Cited by 42Stress Responses and CortisolAdrenal Hormones and DisordersAdipokines, Inflammation, and Metabolic Diseases

Abdominal obesity increases overnight cortisol excretion.

Duclos, M., Corcuff, J.-B., Etcheverry, N., Rashedi, M., Tabarin, A., Roger, P.·1999·Journal of Endocrinological Investigation

Abstract

Although plasma and 24 h urinary free cortisol (UFC) levels are normal in obese subjects, pharmacological investigations have identified minor hypothalamo-pituitary-adrenal axis differences in patients with abdominal body fat distribution (A-BFD) vs peripheral BFD (P-BFD). Using recent tools such as saliva cortisol or overnight urinary free cortisol upon creatinine ratio (UFC/UC) determinations, we have investigated a population of obese females according to their body fat distribution. In-patients subjects (no.=82) were subjected to routine biochemical testing, 24 h and overnight UFC/UC, basal and post-1 mg overnight dexamethasone-suppressing test plasma and saliva cortisol determinations. Central obesity defined by a waist-to-hip ratio (WHR) >0.85 was found in 64% of the subjects vs 87% when defined by waist girth (WG) corrected for age. Despite identical body mass index, A-BFD subjects were more prone to hypertension using both classifications and had higher triglycerides (WHR classification) or higher triglycerides, cholesterol and glycemia (WG classification). Plasma cortisol levels were similar but saliva cortisol levels were lower in the A-BFD group using the WG classification. The 24 h UFC/UC were similar but the overnight UFC/UC were higher in the A-BFD group using the WHR classification. These mild differences in cortisol nocturnal secretion and free cortisol indexes in subjects with different body fat mass distribution suggest that their hypothalamo-pituitary-adrenal axis has a spontaneously subtly different regulation.

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Crossref · 10.1007/bf03343591

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Authors
Duclos, M., Corcuff, J.-B., Etcheverry, N., Rashedi, M., Tabarin, A., & Roger, P.
Affiliations
  • Hôpital Cardiologique du Haut-Lévêque (FR)
  • University of Edinburgh (GB)
Corresponding author
Duclos, M.
Venue
Journal of Endocrinological Investigation
Published
1999-06
Volume
22
Issue
6
Pages
465-471
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
OpenAlex
W2116762161
Cited by
42
References
31
Citations by year
2020: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
1.55
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
abdominal obesity, body fat distribution, cortisol secretion, hypothalamic-pituitary-adrenal axis, urinary free cortisol, salivary cortisol, dexamethasone suppression test, waist-to-hip ratio, waist circumference, hypertension, triglycerides, female obesity
MeSH terms
Abdomen, Adipose Tissue, Adolescent, Adult, Aged, Female, Hormones, Humans, Hydrocortisone, Middle Aged, Obesity, Triglycerides, Body Mass Index

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