D2 dopamine receptor gene (DRD2) Taql A polymorphism: reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele
Open accessAbstract
The relationship between a dopamine D2 receptor genetic polymorphism at the Taq1 A locus and the level of D2 receptor binding was investigated in normal, middle aged to elderly subjects with no psychiatric or neurological disorders. D2 receptor binding was measured by autoradiography in the caudate, putamen and nucleus accumbens, using the specific D2 receptor ligand [3H]-raclopride. In a sample of 44 individuals, only one was homozygous for the A1 allele, 25 were homozygous for A2 and 18 were heterozygotes. The presence of one or two A1 alleles was associated with reduced D2 receptor binding in all areas of the striatum, reaching statistical significance in the ventral caudate and putamen (p = 0.01 and p = 0.044, respectively). This reduction was more marked in males than females, particularly in the putamen. A genetic predisposition to lower D2 receptor expression may increase susceptibility to neuroleptic medication or clinical symptoms that are associated with diseases involving dopaminergic pathology.
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The presence of a TaqIA allele, linked to decreased availability of striatal D2-receptors, is associated with poor response inhibition in the Stop-signal task.
“The presence of a TaqIA allele, which has been linked to decreased availability of striatal D2-receptors (Thompson et al., 1997), was associated with poor response inhibition in the Stop-signal task (White et al., 2008).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Thompson et al., 1997
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- Authors
- Thompson, J., Thomas, N., Singleton, A., Piggot, M., Lloyd, S., Perry, E. K., Morris, C. M., Perry, R. H., Ferrier, I. N., & Court, J. A.
- Affiliations
- Royal Victoria Infirmary (GB)
- Venue
- Pharmacogenetics
- Published
- 1997-12
- Volume
- 7
- Issue
- 6
- Pages
- 479-484
- ISSN
- 0960-314X (ISSN-L)
- OpenAlex
- W2065841438
- Cited by
- 553
- References
- 0
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 15 · 2023: 16 · 2022: 17 · 2021: 9 · 2020: 8 · 2019: 17 · 2018: 13 · 2017: 21 · 2016: 31 · 2015: 32 · 2014: 26 · 2013: 31 · 2012: 27
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Pharmacogenetics (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- DRD2 gene, TaqI polymorphism, dopamine D2 receptor, receptor binding, striatum, caudate nucleus, putamen, nucleus accumbens, A1 allele, sex differences, genetic susceptibility
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Corpus Striatum, Female, Genotype, Humans, Male, Middle Aged, Polymorphism, Genetic, Polymerase Chain Reaction, Receptors, Dopamine D2, Taq Polymerase
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