Vascular endothelial growth factors (VEGFs) and stroke

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Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF

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Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

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VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

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Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat

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Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

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Pathophysiological consequences of VEGF-induced vascular permeability

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Vascular Endothelial Growth Factor Signaling in Hypoxia and Inflammation

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Vascular endothelial growth factor: a neurovascular target in neurological diseases

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CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

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Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

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The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

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Cathepsin K: The Action in and Beyond Bone

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Neural stem cell therapies and hypoxic-ischemic brain injury

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Cell based therapies for ischemic stroke: From basic science to bedside

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Delayed Inhibition of VEGF Signaling after Stroke Attenuates Blood–Brain Barrier Breakdown and Improves Functional Recovery in a Comorbidity-Dependent Manner

Reeson, P. L., Tennant, K. A., Gerrow, K., Wang, J., Novak, S. W., Thompson, K., Lockhart, K.-L., Holmes, A. S., Nahirney, P. C., & Brown, C. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2810-14.2015 · Cited by 136

Cerebrovascular Injuries Induce Lymphatic Invasion into Brain Parenchyma to Guide Vascular Regeneration in Zebrafish

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Neuronal HIF-1α and HIF-2α deficiency improves neuronal survival and sensorimotor function in the early acute phase after ischemic stroke

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VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

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Cystatin C as a potential therapeutic mediator against Parkinson’s disease via VEGF-induced angiogenesis and enhanced neuronal autophagy in neurovascular units

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Neural Stem Cell Protects Aged Rat Brain from Ischemia–Reperfusion Injury through Neurogenesis and Angiogenesis

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The Impact of Physical Activity Before and After Stroke on Stroke Risk and Recovery: a Narrative Review

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Inhibition of HIF prolyl-4-hydroxylases by FG-4497 Reduces Brain Tissue Injury and Edema Formation during Ischemic Stroke

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Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs

Zhang, H.-T., Zhang, P., Gao, Y., Li, C.-L., Wang, H.-J., Chen, L.-C., Feng, Y., Li, R.-Y., Li, Y.-L., & Jiang, C.-L. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5974 · Cited by 101

MSC-Derived Exosomes can Enhance the Angiogenesis of Human Brain MECs and Show Therapeutic Potential in a Mouse Model of Parkinson's Disease

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Cerebral Neovascularization in Diabetes: Implications for Stroke Recovery and beyond

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Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

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The evolving role of neuro‐immune interaction in brain repair after cerebral ischemic stroke

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Post-Ischaemic Immunological Response in the Brain: Targeting Microglia in Ischaemic Stroke Therapy

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Microglial Cells Prevent Hemorrhage in Neonatal Focal Arterial Stroke

Fernández‐López, D., Faustino, J. V., Klibanov, A. L., Derugin, N., Blanchard, E., Simon, F., Leib, S. L., & Vexler, Z. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0140-15.2016 · Cited by 93

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders

Zarriello, S., Tuazon, J. P., Corey, S., Schimmel, S. J., Rajani, M., Gorsky, A., Abraham, D. I., Hammock, B. D., & Borlongan, C. V. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.11.001 · Cited by 92

CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation

Kim, Y., Lee, S., Zhang, H., Lee, S., Kim, H., Kim, Y., Won, M., Kim, Y., & Kwon, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1727-6 · Cited by 84

Preventive Effect of Low Intensity Pulsed Ultrasound against Experimental Cerebral Ischemia/Reperfusion Injury via Apoptosis Reduction and Brain-derived Neurotrophic Factor Induction

Chen, C., Wu, C.-T., Yang, T.-H., Liu, S., & Yang, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-23929-8 · Cited by 80

Lipocalin-2 aggravates blood-brain barrier dysfunction after intravenous thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1/Nrf2/HO-1 pathway

Liu, J., Pang, S.-Y., Zhou, S., He, Q., Zhao, R., Qu, Y., Yang, Y., & Guo, Z. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103342 · Cited by 76

Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery

Xing, C., & Lo, E. H. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.004 · Cited by 76

Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells

Thomas, J., Baker, K. L., Han, J., Calvo, C. F., Nurmi, H. J., Eichmann, A., & Alitalo, K. K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1312-6 · Cited by 77

Insights into the dual role of angiogenesis following stroke

Rust, R. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20906815 · Cited by 74

Growth Factors for the Treatment of Ischemic Brain Injury (Growth Factor Treatment)

Larpthaveesarp, A., Ferriero, D. M., & Gonzalez, F. F. (2015) · Brain Sciences · doi:10.3390/brainsci5020165 · Cited by 76

Leveraging single-cell RNA sequencing to unravel the impact of aging on stroke recovery mechanisms in mice

Jin, C., Shi, Y., Shi, L., Leak, R. K., Zhang, W., Chen, K., Ye, Q., Hassan, S., Lyu, J., Hu, X., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300012120 · Cited by 72

Distinct peripheral blood monocyte and neutrophil transcriptional programs following intracerebral hemorrhage and different etiologies of ischemic stroke

Carmona-Mora, P., Ander, B. P., Jickling, G. C., Dykstra-Aiello, C., Zhan, X., Ferino, E., Hamade, F., Amini, H., Hull, H., Sharp, F. R., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20953912 · Cited by 68

Cognitive Rehabilitation Improves Ischemic Stroke-Induced Cognitive Impairment: Role of Growth Factors

Farokhi-Sisakht, F., Farhoudi, M., Sadigh‐Eteghad, S., Mahmoudi, J., & Mohaddes, G. (2019) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2019.07.015 · Cited by 69

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation

Fantin, A., Λαμπροπούλου, Α., Senatore, V., Brash, J. T., Prahst, C., Lange, C., Liyanage, S. E., Raimondi, C., Bainbridge, J. W., Augustin, H. G., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160311 · Cited by 67

Noggin improves ischemic brain tissue repair and promotes alternative activation of microglia in mice

Shin, J. A., Lim, S. M., Jeong, S. I., Kang, J. L., & Park, E. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.013 · Cited by 65

Microglia as the Critical Regulators of Neuroprotection and Functional Recovery in Cerebral Ischemia

Gaire, B. P. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01145-9 · Cited by 65

Lipocalin‐2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron‐dependent mechanisms

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Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke

Zhang, H., Rzechorzek, W., Aghajanian, A., & Faber, J. E. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20924107 · Cited by 59

VEGF Ameliorates Cognitive Impairment in In Vivo and In Vitro Ischemia via Improving Neuronal Viability and Function

Yang, J., Yao, Y., Chen, T., & Zhang, T. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8284-4 · Cited by 59

The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia

Yang, J. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.12.005 · Cited by 57

DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice

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Microvascular Plasticity After Experimental Stroke: A Molecular and MRI Study

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Neuroprotective and Neurorestorative Effects of Epo and VEGF: Perspectives for New Therapeutic Approaches to Neurological Diseases

Ureña‐Guerrero, M. E., Castañeda‐Cabral, J. L., Rivera-Cervantes, M. C., Vélez, R., Jarero-Basulto, J. J., Gudiño‐Cabrera, G., & Beas‐Zárate, C. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200114104342 · Cited by 52

Modulation of VEGF receptor 2 signaling by protein phosphatases

Corti, F., & Simons, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.022 · Cited by 50

Inhibition of Histone Methyltransferases SUV39H1 and G9a Leads to Neuroprotection in an in vitro Model of Cerebral Ischemia

Schweizer, S., Harms, C., Lerch, H., Flynn, J. A., Hecht, J., Yildirim, F., Meisel, A., & Märschenz, S. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.99 · Cited by 49

Vascular endothelial growth factor aggravates cerebral ischemia and reperfusion-induced blood-brain-barrier disruption through regulating LOC102640519/HOXC13/ZO-1 signaling

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The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats

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l-Borneol Exerted the Neuroprotective Effect by Promoting Angiogenesis Coupled With Neurogenesis via Ang1-VEGF-BDNF Pathway

Ma, R., Xie, Q., Li, H., Guo, X., Wang, J., Li, Y., Ren, M., Gong, D., & Gao, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.641894 · Cited by 46

Neurovascular protection of cilostazol in stroke‐prone spontaneous hypertensive rats associated with angiogenesis and pericyte proliferation

Omote, Y., Deguchi, K., Kono, S., Liu, N., Liu, W., Kurata, T., Yamashita, T., Ikeda, Y., & Abe, K. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23327 · Cited by 47

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia

Hermawati, E., Arfian, N., Mustofa, M., & Partadiredja, G. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14556 · Cited by 44

PPAR‐γ Mediates Ta‐VNS‐Induced Angiogenesis and Subsequent Functional Recovery after Experimental Stroke in Rats

Li, J., Zhang, K., Zhang, Q., Zhou, X., Wen, L., Ma, J., Niu, L., & Li, C. (2020) · BioMed Research International · doi:10.1155/2020/8163789 · Cited by 44

Neutrophil dynamics and inflammaging in acute ischemic stroke: A transcriptomic review

Bui, T. A., Jickling, G. C., & Winship, I. R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1041333 · Cited by 46

A Mesenchymal stem cell line (B10) increases angiogenesis in a rat MCAO model

Sheikh, A. M., Yano, S., Mitaki, S., Haque, M. A., Yamaguchi, S., & Nagai, A. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.10.001 · Cited by 43

Curcumin solid dispersion-loaded in situ hydrogels for local treatment of injured vaginal bacterial infection and improvement of vaginal wound healing

Zhang, M., Zhuang, B. A., Du, G., Han, G., & Jin, Y. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13088 · Cited by 43

Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia

Ren, C., Li, N., Chen, G., Zhang, W., Yang, Y., Li, S., Ji, X., & Ding, Y. (2020) · Neurological Research · doi:10.1080/01616412.2020.1782122 · Cited by 41

Emerging therapeutic targets for cerebral edema

Jha, R. M., Raikwar, S. P., Mihaljević, S., Casabella, A. M., Catapano, J. S., Rani, A., Desai, S. M., Gerzanich, V., & Simard, J. M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.2010045 · Cited by 41

VEGF regulates hippocampal neurogenesis and reverses cognitive deficits in immature rats after status epilepticus through the VEGF R2 signaling pathway

Han, W., Song, X., He, R. Q., Li, T., Cheng, L., Xie, L., Chen, H., & Jiang, L. (2017) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.12.007 · Cited by 41

The Role of the Coagulation System in Peripheral Arterial Disease: Interactions with the Arterial Wall and Its Vascular Microenvironment and Implications for Rational Therapies

Miceli, G., Basso, M. G., Rizzo, G., Pintus, C., & Tuttolomondo, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314914 · Cited by 42

Herbal Formula Danggui-Shaoyao-San Promotes Neurogenesis and Angiogenesis in Rat Following Middle Cerebral Artery Occlusion

Ren, C., Wang, B. Z., Li, N., Jin, K., & Ji, X. (2015) · Aging and Disease · doi:10.14336/ad.2014.1126 · Cited by 39

Systemic Factors Trigger Vasculature Cells to Drive Notch Signaling and Neurogenesis in Neural Stem Cells in the Adult Brain

Lin, R., Cai, J., Kenyon, L. C., Iozzo, R. V., Rosenwasser, R. H., & Iacovitti, L. (2018) · Stem Cells · doi:10.1002/stem.2947 · Cited by 40

Epicatechin Gallate Protects HBMVECs from Ischemia/Reperfusion Injury through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization

Fu, B., Zeng, Q., Zhang, Z., Qian, M., Chen, J., Dong, W., & Li, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7824684 · Cited by 38

Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke

Qiang, X. U. E., Liu, Y., He, R., Yang, S., Tong, J., Xu, L., Chen, Y., & Xu, X. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.14059 · Cited by 39

The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke

Liu, L., Zhao, B., Xiong, X., & Xia, Z. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2645-1 · Cited by 38

Isoflurane Post-conditioning Ameliorates Cerebral Ischemia/Reperfusion Injury by Enhancing Angiogenesis Through Activating the Shh/Gli Signaling Pathway in Rats

Li, P., Yin, J., Ge, M., Wang, S., Xie, L., Li, Y., Si, J., & Ma, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00321 · Cited by 38

Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke

Cun, Y., Jin, Y., Wu, D., Zhou, L., Zhang, C., Zhang, S., Yang, X., Wang, Z., & Zhang, P. (2022) · Mediators of Inflammation · doi:10.1155/2022/7006281 · Cited by 40

Vascular endothelial growth factor is neuroprotective against ischemic brain injury by inhibiting scavenger receptor A expression on microglia

Xu, Z. Q., Han, K., Chen, J., Wang, C., Dong, Y., Yu, M., Bai, R., Huang, C., & Hou, L. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14108 · Cited by 37

Midkine Controls Arteriogenesis by Regulating the Bioavailability of Vascular Endothelial Growth Factor A and the Expression of Nitric Oxide Synthase 1 and 3

Lautz, T., Lasch, M., Borgolte, J., Troidl, K., Pagel, J.-I., Caballero-Martinez, A., Kleinert, E. C., Walzog, B., & Deindl, E. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.11.020 · Cited by 37

Angioneurins – Key regulators of blood–brain barrier integrity during hypoxic and ischemic brain injury

Kunze, R., & Marti, H. H. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.03.004 · Cited by 38

Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons

Caballero, B. R., Sherman, S. J., & Falk, T. (2017) · Parkinson s Disease · doi:10.1155/2017/4263795 · Cited by 35

Inhibition of immunoproteasome promotes angiogenesis via enhancing hypoxia-inducible factor-1α abundance in rats following focal cerebral ischaemia

Chen, X., Zhang, X., Chen, T., Jiang, X., Wang, X., Lei, H., & Wang, Y. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.04.009 · Cited by 36

Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog

Dai, M.-J., Gui, X., Jia, S.-M., Lv, S., Dou, H., & Cui, W. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01137-z · Cited by 35

Reported Prestroke Physical Activity Is Associated with Vascular Endothelial Growth Factor Expression and Good Outcomes after Stroke

Elena López-Cancio, M., Ricciardi, A. C., Sobrino, T., Cortés, J., de la Ossa, N. P., Millán, M., Hernández‐Pérez, M., Gomis, M., Dorado, L., Muñoz-Narbona, L., et al. (2016) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.10.004 · Cited by 34

Engineered stem cell mimics to enhance stroke recovery

George, P. M., Oh, B., Dewi, R. E., Hua, T., Cai, L., Levinson, A., Liang, X., Krajina, B. A., Bliss, T. M., Heilshorn, S. C., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.06.010 · Cited by 34

Oxygen-Glucose Deprivation/Reoxygenation-Induced Barrier Disruption at the Human Blood–Brain Barrier is Partially Mediated Through the HIF-1 Pathway

Page, S., Raut, S., & Al-Ahmad, A. J. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08531-z · Cited by 34

MiR-103 regulates the angiogenesis of ischemic stroke rats by targeting vascular endothelial growth factor (VEGF).

Shi, F., Wang, X., Zhang, H., Shang, M.-M., Liu, X., Sun, H., & Song, Y.-P. (2018) · PubMed Central · doi:10.22038/ijbms.2018.27267.6657 · Cited by 33

Resting-state Functional Magnetic Resonance Imaging Analysis of Brain Functional Activity in Rats with Ischemic Stroke Treated by Electro-acupuncture

Liang, S., Lin, Y., Lin, B., Li, J., Liu, W., Chen, L., Zhao, S., & Tao, J. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.06.018 · Cited by 33

Long Noncoding RNAs MALAT1 and ANRIL Gene Variants and the Risk of Cerebral Ischemic Stroke: An Association Study

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Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke

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