Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell

GLUTATHIONE

Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,694 · see citing works

Practical Flow Cytometry

Shapiro, H. M. (2003) · Wiley eBooks · doi:10.1002/0471722731 · Cited by 2,698 · see citing works

A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030 · see citing works

Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

Smiley, S. T., Reers, M., Mottola-Hartshorn, C., Lin, M., Chen, A. B., Smith, T. W., Steele, G., & Chen, L. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3671 · Cited by 1,629 · see citing works

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

Bignami, A., Eng, L. F., Dahl, D. R., & Uyeda, C. T. (1972) · Brain Research · doi:10.1016/0006-8993(72)90398-8 · Cited by 1,456 · see citing works

Redox Regulation of Cellular Signalling

Kamata, H., & Hirata, H. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(98)00037-0 · Cited by 1,150 · see citing works

Monoclonal antibody to a plasma membrane antigen of neurons.

Eisenbarth, G. S., Walsh, F. S., & Nirenberg, M. W. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.4913 · Cited by 969 · see citing works

Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.

Ranscht, B., Clapshaw, P. A., Price, J., Noble, M., & Seifert, W. E. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2709 · Cited by 834 · see citing works

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

Noble, M., Murray, K., Stroobant, P., Waterfield, M. D., & Riddle, P. (1988) · Nature · doi:10.1038/333560a0 · Cited by 830 · see citing works

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

Richardson, W. D., Pringle, N. P., Mosley, M. J., Westermark, B., & Dubois-Dalcg, M. (1988) · Cell · doi:10.1016/0092-8674(88)90392-3 · Cited by 774 · see citing works

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture

RAFF, M. C., Lillien, L. E., Richardson, W. D., Burne, J. F., & Noble, M. (1988) · Nature · doi:10.1038/333562a0 · Cited by 761 · see citing works

Multiple extracellular signals are required for long-term oligodendrocyte survival

Barres, B. A., Schmid, R., Sendnter, M., & Raff, M. C. (1993) · Development · doi:10.1242/dev.118.1.283 · Cited by 712 · see citing works

Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.

Xanthoudakis, S., & Curran, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05097.x · Cited by 708 · see citing works

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

Lee, A. C., Fenster, B. E., Ito, H., Takeda, K., Bae, N. S., Hirai, T., Yu, Z.-X., Ferrans, V. J., Howard, B. H., & Finkel, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7936 · Cited by 691 · see citing works

A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development

Barrès, A., Lazar, M. A., & RAFF, M. C. (1994) · Development · doi:10.1242/dev.120.5.1097 · Cited by 593 · see citing works

Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells.

Bögler, O., Wren, D. R., Barnett, S. C., Land, H., & Noble, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.16.6368 · Cited by 577 · see citing works

Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions

Temple, S., & RAFF, M. C. (1986) · Cell · doi:10.1016/0092-8674(86)90843-3 · Cited by 455 · see citing works

Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

Groves, A. K., Barnett, S. C., Franklin, R. J. M., Crang, A. J., Mayer, M., Blakemore, W. F., & Noble, M. (1993) · Nature · doi:10.1038/362453a0 · Cited by 445 · see citing works

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

Mayer, M., & Noble, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7496 · Cited by 371 · see citing works

Practical flow cytometry

Borek, F. (1989) · Journal of Immunological Methods · doi:10.1016/0022-1759(89)90304-9 · Cited by 370 · see citing works

A crucial role for neurotrophin-3 in oligodendrocyte development

Barres, B. A., RAFF, M. C., Gaese, F., Bartke, I., Dechant, G., & Barde, Y. (1994) · Nature · doi:10.1038/367371a0 · Cited by 357 · see citing works

Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell.

Noble, M., & Murray, K. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb02122.x · Cited by 334 · see citing works

Accumulation of the cyclin‐dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation

Durand, B., Gao, F., & RAFF, M. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.306 · Cited by 324 · see citing works

Does oligodendrocyte survival depend on axons?

Barres, B. A., Jacobson, M. D., Schmid, R., Sendtner, M., & RAFF, M. C. (1993) · Current Biology · doi:10.1016/0960-9822(93)90039-q · Cited by 299 · see citing works

Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cells

Mabie, P. C., Mehler, M. F., Marmur, R., Papavasiliou, A., Song, Q., & Kessler, J. A. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04112.1997 · Cited by 294 · see citing works

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro

Mayer, M., Bhakoo, K., & Noble, M. (1994) · Development · doi:10.1242/dev.120.1.143 · Cited by 287 · see citing works

Redox Regulation of the Caspases during Apoptosisa

Hampton, M. B., Fadeel, B., & Orrenius, S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09913.x · Cited by 274 · see citing works

Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1Preprint

Casaccia‐Bonnefil, P., Tikoo, R., Kiyokawa, H., Friedrich, V. L., Chao, M. V., & Koff, A. (1997) · Genes & Development · doi:10.1101/gad.11.18.2335 · Cited by 252 · see citing works

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

Staal, F. J. T., Anderson, M. T., Staal, G. E. J., Herzenberg, L. A., Gitler, C., & Herzenberg, L. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3619 · Cited by 217 · see citing works

p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation

Durand, B., Fero, M. L., Roberts, J. M., & RAFF, M. C. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70177-0 · Cited by 207 · see citing works

Multiparameter analysis of transplantable hemopoietic stem cells: I. The separation and enrichment of stem cells homing to marrow and spleen on the basis of rhodamine-123 fluorescence.

Bertoncello, I., Hodgson, G., & Tr, B. (1985) · PubMed · Cited by 200 · see citing works

Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

Mårtensson, J., Jain, A., Stole, E., Frayer, W. W., Auld, P. A. M., & Meister, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9360 · Cited by 199 · see citing works

Rat neural antigen-2 (RAN-2): A cell surface antigen on astrocytes, ependymal cells, Müller cells and lepto-meninges defined by a monoclonal antibody

Bartlett, P. F., Noble, M., Pruss, R. M., RAFF, M. C., Rattray, S., & Williams, C. A. (1981) · Brain Research · doi:10.1016/0006-8993(81)90593-x · Cited by 199 · see citing works

The Macroglial Cells of the Rat Optic Nerve

Miller, R. H., ffrench‐Constant, C., & Raff, M. C. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.002505 · Cited by 193 · see citing works

Intracellular cysteine and glutathione delivery systems.

Meister, A., Anderson, M. E., & Hwang, O. (1986) · Journal of the American College of Nutrition · doi:10.1080/07315724.1986.10720121 · Cited by 192 · see citing works

Rhodamine-123 Staining in Hematopoietic Stem Cells of Young Mice Indicates Mitochondrial Activation Rather Than Dye Efflux

Kim, M., Cooper, D. D., Hayes, S. F., & Spangrude, G. J. (1998) · Blood · doi:10.1182/blood.v91.11.4106 · Cited by 160 · see citing works

Thyroid hormone and gene expression in the regulation of mitochondrial respiratory function

Pillar, T. M., & Seitz, H. J. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1360231 · Cited by 118 · see citing works

Evidence for the Existence of at Least Two Timing Mechanisms That Contribute to Oligodendrocyte Generationin Vitro

Ibarrola, N., Mayer‐Pröschel, M., Rodríguez‐Peña, A., & Noble, M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0280 · Cited by 112 · see citing works

Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids

Roberts, J. C., Nagasawa, H. T., Zera, R. T., et al. (1987) · Journal of Medicinal Chemistry · doi:10.1021/jm00393a034 · Cited by 110 · see citing works

Redox‐Mediated Regulation of p21Waf1/Cip1 Expression Involves a Post‐Transcriptional Mechanism and Activation of the Mitogen‐Activated Protein Kinase Pathway

Esposito, F., Cuccovillo, F., Vanoni, M., Cimino, F., Anderson, C. W., Appella, E., & Russo, T. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00730.x · Cited by 110 · see citing works

TGF-β1 Triggers Oxidative Modifications and Enhances Apoptosis in Hit Cells Through Accumulation of Reactive Oxygen Species by Suppression of Catalase and Glutathione Peroxidase

Islam, K. N., Kayanoki, Y., Kaneto, H., Suzuki, K., Asahi, M., Fujii, J., & Taniguchi, N. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00493-5 · Cited by 108 · see citing works

Separation and functional analysis of bone marrow cells separated by rhodamine-123 fluorescence.

Mulder, A., & Visser, J. W. M. (1987) · PubMed · Cited by 103 · see citing works

Effects of Thyroid Hormone on Embryonic Oligodendrocyte Precursor Cell Developmentin Vivoandin Vitro

Ahlgren, S. C., Wallace, H., Bishop, J. O., Neophytou, C., & RAFF, M. C. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0631 · Cited by 103 · see citing works

Ectopic expression of p27Kip1 in oligodendrocyte progenitor cells results in cell-cycle growth arrest.

Tikoo, R., Osterhout, D. J., Casaccia‐Bonnefil, P., et al. (1998) · PubMed · Cited by 77 · see citing works

BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione

Gabaizadeh, R., Staecker, H., Liu, W., et al. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00173-3 · Cited by 74 · see citing works

Inhibition of Mitochondrial Function by Interferon

Lewis, J. A., Huq, A., & Najarro, P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13184 · Cited by 67 · see citing works

Dihydrotetramethylrosamine: A long wavelength, fluorogenic peroxidase substrate evaluated in vitro and in a model phagocyte

Whitaker, J. E., Moore, P. L., Haugland, R. P., et al. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91576-x · Cited by 53 · see citing works

Mechanisms of insulin-like growth factor regulation of programmed cell death of developing avian motoneurons

D'Costa, A. P., Prevette, D. M., Houenou, L. J., Wang, S., Zackenfels, K., Rohrer, H., Zapf, J., Caroni, P., & Oppenheim, R. W. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(19980905)36:3 · Cited by 49 · see citing works

Regulation of Antioxidant Enzyme Expression by NGF

Sampath, D., & Perez‐Polo, R. J. (1997) · Neurochemical Research · doi:10.1023/a:1027387105882 · Cited by 46 · see citing works

Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation

Lee, J. M. (1998) · Oncogene · doi:10.1038/sj.onc.1202102 · Cited by 44 · see citing works

Glial Cell Lineages in the Rat Optic NervePreprint

RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1983.048.01.061 · Cited by 36 · see citing works

Mechanism for the changes in levels of glutathione upon exposure of cultured mammalian cells to tertiary-butylhydroperoxide and diamide

Ochi, T. (1993) · Archives of Toxicology · doi:10.1007/bf01977401 · Cited by 21 · see citing works

Rhodamine-123 Staining in Hematopoietic Stem Cells of Young Mice Indicates Mitochondrial Activation Rather Than Dye Efflux

Kim, M., Cooper, D. D., Hayes, S. F., et al. (1998) · Blood · doi:10.1182/blood.v91.11.4106.411k40_4106_4117 · Cited by 15 · see citing works

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555 · see citing works

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

Le Belle, J. E., Orozco, N. M., Paucar, A. A., Saxe, J. P., Mottahedeh, J., Pyle, A. D., Wu, H., & Kornblum, H. I. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2010.11.028 · Cited by 789 · see citing works

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

Jones, C. L., Stevens, B. M., D'Alessandro, A., Reisz, J. A., Culp-Hill, R., Nemkov, T., Pei, S., Khan, N., Adane, B., Ye, H., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.10.005 · Cited by 585 · see citing works

Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog

Rera, M., Bahadorani, S., Cho, J., Koehler, C. L., Ulgherait, M., Hur, J. H., Ansari, W. S., Lo, T., Jones, D. L., & Walker, D. W. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.09.013 · Cited by 472 · see citing works

The redox stress hypothesis of aging

Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473 · see citing works

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schröter, F., Ninnemann, O., Siegert, E., Bendix, I., Brüstle, O., Nitsch, R., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1700 · Cited by 451 · see citing works

Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development

Hamanaka, R. B., Glasauer, A., Hoover, P., Yang, S., Blatt, H., Mullen, A. R., Getsios, S., Gottardi, C. J., DeBerardinis, R. J., Lavker, R. M., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2003638 · Cited by 315 · see citing works

Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system

Han, R., Yang, Y. M., Dietrich, J., Luebke, A., Mayer-Pröschel, M., & Noble, M. (2008) · Journal of Biology · doi:10.1186/jbiol69 · Cited by 316 · see citing works

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology?

Steullet, P., Cabungcal, J. H., Monin, A., Dwir, D., O'Donnell, P., Cuenod, M., & Do, K. Q. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.021 · Cited by 262 · see citing works

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

Wirth, E. K., Conrad, M., Winterer, J., Wozny, C., Carlson, B. A., Roth, S., Schmitz, D., Bornkamm, G. W., Coppola, V., Tessarollo, L., et al. (2010) · The FASEB Journal · doi:10.1096/fj.09-143974 · Cited by 237 · see citing works

Iron and Reactive Oxygen Species: Friends or Foes of Cancer Cells?

Bystrom, L. M., Guzman, M. L., & Rivella, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5014 · Cited by 212 · see citing works

Newborn neurons acquire high levels of reactive oxygen species and increased mitochondrial proteins upon differentiation from progenitors

Tsatmali, M., Walcott, E. C., & Crossin, K. L. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.087 · Cited by 133 · see citing works

N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development

das Neves Duarte, J. M., Kulak, A., Gholam-Razaee, M. M., Cuenod, M., Gruetter, R., & Do, K. Q. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.035 · Cited by 124 · see citing works

Glutathione deficit impairs myelin maturation: relevance for white matter integrity in schizophrenia patients

Monin, A., Baumann, P. S., Griffa, A., Xin, L., Mekle, R., Fournier, M., Butticaz, C., Klaey, M., Cabungcal, J. H., Steullet, P., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.88 · Cited by 113 · see citing works

Impact of Lactic Acid on Cell Proliferation and Free Radical-Induced Cell Death in Monolayer Cultures of Neural Precursor Cells

Lampe, K. J., Namba, R. M., Silverman, T. R., Bjugstad, K. B., & Mahoney, M. J. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22352 · Cited by 98 · see citing works

Cellular Antioxidant Levels Influence Muscle Stem Cell Therapy

Drowley, L., Okada, M., Beckman, S., Vella, J., Keller, B., Tobita, K., & Huard, J. (2010) · Molecular Therapy · doi:10.1038/mt.2010.160 · Cited by 94 · see citing works

Reactive oxygen species and the neuronal fate

Kennedy, K. A. M., Sandiford, S. D. E., Skerjanc, I. S., & Li, S. S.-C. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0807-2 · Cited by 89 · see citing works

Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions

Power, J., Mayer-Pröschel, M., Smith, J., & Noble, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0610 · Cited by 88 · see citing works

Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens

Liu, T., Chen, Y., Tian, S., et al. (2023) · Horticulturae · doi:10.3390/horticulturae9020250 · Cited by 9 · see citing works

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E., & Bliska, J. B. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31021-3

Cross-talk between redox regulation and the ubiquitin–proteasome system in mammalian cell differentiation

Demasi, M., Simões, V., & Bonatto, D. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.10.031 · Cited by 18 · see citing works

The Role of Cellular Differentiation and Cell Fate in Malignant Melanoma

Kuzel, P., & Andy, J. C. (2011) · InTech eBooks · doi:10.5772/20002

A Generalized Gene-Regulatory Network Model of Stem Cell Differentiation for Predicting Lineage Specifiers

Okawa, S., Nicklas, S., Zickenrott, S., Schwamborn, J. C., & del Sol, A. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.07.014 · Cited by 50 · see citing works