The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
Vascular endothelial growth factors (VEGFs) and stroke
Open accessAbstract
Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In animal models of cerebral ischemia, expression of Flt-1 is increased in astrocytes, endothelial cells, and neurons.35”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
Keck, P. J., Hauser, S. D., Krivi, G. G., Sanzo, K., Warren, T. G., Feder, J., & Connolly, D. T. (1989) · Science · doi:10.1126/science.2479987 · Cited by 2,058
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507
Self-citationVEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296 · cited 4×
“For example, intravenous VEGF-A increased microvessel density in the cortical ischemia penumbra [31] and intraventricular VEGF increased the number of von Willebrand factor-immunoreactive endothelial cells in the ischemic caudate-putamen after MCA occlusion in rats [50].”
BackgroundMethodInfluentialVEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A. V., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17977 · Cited by 1,201
Self-citationVEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189
Self-citationJin, K., Minami, M., Lan, J. Q., Mao, X. O., Parmentier‐Batteur, S., Simon, R. P., & Greenberg, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081011098 · Cited by 1,061
Self-citationRat forebrain neurogenesis and striatal neuron replacement after focal stroke
Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., & Ferriero, D. M. (2002) · Annals of Neurology · doi:10.1002/ana.10393 · Cited by 1,020
Pathophysiological consequences of VEGF-induced vascular permeability
Weis, S. M., & Cheresh, D. A. (2005) · Nature · doi:10.1038/nature03987 · Cited by 929
Cited by
Sorted by citations
Items 201–269 of 269
Xu, Y., Yang, Y., Yang, J., Cui, J., Yan, J., Jiang, J., Yan, Z., & Yang, H. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2308145 · Cited by 4
Hatamipour, M., Saremi, H., Kesharwani, P., & Sahebkar, A. (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108431 · Cited by 5
Yang, H., Yang, H., Lu, Y.-Y., Ma, S., Liu, Y., Jia, G., Bi, J., & Wang, C. (2014) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2014.08.005 · Cited by 4
Nitrones, Old Fellows for New Therapies in Ischemic Stroke
Escobar-Peso, A., Chioua, M., Frezza, V., Martínez‐Alonso, E., Marco‐Contelles, J., & Alcázar, A. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-45345-3_9 · Cited by 4
Ping, S., Qiu, X., Gonzalez-Toledo, M. E., Liu, X., & Zhao, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.627733 · Cited by 4
Altered levels of circulating natural antibodies against VEGFR1-derived peptide in atherosclerosis
Wang, P., Liu, S., Wang, Z., Zhao, H., & Zhang, X. (2020) · Journal of International Medical Research · doi:10.1177/0300060520948750 · Cited by 4
New perspectives on VEGF signalling in Alzheimer's disease
Emery, C. E. G., Love, S., & Miners, J. S. (2026) · Brain Pathology · doi:10.1111/bpa.70100 · Cited by 3
Stage-adaptive nanotherapeutic design for blood–brain barrier navigation in ischemic stroke
Li, T., Zhou, Y. Q., Chen, Y., & Zou, L. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127020 · Cited by 3
Is Serum VEGF-A Level an Indicator of Early-Onset Poststroke Depression?
Uslu, E. Y., & Yıldız, S. (2024) · Medicina · doi:10.3390/medicina60111828 · Cited by 3
Mechanisms of neurogenesis and angiogenesis in ischaemic stroke: literature review
Koroleva, E. S., & Alifirova, V. M. (2021) · Annals of Clinical and Experimental Neurology · doi:10.54101/acen.2021.3.7 · Cited by 4
Wirelessly Powered‐Electrically Conductive Polymer System for Stem Cell Enhanced Stroke Recovery
Santhanam, S., Chen, C., Oh, B., McConnell, K. W., Azadian, M. M., Patel, J. J., Gardner, E. E., Tanabe, Y., Poon, A. S. Y., & George, P. M. (2023) · Advanced Electronic Materials · doi:10.1002/aelm.202300369 · Cited by 3
Fleischer, A. W., Fox, L. C., Davies, D. R., Vinzant, N. J., Scholl, J. L., & Forster, G. L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23339 · Cited by 3
Li, P., Lu, H., Shi, X., Yan, J., Zhou, L., Yang, J., Wang, B., Zhao, Y., Liu, L., Zhu, Y., et al. (2024) · Neuroreport · doi:10.1097/wnr.0000000000002028 · Cited by 3
The association between vascular endothelial growth factor gene polymorphisms and stroke
Xu, B., Zhan, R., Mai, H., Wu, Z., Zhu, P., Liang, Y., & Zhang, Y. (2019) · Medicine · doi:10.1097/md.0000000000014696 · Cited by 3
Applications of Cord Blood Cells in Neurology
Aidarova, V. S., Kudokotseva, O. V., Lomakin, I. I., & Babijchuk, G. A. (2016) · Problems of Cryobiology and Cryomedicine · doi:10.15407/cryo26.02.103 · Cited by 3
Moradpour, S., Aliaghaei, A., & Bigdeli, M. (2021) · Experimental and Clinical Transplantation · doi:10.6002/ect.2021.0198 · Cited by 3
Zhong, Z., Xiao, R., Zhu, D.-Q., Li, G., Wanling, Z. E. N. G., Dongmei, M. A. I., Jingyi, Q. I. U., Chen, X., Luo, W., Ye, W., et al. (2024) · Chinese Journal of Analytical Chemistry · doi:10.1016/j.cjac.2024.100367 · Cited by 2
The process of angiogenesis in neurodegeneration—pathomechanisms and new therapeutic interventions
Kieliszek-Ryba, P., Jakimiuk, A., Kurek, J., Simola, N., Caria, F., Piątkowska‐Chmiel, I., & Herbet, M. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06874-z · Cited by 4
Clinical, Imaging, and Serum Biomarker Predictors of Malignant Cerebral Infarction
Rodríguez-Vázquez, A., Rudilosso, S., Cubero, A. D.-M., Cabero-Arnold, A., Laredo, C., Ramis, D., Moraleja, D., Serrano, M., González-Romero, Y., Renú, A., et al. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12100392 · Cited by 2
Multi‐omic expression of the VEGF family relates to Alzheimer's disease across diverse populations
Libby, J. B., Deters, K., Ertekin‐Taner, N., Carrasquillo, M. M., Allen, M., Jager, P. L. D., Menon, V., Zhang, B., Haroutunian, V. H., Levey, A. I., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71100 · Cited by 2
Amazon rainforest rodents (Proechimys) are resistant to post-stroke epilepsy
Ortiz‐Villatoro, N. N., Reyes-García, S. Z., Freitas, L., Rodrigues, L. D., Santos, L. E. C., Faber, J., Cavalheiro, É. A., Finsterer, J., Scorza, F. A., de Almeida, A.-C. G., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-96235-5 · Cited by 2
Xiong, Y., Liu, J., Xu, Y., Xie, S., Zhou, X., & Cheng, S.-M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.686199 · Cited by 2
Hypoxia-Inducible Factor-1α Promotes Neuroregeneration and Angiogenesis after Cerebral Ischemia
(2015) · Therapeutic Targets for Neurological Diseases · doi:10.14800/ttnd.719 · Cited by 2
Vascular Endothelial Growth Factor: An Overview Across Multiple Disease Conditions
Canavese, M. (2015) · American Journal of Pharmacology and Toxicology · doi:10.3844/ajptsp.2015.1.12 · Cited by 2
Taroza, S., & Valaikienė, J. (2016) · Journal of Neurology and Neuroscience · doi:10.21767/2171-6625.100081 · Cited by 2
Experimental Therapies for Brain Edema and Intracranial Hypertension
Rauen, K., & Plesnila, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803196-4.00019-9 · Cited by 2
A new analytical model for the changes of vascular endothelial growth factor in ischemic diseases
Qiu, F., Cao, H., & Wu, Y. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.024 · Cited by 2
PREDICTORS OF RECURRENT ISCHEMIC STROKE
Shishkova, V. N., Adasheva, T. V., Remennik, A., Valyaeva, V. N., & Shklovsky, V. M. (2018) · Vrach · doi:10.29296/25877305-2018-02-10 · Cited by 2
Nasution, I., Sjahrir, H., Ilyas, S., & Ichwan, M. (2020) · Medicinski Glasnik · doi:10.17392/1107-20 · Cited by 2
Association of Food Intolerance with Coronary Artery Disease
Tsantsaridou, A., Papathanasiou, V. –. P., & Dimisianos, G. (2019) · Journal of Food and Nutrition Research · doi:10.12691/jfnr-7-1-9 · Cited by 2
MARCH, R. J., Guentert, P., Kloska-Kearney, E., Kwak, D., Yerger, C., McBride, M., Majewski, J. R., McCauley, R. D., Hatch, J. B., Speybroeck, J., et al. (2020) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2020.112006 · Cited by 2
Maes, M. H. J., Nikiforov, N. G., Plaimas, K., Suratanee, A., & Reiche, E. M. V. (2021) · Preprints.org · doi:10.20944/preprints202109.0070.v1 · Cited by 2
Erning, K., Wilson, K. L., Smith, C. S., Nguyen, L., Joseph, N. I., Irengo, R., Cao, L. Y., Cumaran, M., Shi, Y., Lyu, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.30.635733 · Cited by 2
Further analysis of natural antibodies against ischemic stroke
Qi, J., Jiang, Q., Wang, P., Wang, Z., & Zhang, X. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1130748 · Cited by 1
Zhou, K.-G., Zhang, J., Su, J., Tong, W., Li, R., Xiang, X., Jin, L., & Song, Y. (2025) · BMC Medical Genomics · doi:10.1186/s12920-025-02219-z · Cited by 1
The phoenixin-14/GPR173 Axis enhances post-stroke angiogenesis through ETS1-mediated VEGF signaling
Luo, F., Xiaoyun, L. I., Wen, G., Zhu, Z., Junxi, L., & Weng, Y. (2026) · Neuropeptides · doi:10.1016/j.npep.2026.102594 · Cited by 1
Yin, W.-M., He, L.-C., Han, G.-Y., Li, A.-M., Zhu, H., Cao, Y., Xue, X., Zhang, L., Shi, C., Xu, Y.-M., et al. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1771506 · Cited by 1
Insights gained from single-cell sequencing analysis of ischemic stroke
梅艳琴, Guan, T., Fu, L., Kong, J., & Lv, Y. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1784660 · Cited by 1
Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia
Castillo-González, J., Vargas-Rodríguez, P., Serrano-Martínez, I., Cuenca-Martagón, A., Forte‐Lago, I., Price, M., Buscemi, L., Hirt, L., Ruiz, J. L., & González‐Rey, E. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-026-01271-w · Cited by 3
Roslavtceva, V., Salmina, A. B., Prokopenko, S. V., Пожиленкова, Е. А., Кобаненко, И. В., & Rezvitskaya, G. G. (2016) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750816040053 · Cited by 1
Puspitasari, V., Wahid, S., Aliah, A., Suhadi, B., Kaelan, C., As’ád, S., Patellongi, I., Purba, J. S., & Wahjoepramono, E. J. (2015) · Medical Journal of Indonesia · doi:10.13181/mji.v24i2.1196 · Cited by 1
Testerman, T. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801078-5.00008-x · Cited by 1
The Emerging Role of microRNAs in Post-ischemic Angiogenesis and Neurogenesis
Rajanikant, G. K., Gressèns, P., Nampoothiri, S. S., Surendran, G., & Bokobza, C. (2020) · Springer eBooks · doi:10.1007/978-981-15-4798-0_6 · Cited by 1
Arnberg, F. (2015) · Figshare · Cited by 1
Wu, Y., Libby, J. B., Dumitrescu, L. C., Jager, P. L. D., Menon, V., Schneider, J. A., Bennett, D. A., & Hohman, T. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.12.589221 · Cited by 1
PLGA Nano- and Microparticles for VEGF Delivery
Simón‐Yarza, T., Díaz-Herráez, P., Pascual‐Gil, S., Garbayo, E., Prósper, F., & Blanco‐Prieto, M. J. (2016) · Pan Stanford eBooks · doi:10.1201/b20045-15
Potential Mechanisms of Transplanted Cell-Mediated Recovery After Stroke
Wang, B. Z., Hui, A. C. F., & Jin, K. (2016) · Springer eBooks · doi:10.1007/978-981-10-2929-5_12
Self-citationEvers, B. M., Danielsen, T., & Kumar, M. (2017) · Cambridge University Press eBooks · doi:10.1017/9781139696401.008
Zou, D. (2021) · uO Research (University of Ottawa) · doi:10.20381/ruor-26228
Yaneva-Sirakova, T., Vassilev, D. I., Karamfiloff, K. K., Hristova, J., Shumkova, M., & Traykov, L. D. (2023) · Folia Medica · doi:10.3897/folmed.65.e79996
Validação de genes candidatos envolvidos na retinopatia falciforme
Bertozzo, V. D. H. E. (2022) · doi:10.47749/t/unicamp.2021.1239374
Cold in Biology and Medicine: state of the art and perspectives
Team of authors Edited by Professor O. Yu. Petrenko (2023) · doi:10.15407/978-966-00-1867-9
Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study
Zhang, X., Hu, X., Fang, S., Li, J., Liu, Z., Xie, W., Xu, R., Dmytriw, A. A., YANG, K. Y., Ma, Y., et al. (2024) · Neurology and Therapy · doi:10.1007/s40120-024-00601-0
Caramelo, I., Anjo, S. I., Mendes, V. M., Salazar, I. L., Dinis, A., Cardoso, C. M. P., Duarte, C. B., Grãos, M., & Manadas, B. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.26.625525
贾, 月. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.153880
Gompels, B., MacMillan, A., Castagno, S., Vogt, A., & Khan, W. S. (2025) · Current Rheumatology Reviews · doi:10.2174/0115733971371615250825101351
Ye, H., Zhuang, C., Jin, Z., Hu, Y., He, J., Yu, Q., Hu, H., & Zheng, Y. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251385244
Anil, N., McLouth, C. J., Hazelwood, H. S., Dahlke, E., Frank, J. A., Millson, N., Al‐Kawaz, M., Harp, J. P., Cranford, W., Pahwa, S. S., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1672803
Age-related features of neoangiogenesis in the cerebral cortex in ischemic stroke
Vadyukhin, M. A., Tarasov, V. V., Pyatigorskaya, N. V., Paramonova, N. B., Rostovskaya, V. V., Bicherova, I. A., Shestopalov, A. M., Khayitov, A. A., Amrakhov, S. D., & Demyashkin, G. A. (2025) · Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery) · doi:10.33920/med-01-2511-02
Aderinto, N., Babawale, E. A., Olatunji, G. D., Kokori, E., Babarinde, F. O., Donaldy, W., Oyesiji, O. W., Vande-Pallen, F. V., Andibanbang, F., Obaje, A. A., et al. (2026) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-026-01094-4
Zhao, Y., Jin, L., & Zhang, G. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.117545
Maher, S., Scott, M. R., Buckley, R. F., DeCarli, C. S., Aparicio, H. J., Romero, J. R., Vasan, R. S., Murabito, J. M., Bhasin, S., Beiser, A., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.044037
MUNIRUDDIN, A. W., BINTANG, A. K., AKBAR, M., Ladju, R. B., AMRAN, M. Y., & BAAN, J. A. (2026) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.25.06134-0
Amanat, S., Dordevic, A. L., Pase, M. P., & Cardoso, B. R. (2026) · Food & Function · doi:10.1039/d6fo00666c
Neuroplasticity after traumatic brain injury: mechanisms and clinical implications
O’Connor, M., Sankar, S., Sharma, S., Alghazi, D., Chundru, V., Al-Alem, Z. Y. M. Z., Lukin, R., & Banjo, E. (2026) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-026-04624-4
Metadata
- Authors
- Greenberg, D. A., & Jin, K.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Greenberg, David A.
- ORCID
- Jin, Kunlin
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2013-03-12
- Volume
- 70
- Issue
- 10
- Pages
- 1753-1761
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC3634892
- OpenAlex
- W2048468641
- Cited by
- 269
- References
- 105
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 18 · 2021: 23 · 2020: 26 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 15 · 2014: 15 · 2013: 9
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS044921, R01 NS44921)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- vascular endothelial growth factor, stroke, VEGF-A, VEGFR2, VEGF-B, placental growth factor, VEGFR1, angiogenesis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, stem cell transplantation, VEGF pathway, atherosclerosis
- MeSH terms
- Animals, Brain, Humans, Ischemia, Neovascularization, Pathologic, Stroke, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor B, Neurogenesis, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
