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The development and function of regulatory T cells
Open accessAbstract
Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4(+) T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response. While Tregs are critical for the peripheral maintenance of potential autoreactive T cells, they can also be detrimental by preventing effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression.
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Metadata
- Authors
- Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Vignali, Dario A. A.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-04-24
- Volume
- 66
- Issue
- 16
- Pages
- 2603-2622
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC2715449
- OpenAlex
- W2038689503
- Cited by
- 344
- References
- 221
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 25 · 2023: 14 · 2022: 28 · 2021: 17 · 2020: 25 · 2019: 23 · 2018: 16 · 2017: 17 · 2016: 15 · 2015: 12 · 2014: 20 · 2013: 21 · 2012: 24
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (F32AI072816, R01AI091977, R01AI039480, R01AI052199, R01AI058156)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- regulatory T cells, natural regulatory T cells, induced regulatory T cells, thymus development, CD4+ T cells, immunosuppression, peripheral tolerance, autoreactive T cells, antitumor immunity, sterilizing immunity
- MeSH terms
- Animals, Cell Differentiation, Humans, Immune Tolerance, Immunity, Cellular, Receptors, Antigen, T-Cell, Cytokines, Models, Immunological, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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