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Chaperone-mediated autophagy. Machinery, regulation and biological consequences

Li, Wenming, Yang, Qian, Mao, Zixu·2011·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-010-0565-6
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  1. Nedelsky NB, Todd PK, Taylor JP (2008) Autophagy and the ubiquitin–proteasome system: collaborators in neuroprotection. Biochim Biophys Acta 782:691–699 · DOI · Paper page
  2. Kirkin V, McEwan DG, Novak I, Dikic I (2009) A role for ubiquitin in selective autophagy. Mol Cell 34:259–269 · DOI
  3. Orenstein SJ, Cuervo AM (2010) Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol 21:719–726 · DOI · Paper page
  4. Kubota H (2009) Quality control against misfolded proteins in the cytosol: a network for cell survival. J Biochem 146:609–616 · DOI
  5. Sato Y, Sakamoto K, Sei M, Ewis AA, Nakahori Y (2009) Proteasome subunits are regulated and expressed in comparable concentrations as a functional cluster. Biochem Biophys Res Commun 378:795–798 · DOI
  6. Nagy V, Dikic I (2010) Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity. J Biol Chem 391:163–169 · DOI
  7. Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 10:398–409 · DOI
  8. Korolchuk VI, Menzies FM, Rubinsztein DC (2010) Mechanisms of cross-talk between the ubiquitin–proteasome and autophagy-lysosome systems. FEBS Lett 584:1393–1398 · DOI
  9. Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol 20(2):143–148 · DOI
  10. Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mul JJ, Pledger WJ, Wang HG (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 9:1142–1151 · DOI
  11. Koga H, Cuervo AM (2010) 17 Chaperone-mediated autophagy dysfunction in the pathogenesis of neurodegeneration. Neurobiol Dis. doi: 10.1016/j.nbd.2010.07.006 · DOI
  12. Glick D, Barth S, Macleod KF (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221:3–12 · DOI
  13. Dice JF (1982) Altered degradation of proteins microinjected into senescent human fibroblasts. J Biol Chem 257:14624–14627 · DOI · Paper page
  14. Backer JM, Bourret L, Dice JF (1983) Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids. Proc Natl Acad Sci USA 80:2166–2170 · DOI
  15. Dice JF, Chiang HL, Spencer EP, Backer JM (1986) Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7–11 as the essential pentapeptide. J Biol Chem 261:6853–6859 · DOI
  16. Dice JF (1987) Molecular determinants of protein half-lives in eukaryotic cells. FASEB J 1:349–357 · DOI
  17. Chiang HL, Terlecky SR, Plant CP, Dice JF (1989) A role for a 70-KDa heat shock protein in lysosomal degradation of intracellular proteins. Science 246:382–385 · DOI
  18. Cuervo AM, Terlecky SR, Dice JF, Knecht E (1994) Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. J Biol Chem 269:26374–26380 · DOI
  19. Cuervo AM, Dice JF (1996) A receptor for the selective uptake and degradation of proteins by lysosomes. Science 273:501–503 · DOI · Paper page
  20. Agarraberes FA, Terlecky SR, Dice JF (1997) An intralysosomal Hsp70 is required for a selective pathway of lysosomal protein degradation. J Cell Biol 137:825–834 · DOI
  21. Dice JF (2000) Lysosomal pathways of protein degradation, Molecular Biology Intelligence Unit, Landes Bioscience, Austin, TX · DOI
  22. Cuervo AM, Dice JF (2000) Age-related decline in chaperone-mediated autophagy. J Biol Chem 275:31505–31513 · DOI · Paper page
  23. Saftig P, Klumperman J (2009) Lysosome biogenesis and lysosomal membrane proteins: trafficking meeting function. Nat Rev Mol Cell Biol 10:623–635 · DOI · Paper page
  24. Majeski AE, Dice JF (2004) Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell Biol 36:2435–2444 · DOI
  25. Murphy RF (1991) Maturation models for endosome and lysosome biogenesis. Trends Cell Biol 1:77–82 · DOI
  26. Holtzman E (1989) Lysosomes (p. 439). Plenum Press, New York · DOI
  27. Conus S, Simon HU (2008) Cathepsins: key modulators of cell death and inflammatory responses. Biochem Pharmacol 76:1374–1382 · DOI
  28. Eskelinen EL, Tanaka Y, Saftig P (2003) At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol 13:137–145 · DOI
  29. Kettern N, Dreiseidler M, Tawo R, Höhfeld J (2010) Chaperone-assisted degradation: multiple paths to destruction. Biol Chem 391:481–489 · DOI
  30. Newmyer S, Christensen A, Sever S (2003) Auxilindynamin interactions link the uncoating ATPase chaperone machinery with vesicle formation. Developmental Cell 4:929–940 · DOI
  31. Agarraberes F, Dice J (2001) A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci 114:2491–2499 · DOI
  32. Salvador N, Aguado C, Horst M, Knecht E (2000) Import of a cytosolic protein into lysosomes by chaperone-mediated autophagy depends on its folding state. J Biol Chem 275:27447–27456 · DOI
  33. Thoms S (2002) Cdc48 can distinguish between native and nonnative proteins in the absence of cofactors. FEBS Lett 520:107–110 · DOI
  34. Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan J, Singh S, Millson S, Clarke P, Naaby-Hansen S, Stein R, Cramer R, Mollapour M, Workman P, Piper P, Pearl L, Prodromou C (2002) Activation of the ATPase activity of Hsp90 by the stress-regulated cochaperone aha1. Molecular Cell 10:1307–1318 · DOI
  35. Bimston D, Song J, Winchester D, Takayama S, Reed JC, Morimoto RI (1998) BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. EMBO J 17:6871–6878 · DOI
  36. Alberti S, Esser C, Höhfeld J (2003) BAG-1–a nucleotide exchange factor of Hsc70 with multiple cellular functions. Cell Stress Chaperones 8:225–231 · DOI
  37. Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ (2005) The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem 280:23727–23734 · DOI
  38. Jiang J, Ballinger CA, Wu Y, Dai Q, Cyr DM, Höhfeld J, Patterson C (2001) CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J Biol Chem 276(46):42938–42944 · DOI
  39. Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo AM (2008) The chaperonemediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol 28:5747–5763 · DOI
  40. Cuervo A, Dice J (2000) Unique properties of lamp2a compared to other lamp2 isoforms. J Cell Sci 113:4441–4450 · DOI
  41. Tanaka Y, Guhde G, Suter A, Eskelinen EL, Hartmann D, Lüllmann-Rauch R, Janssen PM, Blanz J, von Figura K, Saftig P (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406:902–906 · DOI · Paper page
  42. Eskelinen EL, Schmidt CK, Neu S, Willenborg M, Fuertes G, Salvador N, Tanaka Y, Lüllmann-Rauch R, Hartmann D, Heeren J, von Figura K, Knecht E, Saftig P (2004) Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell 15:3132–3145 · DOI
  43. Dice J (1988) Microinjected ribonuclease A as a probe for lysosomal pathways of intracellular protein degradation. J Protein Chem 7:115–127 · DOI
  44. Finn PF, Mesires NT, Vine M, Dice JF (2005) Effects of small molecules on chaperone-mediated autophagy. Autophagy 1:141–145 · DOI
  45. Dice JF (2007) Chaperone-mediated autophagy. Autophagy 3:295–299 · DOI
  46. Chiang H, Dice J (1988) Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J Biol Chem 262:6797–6805 · DOI
  47. Cuervo A, Gomes J, Barnes A, Dice J (2000) Selective degradation of annexins by chaperone-mediated autophagy. J Biol Chem 275:33329–33335 · DOI
  48. Yang Q, She H, Gearing M, Colla E, Lee M, Shacka JJ, Mao Z (2009) Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy. Science 323:124–127 · DOI
  49. Cuervo AM, Dice JF (2009) Lysosomes, a meeting point of proteins, chaperones, and proteases. J Mol Med 76:6–12
  50. Bandyopadhyay U, Cuervo AM (2007) Chaperone-mediated autophagy in aging and neurodegeneration: lessons from alpha-synuclein. Exp Gerontol 42:120–128 · DOI
  51. Lamark T, Kirkin V, Dikic I, Johansen T (2009) NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 8(13):1986–1990 · DOI · Paper page
  52. Kirkin V, Lamark T, Johansen T, Dikic I (2009) NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets. Autophagy 5:732–733 · DOI
  53. Cuervo AM (2004) Autophagy: many paths to the same end. Mol Cell Biochem 263:55–72 · DOI
  54. Welsch T, Younsi A, Disanza A, Rodriguez JA, Cuervo AM, Scita G, Schmidt J (2010) Eps8 is recruited to lysosomes and subjected to chaperone-mediated autophagy in cancer cells. Exp Cell Res 316:1914–1924 · DOI
  55. Liu H, Wang P, Song W, Sun X (2009) Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J 23:3383–3392 · DOI
  56. Bandyopadhyay U, Cuervo AM (2008) Entering the lysosome through a transient gate by chaperone-mediated autophagy. Autophagy 4:1101–1103 · DOI
  57. Kiffin R, Christian C, Knecht E, Cuervo AM (2004) Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell 15:4829–4840 · DOI
  58. Kaushik S, Massey AC, Cuervo AM (2006) Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J 25:3921–3933 · DOI
  59. Cuervo AM, Dice JF (2000) Regulation of lamp2a levels in the lysosomal membrane. Traffic 1:570–583 · DOI
  60. Kaushik S, Kiffin R, Cuervo AM (2007) Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Autophagy 3:387–389 · DOI
  61. Bandyopadhyay U, Sridhar S, Kaushik S, Kiffin R, Cuervo AM (2010) Identification of regulators of chaperone-mediated autophagy. Mol Cell 39:535–547 · DOI
  62. Kaushik S, Massey AC, Mizushima N, Cuervo AM (2008) Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell 19:2179–2192 · DOI
  63. Massey AC, Kaushik S, Sovak G, Kiffin R, Cuervo AM (2006) Consequences of the selective blockage of chaperone-mediated autophagy. Proc Natl Acad Sci USA 103:5805–5810 · DOI · Paper page
  64. Singh R, Czaja MJ (2008) Compensatory mechanisms and the type of injury determine the fate of cells with impaired macroautophagy. Autophagy 4:516–518 · DOI
  65. Cuervo AM, Dice JF, Knecht E (1997) A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins. J Biol Chem 272:5606–5615 · DOI
  66. Massey AC, Follenzi A, Kiffin R, Zhang C, Cuervo AM (2008) Early cellular changes after blockage of chaperone-mediated autophagy. Autophagy 4:442–4456 · DOI
  67. Kraft C, Peter M, Hofmann K (2010) Selective autophagy: ubiquitin-mediated recognition and beyond. Nat Cell Biol 12:836–841 · DOI · Paper page
  68. Rothenberg C, Monteiro MJ (2010) Ubiquilin at a crossroads in protein degradation pathways. Autophagy 6:101–102 · DOI
  69. Zhou D, Li P, Lin Y, Lott JM, Hislop AD, Canaday DH, Brutkiewicz RR, Blum JS (2005) Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens. Immunity 22:571–581 · DOI
  70. Strawbridge AB, Blum JS (2007) Autophagy in MHC class II antigen processing. Curr Opin Immunol 19:87–92 · DOI
  71. Wing S, Chiang H, Goldberg A, Dice J (1991) Proteins containing peptide sequences related to KFERQ are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats. Biochem J 275:165–169 · DOI
  72. Cuervo AM, Hu W, Lim B, Dice JF (1998) IκB is a substrate for a selective pathway of lysosomal proteolysis. Mol Biol Cell 9:1995–2010 · DOI
  73. Zhang C, Cuervo AM (2008) Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med 14:959–965 · DOI · Paper page
  74. Bejarano E, Cuervo AM (2010) Chaperone-mediated autophagy. Proc Am Thorac Soc 7:29–39 · DOI
  75. Venugopal B, Mesires NT, Kennedy JC, Curcio-Morelli C, Laplante JM, Dice JF, Slaugenhaupt SA (2009) Chaperone-mediated autophagy is defective in mucolipidosis type IV. J Cell Physiol 219:344–353 · DOI
  76. Fidzianska A, Walczak E, Walski M (2007) Abnormal chaperone-mediated autophagy (CMA) in cardiomyocytes of a boy with Danon disease. Folia Neuropathol 45:133–139
  77. Shacka JJ, Roth KA, Zhang J (2008) The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Front Biosci 13:718–736 · DOI
  78. Massey AC, Zhang C, Cuervo AM (2006) Chaperone-mediated autophagy in aging and disease. Curr Top Dev Biol 73:205–235 · DOI · Paper page
  79. Kon Maria, Cuervo AnaMaria (2010) Chaperone-mediated autophagy in health and disease. FEBS Lett 584:1399–1404 · DOI
  80. Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, Cuervo AM (2008) Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 118:777–788
  81. Mak SK, McCormack AL, Manning-Bog AB, Cuervo AM, Di Monte DA (2010) Lysosomal degradation of alpha-synuclein in vivo. J Biol Chem 285:13621–13629 · DOI
  82. Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, Blair LA, Marshall J, Mao Z (2003) Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 38:33–46 · DOI
  83. Wang X, Tang X, Li M, Marshall J, Mao Z (2005) Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival. J Biol Chem 280:16705–16713 · DOI
  84. Tang X, Wang X, Gong X, Tong M, Park D, Xia Z, Mao Z (2005) Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2. J Neurosci 25:4823–4834 · DOI
  85. Irrcher I, Park DS (2009) Parkinson’s disease: to live or die by autophagy. Sci Signal 2:pe21 · DOI
  86. Wang Y, Martinez-Vicente M, Kruger U, Kaushik S, Wong E, Mandelkow EM, Cuervo AM, Mandelkow E (2010) Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation. Autophagy 6:182–183 · DOI · Paper page
  87. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A (2009) IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol 187:1083–1099 · DOI
  88. Cuervo A, Hildebrand H, Bomhard E, Dice J (1999) Direct lysosomal uptake of 2-microglobulin contributes to chemically induced nephropathy. Kidney Int 55:529–545 · DOI
  89. Sooparb S, Price SR, Shaoguang J, Franch HA (2004) Suppression of chaperone mediated autophagy in the renal cortex during acute diabetes mellitus. Kidney Int 65:2135–2144 · DOI
  90. Maalouf M, Rhob J, Mattson M (2009) The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev 59:293–315 · DOI
  91. Mattson M (2008) Dietary factors, hormesis and health. Ageing Res Rev 7:43–48 · DOI
  92. Finn PF, Dice JF (2005) Ketone bodies stimulate chaperone-mediated autophagy. J Biol Chem 280:25864–25870 · DOI

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Metadata

Authors
Li, W., Yang, Q., & Mao, Z.
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2010-10-26
Volume
68
Issue
5
Pages
749-763
ISSN
  • 1420-682X
  • 1420-9071
DOI
10.1007/s00018-010-0565-6
Cited by
119
References
11
Language
en
Licence
www.springer.com/tdm (tdm)

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