The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Non-B DNA structure-induced genetic instability and evolution
Open accessAbstract
Repetitive DNA motifs are abundant in the genomes of various species and have the capacity to adopt non-canonical (i.e., non-B) DNA structures. Several non-B DNA structures, including cruciforms, slipped structures, triplexes, G-quadruplexes, and Z-DNA, have been shown to cause mutations, such as deletions, expansions, and translocations in both prokaryotes and eukaryotes. Their distributions in genomes are not random and often co-localize with sites of chromosomal breakage associated with genetic diseases. Current genome-wide sequence analyses suggest that the genomic instabilities induced by non-B DNA structure-forming sequences not only result in predisposition to disease, but also contribute to rapid evolutionary changes, particularly in genes associated with development and regulatory functions. In this review, we describe the occurrence of non-B DNA-forming sequences in various species, the classes of genes enriched in non-B DNA-forming sequences, and recent mechanistic studies on DNA structure-induced genomic instability to highlight their importance in genomes.
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Cites
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Expandable DNA repeats and human disease
Mirkin, S. M. (2007) · Nature · doi:10.1038/nature05977 · Cited by 934
Repeat instability: mechanisms of dynamic mutations
Pearson, C. E., Edamura, K. N., & Cleary, J. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1689 · Cited by 924 · cited 1×
“Studies using model systems suggest that instability caused by trinucleotide repeats and other non-B DNA-forming sequences may occur via aberrant DNA replication events [16, 113, 114], as well as replication-independent mechanisms in non-proliferating tissues [115].”
Replication fork stalling at natural impediments
Mirkin, E. V., & Mirkin, S. M. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-06 · Cited by 482
Voineagu, I., Narayanan, V., Lobachev, K. S., & Mirkin, S. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804510105 · Cited by 269 · cited 2×
“Using two-dimensional gel electrophoretic analyses and electron microscopy, stalling of replication intermediates by trinucleotide repeats, inverted repeats of Alu elements [118], and an (A ? T)-rich fragile site (FLEX1) from the human FRA16D gene [119] was detected when these elements were cloned into bacterial, yeas…”
Cited by
DNA secondary structures: stability and function of G-quadruplex structures
Bochman, M. L., Paeschke, K., & Zakian, V. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3296 · Cited by 1,446
Recombination centres and the orchestration of V(D)J recombination
Schatz, D. G., & Ji, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2941 · Cited by 658
Heterochromatin: Guardian of the Genome
Janssen, A., Colmenares, S. U., & Karpen, G. H. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062653 · Cited by 500
Holkers, M., Maggio, I., Liu, J., Janssen, J. M., Miselli, F., Mussolino, C., Recchia, A., Cathomen, T., & Gonçalves, M. A. F. V. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1446 · Cited by 312
Bonaglia, M. C., Giorda, R., Beri, S., De Agostini, C., Novara, F., Fichera, M., Grillo, L., Galesi, O., Vetro, A., Ciccone, R., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002173 · Cited by 224
Metadata
- Authors
- Zhao, J., Bacolla, A., Wang, G., & Vasquez, K. M.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-09-01
- Volume
- 67
- Issue
- 1
- Pages
- 43-62
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W1980480427
- Cited by
- 404
- References
- 5
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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