Cited by 269Angiogenesis and VEGF in CancerBarrier Structure and Function StudiesAcute Ischemic Stroke Management

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Vascular endothelial growth factors (VEGFs) and stroke

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Greenberg, David A., Jin, Kunlin·2013·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-013-1282-8PMC PMC3634892

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Abstract

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

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See all 269

Authors: Greenberg, D. A., & Jin, K.
Affiliations: Buck Institute for Research on Aging (US)
Corresponding author: Greenberg, David A.
ORCID: Jin, Kunlin
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2013-03-12
Volume: 70
Issue: 10
Pages: 1753-1761
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-013-1282-8
PMC: PMC3634892
OpenAlex: W2048468641
Cited by: 269
References: 105
Citations by year: 2026: 14 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 18 · 2021: 23 · 2020: 26 · 2019: 24 · 2018: 26 · 2017: 18 · 2016: 23 · 2015: 15 · 2014: 15 · 2013: 9
FWCI: 1.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Neurological Disorders and Stroke (R01NS044921, R01 NS44921)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: vascular endothelial growth factor, stroke, VEGF-A, VEGFR2, VEGF-B, placental growth factor, VEGFR1, angiogenesis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, stem cell transplantation, VEGF pathway, atherosclerosis
MeSH terms: Animals, Brain, Humans, Ischemia, Neovascularization, Pathologic, Stroke, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor B, Neurogenesis, Neural Stem Cells

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Vascular endothelial growth factors (VEGFs) and stroke

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