Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

Microtubules as a target for anticancer drugs

Jordan, M. A., & Wilson, L. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1317 · Cited by 4,000

NF-κB: linking inflammation and immunity to cancer development and progression

Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350

The biological action of saponins in animal systems: a review

Francis, G., Kerem, Z., Makkar, H. P. S., & Becker, K. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002725 · Cited by 1,722

Carotenoid actions and their relation to health and disease

Krinsky, N. I., & Johnson, E. J. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2005.10.001 · Cited by 1,461

Anatomical and chemical defenses of conifer bark against bark beetles and other pests

Franceschi, V. R., Krokene, P., Christiansen, E., & Krekling, T. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01436.x · Cited by 1,124

Terpene synthases and the regulation, diversity and biological roles of terpene metabolism

Tholl, D. (2006) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2006.03.014 · Cited by 886

Saponins, classification and occurrence in the plant kingdom

Vincken, J., Heng, L., de Groot, C. P. G. M., & Gruppen, H. (2006) · Phytochemistry · doi:10.1016/j.phytochem.2006.10.008 · Cited by 798

Carotenoid Action on the Immune Response

Chew, B. P., & Park, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.257s · Cited by 795

Genes, enzymes and chemicals of terpenoid diversity in the constitutive and induced defence of conifers against insects and pathogens*

Keeling, C. I., & Bohlmann, J. (2006) · New Phytologist · doi:10.1111/j.1469-8137.2006.01716.x · Cited by 737

IκB kinase complexes: gateways to NF-κB activation and transcription

Scheidereit, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209934 · Cited by 668

Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials

Corson, T. W., & Crews, C. M. (2007) · Cell · doi:10.1016/j.cell.2007.08.021 · Cited by 656

Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition

Hussein, G. M. E., Sankawa, U., Goto, H., Matsumoto, K., & Watanabe, H. (2005) · Journal of Natural Products · doi:10.1021/np050354+ · Cited by 653

Pharmacological properties of the ubiquitous natural product betulin

Alakurtti, S., Mäkelä, T., Koskimies, S., & Yli‐Kauhaluoma, J. T. (2006) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2006.04.006 · Cited by 650

IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639

Prevention and Therapy of Cancer by Dietary Monoterpenes

Crowell, P. L. (1999) · Journal of Nutrition · doi:10.1093/jn/129.3.775s · Cited by 632

Limb and Skin Abnormalities in Mice Lacking IKKα

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 606

Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585

Biogenesis, molecular regulation and function of plant isoprenoids.

Bouvier, F., Rahier, A., & Camara, B. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.09.003 · Cited by 498

The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65

Lyß, G., Knorre, A., Schmidt, T. J., Pahl, H. L., & Merfort, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33508 · Cited by 479

Overview of Mechanisms of Action of Lycopene

Heber, D., & Lu, Q. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701013 · Cited by 478

A Review of 12 Commonly Used Medicinal Herbs

Ohara, M. (1998) · Archives of Family Medicine · doi:10.1001/archfami.7.6.523 · Cited by 476

Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.

Shishodia, S., Majumdar, S., Banerjee, S., & Aggarwal, B. B. (2003) · PubMed · Cited by 426

Cafestol and Kahweol, Two Coffee Specific Diterpenes with Anticarcinogenic Activity

Cavin, C., Holzhaeuser, D., Scharf, G., Constable, A., Huber, W. W., & Schilter, B. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(02)00029-7 · Cited by 422

Current insights into the regulation of programmed cell death by NF-κB

Dutta, J., Fan, Y., Gupta, N., Fan, G., & Gélinas, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209938 · Cited by 415

Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

García‐Piñeres, A., Castro, V., MORA, G. A., Schmidt, T. J., Strunck, E., Pahl, H. L., & Merfort, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101985200 · Cited by 413

Natural products as a gold mine for arthritis treatment

Khanna, D., Sethi, G., AHN, K., PANDEY, M., Kunnumakkara, A. B., SUNG, B., Aggarwal, A. N., & Aggarwal, B. B. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.03.002 · Cited by 391

A history of the therapeutic use of liquorice in Europe

Fiore, C., Eisenhut, M., Ragazzi, E., Zanchin, G., & Armanini, D. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.04.015 · Cited by 382

Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention with Anti-Inflammatory and Antioxidative Phytochemicals –

Surh, Y., Kundu, J. K., Na, H., & Lee, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2993s · Cited by 365

Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1-mediated NF-κB activation

Sethi, G., Ahn, K. S., Pandey, M. K., & Aggarwal, B. B. (2006) · Blood · doi:10.1182/blood-2006-10-050807 · Cited by 340

Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention

Ribaya‐Mercado, J. D., & Blumberg, J. B. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719427 · Cited by 315

Natural products as targeted modulators of the nuclear factor-κB pathway

Bremner, P., & Heinrich, M. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021778637 · Cited by 312

Antiinflammatory effects of genipin, an active principle of gardenia

Koo, H.-J., Song, Y. S., Kim, H.-J., Lee, Y.-H., Hong, S.-M., Kim, S., Kim, B.-C., Jin, C., Lim, C., & Park, E. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.05.031 · Cited by 311

Lutein and Zeaxanthin Dietary Supplements Raise Macular Pigment Density and Serum Concentrations of these Carotenoids in Humans

Bone, R. A., Ruiz, C. A., Landrum, J. T., & Guerra, L. H. (2003) · Journal of Nutrition · doi:10.1093/jn/133.4.992 · Cited by 310

Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

Lee, J., Koo, T. H., Yoon, H.-K., Jung, H. S., Jin, H. Z., Lee, K., Hong, Y., & Lee, J. J. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.014 · Cited by 310

Biological Relevance of Terpenoids

Wagner, K., & Elmadfa, I. (2003) · Annals of Nutrition and Metabolism · doi:10.1159/000070030 · Cited by 306

The CNS effects of Ginkgo biloba extracts and ginkgolide B

Maclennan, K. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00015-1 · Cited by 303

Coffee and cardiovascular disease: In vitro, cellular, animal, and human studies

BONITA, J., Mandarano, M. A., Shuta, D., & Vinson, J. A. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.006 · Cited by 303

Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages

Lo, A.-H., Liang, Y., Lin‐Shiau, S., Ho, C., & Lin, J.-K. (2002) · Carcinogenesis · doi:10.1093/carcin/23.6.983 · Cited by 292

Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

Lee, S., Bai, S.-K., Lee, K.-S., Namkoong, S., Na, H. J., Ha, K., Han, J. A., Yim, S. V., Chang, K., Kwon, Y. G., et al. (2003) · PubMed · Cited by 279

Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to Bedside

Efferth, T. (2007) · Planta Medica · doi:10.1055/s-2007-967138 · Cited by 275

Saussurea costus: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant

Pandey, M. M., Rastogi, S., & Rawat, A. K. S. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.12.033 · Cited by 272

β-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-κB activation

Bai, S.-K., Lee, S.-J., Na, H.-J., Ha, K.-S., Han, J.-A., Lee, H., Kwon, Y.-G., Chung, C.-K., & Kim, Y.-M. (2005) · Experimental & Molecular Medicine · doi:10.1038/emm.2005.42 · Cited by 269

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Radad, K., Gille, G., Liu, L., & Rausch, W. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05010x · Cited by 268

Naturally Occurring Iridoids. A Review, Part 1

Dinda, B., Debnath, S., & Harigaya, Y. (2007) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.55.159 · Cited by 268

Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice

Saleem, M., Afaq, F., Adhami, V. M., & Mukhtar, H. (2004) · Oncogene · doi:10.1038/sj.onc.1207641 · Cited by 254

Quantitative Structure−Activity Relationship of Sesquiterpene Lactones as Inhibitors of the Transcription Factor NF-κB

Siedle, B., García‐Piñeres, A., Murillo, R., Schulte‐Mönting, J., Castro, V., Rüngeler, P., Klaas, C. A., Costa, F. B. D., Kisiel, W., & Merfort, I. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049937r · Cited by 248

Triterpenoid CDDO-Me Blocks the NF-κB Pathway by Direct Inhibition of IKKβ on Cys-179

Ahmad, R., Raina, D. B., Meyer, C. J., Kharbanda, S. M., & Kufe, D. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607160200 · Cited by 238

Potential anticancer activity of tanshinone IIA against human breast cancer

Wang, X., Wei, Y., Yuan, S.-L., Liu, G., Lu, Y., Zhang, J., & Wang, W. (2005) · International Journal of Cancer · doi:10.1002/ijc.20880 · Cited by 237

Betulinic Acid Suppresses Carcinogen-Induced NF-κB Activation Through Inhibition of IκBα Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and Matrix Metalloprotease-9

Takada, Y., & Aggarwal, B. B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3278 · Cited by 215

Inflammation, Cancer, and Targets of Ginseng

Hofseth, L. J., & Wargovich, M. J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.183s · Cited by 209

New insights into the mechanism of action of the anti-inflammatory triterpene lupeol

Fernández, Á., Heras, B. D. L., García, M. D., Sáenz, T., & Villar, Á. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011777909 · Cited by 206

Celastrol Blocks Neuronal Cell Death and Extends Life in Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Kiaei, M., Kipiani, K., Petri, S., Chen, J., Calingasan, N. Y., & Beal, M. F. (2005) · Neurodegenerative Diseases · doi:10.1159/000090364 · Cited by 199

Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion

Takada, Y., Murakami, A., & Aggarwal, B. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208845 · Cited by 199

Acetyl-Boswellic Acids Inhibit Lipopolysaccharide-Mediated TNF-α Induction in Monocytes by Direct Interaction with IκB Kinases

Syrovets, T., Büchele, B., Krauss, C., Laumonnier, Y., & Simmet, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.498 · Cited by 196

Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappaB and c-Jun

Huang, S.-C., Ho, C., Lin‐Shiau, S., & Lin, J.-K. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.09.019 · Cited by 192

Neuroprotective Effects of Huperzine A

Wang, R., & Tang, X. C. (2005) · Neurosignals · doi:10.1159/000085387 · Cited by 174

Antiinflammatory and Antiatherogenic Effects of the NF-κB Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE −/− Mice

Cuaz‐Pérolin, C., Billiet, L., Baugé, E., Copin, C., Scott‐Algara, D., Genze, F., Büchele, B., Syrovets, T., Simmet, T., & Rouis, M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.155606 · Cited by 171

Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw

Medeiros, R., Passos, G. F., Vitor, C. E., Koepp, J., Mazzuco, T. L., Pianowski, L. F., Campos, M. M., & Calixto, J. B. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707270 · Cited by 167

Macular Pigment Lutein Is Antiinflammatory in Preventing Choroidal Neovascularization

Izumi‐Nagai, K., Nagai, N., Ohgami, K., Satofuka, S., Ozawa, Y., Tsubota, K., Umezawa, K., Ohno, S., Oike, Y., & Ishida, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151431 · Cited by 162

Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-κB signaling pathway

Suzuki, Y., Ohgami, K., Shiratori, K., Jin, X.-H., Ilieva, I. B., Koyama, Y., Yazawa, K., Yoshida, K., Kase, S., & Ohno, S. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.06.023 · Cited by 158

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

García, P. A., de Oliveira, A. B., & Batista, R. (2007) · Molecules · doi:10.3390/12030455 · Cited by 156

Oridonin, a diterpenoid purified fromRabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways

Ikezoe, T., Yang, Y., Bandobashi, K., Saito, T., Takemoto, S., Machida, H., Togitani, K., Koeffler, H. P., & Taguchi, H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-04-0277 · Cited by 154

Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-κB by inhibiting both its nuclear localization and ability to bind DNA

Haridas, V., Arntzen, C. J., & Gutterman, J. U. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191363498 · Cited by 154

Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF‐kB activation

Aldieri, E., Atragene, D., Bergandi, L., Riganti, C., Costamagna, C., Bosìa, A., & Ghigo, D. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00905-0 · Cited by 153

Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.

Hsieh, T.-C., Wijeratne, E. M. K., Liang, J.-Y., Gunatilaka, A. A. L., & Wu, J. M. (2005) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2005.09.040 · Cited by 153

Inhibition of growth and metastasis of human gastric cancer implanted in nude mice byd-limonene

Lu, X.-G. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i14.2140 · Cited by 152

The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo.

Place, A. E., Suh, N., Williams, C. R., Risingsong, R., Honda, T., Honda, Y., Gribble, G. W., Leesnitzer, L. M., Stimmel, J. B., Willson, T. M., et al. (2003) · PubMed · Cited by 147

Role of cysteine residues of p65/NF-$kappa;B on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential

García‐Piñeres, A., Lindenmeyer, M. T., & Merfort, I. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.024 · Cited by 147

A Synthetic Triterpenoid, CDDO-Me, Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor κB–Regulated Gene Products in Human Leukemic Cells

Shishodia, S., Sethi, G., Konopleva, M. Y., Andreeff, M., & Aggarwal, B. B. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2044 · Cited by 147

Suppressive Effects of the Kahweol and Cafestol on Cyclooxygenase-2 Expression in Macrophages

Kim, J. Y., Jung, K. S., & Jeong, H. G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.070 · Cited by 146

In vivo and in vitro antiinflammatory activity of saikosaponins

Bermejo, P., Martínez, M. J. A., Sen, A., Gomez, A., Matellano, L. F., Contreras, S. S., & Dı́az-Lanza, A. M. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00376-2 · Cited by 140

Kaurane Diterpene, Kamebakaurin, Inhibits NF-κB by Directly Targeting the DNA-binding Activity of p50 and Blocks the Expression of Antiapoptotic NF-κB Target Genes

Lee, J.-H., Koo, T. H., Hwang, B. Y., & Lee, J. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201368200 · Cited by 135

β-Carotene Regulates NF-κB DNA-Binding Activity by a Redox Mechanism in Human Leukemia and Colon Adenocarcinoma Cells

Palozza, P., Serini, S., Torsello, A., Nicuolo, F. D., Piccioni, E., Wolf, F. I., Calviello, G., Ubaldi, V., & Pioli, C. (2003) · Journal of Nutrition · doi:10.1093/jn/133.2.381 · Cited by 133

Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: Structure requirement and role of heat shock protein induction

Matsuda, H., Kagerura, T., Toguchida, I., Ueda, H. R., Morikawa, T., & Yoshikawa, M. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00542-7 · Cited by 127

Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-γ

Stefano, D. D., Maiuri, M. C., Simeon, V., Grassia, G., Soscia, A., Cinelli, M. P., & Carnuccio, R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.03.051 · Cited by 124

Novel Mechanism of Inhibition of Nuclear Factor-κB DNA-Binding Activity by Diterpenoids Isolated from Isodon rubescens

Leung, C., Grill, S. P., Lam, W., Han, Q., Sun, H., & Cheng, Y.-C. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.012765 · Cited by 124

Inhibitory Effects of Lutein on Endotoxin-Induced Uveitis in Lewis Rats

Jin, X.-H., Ohgami, K., Shiratori, K., Suzuki, Y., Hirano, T., Koyama, Y., Yoshida, K., Ilieva, I. B., Iseki, K., & Ohno, S. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1429 · Cited by 121

Ginsenosides compound K and Rh2 inhibit tumor necrosis factor-α-induced activation of the NF-κB and JNK pathways in human astroglial cells

Choi, K., Kim, M., Ryu, J., & Choi, C. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.017 · Cited by 119

Lupeol Suppresses Cisplatin-Induced Nuclear Factor-κB Activation in Head and Neck Squamous Cell Carcinoma and Inhibits Local Invasion and Nodal Metastasis in an Orthotopic Nude Mouse Model

Lee, T. K., Poon, R. T. P., Wo, J. Y. H., Ma, S., Guan, X., Myers, J. N., Altevogt, P., & Yuen, A. P. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0801 · Cited by 117

The immunopharmacology of paclitaxel (Taxol®), docetaxel (Taxotere®), and related agents

Fitzpatrick, F. A., & Wheeler, R. H. (2003) · International Immunopharmacology · doi:10.1016/j.intimp.2003.08.007 · Cited by 115

Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-γ-induced IκB degradation in RAW264.7 macrophages

Murakami, A., Matsumoto, K., Koshimįzu, K., & Ohigashi, H. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00058-2 · Cited by 114

Inhibition of the Nuclear Factor κB (NF-κB) Pathway by Tetracyclic Kaurene Diterpenes in Macrophages

Castrillo, A., Heras, B. D. L., Hortelano, S., Rodrı́guez, B., Villar, Á., & Boscá, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100010200 · Cited by 113

Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice

Lin, N., Liu, C., Xiao, C., Jia, H., Imada, K., Wu, H., & Itô, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.08.027 · Cited by 112

A Sesquiterpene Lactone, Costunolide, from Magnolia grandiflora Inhibits NF-κB by Targeting IκB Phosphorylation

Koo, T. H., Lee, J., Park, Y. J., Hong, Y., Kim, H. S., Kim, K., & Lee, J. J. (2001) · Planta Medica · doi:10.1055/s-2001-11503 · Cited by 106

Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-κB and c-Jun NH2-terminal kinase

Kim, Y.-H., Lee, S., Lee, J.-Y., Choi, S., Park, J., & Kwon, T. K. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.04.040 · Cited by 101

Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90

Salminen, A., Paimela, T., Suuronen, T., & Kaarniranta, K. (2008) · Immunology Letters · doi:10.1016/j.imlet.2007.12.017 · Cited by 99

Involvement of p53, nuclear factor κB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines

Hsu, Y., Kuo, P., Chiang, L., & Lin, C. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.03.044 · Cited by 94

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

Kalariya, N. M., Ramana, K. V., Sk, S., & van Kuijk, F. J. G. M. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.09.010 · Cited by 91

Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery

Haridas, V., Hanausek, M., Nishimura, G., Soehnge, H., Gaikwad, A. S., Naróg, M., Spears, E., Żółtaszek, R., Wałaszek, Z., & Gutterman, J. U. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18699 · Cited by 86

Inhibition of nuclear factor κB is associated with neuroprotective effects of glycyrrhizic acid on glutamate-induced excitotoxicity in primary neurons

Cherng, J., Lin, H. J., Hung, M.-S., Lin, Y.-R., Chan, M., & Lin, J. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.080 · Cited by 84

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