity. However, training-induced adaptations in skeletal muscle are variable and unpredictable between individuals. With the recent application of molecular techniques to exercise biology, there has been a greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses. This review summarizes the molecular and cellular events mediating adaptation processes in skeletal muscle in response to exercise. We discuss established and novel cell signaling proteins mediating key physiological responses associated with enhanced exercise performance and the capacity for reactive oxygen and nitrogen species to modulate training adaptation responses. We also examine the molecular bases underpinning heterogeneous responses to resistance and endurance exercise and the dissociation between molecular 'markers' of training adaptation and subsequent exercise performance.

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Crossref · 10.1016/j.freeradbiomed.2016.02.007

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184 of 184 references verified0 citation errors · 0 not checkable

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Authors
Camera, D. M., Smiles, W. J., & Hawley, J. A.
Affiliations
  • Australian Catholic University (AU)
  • Liverpool John Moores University (GB)
Corresponding author
Hawley, John A.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2016-09
Volume
98
Pages
131-143
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2291295533
Cited by
128
References
185
Citations by year
2026: 8 · 2025: 7 · 2024: 7 · 2023: 19 · 2022: 8 · 2021: 20 · 2020: 23 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 5
FWCI
1.53
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion)
Funders
ACURF Grant (36331)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
skeletal muscle, exercise adaptation, signal transduction, athletic performance, endurance exercise, resistance training, reactive oxygen species, reactive nitrogen species, training effects, interindividual variability
MeSH terms
Adaptation, Physiological, Humans, Physical Endurance, Signal Transduction, Exercise, Muscle, Skeletal, Athletic Performance, Resistance Training

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