The DOI matches its Crossref record; 121 of the 122 references it cites were found in a registry or an index.
Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential
Open accessAbstract
Traditional medicine has been a fertile source for revealing novel lead molecules for modern drug discovery. In plants, terpenoids represent a chemical defense against environmental stress and provide a repair mechanism for wounds and injuries. Interestingly, effective ingredients in several plant-derived medicinal extracts are also terpenoid compounds of monoterpenoid, sesquiterpenoid, diterpenoid, triterpenoid and carotenoid groups. Inflammatory diseases and cancer are typical therapeutic indications of traditional medicines. Thus folk medicine supports the studies which have demonstrated that plant-derived terpenoid ingredients can suppress nuclear factor-kappaB (NF-kappaB) signaling, the major regulator in the pathogenesis of inflammatory diseases and cancer.We review the extensive literature on the different types of terpenoid molecules, totalling 43, which have been verified both inhibiting the NF-kappaB signaling and suppressing the process of inflammation and cancer. It seems that during evolution, plants have established a terpene-based host defense which also represents a cornucopia of effective therapeutic compounds for common human diseases.
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“Some authors reported that α-pinene clearly inhibited the translocation of NF-κB/p65 protein into nuclei in LPS-stimulated THP-1 cells, through the increase of expression of IκBα protein [150,151].”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [151]
Citations
Cites
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Cited by
Sorted by citations
Kauppinen, A., Suuronen, T., Ojala, J. O., Kaarniranta, K., & Salminen, A. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.06.007 · Cited by 1,016
Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review
Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933
Potential Health Benefits of Plant Food-Derived Bioactive Components: An Overview
Samtiya, M., Aluko, R. E., Dhewa, T., & Moreno‐Rojas, J. M. (2021) · Foods · doi:10.3390/foods10040839 · Cited by 686
A Review on Anti-Inflammatory Activity of Monoterpenes
Sá, R. D. C. D. S. E., Andrade, L., & de Sousa, D. P. (2013) · Molecules · doi:10.3390/molecules18011227 · Cited by 579
Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases
Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 546
Metadata
- Authors
- Salminen, A., Lehtonen, M., Suuronen, T., Kaarniranta, K., & Huuskonen, J.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Salminen, A.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-05-31
- Volume
- 65
- Issue
- 19
- Pages
- 2979-2999
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11131807
- OpenAlex
- W2064721285
- Cited by
- 406
- References
- 122
- Citations by year
- 2026: 14 · 2025: 27 · 2024: 22 · 2023: 26 · 2022: 20 · 2021: 26 · 2020: 24 · 2019: 26 · 2018: 26 · 2017: 26 · 2016: 28 · 2015: 19 · 2014: 28 · 2013: 25 · 2012: 19
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Physical Sciences › Chemistry › Organic Chemistry › Natural product bioactivities and synthesis
- Keywords
- terpenoids, NF-κB signaling, anti-inflammatory agents, anticancer agents, monoterpenoids, sesquiterpenes, diterpenoids, triterpenoids, carotenoids, traditional medicine, plant defense, inflammatory diseases
- MeSH terms
- Anti-Inflammatory Agents, Antineoplastic Agents, Humans, Medicine, Traditional, Neoplasms, Plants, Terpenes, Molecular Structure, NF-kappa B
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