microRNAs at the synapse
Abstract
MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation. Furthermore, studies from invertebrates indicate that miRNAs might contribute to the control of synapse function and plasticity in the adult. Key features of synapse-relevant miRNAs include their ability to regulate mRNA translation locally in the synaptodendritic compartment and the modulation of their expression and function by neuronal activity. The potentially huge impact of miRNA-based mechanisms on higher-order processing, memory and neuropsychiatric disorders in vertebrates is just starting to be recognized.
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FACS sorted neurons only retain cell body whereas most of their neuronal processes are lost, along with miRNAs localized in dendrites and synapses.
“FACS sorted neurons only retain cell body whereas most of their neuronal processes are lost, along with the miRNAs that are localized in dendrites (Tai and Schuman, 2006) and synapses (Schratt, 2009, Lugli et al., 2008).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Schratt, 2009
Only a small number of miRNA targets have been validated and shown to be functionally important in vivo.
“Yet, only a small number of miRNA targets have been validated and shown to be functionally important in vivo (Schratt, 2009).”
From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Schratt, 2009
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Self-citation
- Authors
- Schratt, G.
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-11-04
- Volume
- 10
- Issue
- 12
- Pages
- 842-849
- ISSN
- 1471-003X
- 1471-0048
- Cited by
- 455
- References
- 1
- Language
- en
- Update notices
- erratum (2011-03-18)
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