Cited by 89Redox biology and oxidative stressNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Reactive oxygen species and the neuronal fate

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Kennedy, Karen A. M., Sandiford, Shelley D. E., Skerjanc, Ilona S., Li, Shawn S.-C.·2012·Cellular and Molecular Life Sciences

Abstract

Aberrant or elevated levels of reactive oxygen species (ROS) can mediate deleterious cellular effects, including neuronal toxicity and degeneration observed in the etiology of a number of pathological conditions, including Alzheimer's and Parkinson's diseases. Nevertheless, ROS can be generated in a controlled manner and can regulate redox sensitive transcription factors such as NFκB, AP-1 and NFAT. Moreover, ROS can modulate the redox state of tyrosine phosphorylated proteins, thereby having an impact on many transcriptional networks and signaling cascades important for neurogenesis. A large body of literature links the controlled generation of ROS at low-to-moderate levels with the stimulation of differentiation in certain developmental programs such as neurogenesis. In this regard, ROS are involved in governing the acquisition of the neural fate-from neural induction to the elaboration of axons. Here, we summarize and discuss the growing body of literature that describe a role for ROS signaling in neuronal development.

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  • Evidence for oxidative stress has been found in patients with schizophrenia, including increased lipid and protein oxidation in blood, CSF and post-mortem tissue, altered plasma antioxidants, and altered CSF superoxide dismutase-1 levels.

    “Evidence for oxidative stress has been found in patients with schizophrenia, including increased lipid and protein oxidation in blood, cerebrospinal fluid (CSF) and post-mortem tissue 36,37 , as well as altered levels of plasma antioxidants (such as vitamins C and E, catalase, GSH and GSH-peroxidase) 36,38 and CSF superoxide dismutase-1 levels 39 .”

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Authors
Kennedy, K. A. M., Sandiford, S. D. E., Skerjanc, I. S., & Li, S. S.-C.
Affiliations
  • Western University (CA)
  • University of Ottawa (CA)
Corresponding author
Li, Shawn S.-C.
Venue
Cellular and Molecular Life Sciences
Published
2011-09-23
Volume
69
Issue
2
Pages
215-221
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2021375247
Cited by
89
References
84
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 8 · 2012: 6
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canada Research Chairs
  • Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
reactive oxygen species, neuronal fate, neurogenesis, neuronal differentiation, redox signaling, redox-sensitive transcription factors, NF-κB, AP-1, NFAT, tyrosine phosphorylation, oxidative stress, neurotoxicity, neural induction, axon development, Alzheimer's disease, Parkinson's disease
MeSH terms
Animals, Female, Humans, Male, Nervous System, Neurons, Signal Transduction, Reactive Oxygen Species, NADPH Oxidases, Mice, Neurogenesis

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