Cited by 328Wound Healing and TreatmentsLiver physiology and pathologyTGF-β signaling in diseases

The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.

The myofibroblast, a key cell in normal and pathological tissue repair

Open access

Darby, Ian A., Zakuan, Noraina, Billet, Fabrice, Desmoulière, Alexis·2016·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-015-2110-0PMC PMC11108523

Open this paper in CoChat — free account

Abstract

Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particularly in the skin where they were first described. During normal tissue repair, they appear transiently and are then lost via apoptosis. However, the chronic presence and continued activity of myofibroblasts characterize many fibrotic pathologies, in the skin and internal organs including the liver, kidney and lung. More recently, it has become clear that myofibroblasts also play a role in many types of cancer as stromal or cancer-associated myofibroblast. The fact that myofibroblasts are now known to be key players in many pathologies makes understanding their functions, origin and the regulation of their differentiation important to enable them to be regulated in normal physiology and targeted in fibrosis, scarring and cancer.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-015-2110-0

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
J. Submicrosc. Cytol. Pathol.
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,269
Self-citation
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
The extracellular matrix modulates the hallmarks of cancer
Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,098
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.
Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754
A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.
Skalli, O., Ropraz, P., Trzeciak, A. M., Benzonana, G., Gillessen, D., & Gabbiani, G. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.103.6.2787 · Cited by 1,622
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
Gabbiani, G., Ryan, G. B., & Majno, G. (1971) · Experientia · doi:10.1007/bf02147594 · Cited by 1,485
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Humphreys, B. D., Lin, S., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,474
Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
Gauglitz, G. G., Korting, H. C., Pavicic, T., Ruzicka, T., & Jeschke, M. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2009.00153 · Cited by 1,462
Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346
Interactions between cancer stem cells and their niche govern metastatic colonization
Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339
Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar.
Desmoulière, A., Redard, M., Darby, I. A., & Gabbiani, G. (1995) · Europe PMC (PubMed Central) · Cited by 1,185
Self-citation
Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing.
Darby, I. A., Skalli, O., & Gabbiani, G. (1990) · PubMed · Cited by 1,180
Self-citation
Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration
Acerbi, I., Cassereau, L., Dean, I. S., Shi, Q., Au, A., Park, C., Chen, Y. Y., Liphardt, J., Hwang, E. S., & Weaver, V. M. (2015) · Integrative Biology · doi:10.1039/c5ib00040h · Cited by 1,086
Identification and characterization of a fibroblast marker: FSP1.
Strutz, F. M., Okada, H., Lo, C. W., Danoff, T. M., Carone, R. L., Tomaszewski, J. E., & Neilson, E. G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.2.393 · Cited by 1,075
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
Liu, G., Friggeri, A., Yang, Y., Milosevic, J., Ding, Q., Thannickal, V. J., Kaminski, N., & Abraham, E. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100035 · Cited by 935
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
Hecker, L., Vittal, R., Jones, T., Jagirdar, R., Luckhardt, T. R., Horowitz, J. C., Pennathur, S., Martinez, F. J., & Thannickal, V. J. (2009) · Nature Medicine · doi:10.1038/nm.2005 · Cited by 852
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis
Roderburg, C., Urban, G.-W., Bettermann, K., Vucur, M., Zimmermann, H. W., Schmidt, S., Janssen, J., Koppe, C., Knolle, P. A., Castoldi, M., et al. (2010) · Hepatology · doi:10.1002/hep.23922 · Cited by 821
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Kisseleva, T., Cong, M., Paik, Y., Scholten, D., Jiang, C., Benner, C., Iwaisako, K., Moore-Morris, T., Scott, B., Tsukamoto, H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201840109 · Cited by 805
NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts
Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D. (2005) · Circulation Research · doi:10.1161/01.res.0000187457.24338.3d · Cited by 786
The myofibroblast: Paradigm for a mechanically active cell
Hinz, B. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.09.020 · Cited by 717
Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708
Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers
Goffin, J. M., Pittet, P., Csúcs, G., Lussi, J. W., Meister, J.-J., & Hinz, B. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506179 · Cited by 703
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 693
Myofibroblast-mediated mechanisms of pathological remodelling of the heart
Weber, K. T., Sun, Y., Bhattacharya, S. K., Ahokas, R. A., & Gerling, I. (2012) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2012.158 · Cited by 692
Mechanical Tension Controls Granulation Tissue Contractile Activity and Myofibroblast Differentiation
Hinz, B., Mastrangelo, D., Iselin, C. E., Chaponnier, C., & Gabbiani, G. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61776-2 · Cited by 638
Localized scleroderma-response to 1,25-dihydroxyvitamin D3
Humbert, P. G., DUPOND, J. L., ROCHEFORT, A., VASSELET, R., LUCAS, A., Laurent, R., & Agache, P. G. (1990) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1990.tb02127.x · Cited by 633
Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis
Wollin, L., Maillet, I., Quesniaux, V., Holweg, A., & Ryffel, B. (2014) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.208223 · Cited by 633
Fibroblast Differentiation in Wound Healing and Fibrosis
Darby, I. A., & Hewitson, T. D. (2007) · International review of cytology · doi:10.1016/s0074-7696(07)57004-x · Cited by 625
Self-citation
Neuroinflammation and the generation of neuropathic pain
Ellis, A., & Bennett, D. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet128 · Cited by 610
Looking Older: Fibroblast Collapse and Therapeutic Implications
Fisher, G. J., Varani, J., & Voorhees, J. J. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.5.666 · Cited by 540
Morphological and immunochemical differences between keloid and hypertrophic scar.
Ehrlich, H. P., Desmoulière, A., Diegelmann, R. F., Cohen, I. K., Compton, C. C., Garner, W. L., Kapançi, Y., & Gabbiani, G. (1994) · PubMed Central · Cited by 532
Self-citation
Integrins and the activation of latent transforming growth factor β1 – An intimate relationship
Wipff, P., & Hinz, B. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.012 · Cited by 532
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis
Aarabi, S., Bhatt, K. A., Shi, Y., Paterno, J., Chang, E. I.-F., Loh, S. A., Holmes, J. W., Longaker, M. T., Yee, H. T., & Gurtner, G. C. (2007) · The FASEB Journal · doi:10.1096/fj.07-8218com · Cited by 522
Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.
Rønnov‐Jessen, L., & PETERSEN, O. W. (1993) · PubMed · Cited by 514
Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1
Annes, J. P., Chen, Y., Munger, J. S., & Rifkin, D. B. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312172 · Cited by 500
The cutaneous sensory system
McGlone, F. P., & Reilly, D. M. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.004 · Cited by 470
Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]
Schultz‐Cherry, S. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.4.923 · Cited by 468
Myofibroblasts
Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424
Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-805oc · Cited by 420
Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury
Dulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418
Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Kim, K. K., Wei, Y., Szekeres, C. K., Kugler, M. C., Wolters, P. J., Hill, M. L., Frank, J. A., Brumwell, A. N., Wheeler, S. E., Kreidberg, J. A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36940 · Cited by 399
Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats
Ng, Y.-Y., Huang, T., Yang, W.-C., Chen, Z.-P., Yang, A., Mu, W., Nikolic‐Paterson, D. J., Atkins, R. C., & Lan, H. Y. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00076.x · Cited by 396
Tenascin-C induced signaling in cancer
Orend, G., & Chiquet-Ehrismann, R. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.02.017 · Cited by 384
Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts
Conte, E., Gili, E., Fagone, E., Fruciano, M., Iemmolo, M., & Vancheri, C. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.02.014 · Cited by 368
Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro
Ng, C. P., Hinz, B., & Swartz, M. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02605 · Cited by 360
Angiotensin II Stimulated Expression of Transforming Growth Factor-β1in Cardiac Fibroblasts and Myofibroblasts
Campbell, S. E., & Katwa, L. C. (1997) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0435 · Cited by 357
Inhibition of Myofibroblast Apoptosis by Transforming Growth Factor β1
Zhang, H. Y., & Phan, S. H. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.21.6.3720 · Cited by 354
Stromal Myofibroblasts Predict Disease Recurrence for Colorectal Cancer
辻野, 督., Seshimo, I., Yamamoto, H., Ngan, C. Y., Ezumi, K., Takemasa, I., Ikeda, M., Sekimoto, M., Matsuura∥, N., & Monden, M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2191 · Cited by 353
Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis
Chen, Y., Chang, F., Wu, C.-F., Chou, Y., Hsu, H., Chiang, W., Shen, J., Chen, Y., Wu, K., Tsai, T., et al. (2011) · Kidney International · doi:10.1038/ki.2011.208 · Cited by 341
Transforming growth factor β as a therapeutic target in systemic sclerosis
Varga, J., & Pasche, B. (2009) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2009.26 · Cited by 298
The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function
Achterberg, V., Buscemi, L., Diekmann, H., Smith-Clerc, J., Schwengler, H., Meister, J.-J., Wenck, H., Gallinat, S., & Hinz, B. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.90 · Cited by 288
Histopathological Differential Diagnosis of Keloid and Hypertrophic Scar
Lee, J. Y., Yang, C., Chao, S., & Wong, T. (2004) · American Journal of Dermatopathology · doi:10.1097/00000372-200410000-00006 · Cited by 281
Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts
Wang, J., Chen, H., Seth, A. K., & McCulloch, C. A. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00387.2003 · Cited by 269
The Single-Molecule Mechanics of the Latent TGF-β1 Complex
Buscemi, L., Ramonet, D., Klingberg, F., Formey, A., Smith-Clerc, J., Meister, J.-J., & Hinz, B. (2011) · Current Biology · doi:10.1016/j.cub.2011.11.037 · Cited by 266
A Case of Multiple Spontaneous Keloid Scars
Jfri, A. H., Rajeh, N., & Karkashan, E. M. (2015) · Case Reports in Dermatology · doi:10.1159/000437249 · Cited by 263
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine
Eyden, B. P. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00213.x · Cited by 261
Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells.
van der Loop, F. T. L., Schaart, G., Timmer, E. D. J., Ramaekers, F. C. S., & van Eys, G. J. J. M. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.2.401 · Cited by 251
Emerging Concepts in the Pathogenesis of Lung Fibrosis
Hardie, W. D., Glasser, S. W., & Hagood, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081170 · Cited by 244
miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7
McClelland, A., Herman‐Edelstein, M., Komers, R., Jha, J. C., Winbanks, C. E., Hagiwara, S., Gregorevic, P., Kantharidis, P., & Cooper, M. E. (2015) · Clinical Science · doi:10.1042/cs20150427 · Cited by 242
Novel mechanisms for the antifibrotic action of nintedanib
Rangarajan, S., Kurundkar, A., Kurundkar, D., Bernard, K., Sanders, Y. Y., Ding, Q., Antony, V. B., Zhang, J., Zmijewski, J., & Thannickal, V. J. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0445oc · Cited by 238
Myofibroblast development is characterized by specific cell-cell adherens junctions
Hinz, B., Pittet, P., Smith-Clerc, J., Chaponnier, C., & Meister, J.-J. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0386 · Cited by 231
The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo
Hinz, B., Gabbiani, G., & Chaponnier, C. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201049 · Cited by 226
Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation
Klingberg, F., Chow, M. L., Koehler, A., Boo, S., Buscemi, L., Quinn, T. M., Costell, M., Alman, B. A., Genot, E. M., & Hinz, B. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201402006 · Cited by 226
Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells
Talele, N. P., Fradette, J., Davies, J. E., Kapùs, A., & Hinz, B. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.05.004 · Cited by 218
Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon
van der Slot, A. J., Zuurmond, A., van den Bogaerdt, A. J., Ulrich, M. M. W., Middelkoop, E., BOERS, W., Ronday, H. K., DeGroot, J., Huizinga, T. W. J., & Bank, R. A. (2004) · Matrix Biology · doi:10.1016/j.matbio.2004.06.001 · Cited by 214
Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation
Lagares, D., Busnadiego, Ó., García-Fernández, R. A., Kapoor, M., Liu, S., Carter, D. E., Abraham, D., Shiwen, X., Carreira, P. E., Fontaine, B. A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33482 · Cited by 194
Neurotrophins in Skin Biology and Pathology
Botchkarev, V. A., Yaar, M., Peters, E. M. J., Raychaudhuri, S. P., Botchkareva, N. V., Marconi, A., Raychaudhuri, S. K., Paus, R., & Pincelli, C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700270 · Cited by 191
Studies on Wound Healing, with Special Reference to the Phenomenon of Contracture in Experimental Wounds in Rabbitsʼ Skin*
Billingham, R. E., & Russell, P. S. (1956) · Annals of Surgery · doi:10.1097/00000658-195612000-00005 · Cited by 181
Pruritus, pain, and small nerve fiber function in keloids: A controlled study
Lee, S.-S., Yosipovitch, G., Chan, Y.-H., & Goh, C. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.07.054 · Cited by 180
Differences in the Regulation of Fibroblast Contraction of Floating Versus Stressed Collagen Matrices
Grinnell, F., Ho, C.-H., Lin, Y., & Skuta, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.918 · Cited by 178
Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts
Asano, Y., Ihn, H., Yamane, K., Jinnin, M., & Tamaki, K. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.041306 · Cited by 175
Pirfenidone improves renal function and fibrosis in the post-obstructed kidney
Shimizu, T., Kuroda, T., Hata, S., Fukagawa, M., Margolin, S. B., & Kurokawa, K. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.00962.x · Cited by 161
Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4
Jiang, D., Liang, J., Campanella, G. S. V., Guo, R., Yu, S., Xie, T., Liu, N., Jung, Y., Homer, R., Meltzer, E. B., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38644 · Cited by 159
EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling
Park, S.-A., Kim, M.-J., Park, S.-Y., Kim, J.-S., Lee, S., Woo, H. A., Kim, D.-K., Nam, J., & Sheen, Y. Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1798-6 · Cited by 156
Locally applied GM-CSF induces the accumulation of α-smooth muscle act in containing myofibroblasts
Rubbia‐Brandt, L., Sappino, A., & Gabbiani, G. (1991) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899530 · Cited by 155
Reversible differentiation of myofibroblasts by MyoD
Hecker, L., JAGIRDAR, R. M., Jin, T., & Thannickal, V. J. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.03.016 · Cited by 153
The Fibroblast Integrin α11β1 Is Induced in a Mechanosensitive Manner Involving Activin A and Regulates Myofibroblast Differentiation
Carracedo, S., Lü, N., Popova, S. N., Jonsson, R., Eckes, B., & Gullberg, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078766 · Cited by 147
Keloid and hypertrophic scar: Neurogenic inflammation hypotheses
Akaishi, S., Ogawa, R., & Hyakusoku, H. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.01.032 · Cited by 143
Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals
Brigstock, D. R. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0071-5 · Cited by 134
Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts.
Desmoulière, A., Rubbia‐Brandt, L., Grau, G. E., & Gabbiani, G. (1992) · PubMed · Cited by 134
Self-citation
Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling
Sassoli, C., Chellini, F., Pini, A., Tani, A., Nistri, S., Nosi, D., Zecchi‐Orlandini, S., Bani, D., & Formigli, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063896 · Cited by 129
CICATRIZATION OF WOUNDS
Carrel, A., & Hartmann, A. (1916) · The Journal of Experimental Medicine · doi:10.1084/jem.24.5.429 · Cited by 129
Effect of γ-Interferon on the Clinical and Biologic Evolution of Hypertrophic Scars and Dupuytrenʼs Disease
Pittet, B., Rubbia‐Brandt, L., Desmoulière, A., Sappino, A., Roggero, P., Grimaud, J.-A., Montandon, D., & Gabbiani, G. (1994) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199405000-00018 · Cited by 129
Self-citation
Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma
Zhou, L., YANG, K. Y., Andl, T., Wickett, R. R., & Zhang, Y. (2015) · Journal of Cancer · doi:10.7150/jca.10865 · Cited by 126
Myofibroblast communication is controlled by intercellular mechanical coupling
Castella, L. F., Schaub, S., Meister, J.-J., & Hinz, B. (2008) · Journal of Cell Science · doi:10.1242/jcs.024521 · Cited by 124
Regulation of myofibroblast activities: Calcium pulls some strings behind the scene
Castella, L. F., Gabbiani, G., McCulloch, C. A., & Hinz, B. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.04.033 · Cited by 124
Thy-1-Integrin αvβ5 Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation
Zhou, Y., Hagood, J. S., Lu, B., Merryman, W. D., & Murphy-Ullrich, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126227 · Cited by 119
Advantage of the Presence of Living Dermal Fibroblasts within in Vitro Reconstructed Skin for Grafting in Humans
Coulomb, B., Friteau, L., Baruch, J. P., Guilbaud, J., Chrétien-Marquet, B., Glicenstein, J., Lebreton, C., Bell, E., & Dubertret, L. (1998) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-199806000-00018 · Cited by 108
Delayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β
Sandbo, N. K., Lau, A., Kach, J., Ngam, C. R., Yau, D. M., & Dulin, N. O. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00166.2011 · Cited by 106
Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis
Zeisberg, M. (2008) · Frontiers in bioscience · doi:10.2741/3204 · Cited by 105
Extracellular matrix players in metastatic niches
Óskarsson, T., & Massagué, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.469 · Cited by 104
Influence of sensory neuropeptides on human cutaneous wound healing process
Chéret, J., Lebonvallet, N., Buhé, V., Carre, J. L., Misery, L., & Le Gall-Ianotto, C. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.02.001 · Cited by 103
Correlation between the distribution of smooth muscle or non muscle myosins and α‐smooth muscle actin in normal and pathological soft tissues
Benzonana, G., Skalli, O., & Gabbiani, G. (1988) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970110405 · Cited by 100
Sensory Peptides as Neuromodulators of Wound Healing in Aged Rats
Khalil, Z. G., & Helme, R. D. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.5.b354 · Cited by 99
Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis
Huang, X., Gai, Y., Yang, N., Lu, B., Samuel, C. S., Thannickal, V. J., & Zhou, Y. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.018 · Cited by 97
miR-21 Induces Myofibroblast Differentiation and Promotes the Malignant Progression of Breast Phyllodes Tumors
Gong, C., Nie, Y., Qu, S., Liao, J.-Y., Cui, X., Yao, H., Zeng, Y., Su, F., Song, E., & Liu, Q. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0125 · Cited by 95
Hypoxia Impairs Skin Myofibroblast Differentiation and Function
Modarressi, A., Pietramaggiori, G., Godbout, C., Vigato, E., Pittet, B., & Hinz, B. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.224 · Cited by 93
Studies in Wound Healing
Watts, G. T., Grillo, H. C., & Gross, J. (1958) · Annals of Surgery · doi:10.1097/00000658-195808000-00002 · Cited by 91
The complex dialogue between (myo)fibroblasts and the extracellular matrix during skin repair processes and ageing
Vedrenne, N., Coulomb, B., Danigo, A., Bonté, F., & Desmoulière, A. (2012) · Pathologie Biologie · doi:10.1016/j.patbio.2011.10.002 · Cited by 89
Self-citation
Making sense of hypertrophic scar: a role for nerves
Scott, J. R., Muangman, P., & Gibran, N. S. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00222.x · Cited by 89
Myofibroblasts contribute to but are not necessary for wound contraction
Ibrahim, M. M., Chen, L., Bond, J. E., Medina, M. A., Ren, L., Kokosis, G., Selim, A. M., & Levinson, H. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.116 · Cited by 88
Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy
González-Cadavid, N. F., & Rajfer, J. (2010) · Nature Reviews Urology · doi:10.1038/nrurol.2010.24 · Cited by 86
Inhibition of rat liver fibrogenesis through noradrenergic antagonism
Dubuisson, L., Desmoulière, A., Decourt, B., Evadé, L., Bedin, C., Boussarie, L., Barrier, L., Vidaud, M., & Rosenbaum, J. (2002) · Hepatology · doi:10.1053/jhep.2002.31166 · Cited by 85
Self-citation
Defining therapeutic targets for liver fibrosis: Exploiting the biology of inflammation and repair
Iredale, J. P. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.011 · Cited by 80
Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats
Kant, V., Kumar, D., Kumar, D., Prasad, R., Gopal, A., Pathak, N. N., Kumar, P., & Tandan, S. K. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.015 · Cited by 79
Role of neurotrophins on dermal fibroblast survival and differentiation
Palazzo, E., Marconi, A., Truzzi, F., Dallaglio, K., Petrachi, T., Humbert, P. G., Schnebert, S., Perrier, É., Dumas, M., & Pincelli, C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22811 · Cited by 79
The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure.
Eyden, B. P. (2007) · PubMed · Cited by 77
Physiological ER Stress Mediates the Differentiation of Fibroblasts
Matsuzaki, S., Hiratsuka, T., Taniguchi, M., Shingaki, K., Kubo, T., Kiya, K., 藤原敏宏, Kanazawa, S., Kanematsu, R., Maeda, T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123578 · Cited by 75
Neuropeptide-containing nerves in painful hypertrophic human scar tissue
CROWE, R., Parkhouse, N., McGrouther, D. A., & Burnstock, G. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb03376.x · Cited by 74
Nox-2 Is a Modulator of Fibrogenesis in Kidney Allografts
Djamali, A., Vidyasagar, A., Adulla, M., Hullett, D. A., & Reese, S. R. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02463.x · Cited by 73
Collagen Formation and Wound Contraction during Repair of Small Excised Wounds in the Skin of Rats
Abercrombie, M., Flint, M. H., & James, D. W. (1954) · Development · doi:10.1242/dev.2.3.264 · Cited by 67
The α4β1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts
Shinde, A. V., Kelsh, R., Peters, J. H., Sekiguchi, K., Water, L. V. D., & McKeown‐Longo, P. J. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.11.004 · Cited by 66
The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1--normal and reactive cells.
Eyden, B. P. (2005) · PubMed · Cited by 61
Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells
Oben, J. A., Yang, S., Lin, H., Ono, M., & Diehl, A. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02773-0 · Cited by 61
Topically applied substance P enhanced healing of open excision wound in rats
Kant, V., Gopal, A., Kumar, D., Bag, S., Kurade, N. P., Kumar, A., Tandan, S. K., & Kumar, D. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.042 · Cited by 60
Force-induced Myofibroblast Differentiation through Collagen Receptors Is Dependent on Mammalian Diaphanous (mDia)
Chan, M. W. C., Chaudary, F., Lee, W., Copeland, J. W. R., & McCulloch, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075218 · Cited by 60
BLOCKADE OF β1‐ AND β2‐ADRENOCEPTORS DELAYS WOUND CONTRACTION AND RE‐EPITHELIALIZATION IN RATS
Romana‐Souza, B., dos Santos, J. S., & Monte‐Alto‐Costa, A. (2006) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2006.04383.x · Cited by 59
Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target
El‐Khattouti, A., Hassan, M., & Gómez, C. R. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00158 · Cited by 57
Changes in cutaneous innervation in patients with chronic pain after burns
Hamed, K., Giles, N. L., Anderson, J. R., Phillips, J. K., Dawson, L. F., Drummond, P. D., Wallace, H. J., Wood, F. M., Rea, S. M., & Fear, M. W. (2011) · Burns · doi:10.1016/j.burns.2010.11.010 · Cited by 56
Sympathetic denervation accelerates wound contraction but delays reepithelialization in rats
Romana‐Souza, B., Cardoso, J. F., Amadeu, T. P., Desmoulière, A., & Monte‐Alto‐Costa, A. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.00070.x · Cited by 53
Self-citation
Transforming growth factor-β1differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells
Qi, W., Chen, X., Holian, J., Mreich, E., Twigg, S., Gilbert, R. E., & Pollock, C. A. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00013.2006 · Cited by 48
Endothelin-1 Induces Bronchial Myofibroblast Differentiation
Sun, G. Y., Stacey, M. A., Bellini, A., Marini, M. A., & Mattoli, S. (1997) · Peptides · doi:10.1016/s0196-9781(97)00194-0 · Cited by 47
Brief Report: Fibrosis Caused by Loss of PTEN Expression in Mouse Fibroblasts Is Crucially Dependent on CCN2
Liu, S., Parapuram, S. K., & Leask, A. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38121 · Cited by 46
Human dermal and gingival fibroblasts in a three-dimensional culture: a comparative study on matrix remodeling
Chaussain, C., Septier, D., Bonnefoix, M., Lécolle, S., Lebreton, C., Coulomb, B., Pellat, B., & Godeau, G. (2002) · Clinical Oral Investigations · doi:10.1007/s00784-001-0143-2 · Cited by 46
Emerging cellular and molecular targets in fibrosis
Castelino, F. V., & Varga, J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000110 · Cited by 46
Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling
Gong, W., Yan, M., Chen, J., Chaugai, S., Chen, C., & Wang, D. W. (2014) · Frontiers of Medicine · doi:10.1007/s11684-014-0378-3 · Cited by 42
Nerve fibres: a possible role in keloid pathogenesis
Hochman, B., Nahas, F. X., Sobral, C. S., Arias, V., Locali, R. F., Juliano, Y., & Ferreira, L. M. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08401.x · Cited by 40
Relationships between nerves and myofibroblasts during cutaneous wound healing in the developing rat
Liu, M., Warn, J. D., Fan, Q., Smith, P. G., & Smith, R. L. (1999) · Cell and Tissue Research · doi:10.1007/s004410051369 · Cited by 38
Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis
LeBleu, V. S., & Kalluri, R. (2011) · Kidney International · doi:10.1038/ki.2011.300 · Cited by 37
Direct contact of fibroblasts with neuronal processes promotes differentiation to myofibroblasts and induces contraction of collagen matrix in vitro
Fujiwara, T., Kubo, T., Kanazawa, S., Shingaki, K., Taniguchi, M., Matsuzaki, S., Gurtner, G. C., Tohyama, M., & Hosokawa, K. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12059 · Cited by 31
Proteomic Analysis of Differentially Expressed Proteins in Peripheral Cholangiocarcinoma
Darby, I. A., Vuillier-Devillers, K., Pinault, É., Sarrazy, V., Lepreux, S., Balabaud, C. P., Bioulac‐Sage, P., & Desmoulière, A. (2010) · Cancer Microenvironment · doi:10.1007/s12307-010-0047-2 · Cited by 27
Self-citation
Innovative approaches to the therapy of fibrosis
de Andrade, J. A., & Thannickal, V. J. (2009) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328330da9b · Cited by 22
Effect of cholinergic denervation on hepatic fibrosis induced by carbon tetrachloride in rats
Lam, H.-B., Yeh, C., Cheng, K., Hsu, C., & Cheng, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.04.048 · Cited by 21
Myofibroblasts contribute to but are not necessary for wound contraction
Ibrahim, M. M., Chen, L., Bond, J. E., Medina, M. A., Ren, L., Selim, A. M., & Levinson, H. (2015) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2015.08.220

Sorted by citations

Cancer-associated fibroblasts in the single-cell era
Lavie, D., Ben‐Shmuel, A., Erez, N., & Scherz‐Shouval, R. (2022) · Nature Cancer · doi:10.1038/s43018-022-00411-z · Cited by 656
The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
Shinde, A. V., Humeres, C. D., & Frangogiannis, N. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.006 · Cited by 602
NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors
Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., Wood, O., Machado, M., Lopez, M.-A., Ganesan, A.-P., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3158 · Cited by 411
Epithelial-Mesenchymal Transition (EMT): The Type-2 EMT in Wound Healing, Tissue Regeneration and Organ Fibrosis
Marconi, G. D., Fonticoli, L., Rajan, T. S., Pierdomenico, S. D., Trubiani, O., Pizzicannella, J., & Diomede, F. (2021) · Cells · doi:10.3390/cells10071587 · Cited by 449
Skeletal muscle fibrosis: an overview
Mahdy, M. A. A. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2955-2 · Cited by 320

See all 328

Authors: Darby, I. A., Zakuan, N., Billet, F., & Desmoulière, A.
Affiliations: RMIT University (AU)
Maintenance Myélinique et Neuropathies Périphériques (FR)
Corresponding author: Darby, Ian A.
Desmoulière, Alexis
ORCID: Darby, Ian A.
Billet, Fabrice
Desmoulière, Alexis
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2015-12-17
Volume: 73
Issue: 6
Pages: 1145-1157
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-015-2110-0
PMC: PMC11108523
OpenAlex: W2200832510
Cited by: 328
References: 143
Citations by year: 2026: 25 · 2025: 36 · 2024: 42 · 2023: 22 · 2022: 26 · 2021: 30 · 2020: 48 · 2019: 25 · 2018: 36 · 2017: 30 · 2016: 8
FWCI: 3.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
RMIT Research Repository (RMIT University Library) (submittedVersion)
Figshare (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: myofibroblasts, tissue repair, fibrosis, alpha-smooth muscle actin, extracellular matrix synthesis, skin wound healing, cancer-associated fibroblasts, stromal cells, fibroblast differentiation, apoptosis, scar formation, liver fibrosis, renal fibrosis, pulmonary fibrosis, tumor stroma
MeSH terms: Animals, Cicatrix, Humans, Neoplasms, Wound Healing, Myofibroblasts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The myofibroblast, a key cell in normal and pathological tissue repair

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks