The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response
Open accessAbstract
Mesial temporal lobe epilepsy (mTLE) is a chronic neurological disorder characterized by recurrent seizures. The pathogenic mechanisms underlying mTLE may involve defects in the post-transcriptional regulation of gene expression. MicroRNAs (miRNAs) are non-coding RNAs that control the expression of genes at the post-transcriptional level. Here, we performed a genome-wide miRNA profiling study to examine whether miRNA-mediated mechanisms are affected in human mTLE. miRNA profiles of the hippocampus of autopsy control patients and two mTLE patient groups were compared. This revealed segregated miRNA signatures for the three different patient groups and 165 miRNAs with up- or down-regulated expression in mTLE. miRNA in situ hybridization detected cell type-specific changes in miRNA expression and an abnormal nuclear localization of select miRNAs in neurons and glial cells of mTLE patients. Of several cellular processes implicated in mTLE, the immune response was most prominently targeted by deregulated miRNAs. Enhanced expression of inflammatory mediators was paralleled by a reduction in miRNAs that were found to target the 3'-untranslated regions of these genes in reporter assays. miR-221 and miR-222 were shown to regulate endogenous ICAM1 expression and were selectively co-expressed with ICAM1 in astrocytes in mTLE patients. Our findings suggest that miRNA changes in mTLE affect the expression of immunomodulatory proteins thereby further facilitating the immune response. This mechanism may have broad implications given the central role of astrocytes and the immune system in human neurological disease. Overall, this work extends the current concepts of human mTLE pathogenesis to the level of miRNA-mediated gene regulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
A comparison of background correction methods for two-colour microarrays
Ritchie, M. E., Silver, J., Oshlack, A., Holmes, M., Diyagama, D., Holloway, A., & Smyth, G. K. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm412 · Cited by 907
Schratt, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2763 · Cited by 748
Glial reactions in Parkinson's disease
McGeer, P. L., & McGeer, E. G. (2008) · Movement Disorders · doi:10.1002/mds.21751 · Cited by 701
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy
Rigau, V., Morin, M., Rousset, M.-C., de Bock, F., Lebrun, A., Coubes, P., Picot, M.-C., Baldy-Moulinier, M., Bockaert, J., Crespel, A., et al. (2007) · Brain · doi:10.1093/brain/awm118 · Cited by 429
Gorter, J. A., van Vliet, E. A., Aronica, E., Breit, T., Rauwerda, H., Lopes da Silva, F. H., & Wadman, W. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-06.2006 · Cited by 316
Effects of Antemortem and Postmortem Variables on Human Brain mRNA Quality: A BrainNet Europe Study
Durrenberger, P. F., Fernando, S., Kashefi, S. N., Ferrer, I., Hauw, J.-J., Seilhean, D., Smith, C., Walker, R., Al-Sarraj, S., Troakes, C., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181c7e32f · Cited by 161
Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica · doi:10.1007/bf00334673 · Cited by 137
Cited by
Gorter, J. A., Iyer, A., White, I., Colzi, A., van Vliet, E. A., Sisodiya, S., & Aronica, E. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.026 · Cited by 172
MicroRNAs as regulators of brain function and targets for treatment of epilepsy
Brennan, G. P., & Henshall, D. C. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0369-8 · Cited by 169
Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy
Wang, J., Yu, J.-T., Tan, L., Tian, Y., Ma, J., Tan, C.-C., Wang, H.-F., Liu, Y., Tan, M.-S., Jiang, T., et al. (2015) · Scientific Reports · doi:10.1038/srep09522 · Cited by 140
Raoof, R., Jimenez-Mateos, E. M., Bauer, S., Tackenberg, B., Rosenow, F., Lang, J., Onugoren, M. D., Hamer, H., Huchtemann, T., Körtvélyessy, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02969-6 · Cited by 109
Raoof, R., Bauer, S., El Naggar, H., Connolly, N. M. C., Brennan, G. P., Brindley, E., Hill, T., McArdle, H., Spain, E., Forster, R. J., et al. (2018) · eBioMedicine · doi:10.1016/j.ebiom.2018.10.068 · Cited by 106
Metadata
- Authors
- Kan, A. A., van Erp, S., Derijck, A. A. H. A., de Wit, M., Hessel, E. V. S., O’Duibhir, E., de Jager, W., Van Rijen, P. C., Gosselaar, P. H., de Graan, P. N. E., & Pasterkamp, R. J.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2012-04-26
- Volume
- 69
- Issue
- 18
- Pages
- 3127-3145
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W1983949013
- Cited by
- 187
- References
- 8
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. https://app.cochat.ai/papers/10.1007/s00018-012-0992-7
- The paper
- Kan, A. A., van Erp, S., Derijck, A. A. H. A., de Wit, M., Hessel, E. V. S., O’Duibhir, E., de Jager, W., Van Rijen, P. C., Gosselaar, P. H., de Graan, P. N. E., & Pasterkamp, R. J. (2012). Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-012-0992-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
