Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise
Open accessAbstract
The purpose of this study was to evaluate whether ultra endurance exercise changes the mRNA levels of the autophagy-related and autophagy-regulatory genes. Eight men (44 ± 1 years, range: 38-50 years) took part in a 200-km running race. The average running time was 28 h 03 min ± 2 h 01 min (range: 22 h 15 min-35 h 04 min). A muscle sample was taken from the vastus lateralis 2 weeks prior to the race and 3 h after arrival. Gene expression was assessed by RT-qPCR. Transcript levels of autophagy-related genes were increased by 49% for ATG4b (P = 0.025), 57% for ATG12 (P = 0.013), 286% for Gabarapl1 (P = 0.008) and 103% for LC3b (P = 0.011). The lysosomal enzyme cathepsin L mRNA was upregulated by 123% (P = 0.003). Similarly, transcript levels of the autophagy-regulatory genes BNIP3 and BNIP3l were both increased by 113% (P = 0.031 and P = 0.007, respectively). Since upregulation of these genes has been related with an increased autophagic flux in various models, our results strongly suggest that autophagy is activated in response to ultra endurance exercise.
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Vastus lateralis biopsies from human runners after a 200-kilometer race showed increased transcription of autophagy factors ATG4B, ATG12, GABARAPL1, LC3B, CSTL, BNIP3, and BNIP3L.
“Similarly, vastus lateralis biopsies taken from human runners after a 200-kilometer race showed increased transcription of autophagy factors ATG4B, ATG12, GABARAPL1, LC3B, CSTL (cathepsin L), BNIP3, and BNIP3L [487],”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [487]
Increased transcription of autophagy factors after a 200-kilometer race may be an adaptive response to muscle injury related to long-distance running.
“which may be an adaptive response to muscle injury related to long-distance running.”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [487]
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- Authors
- Jamart, C., Benoit, N., Raymackers, J.-M., Kim, H. J., Kim, C. K., & Francaux, M.
- Affiliations
- UCLouvain (BE)
- Korea National Sport University (KR)
- Corresponding author
- Francaux, Marc
- Venue
- European Journal of Applied Physiology
- Published
- 2011-12-23
- Volume
- 112
- Issue
- 8
- Pages
- 3173-3177
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W2009618449
- Cited by
- 121
- References
- 26
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 8 · 2017: 16 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 6 · 2012: 4
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- autophagy, skeletal muscle, gene expression, ATG4B, ATG12, GABARAPL1, LC3B, cathepsin L, BNIP3, BNIP3L, autophagic flux, vastus lateralis, endurance running
- MeSH terms
- Autophagy-Related Proteins, Autophagy-Related Protein 12, Adult, Autophagy, Biopsy, Cysteine Endopeptidases, Genetic Markers, Humans, Male, Membrane Proteins, Microtubule-Associated Proteins, Middle Aged, Muscle Contraction, Physical Endurance, Proto-Oncogene Proteins, RNA, Messenger, Running, Time Factors, Transcription, Genetic, Up-Regulation, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Small Ubiquitin-Related Modifier Proteins, Adaptor Proteins, Signal Transducing, Quadriceps Muscle, Cathepsin L, Real-Time Polymerase Chain Reaction
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