The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
The myofibroblast, a key cell in normal and pathological tissue repair
Open accessAbstract
Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particularly in the skin where they were first described. During normal tissue repair, they appear transiently and are then lost via apoptosis. However, the chronic presence and continued activity of myofibroblasts characterize many fibrotic pathologies, in the skin and internal organs including the liver, kidney and lung. More recently, it has become clear that myofibroblasts also play a role in many types of cancer as stromal or cancer-associated myofibroblast. The fact that myofibroblasts are now known to be key players in many pathologies makes understanding their functions, origin and the regulation of their differentiation important to enable them to be regulated in normal physiology and targeted in fibrosis, scarring and cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, during tissue repair, growth factors are induced by tissue injury and inflammation including CCN2/CTGF and CCN1/CYR61 that have respectively a stimulatory and antagonist effect on myofibroblasts proliferation and differentiation and on the resolution phase of the inflammatory state [24,25].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,269
Self-citationPericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
The extracellular matrix modulates the hallmarks of cancer
Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,098
Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809
Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754
Cited by
Sorted by citations
Items 301–328 of 328
Xue, X., Xue, H., Lu, R., & Ji, J. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.38008
Bgatova, N. P., Skudin, N., Shatruk, A., Taskaeva, I. S., Obanina, N. A., Ryaguzov, M. E., Lomakin, A., Karpov, M., & Fursov, S. A. (2025) · Histochemistry and Cell Biology · doi:10.1007/s00418-025-02445-7
Higginbotham, S., Workman, V. L., Giblin, A.-V., Green, N. H., Lambert, D., & Hearnden, V. (2024) · Figshare · doi:10.6084/m9.figshare.26027467
Huang, W., Zhang, Z., Li, X., Zheng, Q., Wu, C., Liu, L., Chen, Y., Zhang, J., & Jiang, X. (2024) · Figshare · doi:10.6084/m9.figshare.27124063
Wang, Y., Yang, H., Su, X., Cao, A., Chen, F., Chen, P., Yan, F., & Hu, H. (2021) · Figshare · doi:10.6084/m9.figshare.17140555
Yao, F., Xu, M., Dong, L., Shen, X., Shen, Y., Jiang, Y., Zhu, T., Zhang, C., & Yu, G. (2024) · Figshare · doi:10.6084/m9.figshare.26718996
Huang, W., Zhang, Z., Li, X., Zheng, Q., Wu, C., Liu, L., Chen, Y., Zhang, J., & Jiang, X. (2024) · Figshare · doi:10.6084/m9.figshare.27124066
Toxoplasma gondii infection inhibits myotube formation in a 3D model of chicken muscle cell culture
Epifânio, C., Bagri, K. M., Vieira, P. D. C., Monteiro-Neto, J. R., Costa, M. L., Mermelstein, C., & Adesse, D. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04621-0
Cutaneous Wound Epithelialization: Role of Cadherin- and Integrin-Mediated Adhesions
Rothenberg, K. E., & Dunnwald, M. (2026) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-032-12442-5_7
A THERAPEUTIC INSIGHT ON MUTRAVIRAJANEEYA MAHAKASHAYA IN HE-PATIC FIBROSIS – A LITERATURE REVIEW
Yashaswini, A., Mamatha Sri, S., & Rao, M. V. (2025) · International Ayurvedic Medical Journal · doi:10.46607/iamj2813102025
Florent, L. (2024) · theses.fr (ABES) · doi:10.70675/88568e70z24dfz47bfzba55z457d2e65d84d
Yang, L., He, X., Luo, K., Zhang, X., Li, H., Zhou, W., Pang, J., Zhang, M., Zhou, Z., & Ren, M. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05547-5
Streetman, D. R., Hutchinson, A., Hahn, J. M., Huang, F. S., & Supp, D. M. (2026) · American Journal of Infection Control · doi:10.1016/j.ajic.2026.04.022
Li, A., Jia, M., Li, Y., Li, J. D., & 曲牟文 (2026) · Journal of Biomaterials Applications · doi:10.1177/08853282261449328
Metabolic reprogramming in cardiac fibrosis: mechanisms, crosstalk, and therapeutic interventions
Wang, X. Y., Wang, X. Y., Guo, F., Ding, Q., & Jin, H. (2026) · Frontiers in Physiology · doi:10.3389/fphys.2026.1811882
He, X., Yang, Y., Liu, J., & Hu, D. (2026) · Plastic & Reconstructive Surgery Global Open · doi:10.1097/gox.0000000000007723
Hwang, Y., Son, K., Chaudhary, M., Lee, E., Kim, M., You, S., Smith, T. J., Aakalu, V. K., & Han, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167320
Cortès, B. M., Groetzner, S., Mayr, C. H., Kallabis, S., Boryń, Ł. M., Thomas, M. J., Meissner, F., Skrońska-Wąsek, W., & Herrmann, F. E. (2026) · Research Square · doi:10.21203/rs.3.rs-10626944/v1
Current therapeutic strategies and available research models for investigating hypertrophic scars
Chu, A., Kumar, S., & Francois Berthiaume, B. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1887685 · Cited by 1
Gong, Y., Cui, Y., Pan, M., Zhang, H., Abudusaimaiti, Y., Tang, G., Ren, H., Fu, L., Yang, J., & Hu, J. (2026) · Journal of Immunology Research · doi:10.1155/jimr/8865338
Zhou, X., Liao, W., Ye, H., Wang, X., Sun, J., Tu, J., & Lv, J. (2026) · Molecular & Cellular Toxicology · doi:10.1007/s13273-026-00662-2
Grigorieva, I. V., Midgley, A. C., Brown, C., Pino‐Chavez, G., Szomolay, B., Williams, A., DePaul, R., Stanton, R. J., Hancock, J. M., Bowen, T., et al. (2026) · Biomolecules · doi:10.3390/biom16101442
Wang, H., Zhao, A., Li, X., Hu, R., & Xu, W. (2026) · World Journal of Otorhinolaryngology - Head and Neck Surgery · doi:10.1002/wjo2.70167
Tao, S., Yu, L., Li, J., 张振鹏, Liu, Y., Wu, J., Xia, X., Zicong, X., & Tan, Y. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158878
NRF2 in hypertrophic scarring: A stage-dependent redox hub poised between resolution and persistence
Thangboonjit, W., Pluempreecha, M., Soingam, T., & Panich, U. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104460
Defining the ideal timing for wound closure in reconstructive surgery: an international consensus
Ranade, S., Alawadi, K., Bailey, J. K., Bassetto, F., Chew, K. Y., Cordova-Orrillo, J., Endress, R. D., Hong, J. P., Jukema, G. N., Kim, S. W., et al. (2026) · European Journal of Plastic Surgery · doi:10.1007/s00238-026-02548-x
Metadata
- Authors
- Darby, I. A., Zakuan, N., Billet, F., & Desmoulière, A.
- Affiliations
- RMIT University (AU)
- Maintenance Myélinique et Neuropathies Périphériques (FR)
- Corresponding author
- Darby, Ian A.
- Desmoulière, Alexis
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2015-12-17
- Volume
- 73
- Issue
- 6
- Pages
- 1145-1157
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11108523
- OpenAlex
- W2200832510
- Cited by
- 328
- References
- 143
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 42 · 2023: 22 · 2022: 26 · 2021: 30 · 2020: 48 · 2019: 25 · 2018: 36 · 2017: 30 · 2016: 8
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- myofibroblasts, tissue repair, fibrosis, alpha-smooth muscle actin, extracellular matrix synthesis, skin wound healing, cancer-associated fibroblasts, stromal cells, fibroblast differentiation, apoptosis, scar formation, liver fibrosis, renal fibrosis, pulmonary fibrosis, tumor stroma
- MeSH terms
- Animals, Cicatrix, Humans, Neoplasms, Wound Healing, Myofibroblasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
