D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eatingrelated psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity
Abstract
Objective Food is considered a reinforcing agent, like a variety of substances such as alcohol and other drugs of abuse that produce pleasure. Psychopathological traits related to food intake are demonstrated in eating disorders as in obesity with different genetic aspects for these diseases. Recently, the prevalence of TaqA1 allele has been associated to alcohol, drug abuse and carbohydrate preference. For this reason, the aim of this study was to evaluate if the presence of A1 allele, in eating disorders and obesity, is associated with some particular psycho-pathological characteristics.Methods We studied the presence of TaqA1 in Italian subjects affected by obesity (n=71), anorexia (n=28), bulimia (n=20) and in control group (n=54). The Eating Disorders Inventory (EDI test) was used to evaluate the psychological profiles. Patients without alcohol and drugs abuse were selected (>125 ml/day).Results The A1+ allele, both in A1/A1 and A1/A2 genotypes, was not differently distributed among disease groups; on the contrary two EDI subscales (Drive for thinness and Ineffectiveness) resulted associated with A1+ allele without effect of the eating disease or obesity.Conclusion These results confirm that the presence of A1+ allele is not simply related to body weight but the A1+ allele might be a marker of a genetic psychological condition in people with high risk to develop pathological eating behaviour.
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Candidate genetic behavior investigations in BN have reported altered allelic frequencies for the DAT gene and DA receptor genes in individuals with bulimia.
“These studies compliment candidate genetic behavior investigations in BN that have reported altered allelic frequencies for the DAT gene [328] and DA receptor genes [329,330] in individuals with bulimia.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [330]
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- Authors
- Nisoli, E., Brunani, A., Borgomainerio, E., Tonello, C., Dioni, L., Briscini, L., Redaelli, G., Molinari, E., Cavagnini, F., & Carruba, M. O.
- Affiliations
- University of Milan (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Corresponding author
- Brunani, A.
- Venue
- Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity
- Published
- 2007-06
- Volume
- 12
- Issue
- 2
- Pages
- 91-96
- ISSN
- 1124-4909 (ISSN-L)
- 1590-1262
- OpenAlex
- W2008268917
- Cited by
- 75
- References
- 40
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 5 · 2012: 4
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- TaqI polymorphism, anorexia nervosa, bulimia nervosa, obesity, eating disorders, drive for thinness, ineffectiveness, psychological characteristics, genetic polymorphism, food reinforcement
- MeSH terms
- Adult, Anorexia Nervosa, Body Image, Body Weight, Bulimia, Female, Genetic Markers, Genotype, Humans, Male, Middle Aged, Obesity, Polymorphism, Genetic, Psychological Tests, Self Concept, Body Mass Index, Case-Control Studies, Receptors, Dopamine D2
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