Cited by 302Redox biology and oxidative stressNeuroscience and Neuropharmacology ResearchAntioxidant Activity and Oxidative Stress

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity: Supplementary Issue: Brain Plasticity and Repair

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Beckhauser, Thiago Fernando, Francis-Oliveira, José, De Pasquale, Roberto·2016·Journal of Experimental Neuroscience

Abstract

In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate, antioxidant mechanisms become overwhelmed and oxidative cellular stress may occur. Therefore, ROS are typically characterized as toxic molecules, oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids, and causing deficits in synaptic plasticity. High ROS concentrations are associated with a decline in cognitive functions, as observed in some neurodegenerative disorders and age-dependent decay of neuroplasticity. Nevertheless, controlled ROS production provides the optimal redox state for the activation of transductional pathways involved in synaptic changes. Since ROS may regulate neuronal activity and elicit negative effects at the same time, the distinction between beneficial and deleterious consequences is unclear. In this regard, this review assesses current research and describes the main sources of ROS in neurons, specifying their involvement in synaptic plasticity and distinguishing between physiological and pathological processes implicated.

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  1. [81]Fang M Jaffrey SR Sawa A Ye K Luo X Snyder SH Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON Neuron 2000 28 1 183 193 11086993
  2. [323]Mattson MP Goodman Y Luo H Fu W Furukawa K Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration J Neurosci Res 1997 49 6 681 697 9335256

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Authors
Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R.
Affiliations
  • Universidade de São Paulo (BR)
  • Physiology and Biophysics Department, Biomedical Sciences Institute, Sao Paulo University (USP), Butanta, Sao Paulo, Brazil
Venue
Journal of Experimental Neuroscience
Published
2016-01
Volume
10s1
Issue
Suppl 1
Pages
23-48
ISSN
1179-0695 (ISSN-L)
OpenAlex
W2508720811
Cited by
301
References
371
Citations by year
2026: 20 · 2025: 33 · 2024: 27 · 2023: 28 · 2022: 43 · 2021: 45 · 2020: 40 · 2019: 35 · 2018: 21 · 2017: 9
FWCI
1.96
Type
journal article
Language
en
Open access
Locations
  • Journal of Experimental Neuroscience (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
reactive oxygen species, synaptic plasticity, oxidative stress, antioxidant defense, redox signaling, neurodegenerative diseases, cognitive decline, lipid peroxidation, protein oxidation, neuroplasticity

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