Stress, cortisol, and obesity: A role for cortisol responsiveness in identifying individuals prone to obesity
Abstract
There is a strong inter-relationship between activation of the hypothalamo-pituitary-adrenal axis and energy homeostasis. Patients with abdominal obesity have elevated cortisol levels. Furthermore, stress and glucocorticoids act to control both food intake and energy expenditure. In particular, glucocorticoids are known to increase the consumption of foods enriched in fat and sugar. It is well-known that, in all species, the cortisol response to stress or adrenocorticotropin is highly variable. It has now emerged that cortisol responsiveness is an important determinant in the metabolic sequelae to stress. Sheep that are characterized as high-cortisol responders (HRs) have greater propensity to weight gain and obesity than low-cortisol responders (LRs). This difference in susceptibility to become obese is associated with a distinct metabolic, neuroendocrine, and behavioral phenotype. In women and ewes, HR individuals eat more in response to stress than LR. Furthermore, HR sheep have impaired melanocortin signaling and reduced skeletal muscle thermogenesis. High-cortisol responder sheep exhibit reactive coping strategies, whereas LRs exhibit proactive coping strategies. This complex set of traits leads to increased food intake and reduced energy expenditure in HR and thus, predisposition to obesity. We predict that cortisol responsiveness may be used as a marker to identify individuals who are at risk of weight gain and subsequent obesity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lifestyle behaviors like exercise, stress management, and sleep quality significantly affect insulin sensitivity and lipid metabolism, modifying fat gain tendencies during overfeeding.
“Lifestyle behaviors like exercise, stress management, and sleep quality significantly affect insulin sensitivity and lipid metabolism, modifying fat gain tendencies during overfeeding.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [53]
Chronic stress elevates cortisol, which can impair insulin sensitivity and promote visceral fat storage.
“Additionally, chronic stress elevates cortisol, which can impair insulin sensitivity and promote visceral fat storage [53].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [53]
High cortisol sensitivity due to polymorphisms in the glucocorticoid receptor gene can predispose some individuals to greater fat retention during caloric restriction, particularly in the abdominal region.
“High cortisol sensitivity, due to polymorphisms in the glucocorticoid receptor gene, can predispose some individuals to greater fat retention during caloric restriction, particularly in the abdominal region [53].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [53]
Chronic stress elevates cortisol, which promotes visceral fat storage and impairs lipolysis by increasing insulin resistance.
“Chronic stress elevates cortisol, which promotes visceral fat storage and impairs lipolysis by increasing insulin resistance.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [53]
Cites
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965 · see citing works
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904 · see citing works
Coping styles in animals: current status in behavior and stress-physiology
Koolhaas, J. M., Korte, S. M., De Boer, S. F., Van Der Vegt, B. J., Van Reenen, C. G., Hopster, H., De Jong, I. C., Ruis, M. A. W., & Blokhuis, H. J. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00026-3 · Cited by 2,875 · see citing works
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732 · see citing works
Ohlson, L., Larsson, B., Svärdsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Björntorp, P., & Tibblin, G. (1985) · Diabetes · doi:10.2337/diab.34.10.1055 · Cited by 1,143 · see citing works
Epel, E., Lapidus, R., McEwen, B., & Brownell, K. (2001) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00035-4 · Cited by 1,060 · see citing works
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965 · see citing works
Rosmond, R., Dallman, M. F., & Björntorp, P. A. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4843 · Cited by 892 · see citing works
Chronic stress and comfort foods: Self-medication and abdominal obesity
Dallman, M. F., Pecoraro, N. C., & la Fleur, S. E. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.11.004 · Cited by 656 · see citing works
Rosmond, R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.6.1853 · Cited by 591 · see citing works
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582 · see citing works
Pecoraro, N., Reyes, F., Gomez, F., Bhargava, A., & Dallman, M. F. (2004) · Endocrinology · doi:10.1210/en.2004-0305 · Cited by 574 · see citing works
VALE, W., VAUGHAN, J., SMITH, M., & YAMAMOTO, G. (1983) · Endocrinology · doi:10.1210/endo-113-3-1121 · Cited by 563 · see citing works
Orth, D. N. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503233321207 · Cited by 562 · see citing works
Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin
Clegg, D. J., Brown, L. M., Woods, S. C., & Benoit, S. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1339 · Cited by 552 · see citing works
The effects of glucocorticoids on adipose tissue lipid metabolism
Peckett, A. J., Wright, D. C., & Riddell, M. C. (2011) · Metabolism · doi:10.1016/j.metabol.2011.06.012 · Cited by 548 · see citing works
Rivier, C., & Vale, W. (1983) · Nature · doi:10.1038/305325a0 · Cited by 539 · see citing works
Rodriguez, A. C. I., Epel, E. S., White, M. L., Standen, E. C., Seckl, J. R., & Tomiyama, A. J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.014 · Cited by 422 · see citing works
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
Williams, K. W., & Elmquist, J. K. (2012) · Nature Neuroscience · doi:10.1038/nn.3217 · Cited by 421 · see citing works
Minireview: Glucocorticoids—Food Intake, Abdominal Obesity, and Wealthy Nations in 2004
Dallman, M. F., la Fleur, S. E., Pecoraro, N. C., Gómez-Oliver, F., Houshyar, H., & Akana, S. F. (2004) · Endocrinology · doi:10.1210/en.2004-0037 · Cited by 413 · see citing works
Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids
Picard, M., Juster, R.-P., & McEwen, B. S. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.22 · Cited by 405 · see citing works
Modification of the Plasma Cortisol Response to Stress in Rainbow Trout by Selective Breeding
Pottinger, T. G., & Carrick, T. R. (1999) · General and Comparative Endocrinology · doi:10.1006/gcen.1999.7355 · Cited by 393 · see citing works
Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., & Lowell, B. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20786 · Cited by 388 · see citing works
Suppression of hypothalmic-pituitary-adrenal axis responses to stress in lactating women
Altemus, M. M., Deuster, P. A., Galliven, E., Carter, C. S., & Gold, P. W. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.10.7559880 · Cited by 383 · see citing works
Regulation of the Hypothalamic-Pituitary-Adrenal Axis
Papadimitriou, A., & Priftis, K. Ν. (2009) · NeuroImmunoModulation · doi:10.1159/000216184 · Cited by 367 · see citing works
Pasquali, R., Cantobelli, S., Casimirri, F., Capelli, M., Bortoluzzi, L., Flamia, R., Labate, A. M., & Barbara, L. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.2.8393881 · Cited by 366 · see citing works
Tomiyama, A. J., Dallman, M. F., & Epel, E. S. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.04.005 · Cited by 363 · see citing works
Sakanaka, M., Shibasaki, T., & Lederis, K. P. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902600209 · Cited by 335 · see citing works
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C. (2003) · Diabetes · doi:10.2337/diabetes.52.3.682 · Cited by 332 · see citing works
Elfhag, K., & Morey, L. C. (2007) · Eating Behaviors · doi:10.1016/j.eatbeh.2007.10.003 · Cited by 330 · see citing works
Daily hassles and eating behaviour: The role of cortisol reactivity status
Newman, E., O'Connor, D. B., & Conner, M. T. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.11.006 · Cited by 292 · see citing works
Relationship between Cortisol Responses to Stress and Personality
Oswald, L. M., Zandi, P. P., Nestadt, G., Potash, J. B., Kalaydjian, A., & Wand, G. S. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301012 · Cited by 273 · see citing works
Heritability of cortisol levels: review and simultaneous analysis of twin studies
Bartels, M., den Berg, M. V., Sluyter, F., Boomsma, D. I., & de Geus, E. J. C. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00003-3 · Cited by 259 · see citing works
Hypothalamic-pituitary-adrenocortical axis regulation
Jacobson, L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.003 · Cited by 248 · see citing works
Potentiation by Vasopressin of Corticotropin Release Induced by Corticotropin-Releasing Factor1
Yates, F. E., Russell, S. M., Dallman, M. F., Hedge, G. A., McCann, S. M., & DHARIWAL, A. P. S. (1971) · Endocrinology · doi:10.1210/endo-88-1-3 · Cited by 245 · see citing works
Engler, D., Pham, T., Fullerton, M. J., Ooi, G., Funder, J. W., & Clarke, I. J. (2008) · Neuroendocrinology · doi:10.1159/000125141 · Cited by 235 · see citing works
Hypothalamic neuropeptides and the regulation of appetite
Parker, J., & Bloom, S. R. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.004 · Cited by 233 · see citing works
Whitnall, M. H., Mezey, É., & Gainer, H. (1985) · Nature · doi:10.1038/317248a0 · Cited by 231 · see citing works
Adipogenic and lipolytic effects of chronic glucocorticoid exposure
Campbell, J. E., Peckett, A. J., D'souza, A. M., Hawke, T. J., & Riddell, M. C. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00045.2010 · Cited by 228 · see citing works
The role of gender and taste class in the effects of stress on eating.
Grunberg, N. E., & Straub, R. O. (1992) · Health Psychology · doi:10.1037//0278-6133.11.2.97 · Cited by 207 · see citing works
Richard, D., Lin, Q., & Timofeeva, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01428-0 · Cited by 204 · see citing works
Born, J. R., Lemmens, S. G. T., Rutters, F., Nieuwenhuizen, A. G., Formisano, E., Goebel, R., & Westerterp‐Plantenga, M. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.221 · Cited by 191 · see citing works
The role of gender and taste class in the effects of stress on eating.
Grunberg, N. E., & Straub, R. O. (1992) · Health Psychology · doi:10.1037/0278-6133.11.2.97 · Cited by 191 · see citing works
Mice selected for high versus low stress reactivity: A new animal model for affective disorders
Touma, C., Bunck, M., Glasl, L., Nußbaumer, M., Palme, R., Stein, H., Wolferstätter, M., Zeh, R., Zimbelmann, M., Holsboer, F., et al. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.013 · Cited by 188 · see citing works
Foster, M. T., Warne, J. P., Ginsberg, A. B., Horneman, H. F., Pecoraro, N. C., Akana, S. F., & Dallman, M. F. (2008) · Endocrinology · doi:10.1210/en.2008-1426 · Cited by 182 · see citing works
Corticotrophin releasing factor may be modulated vasopressin
Gillies, G. E., & Lowry, P. (1979) · Nature · doi:10.1038/278463a0 · Cited by 174 · see citing works
Chronic Stress‐Induced Effects of Corticosterone on Brain: Direct and Indirect
Dallman, M. F., Akana, S. F., Strack, A. M., SCRIBNER, K. S., Pecoraro, N. C., la Fleur, S. E., Houshyar, H., & Gómez-Oliver, F. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.017 · Cited by 167 · see citing works
Savontaus, E., Conwell, I. M., & Wardlaw, S. L. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03674-0 · Cited by 156 · see citing works
Choice of Lard, But Not Total Lard Calories, Damps Adrenocorticotropin Responses to Restraint
la Fleur, S. E., Houshyar, H., Roy, M., & Dallman, M. F. (2005) · Endocrinology · doi:10.1210/en.2004-1603 · Cited by 148 · see citing works
Single exposure to stressors causes long-lasting, stress-dependent reduction of food intake in rats
Vallès, A., Martı́, O., García, A., & Armario, A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.3.r1138 · Cited by 145 · see citing works
Resistance to Glucocorticoid Feedback in Obesity
Jessop, D. S., Dallman, M. F., Fleming, D., & Lightman, S. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7826 · Cited by 141 · see citing works
Fevolden, S. E., Refstie, T., & Røed, K. H. (1991) · Aquaculture · doi:10.1016/0044-8486(91)90072-f · Cited by 132 · see citing works
Heritability of variation of plasma cortisol levels
Meikle, A. W., Stringham, J. D., Woodward, M. G., & Bishop, D. T. (1988) · Metabolism · doi:10.1016/0026-0495(88)90164-3 · Cited by 132 · see citing works
Stress response and binge eating disorder
Gluck, M. E. (2006) · Appetite · doi:10.1016/j.appet.2005.05.004 · Cited by 130 · see citing works
Pedersen, S. B., Jønler, M., & Richelsen, B. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.6.8200937 · Cited by 130 · see citing works
The glucocorticoid contribution to obesity
Spencer, S. J., & Tilbrook, A. J. (2011) · Stress · doi:10.3109/10253890.2010.534831 · Cited by 128 · see citing works
Laugero, K. D., Bell, M. E., Bhatnagar, S., Soriano, L., & Dallman, M. F. (2001) · Endocrinology · doi:10.1210/endo.142.7.8250 · Cited by 124 · see citing works
Whitnall, M. H., Smyth, D. G., & Gainer, H. (2008) · Neuroendocrinology · doi:10.1159/000124768 · Cited by 121 · see citing works
Stress‐Induced Cortisol Response and Fat Distribution in Women
Moyer, A. E., Rodin, J., Grilo, C. M., Cummings, N., Larson, L. M., & Rebuffé-Scrive, M. (1994) · Obesity Research · doi:10.1002/j.1550-8528.1994.tb00055.x · Cited by 114 · see citing works
Tilbrook, A. J., & Clarke, I. J. (2006) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2006.06.002 · Cited by 113 · see citing works
Self-citationBell, S., Bhatnagar, Liang, L., Soriano, Nagy, T. R., & Dallman (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00488.x · Cited by 112 · see citing works
The corticotropin-releasing hormone system in the regulation of energy balance in obesity
Richard, D., Huang, Q., & Timofeeva, E. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801275 · Cited by 107 · see citing works
Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity
Laryea, G., Schütz, G., & Muglia, L. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1187 · Cited by 106 · see citing works
Duclos, M., Gatta‐Cherifi, B., Corcuff, J., Rashedi, M., Péhourcq, F., & Roger, P. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01384.x · Cited by 105 · see citing works
Bhatnagar, Bell, S., Liang, L., Soriano, Nagy, T. R., & Dallman (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00487.x · Cited by 104 · see citing works
Sainsbury, A., Cusin, I., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1997) · Diabetes · doi:10.2337/diab.46.2.209 · Cited by 103 · see citing works
Makimura, H., Mizuno, T. M., Roberts, J. L., Silverstein, J. H., Beasley, J., & Mobbs, C. V. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1917 · Cited by 102 · see citing works
Lee, M.-J., & Fried, S. K. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.6 · Cited by 100 · see citing works
The Hypothalamic‐Pituitary‐Adrenal Axis Response to Endotoxin is Attenuated During Lactation
Shanks, Windle, Perks, Wood, Ingram, I., & Lightman, S. L. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00400.x · Cited by 97 · see citing works
Regulatory Mechanisms Underlying Corticotropin-Releasing Factor Gene Expression in the Hypothalam
Kageyama, K., & Suda, T. (2009) · Endocrine Journal · doi:10.1507/endocrj.k09e-075 · Cited by 95 · see citing works
Muráni, E., Ponsuksili, S., D’Eath, R. B., Turner, S. P., Kurt, E., Evans, G., Thölking, L., Klont, R. E., Foury, A., Mormède, P., et al. (2010) · BMC Genetics · doi:10.1186/1471-2156-11-74 · Cited by 95 · see citing works
Cortisol Measures Across the Weight Spectrum
Haines, M. S., Lawson, E. A., Dichtel, L. E., Klibanski, A., & Miller, K. K. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2078 · Cited by 93 · see citing works
The Effects of Stress on Body Weight: Biological and Psychological Predictors of Change in BMI
Roberts, C., Troop, N. A., Connan, F., Treasure, J. L., & Campbell, I. C. (2007) · Obesity · doi:10.1038/oby.2007.363 · Cited by 92 · see citing works
Mormède, P., Courvoisier, H., Ramos, A., Marissal‐Arvy, N., Ousova, O., Désautés, C., Duclos, M., Chaouloff, F., & Moisan, M. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00093-2 · Cited by 89 · see citing works
Adrenalectomy and food restriction in the genetically obese (ob/ob) mouse
Saito, M. K., & Bray, G. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.1.r20 · Cited by 87 · see citing works
The effects of glucocorticoids on feeding behavior in rats
la Fleur, S. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.01.028 · Cited by 86 · see citing works
Some metabolic and behavioral effects of adrenalectomy on obese Zucker rats
Castonguay, T. W., Dallman, M. F., & Stern, J. S. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.251.5.r923 · Cited by 86 · see citing works
Corticosterone Regulates Synaptic Input Organization of POMC and NPY/AgRP Neurons in Adult Mice
Gyengési, E., Liu, Z.-W., D’Agostino, G., Gan, G., Horváth, T. L., Gao, X., & Diano, S. (2010) · Endocrinology · doi:10.1210/en.2010-0681 · Cited by 84 · see citing works
Tu, M. T., LUPIEN, S. J., & Walker, C. (2005) · Stress · doi:10.1080/10253890500103806 · Cited by 82 · see citing works
Turner, A. I., Canny, B., Hobbs, R. J., Bond, J., Clarke, I. J., & Tilbrook, A. J. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1730113 · Cited by 82 · see citing works
Self-citationAdrenalectomy and Steroid Treatment in Obese (ob/ob) and Diabetic (db/db) Mice
Shimomura, Y., Bray, G. A., & Lee, M. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011804 · Cited by 79 · see citing works
Inhibition of food intake induced by acute stress in rats is due to satiation effects
Calvez, J., Fromentin, G., Nadkarni, N. A., Darcel, N., Even, P. C., Tomé, D., Ballet, N., & Chaumontet, C. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.07.012 · Cited by 78 · see citing works
Lincoln, G. A., Rhind, S. M., Pompolo, S., & Clarke, I. J. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.1.r76 · Cited by 77 · see citing works
Self-citationKnott, S., Cummins, L. J., Dunshea, F. R., & Leury, B. J. (2007) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2007.07.002 · Cited by 75 · see citing works
Bell, M. E., Bhargava, A., Soriano, L., Laugero, K. D., Akana, S. F., & Dallman, M. F. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00784.x · Cited by 63 · see citing works
Effects of glucocorticoids on human brown adipocytes
Barclay, J. L., Agada, H., Jang, C., Ward, M. S., Wetzig, N. R., & Ho, K. K. Y. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0538 · Cited by 57 · see citing works
Pituitary-Adrenal Axis Regulation in Crh-Deficient Mice
Muglia, L. J., Bethin, K. E., Jacobson, L., Vogt, S. K., & Majzoub, J. A. (2000) · Endocrine Research · doi:10.3109/07435800009048638 · Cited by 55 · see citing works
Central Leptin Activates Mitochondrial Function and Increases Heat Production in Skeletal Muscle
Henry, B. A., Andrews, Z. B., Rao, A., & Clarke, I. J. (2011) · Endocrinology · doi:10.1210/en.2011-0143 · Cited by 54 · see citing works
Self-citationHenry, B. A., Dunshea, F. R., Gould, M., & Clarke, I. J. (2007) · Endocrinology · doi:10.1210/en.2007-1311 · Cited by 54 · see citing works
Self-citationKnott, S., Cummins, L. J., Dunshea, F. R., & Leury, B. J. (2010) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2010.03.003 · Cited by 54 · see citing works
Clarke, I. J., Tilbrook, A. J., Turner, A. I., et al. (2001) · Endocrinology · doi:10.1210/endo.142.6.8318 · Cited by 53 · see citing works
Self-citationDuclos, M., Gouarné, C., Martin, C., Rocher, C., Mormède, P., & Letellier, T. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00281.2003 · Cited by 51 · see citing works
Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System
Drazen, D. L., Wortman, M. D., Schwartz, M. W., Clegg, D. J., van Dijk, G., Woods, S. C., & Seeley, R. J. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2928 · Cited by 50 · see citing works
Clarke, I. J., Scott, C., Rao, A., Pompolo, S., & Barker-Gibb, M. L. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00570.x · Cited by 45 · see citing works
Self-citationEngler, D., Pham, T., Fullerton, M. J., Clarke, I. J., & Funder, J. W. (2008) · Neuroendocrinology · doi:10.1159/000125139 · Cited by 44 · see citing works
Self-citationEstcourt, C. S., Sutcliffe, L. J., Cassell, J., Mercer, C. H., Copas, A. J., James, L., Low, N. N., Horner, P., Clarke, M., Symonds, M., et al. (2011) · Sexually Transmitted Infections · doi:10.1136/sti.2010.047258 · Cited by 44 · see citing works
Central role of the melanocortin-4 receptors in appetite regulation after endotoxin1
Sartin, J. L., Marks, D. L., McMahon, C. D., Daniel, J. A., Levasseur, P. R., Wagner, C. G., Whitlock, B. K., & Steele, B. (2008) · Journal of Animal Science · doi:10.2527/jas.2008-0916 · Cited by 42 · see citing works
Abdominal obesity increases overnight cortisol excretion.
Duclos, M., Corcuff, J.-B., Etcheverry, N., Rashedi, M., Tabarin, A., & Roger, P. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03343591 · Cited by 42 · see citing works
Central mechanisms involved with catabolism
Nandi, J., Meguid, M. M., Inui, A., Xu, Y., Makarenko, I. G., Tada, T., & Chen, C. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200207000-00010 · Cited by 41 · see citing works
Tilbrook, A. J., Rivalland, E. T. A., Turner, A. I., Lambert, G. W., & Clarke, I. J. (2008) · Neuroendocrinology · doi:10.1159/000117576 · Cited by 40 · see citing works
Self-citationHypophysiotrophic neurons are capable of altering the ratio of co-packaged neurohormones
Bertini, L. T., & Kiss, J. Z. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90161-g · Cited by 36 · see citing works
Stackpole, C. A. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.016428 · Cited by 36 · see citing works
Orexin Expression and Function: Glucocorticoid Manipulation, Stress, and Feeding Studies
Ford, G. K., Albarazanji, K. A., Wilson, S., Jones, D. N. C., Harbuz, M. S., & Jessop, D. S. (2005) · Endocrinology · doi:10.1210/en.2005-0496 · Cited by 34 · see citing works
Marissal‐Arvy, N., Gaumont, A., Langlois, A., Dabertrand, F., Bouchecareilh, M., Tridon, C., & Mormède, P. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0077 · Cited by 34 · see citing works
Hazard, D., Liaubet, L., SanCristobal, M., & Mormède, P. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-101 · Cited by 33 · see citing works
Anukulkitch, C., Rao, A., Dunshea, F. R., Blache, D., Lincoln, G. A., & Clarke, I. J. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00417.2006 · Cited by 33 · see citing works
Self-citationSex and season are major determinants of voluntary food intake in sheep
Clarke, I. J. (2002) · Reproduction Fertility and Development · doi:10.1071/rd01087 · Cited by 32 · see citing works
Self-citationTurner, A. I., Rivalland, E. T. A., Clarke, I. J., & Tilbrook, A. J. (2010) · Endocrinology · doi:10.1210/en.2010-0234 · Cited by 31 · see citing works
Self-citationTerenina, E. E., Babigumira, B. M., Mignon, G. L., Базовкина, Д. В., Rousseau, S., Salin, F., Bendixen, C., & Mormède, P. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.09.004 · Cited by 29 · see citing works
Lee, K., Lee, C., Bischof, R. J., Lambert, G. W., Clarke, I. J., & Henry, B. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.015 · Cited by 29 · see citing works
Self-citationClarke, S. D., Lee, K., Andrews, Z. B., Bischof, R. J., Fahri, F., Evans, R. G., Clarke, I. J., & Henry, B. A. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00036.2012 · Cited by 25 · see citing works
Self-citationDifferential Effects of Adrenalectomy on Melanin-Concentrating Hormone and Orexin A
Drazen, D. L., Coolen, L. M., Strader, A. D., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1760 · Cited by 22 · see citing works
Lee, T. K., Clarke, I., John, J. S. S., Young, I., Leury, B., Rao, A., Andrews, Z., & Henry, B. (2014) · The FASEB Journal · doi:10.1096/fj.13-238345 · Cited by 21 · see citing works
Self-citationHewagalamulage, S. D., Clarke, I. J., Young, I. R., Rao, A., & Henry, B. A. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12233 · Cited by 15 · see citing works
Self-citationHenry, B. A., Blache, D., Dunshea, F. R., & Clarke, I. J. (2009) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2009.07.006 · Cited by 10 · see citing works
Self-citationAdrenalectomy in Genetically Obese ob/ob and db/db Mice Increases the Proton Conductance Pathway
Shargill, N. S., Lupien, J., & Bray, G. A. (1989) · Hormone and Metabolic Research · doi:10.1055/s-2007-1009264 · Cited by 8 · see citing works
Rothwell, N. J., & Stock, M. J. (1988) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(88)91091-2 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Theodorakis, N., Kreouzi, M., Pappas, A., & Nikolaou, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413438 · Cited by 43 · see citing works
- Authors
- Hewagalamulage, S. D., Lee, T. K., Clarke, I. J., & Henry, B. A.
- Affiliations
- Monash University (AU)
- Corresponding author
- Henry, B.A.
- Venue
- Domestic Animal Endocrinology
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 56
- Pages
- S112-S120
- ISSN
- 0739-7240 (ISSN-L)
- OpenAlex
- W2314179020
- Cited by
- 167
- References
- 117
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 30 · 2023: 26 · 2022: 18 · 2021: 19 · 2020: 13 · 2019: 14 · 2018: 12 · 2017: 6
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Domestic Animal Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- obesity, hypothalamic-pituitary-adrenal axis, stress, glucocorticoids, energy homeostasis, dietary intake, energy expenditure, melanocortin signaling, skeletal muscle thermogenesis, coping strategies, sheep, abdominal obesity
- MeSH terms
- Animals, Eating, Energy Metabolism, Humans, Hydrocortisone, Obesity, Stress, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review