Cited by 443Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentGenetic Associations and Epidemiology

The D 2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome

Open access
Blum, K, Sheridan, P J, Wood, R C, Braverman, E R, Chen, T J H, phd, J G Cull, Comings, D E·1996·Journal of the Royal Society of Medicine

Abstract

The dopaminergic system, and in particular the dopamine D2 receptor, has been profoundly implicated in reward mechanisms in the brain. Dysfunction of the D2 dopamine receptors leads to aberrant substance seeking behaviour (alcohol, drug, tobacco, and food) and other related behaviours (pathological gambling, Tourette's syndrome, and attention deficit hyperactivity disorder). We propose that variants of the D2 dopamine receptor gene are important common genetic determinants of the 'reward deficiency syndrome'.

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Crossref · 10.1177/014107689608900711

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59 of 59 references verified0 citation errors · 0 not checkable

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Authors
Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E.
Affiliations
  • The University of Texas at San Antonio Health Science Center (US)
  • Department of Clinical Science, The PATH Foundation, Princeton, New Jersey, USA
  • Chang Jung University, College of Public Health, Tainan, Taiwan, Republic of China
  • Neurodevelopmental Institutes of North America, Ltd, San Antonio, Texas
  • City Of Hope National Medical Center (US)
Venue
Journal of the Royal Society of Medicine
Published
1996-07
Volume
89
Issue
7
Pages
396-400
ISSN
  • 0141-0768 (ISSN-L)
  • 1758-1095
OpenAlex
W1920680810
Cited by
443
References
58
Citations by year
2026: 6 · 2025: 14 · 2024: 17 · 2023: 11 · 2022: 22 · 2021: 16 · 2020: 19 · 2019: 23 · 2018: 27 · 2017: 21 · 2016: 29 · 2015: 35 · 2014: 28 · 2013: 27 · 2012: 31
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • Journal of the Royal Society of Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
dopamine D2 receptor, reward deficiency syndrome, dopaminergic system, reward processing, genetic variants, alcoholism, drug addiction, tobacco use, gambling addiction, Tourette syndrome, attention deficit hyperactivity disorder
MeSH terms
Compulsive Behavior, Humans, Genetic Linkage, Risk Factors, Syndrome, Receptors, Dopamine D2, Substance-Related Disorders

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