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Vascular endothelial growth factors (VEGFs) and stroke
Open accessAbstract
Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.
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“In animal models of cerebral ischemia, expression of Flt-1 is increased in astrocytes, endothelial cells, and neurons.35”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [35]
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Metadata
- Authors
- Greenberg, D. A., & Jin, K.
- Affiliations
- Buck Institute for Research on Aging (US)
- Corresponding author
- Greenberg, David A.
- ORCID
- Jin, Kunlin
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2013-03-12
- Volume
- 70
- Issue
- 10
- Pages
- 1753-1761
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC3634892
- OpenAlex
- W2048468641
- Cited by
- 269
- References
- 105
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 18 · 2021: 23 · 2020: 26 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 15 · 2014: 15 · 2013: 9
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS044921, R01 NS44921)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- vascular endothelial growth factor, stroke, VEGF-A, VEGFR2, VEGF-B, placental growth factor, VEGFR1, angiogenesis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, stem cell transplantation, VEGF pathway, atherosclerosis
- MeSH terms
- Animals, Brain, Humans, Ischemia, Neovascularization, Pathologic, Stroke, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor B, Neurogenesis, Neural Stem Cells
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