Association of Multiple DRD2 Polymorphisms with Anorexia Nervosa
Open accessAbstract
To investigate whether the dopaminergic system plays a role in the etiology of anorexia nervosa (AN) via the dopamine D2 receptor, we investigated association and transmission disequilibrium at seven single-nucleotide polymorphisms (SNPs) spanning about 75 kbp of the gene DRD2. We studied 191 probands with a DSM-IV diagnosis of AN, 457 parents and affected relatives with a DSM-IV eating disorder diagnosis, and 98 unrelated, female, normal weight controls. The -141 C/- insertion/deletion (-141 Indel), previously shown to affect DRD2 transcription efficiency, and multiple exon seven polymorphisms, one of which has previously been shown to affect DRD2 transcript stability, exhibited statistically significant association with diagnosis in haplotype transmission disequilibrium and in haplotype case : control analyses. Significant linkage disequilibrium between the -141 Indel and two exon seven SNPs (939Y and 957Y) was observed over a distance of >50 kbp in the AN probands but not in the controls. Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There are significant relations between multiple DRD2 polymorphisms and anorexia nervosa.
“significant relations between multiple DRD2 polymorphisms and AN [344].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [344]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,742 · see citing works
PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis
O'Connell, J. R., & Weeks, D. E. (1998) · The American Journal of Human Genetics · doi:10.1086/301904 · Cited by 2,063 · see citing works
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
(1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040269 · Cited by 1,950 · see citing works
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864 · see citing works
Characterization of single-nucleotide polymorphisms in coding regions of human genes
Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., Nemesh, J., et al. (1999) · Nature Genetics · doi:10.1038/10290 · Cited by 1,547 · see citing works
Comorbidity of Anxiety Disorders With Anorexia and Bulimia Nervosa
Kaye, W. H., Bulik, C. M., Thornton, L., Barbarich, N., Masters, K., & the Price Foundation Collaborative Group (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2215 · Cited by 1,162 · see citing works
Self-citationMortality in anorexia nervosa.
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.1073 · Cited by 974 · see citing works
Duan, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg055 · Cited by 916 · see citing works
Testing heterozygote excess and deficiency.
Rousset, F., & Michel Raymond, A. (1995) · Genetics · doi:10.1093/genetics/140.4.1413 · Cited by 762 · see citing works
Distinct functions of the two isoforms of dopamine D2 receptors
Usiello, A., Baik, J.-H., Rougé-Pont, F., Picetti, R., Dierich, A., LeMeur, M., Piazza, P. V., & Borrelli, E. (2000) · Nature · doi:10.1038/35041572 · Cited by 717 · see citing works
Neurotransmitter regulation of dopamine neurons in the ventral tegmental area
Kalivas, P. W. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90008-n · Cited by 704 · see citing works
Psychobiology of novelty seeking and drug seeking behavior
Bardo, M. T., Donohew, R. L., & Harrington, N. G. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00203-0 · Cited by 667 · see citing works
Reward deficiency syndrome: genetic aspects of behavioral disorders
Comings, D. E., & Blum, K. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26022-6 · Cited by 621 · see citing works
A Controlled Family Study of Anorexia Nervosa and Bulimia Nervosa
Lilenfeld, L. R., Kaye, W. H., Greeno, C. G., Merikangas, K. R., Plotnicov, K. H., Pollice, C., Rao, R., Strober, M. A., Bulik, C. M., & Nagy, L. M. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.603 · Cited by 599 · see citing works
Self-citationStrober, M. A., Freeman, R., Lampert, C., Diamond, J., & Kaye, W. H. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.393 · Cited by 557 · see citing works
Self-citationArinami, T. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.4.577 · Cited by 455 · see citing works
Grandy, D. K., Litt, M. J., Allen, L., Bunzow, J. R., Marchionni, M. A., Makam, H., Reed, L., Magenis, R. E., & Civelli, O. (1989) · PubMed · Cited by 421 · see citing works
Anorexia Nervosa and Major Depression: Shared Genetic and Environmental Risk Factors
Wade, T. D., Bulik, C. M., Neale, M., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.469 · Cited by 375 · see citing works
Self-citationFrank, G. K., Bailer, U. F., Henry, S. E., Drevets, W., Meltzer, C. C., Price, J. C., Mathis, C. A., Wagner, A., Hoge, J., Ziolko, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.003 · Cited by 361 · see citing works
Self-citationHalmi, K. A., Sunday, S. R., Strober, M. A., Kaplan, A., Woodside, D. B., Fichter, M. M., Treasure, J. L., Berrettini, W. H., & Kaye, W. H. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1799 · Cited by 343 · see citing works
Self-citationBacanu, S.-A., Devlin, B., & Roeder, K. (2000) · The American Journal of Human Genetics · doi:10.1086/302929 · Cited by 340 · see citing works
Self-citationThe Relation Between Eating Disorders and Components of Perfectionism
Bulik, C. M., Tozzi, F., Anderson, C., Mazzeo, S. E., Aggen, S., & Sullivan, P. F. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.366 · Cited by 303 · see citing works
Self-citationBlum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., & Comings, D. E. (1995) · Pharmacogenetics · doi:10.1097/00008571-199506000-00001 · Cited by 279 · see citing works
Prominence of the dopamine D2 short isoform in dopaminergic pathways
Khan, Z. U., Mrzljak, L., Gutierrez, A., de la Calle, A., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7731 · Cited by 278 · see citing works
Genetic and environmental influences on anorexia nervosa syndromes in a population–based twin sample
Klump, K. L., Miller, K. B., Keel, P. K., McGue, M. K., & Iacono, W. G. (2001) · Psychological Medicine · doi:10.1017/s0033291701003725 · Cited by 270 · see citing works
Brain reward circuitry: Four circuit elements “wired” in apparent series
Wise, R. A., & Bozarth, M. A. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90190-4 · Cited by 252 · see citing works
Hyperactivity in anorexia nervosa: A fundamental clinical feature
Kron, L., Katz, J. L., Gorzynski, G., & Weiner, H. (1978) · Comprehensive Psychiatry · doi:10.1016/0010-440x(78)90072-x · Cited by 252 · see citing works
Drs. Sullivan and Youngner Reply
Sullivan, M. D., & Youngner, S. J. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.10.1533 · Cited by 251 · see citing works
Feeding behavior in dopamine-deficient mice
Szczypka, M. S., Rainey, M. A., Kim, D. S., Alaynick, W. A., Marck, B. T., Matsumoto, A. M., & Palmiter, R. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12138 · Cited by 242 · see citing works
Sensitivity to the rewarding effects of food and exercise in the eating disorders
Davis, C., & Woodside, D. B. (2002) · Comprehensive Psychiatry · doi:10.1053/comp.2002.32356 · Cited by 238 · see citing works
Self-citationEvidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1
Grice, D. E., Halmi, K. A., Fichter, M. M., Strober, M., Woodside, D. B., Treasure, J. T., Kaplan, A. S., Magistretti, P. J., Goldman, D., Bulik, C. M., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339250 · Cited by 222 · cited 1× · see citing works
“Finally, based on the results of published linkage analyses (Grice et al, 2002; Devlin et al, 2002) of these samples, DRD2 (at 11q22) does not lie in a compelling linkage region.”
Self-citationA global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus
Kidd, K., Morar, B., Castiglione, C., Zhao, H.-Y., Pakstis, A., Speed, W. C., Bonné-Tamir, B., Lu, R., Goldman, D., Lee, C., et al. (1998) · Human Genetics · doi:10.1007/s004390050809 · Cited by 202 · see citing works
Self-citationAltered Dopamine Activity after Recovery from Restricting-Type Anorexia Nervosa
Kaye, W. H. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00053-6 · Cited by 194 · see citing works
Self-citationLinkage analysis of anorexia nervosa incorporating behavioral covariates
Devlin, B. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.6.689 · Cited by 161 · see citing works
Self-citationBergen, A. W., van den Bree, M. B. M., Yeager, M., Welch, R., Ganjei, J. K., Haque, K. A., Bacanu, S., Berrettini, W. H., Grice, D. E., Goldman, D. A., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001318 · Cited by 157 · see citing works
Self-citationSalamone, J. D. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00125-5 · Cited by 156 · see citing works
A Structural Polymorphism of Human Dopamine D2 Receptor D2(Ser311 → Cys)
Itokawa, M., Arinami, T., Futamura, N., Hamaguchi, H., & Toru, M. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2404 · Cited by 139 · see citing works
A preliminary population-based twin study of self-reported eating disorder
Kortegaard, L. S., Hørder, K., Joergensen, J. S., Gillberg, C., & Kyvik, K. O. (2001) · Psychological Medicine · doi:10.1017/s0033291701003087 · Cited by 137 · see citing works
Dopamine is required for hyperphagia in Lepob/ob mice
Szczypka, M. S., Rainey, M. A., & Palmiter, R. D. (2000) · Nature Genetics · doi:10.1038/75484 · Cited by 134 · see citing works
Functional Analysis of the Human D2 Dopamine Receptor Missense Variants
Cravchik, A., Sibley, D. R., & Gejman, P. V. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26013 · Cited by 127 · see citing works
Power Calculations for a General Class of Family-Based Association Tests: Dichotomous Traits
Lange, C., & Laird, N. M. (2002) · The American Journal of Human Genetics · doi:10.1086/342406 · Cited by 119 · see citing works
A search for susceptibility loci for anorexia nervosa: methods and sample description
Kaye, W. H., Lilenfeld, L. R., Berrettini, W. H., Strober, M., Devlin, B., Klump, K. L., Goldman, D., Bulik, C. M., Halmi, K. A., Fichter, M. M., et al. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00240-1 · Cited by 116 · see citing works
Self-citationSarkar, G., Kapelner, S., Grandy, D. K., Marchionni, M. A., Civelli, O., Sobell, J. L., Heston, L. L., & Sommer, S. S. (1991) · Genomics · doi:10.1016/0888-7543(91)90096-w · Cited by 110 · see citing works
Lange, C., & Laird, N. M. (2002) · Genetic Epidemiology · doi:10.1002/gepi.209 · Cited by 108 · see citing works
Cravchik, A., & Goldman, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1105 · Cited by 94 · see citing works
Self-citationHigh-Throughput Single Nucleotide Polymorphism Genotyping by Fluorescent 5′ Exonuclease Assay
Morin, P. A., Saiz, R., & Monjazeb, A. (1999) · BioTechniques · doi:10.2144/99273rr02 · Cited by 86 · see citing works
Personality in Anorexia nervosa: An update and a theoretical integration
Sohlberg, S., & Strober, M. A. (1994) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1994.tb05809.x · Cited by 67 · see citing works
Self-citationMukherjee, J., Yang, Z., Brown, T., Roemer, J., & Cooper, M. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00348-7 · Cited by 41 · see citing works
Polymorphism of Dopamine Receptors and Transporter Genes in Neuropsychiatric Diseases
Fujiwara, Y., Yamaguchi, K., Tanaka, Y., Tomita, H., Shiro, Y., Kashihara, K., Sato, K., & Kuroda, S. (2008) · European Neurology · doi:10.1159/000113436 · Cited by 25 · see citing works
Candidate Gene Analysis of the Price Foundation Anorexia Nervosa Affected Relative Pair Dataset
Bergen, A. W., Yeager, M., Welch, R., Ganjei, J. K., Deep‐Soboslay, A., Haque, K. A., van den Bree, M. B. M., Goldman, D. A., Berrettini, W., & Kaye, W. H. (2003) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007033338760 · Cited by 14 · see citing works
Self-citationTelch (1994) · doi:10.1002/1098-108x(199401)15:1
Fichter (1998) · doi:10.1002/(sici)1098-108x(199811)24:3
Self-citation
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
New insights into symptoms and neurocircuit function of anorexia nervosa
Kaye, W. H., Fudge, J. L., & Paulus, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2682 · Cited by 843 · see citing works
Self-citationNeurobiology of anorexia and bulimia nervosa
Kaye, W. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.037 · Cited by 625 · see citing works
Self-citationSleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms
Harvey, A. G., Murray, G., Chandler, R. A., & Soehner, A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2010.04.003 · Cited by 609 · see citing works
Frank, G. K., Bailer, U. F., Henry, S. E., Drevets, W., Meltzer, C. C., Price, J. C., Mathis, C. A., Wagner, A., Hoge, J., Ziolko, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.003 · Cited by 361 · see citing works
Self-citationAltered Reward Processing in Women Recovered From Anorexia Nervosa
Wagner, A., Aizenstein, H., Venkatraman, V. K., Fudge, J., May, J. C., Mazurkewicz, L., Frank, G. K., Bailer, U. F., Fischer, L., Nguyen, V., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07040575 · Cited by 342 · see citing works
Self-citationDichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
O'Hara, C., Campbell, I. C., & Schmidt, U. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.012 · Cited by 271 · see citing works
Genetics and epigenetics of eating disorders
Bulik, C., Yilmaz, Z., & HArdaway, A. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s55776 · Cited by 278 · see citing works
Self-citationAvena, N. M., & Bocarsly, M. E. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.010 · Cited by 262 · see citing works
The Genetics of Eating Disorders
Trace, S. E., Baker, J. H., Peñas‐Lledó, E., & Bulik, C. M. (2013) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185546 · Cited by 247 · see citing works
Self-citationDopamine and glucose, obesity, and reward deficiency syndrome
Blum, K., Thanos, P. K., & Gold, M. S. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00919 · Cited by 230 · see citing works
A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa
Wang, K., Zhang, H., Bloss, C. S., Duvvuri, V, Kaye, W., Schork, N. J., Berrettini, W., Hakonarson, H., & the Price Foundation Collaborative Group (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.107 · Cited by 212 · see citing works
Self-citationNew Insights in Anorexia Nervosa
Gorwood, P. A. P. M., Blanchet, C., Chartrel, N., Duclos, J., Déchelotte, P., Hanachi, M., Fetissov, S. O., Godart, N. T., Melchior, J., Ramoz, N., et al. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00256 · Cited by 193 · see citing works
Tchanturia, K., Liao, P., Uher, R., Lawrence, N., Treasure, J. L., & Campbell, I. C. (2007) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617707070798 · Cited by 174 · see citing works
Self-citationEpigenetic dysregulation of dopaminergic genes in eating disorders
Frieling, H., Römer, K. D., Scholz, S., Mittelbach, F., Wilhelm, J., De Zwaan, M., Jacoby, G. E., Kornhuber, J., Hillemacher, T., & Bleich, S. (2010) · International Journal of Eating Disorders · doi:10.1002/eat.20745 · Cited by 162 · see citing works
The Genetics of Anorexia Nervosa
Bulik, C. M., Slof-Op't Landt, M. C. T., van Furth, E. F., & Sullivan, P. F. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093713 · Cited by 150 · see citing works
Self-citationReward processing in anorexia nervosa
Keating, C., Tilbrook, A. J., Rossell, S. L., Enticott, P. G., & Fitzgerald, P. B. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.01.036 · Cited by 151 · see citing works
Compulsivity in anorexia nervosa: a transdiagnostic concept
Godier-McBard, L. R., & Park, R. J. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00778 · Cited by 148 · see citing works
Neurocircuity of Eating Disorders
Kaye, W. H., Wagner, A., Fudge, J. L., & Paulus, M. P. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_85 · Cited by 138 · see citing works
Self-citationFriederich, H., Kumari, V., Uher, R., RIGA, M., Schmidt, U. H., Campbell, I. C., Herzog, W., & Treasure, J. L. (2006) · Psychological Medicine · doi:10.1017/s0033291706008129 · Cited by 138 · see citing works
Self-citationDopaminergic drugs in type 2 diabetes and glucose homeostasis
Vicchi, F. L., Luque, G. M., Brie, B., Nogueira, J. P., Tornadu, I. A. G., & Becú‐Villalobos, D. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.12.029 · Cited by 118 · see citing works
Rask‐Andersen, M., Olszewski, P. K., Levine, A. S., & Schiöth, H. B. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.10.007 · Cited by 114 · see citing works
Neurobiology of hyperactivity and reward: Agreeable restlessness in Anorexia Nervosa
Scheurink, A. J. W., Boersma, G. J., Nergårdh, R., & Södersten, P. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.016 · Cited by 99 · see citing works
Altered striatal response to reward in bulimia nervosa after recovery
Wagner, A., Aizenstein, H., Venkatraman, V. K., Bischoff‐Grethe, A., Fudge, J., May, J. C., Frank, G. K., Bailer, U. F., Fischer, L., Putnam, K., et al. (2010) · International Journal of Eating Disorders · doi:10.1002/eat.20699 · Cited by 93 · see citing works
Self-citationEating disorders: the current status of molecular genetic research
Scherag, S., Hebebrand, J., & Hinney, A. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0085-9 · Cited by 88 · see citing works
Bailer, U. F., Frank, G., Price, J. C., MELTZER, C. C., Becker, C. R., Mathis, C. A., Wagner, A., Barbarich-Marsteller, N. C., Bloss, C. S., Putnam, K. T., et al. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.06.010 · Cited by 82 · see citing works
Self-citationFoldi, C. J., Milton, L. K., & Oldfield, B. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.63 · Cited by 80 · see citing works
Eisenberg, D. T. A., Campbell, B., MacKillop, J., Lum, J., & Wilson, D. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001216 · Cited by 89 · see citing works
Nisoli, E., Brunani, A., Borgomainerio, E., Tonello, C., Dioni, L., Briscini, L., Redaelli, G., Molinari, E., Cavagnini, F., & Carruba, M. O. (2007) · Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity · doi:10.1007/bf03327583 · Cited by 75 · see citing works
Current status of functional imaging in eating disorders
Frank, G., & Kaye, W. H. (2012) · International Journal of Eating Disorders · doi:10.1002/eat.22016 · Cited by 78 · see citing works
Self-citationAnorexia nervosa: Towards an integrative neuroscience model
Hatch, A., Madden, S., Kohn, M. R., Clarke, S. P., Touyz, S. W., & Williams, L. M. (2010) · European Eating Disorders Review · doi:10.1002/erv.974 · Cited by 77 · see citing works
Neurobiology Driving Hyperactivity in Activity-Based Anorexia
Adan, R. A. H., Hillebrand, J. J., Danner, U. N., Cano, S. C., Kas, M. J., & Verhagen, L. A. W. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_77 · Cited by 75 · see citing works
Hinney, A., & Volckmar, A. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0423-y · Cited by 72 · see citing works
Gelegen, Ç., van den Heuvel, J. K., Collier, D. A., Campbell, I. C., Oppelaar, H., Hessel, E. V. S., & Kas, M. J. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00394.x · Cited by 71 · see citing works
Southgate, L., Tchanturia, K., & Treasure, J. L. (2005) · Journal of Mental Health · doi:10.1080/09638230500347541 · Cited by 69 · see citing works
Self-citationBacanu, S., Bulik, C. M., Klump, K. L., Fichter, M. M., Halmi, K. A., Keel, P. K., Kaplan, A. S., Mitchell, J. E., Rotondo, A., Strober, M. A., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30226 · Cited by 68 · see citing works
Self-citationSystematic analysis of dopamine receptor genes (DRD1–DRD5) in antipsychotic-induced weight gain
Müller, D., Zai, C. C. H., Sicard, M. N., Remington, E., de Souza, R. P., Tiwari, A. K., Hwang, R., Likhodi, O., Shaikh, S. A., Freeman, N., et al. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.65 · Cited by 67 · see citing works
Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa
Verhagen, L. A. W., Luijendijk, M. C. M., Hillebrand, J. J., & Adan, R. A. H. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.09.005 · Cited by 66 · see citing works
Soussignan, R., Schaal, B., Rigaud, D., Royet, J.-P., & Jiang, T. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2010.12.007 · Cited by 62 · see citing works
Soussignan, R., Jiang, T., Rigaud, D., Royet, J., & Schaal, B. (2009) · Psychological Medicine · doi:10.1017/s0033291709990377 · Cited by 62 · see citing works
Genetic Susceptibility to Eating Disorders: Associated Polymorphisms and Pharmacogenetic Suggestions
Monteleone, P., & Maj, M. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.10.1487 · Cited by 61 · see citing works
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
Cai, X., Liu, H., Feng, B. C., Yu, M., He, Y., Liu, H., Liang, C., Yang, Y., Tu, L., Zhang, N., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01062-0 · Cited by 56 · see citing works
Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity
Verhagen, L. A. W., Luijendijk, M. C. M., Korte-Bouws, G. A. H., Korte, S. M., & Adan, R. A. H. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.12.008 · Cited by 59 · see citing works
Bailer, U., Narendran, R., Frankle, W., Himes, M. L., Duvvuri, V., Mathis, C., & Kaye, W. (2011) · International Journal of Eating Disorders · doi:10.1002/eat.20937 · Cited by 54 · see citing works
Self-citationActivity-based anorexia animal model: a review of the main neurobiological findings
Spadini, S., Ferro, M., Lamanna, J., & Malgaroli, A. (2021) · Journal of Eating Disorders · doi:10.1186/s40337-021-00481-x · Cited by 54 · see citing works
The Genetics of Eating Disorders
Helder, S. G., & Collier, D. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_79 · Cited by 48 · see citing works
Paolacci, S., Kiani, A. K., Manara, E., Beccari, T., Ceccarini, M. R., Stuppia, L., Chiurazzi, P., Dalla Ragione, L., & Bertelli, M. (2020) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.1244 · Cited by 47 · see citing works
The Genetics of Anorexia Nervosa
Clarke, T., Weiss, A. R. D., & Berrettini, W. H. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.253 · Cited by 45 · see citing works
Self-citationIs deep brain stimulation a treatment option for anorexia nervosa?
Oudijn, M. S., Storosum, J. G., Nelis, E., & Denys, D. A. J. P. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-277 · Cited by 43 · see citing works
Costanzo, F., Menghini, D., Maritato, A., Castiglioni, M. C., Mereu, A., Varuzza, C., Zanna, V., & Vicari, S. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00133 · Cited by 44 · see citing works
Applying neurobiology to the treatment of adults with anorexia nervosa
Hill, L., Peck, S. K., Wierenga, C. E., & Kaye, W. H. (2016) · Journal of Eating Disorders · doi:10.1186/s40337-016-0119-x · Cited by 41 · see citing works
Self-citationStievenard, A., Méquinion, M., Andrews, Z. B., Destée, A., Chartier-Harlin, M.-C., Viltart, O., & Vanbesien-Mailliot, C. C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.021 · Cited by 39 · see citing works
A focus on reward in anorexia nervosa through the lens of the activity‐based anorexia rodent model
Foldi, C. J., Milton, L. K., & Oldfield, B. J. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12479 · Cited by 40 · see citing works
Perplexities and provocations of eating disorders
Halmi, K. A. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01983.x · Cited by 37 · see citing works
Self-citationThe Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
Pinheiro, A. P., Root, T. L., & Bulik, C. M. (2009) · PubMed · Cited by 35 · see citing works
Self-citationRamoz, N., Versini, A., & Gorwood, P. A. P. M. (2007) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.8.13.2029 · Cited by 35 · see citing works
O'Hara, C., Keyes, A., Renwick, B., Leyton, M., Campbell, I. C., & Schmidt, U. (2016) · PLoS ONE · doi:10.1371/journal.pone.0145894 · Cited by 34 · see citing works
Kolar, D. R., & Gorrell, S. (2020) · International Journal of Eating Disorders · doi:10.1002/eat.23427 · Cited by 33 · see citing works
Thaler, L., Groleau, P., Badawi, G., Sycz, L., Zeramdini, N., Too, A., Israël, M., Joober, R., Bruce, K. R., & Steiger, H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.019 · Cited by 31 · see citing works
Machine learning derived risk prediction of anorexia nervosa
Guo, Y., Wei, Z., Keating, B. J., & Hakonarson, H. H. (2015) · BMC Medical Genomics · doi:10.1186/s12920-016-0165-x · Cited by 30 · see citing works
Bone loss in anorexia nervosa: leptin, serotonin, and the sympathetic nervous system
Kumar, K. K., Tung, S., & Iqbal, J. Z. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05810.x · Cited by 27 · see citing works
Shih, P.-A. B. (2017) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2017.02.002 · Cited by 27 · see citing works
Genetic Findings in Anorexia and Bulimia Nervosa
Hinney, A., Scherag, S., & Hebebrand, J. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-375003-7.00009-1 · Cited by 26 · see citing works
Mercader, J., Lozano, J., Sumoy, L., Dierssen, M., Visa, J., Gratacòs, M., & Estivill, X. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90255.2008 · Cited by 24 · see citing works
Interspecies genetics of eating disorder traits
Kas, M. J., Kaye, W. H., Mathes, W. F., & Bulik, C. M. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30832 · Cited by 23 · see citing works
Self-citationContemporary views on the genetics of anorexia nervosa
Shih, P.-A. B., & Woodside, D. B. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.02.008 · Cited by 22 · see citing works
Self-citationAdvances in the diagnosis of anorexia nervosa and bulimia nervosa using brain imaging
Frank, G. (2012) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2012.673583 · Cited by 22 · see citing works
Maitra, S., Sarkar, K., Ghosh, P., Karmakar, A., Bhattacharjee, A., Sinha, S., & Mukhopadhyay, K. (2014) · Cellular and molecular neurobiology · doi:10.1007/s10571-014-0038-9 · Cited by 20 · see citing works
Los trastornos de la conducta alimentaria
Méndez, J. P., Vázquez‐Velázquez, V., & García‐García, E. (2008) · Boletín Médico del Hospital Infantil de México · Cited by 20 · see citing works
Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa
PGC-ED, Walton, E., ENIGMA Genetics Working Group, Hibar, D. P., Yılmaz, Z., Jahanshad, N., Cheung, J. T. P., Batury, V.-L., Seitz, J., Bulik, C. M., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1439-4 · Cited by 19 · see citing works
Self-citationPeng, S., Yu, S., Wang, Q., Kang, Q., Zhang, Y., Zhang, R., Jiang, W., Qian, Y., Zhang, H., Zhang, M., et al. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.036 · Cited by 20 · see citing works
Herpertz‐Dahlmann, B., Holtkamp, K., & Konrad, K. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00026-7 · Cited by 19 · see citing works
Neurobiology of eating disorders - an overview
Mishra, A., Anand, M., & Shreekantiah, U. (2016) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2016.10.009 · Cited by 19 · see citing works
Pharmacogenetics of D2 dopamine receptor gene in prolactin-secreting pituitary adenomas
Filopanti, M., Lania, A. G., & Spada, A. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903352501 · Cited by 17 · see citing works
Food vs money? Effects of hunger on mood and behavioral reactivity to reward in anorexia nervosa
Piccolo, M., Milos, G. F., Bluemel, S., Schumacher, S., Mueller‐Pfeiffer, C., Fried, M., Monique Ernst, D., & Martin-Söelch, C. (2018) · Appetite · doi:10.1016/j.appet.2018.12.017 · Cited by 17 · see citing works
Significance of Dopaminergic Gene Variants in the Male Biasness of ADHD
Bhowmik, A. D., Sarkar, K., Ghosh, P., Das, M., Bhaduri, N., Sarkar, K., Ray, A., Sinha, S., & Mukhopadhyay, K. (2017) · Journal of Attention Disorders · doi:10.1177/1087054713494004 · Cited by 13 · see citing works
Castro‐Fornieles, J., Deulofeu, R., Baeza, I., Casulà, V., Saura, B., Lázaro, L., Puig, J., Toro, J., & Bernardo, M. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.009 · Cited by 16 · see citing works
Animal Models of Eating Disorder Traits
Kas, M. J., & Adan, R. A. H. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_84 · Cited by 15 · see citing works
Kim, Y., Trace, S. E., Crowley, J. J., Brownley, K. A., Hamer, R. M., Pisetsky, D. S., Sullivan, P. F., & Bulik, C. M. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.05.026 · Cited by 18 · see citing works
Self-citationSLC6A3and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Azzato, E. M., Morton, L. M., Bergen, A. W., WANG, S. S., Chatterjee, N., Kvale, P. A., Yeager, M., Hayes, R. B., Chanock, S. J., & Caporaso, N. E. (2009) · BMC Medical Genetics · doi:10.1186/1471-2350-10-9 · Cited by 15 · see citing works
Self-citationAssociation Between DRD2 and DRD4 Polymorphisms and Eating Disorders in an Italian Population
Ceccarini, M. R., Fittipaldi, S., Ciccacci, C., Granese, E., Centofanti, F., Ragione, L. D., Bertelli, M., Beccari, T., & Botta, A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.838177 · Cited by 14 · see citing works
Psychobiology of eating disorders
Jimerson, D. C., & Wolfe, B. E. (2018) · CRC Press eBooks · doi:10.4324/9781315384924-1 · Cited by 14 · see citing works
Dopaminergic Activity and Exercise Behavior in Anorexia Nervosa
Gorrell, S., Collins, A. G. E., Grange, D. L., & Yang, T. T. (2020) · OBM Neurobiology · doi:10.21926/obm.neurobiol.2001053 · Cited by 15 · see citing works
On dopamine, D2 receptor, and Taq1A polymorphism in obesity and anorexia
Fetissov, S. O., & Meguid, M. M. (2009) · Nutrition · doi:10.1016/j.nut.2008.12.001 · Cited by 13 · see citing works
Where do eating disorders lie on the diagnostic spectrum and what does it mean?
Treasure, J. L. (2006) · Nordic Journal of Psychiatry · doi:10.1080/08039480500517984 · Cited by 13 · see citing works
Self-citationSurgical Treatments for Anorexia Nervosa
Sun, B., Li, D., Liu, W., Zhan, S., Pan, Y., & Zhang, X. (2014) · Springer eBooks · doi:10.1007/978-94-017-9576-0_15 · Cited by 9 · see citing works
Vicario, C. M. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00016 · Cited by 7 · see citing works
Arrúe, A., Olivas, O., Erkoreka, L., Alvarez, F. J., Arnaiz, A., Varela, N., Bilbao, A., Rodríguez, J.-J., Moreno-Calle, M. T., Gordo, E., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082134 · Cited by 7 · see citing works
Almaghrbi, H., & Bawadi, H. A. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1386233 · Cited by 7 · see citing works
Neuronal Substrate of Eating Disorders
Calvez, J. (2014) · Brain Disorders & Therapy · doi:10.4172/2168-975x.1000121 · Cited by 6 · see citing works
Lapides, F. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375668-8.10003-8 · Cited by 7 · see citing works
Genetic Vulnerability to Eating Disorders and Substance Use Disorders
Baker, J. H., & Munn‐Chernoff, M. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-45378-6_5 · Cited by 5 · see citing works
Food-Anticipatory Activity: Rat Models and Underlying Mechanisms
Merkestein, M., Verhagen, L. A. W., & Adan, R. A. H. (2012) · Neuromethods · doi:10.1007/978-1-62703-104-2_18 · Cited by 5 · see citing works
The Connection Between Eating Disorders and Substance Use Disorders
Claudat, K., Simpson, C. C., Bohrer, B. K., & Bongiornio, G. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-16691-4_16 · Cited by 5 · see citing works
Евгеньевна, Ч. Г., Вадимович, Г. Д., Tabeeva, G. I., & Юрьевна, П. В. (2018) · GYNECOLOGY · doi:10.26442/2079-5696_20.1.16-22 · Cited by 4 · see citing works
The Neurobiology of Anorexia Nervosa
Higgins, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82751 · Cited by 4 · see citing works
Biopsychiatric Theories of Eating Disorders
Madden, S. (2015) · doi:10.1002/9781118574089.ch17 · Cited by 2 · see citing works
Kaye, W. H., Bailer, U. F., Frank, G., & Wagner, A. (2006) · International Congress Series · doi:10.1016/j.ics.2005.12.038 · Cited by 3 · see citing works
Self-citationGenetic Risk Factors for Eating Disorders
Baker, J. H., Janson, L. E., Trace, S. E., & Bulik, C. M. (2015) · Wiley eBooks · doi:10.1002/9781118574089.ch28 · Cited by 3 · see citing works
Self-citationBrain Neurotransmitters and Eating Disorders
Murray, S. M., & Kaye, W. H. (2023) · Springer eBooks · doi:10.1007/978-3-030-97416-9_46-1 · Cited by 3 · see citing works
Self-citation
- Authors
- Bergen, A. W., Yeager, M., Welch, R. A., Haque, K., Ganjei, J. K., van den Bree, M. B. M., Mazzanti, C., Nardi, I., Fichter, M. M., Halmi, K. A., Kaplan, A. S., Strober, M., Treasure, J., Woodside, D. B., Bulik, C. M., Bacanu, S.-A., Devlin, B., Berrettini, W. H., Goldman, D., & Kaye, W. H.
- Affiliations
- National Institutes of Health (US)
- Tissue Gene (United States) (US)
- Cancer Research UK (GB)
- University of Pisa (IT)
- Schön Klinik Roseneck (DE)
- Cornell University (US)
- University Health Network (CA)
- University of California, Los Angeles (US)
- King's College London (GB)
- University of North Carolina at Chapel Hill (US)
- University of Pittsburgh (US)
- University of Pennsylvania Health System (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Corresponding author
- Bergen, Andrew W
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2005-05-25
- Volume
- 30
- Issue
- 9
- Pages
- 1703-1710
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2111445266
- Cited by
- 137
- References
- 53
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 8 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 7 · 2012: 10
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Funders
- U.S. Department of Health and Human Services
- Louis and Harold Price Foundation
- National Alliance for Research on Schizophrenia and Depression
- Australian Government
- European Commission (644690)
- National Institutes of Health
- National Institute of Mental Health (MH 57881)
- National Center for Research Resources (RR-03655, P41RR003655)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- anorexia nervosa, DRD2, dopamine D2 receptor, single nucleotide polymorphisms, linkage disequilibrium, dopaminergic system, genetic susceptibility, eating disorders, transcription efficiency, transcript stability
- MeSH terms
- Adolescent, Adult, Aged, Anorexia Nervosa, Exons, Female, Genotype, Humans, Male, Middle Aged, Linkage Disequilibrium, Chi-Square Distribution, Receptors, Dopamine D2, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review