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Chaperone-mediated autophagy. Machinery, regulation and biological consequences
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“As LAMP-2A receptormediated lysosomal protein uptake requires a specific recognition sequence and substrate translocation occurs in a stoichiometric fashion in CMA”
From A Unique Carboxyl-terminal Insert Domain in the Hematopoietic-specific, GTPase-deficient Rho GTPase RhoH Regulates Post-translational Processing (2013) · cites this paper as [43]
In the citing paper
“CMA is a very specific lysosomal degradation pathway where proteins bound to Hsc70-containing chaperone and co-chaperone complexes are recognized by the LAMP-2A receptor via a specific consensus sequence and subsequently degraded in lysosomes (41)(42)(43).”
From A Unique Carboxyl-terminal Insert Domain in the Hematopoietic-specific, GTPase-deficient Rho GTPase RhoH Regulates Post-translational Processing (2013) · cites this paper as [43]
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Citations
Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
Cuervo, A. M., Stefanis, L., Fredenburg, R., Lansbury, P. T., & Sulzer, D. (2004) · Science · doi:10.1126/science.1101738 · Cited by 2,024 · cited 3×
“sequences and have been proved to be CMA substrates [49, 83, 84].”
BackgroundTau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617 · cited 2×
“Tau mutants in the cytosol are targeted for CMA and cleaved by lysosomal enzymes [95].”
BackgroundChoi, J., Levey, A. I., Weintraub, S. T., Rees, H. D., Gearing, M., Chin, L.-S., & Li, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314124200 · Cited by 568
Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
Bauer, P. O., Goswami, A., Wong, H. K., Okuno, M., Kurosawa, M., Yamada, M., Miyazaki, H., Matsumoto, G., Kino, Y., Nagai, Y., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1608 · Cited by 280 · cited 2×
“Therefore, similar adaptor molecules comprising Hsc70-binding motifs fused to an appropriate structure-specific binding agent may have broader therapeutic potential for treating diseases caused by misfolded proteins [97].”
BackgroundChaperone-mediated autophagy: selectivity pays off
Cuervo, A. M. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.003 · Cited by 260 · cited 2×
“Selectivity thus became one of the hallmarks of CMA [51].”
BackgroundKabuta, T., Furuta, A., Aoki, S., Furuta, K., & Wada, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801918200 · Cited by 227
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
Rothenberg, C., Srinivasan, D., Mah, L., Kaushik, S., Peterhoff, C. M., Ugolino, J., Fang, S., Cuervo, A. M., Nixon, R. A., & Monteiro, M. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq231 · Cited by 225 · cited 1×
“Furthermore, ubiquilin, a ubiquitin-like protein, functions to regulate macroautophagy by facilitating maturation of LC3 protein, and is also a substrate of CMA, indicating that ubiquilin may also be at a crossroad between protein degradation pathways [ 71 , 72].”
BackgroundCathepsin A regulates chaperone‐mediated autophagy through cleavage of the lysosomal receptor
Cuervo, A. M., Mann, L., Bonten, E. J., d'Azzo, A., & Dice, J. F. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg002 · Cited by 182
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationTroeger, A., Chae, H.-D., Senturk, M., Wood, J., & Williams, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.505727 · Cited by 15
Metadata
- Authors
- Li, W., Yang, Q., & Mao, Z.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2010-10-26
- Volume
- 68
- Issue
- 5
- Pages
- 749-763
- ISSN
- 1420-682X
- 1420-9071
- Cited by
- 119
- References
- 11
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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