Exercise-induced skeletal muscle signaling pathways and human athletic performance
Abstract
Skeletal muscle is a highly malleable tissue capable of altering its phenotype in response to external stimuli including exercise. This response is determined by the mode, (endurance- versus resistance-based), volume, intensity and frequency of exercise performed with the magnitude of this response-adaptation the basis for enhanced physical work capacity. However, training-induced adaptations in skeletal muscle are variable and unpredictable between individuals. With the recent application of molecular techniques to exercise biology, there has been a greater understanding of the multiplicity and complexity of cellular networks involved in exercise responses. This review summarizes the molecular and cellular events mediating adaptation processes in skeletal muscle in response to exercise. We discuss established and novel cell signaling proteins mediating key physiological responses associated with enhanced exercise performance and the capacity for reactive oxygen and nitrogen species to modulate training adaptation responses. We also examine the molecular bases underpinning heterogeneous responses to resistance and endurance exercise and the dissociation between molecular 'markers' of training adaptation and subsequent exercise performance.
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- Authors
- Camera, D. M., Smiles, W. J., & Hawley, J. A.
- Affiliations
- Australian Catholic University (AU)
- Liverpool John Moores University (GB)
- Corresponding author
- Hawley, John A.
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 98
- Pages
- 131-143
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2291295533
- Cited by
- 128
- References
- 185
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 7 · 2023: 19 · 2022: 8 · 2021: 20 · 2020: 23 · 2019: 8 · 2018: 13 · 2017: 10 · 2016: 5
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Funders
- ACURF Grant (36331)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- skeletal muscle, exercise adaptation, signal transduction, athletic performance, endurance exercise, resistance training, reactive oxygen species, reactive nitrogen species, training effects, interindividual variability
- MeSH terms
- Adaptation, Physiological, Humans, Physical Endurance, Signal Transduction, Exercise, Muscle, Skeletal, Athletic Performance, Resistance Training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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