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Cited by 73Inflammatory Biomarkers in Disease PrognosisSepsis Diagnosis and TreatmentNutrition and Health in Aging

Prognostic value of serum albumin combined with serum C-reactive protein levels in older hospitalized patients: continuing importance of serum albumin

Iwata, Mitsunaga, Kuzuya, Masafumi, Kitagawa, Yoshimi, Iguchi, Akihisa·2006·Aging Clinical and Experimental Research
DOI 10.1007/bf03324664
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Abstract

Background and aims Although both serum albumin and C-reactive protein (CRP) levels are separately recognized as predictors of adverse outcomes in many illnesses, the predictive value of their combination for adverse outcomes has not been evaluated. We therefore sought to examine the prognostic value of serum albumin for in-hospital mortality in the presence or absence of severe inflammation, as indicated by high CRP levels.Methods In this cohort study, we measured serum albumin and CRP levels in 1638 older patients (aged 65 years or older) hospitalized for medical problems, and examined their utility, both separately and in combination, for predicting in-hospital mortality.Results In separate analyses of CRP and albumin, both high CRP levels (> or =5 mg/dl) and hypoalbuminemia (<3.5 g/dl) were associated with risk of in-hospital death. After dividing participants into four groups based on CRP and albumin levels (<5 mg/dl CRP and <3.5 mg/dl albumin), subjects with severe inflammation (CRP > or =5 mg/dl) and hypoalbuminemia were associated with an adjusted relative risk (ARR) of 3.8 for in-hospital mortality when compared with the reference (high albumin and low CRP). Even in the absence of severe inflammation, the presence of severe hypoalbuminemia was associated with an ARR of 2.6 for in-hospital mortality, when compared with patients without hypoalbuminemia.Conclusions Both serum CRP and albumin levels are predictors of in-hospital mortality. However, high serum albumin levels may have a protective effect in older patients, regardless of degree of inflammation. Serum albumin levels remain a useful predictor for in-hospital mortality in older hospitalized patients.

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  • Hypoalbuminemia caused by inflammatory activity related to chronic disease or lifestyle is associated with reduced quality of life and diminished life expectancy.

    “Hypoalbuminemia caused by inflammatory activity related to chronic disease or lifestyle (smoking, alcoholism, obesity) is associated with reduced quality of life due to diminished muscle mass and function and cognitive and immune function and, consequently, to diminished life expectancy.113, 114, 115, 116”

    From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [114]

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Authors
Iwata, M., Kuzuya, M., Kitagawa, Y., & Iguchi, A.
Affiliations
  • Nagoya University (JP)
  • Nagoya Ekisaikai Hospital (JP)
Corresponding author
Iwata, Mitsunaga
ORCID
Venue
Aging Clinical and Experimental Research
Publisher
Springer Science and Business Media LLC
Published
2006-08
Volume
18
Issue
4
Pages
307-311
ISSN
  • 1594-0667 (ISSN-L)
  • 1720-8319
DOI
10.1007/bf03324664
OpenAlex
W2037764761
Cited by
73
References
29
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 3 · 2013: 7 · 2012: 4
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Aging Clinical and Experimental Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Keywords
serum albumin, C-reactive protein, hypoalbuminemia, in-hospital mortality, prognostic factors, hospitalized older adults, inflammation, combined biomarker prediction
MeSH terms
Acute Disease, Aged, Aged, 80 and over, Aging, C-Reactive Protein, Female, Humans, Inpatients, Male, Predictive Value of Tests, Prognosis, Risk Factors, Serum Albumin, Cohort Studies, Hospital Mortality

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