The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
The myofibroblast, a key cell in normal and pathological tissue repair
Open accessAbstract
Myofibroblasts are characterized by their expression of α-smooth muscle actin, their enhanced contractility when compared to normal fibroblasts and their increased synthetic activity of extracellular matrix proteins. Myofibroblasts play an important role in normal tissue repair processes, particularly in the skin where they were first described. During normal tissue repair, they appear transiently and are then lost via apoptosis. However, the chronic presence and continued activity of myofibroblasts characterize many fibrotic pathologies, in the skin and internal organs including the liver, kidney and lung. More recently, it has become clear that myofibroblasts also play a role in many types of cancer as stromal or cancer-associated myofibroblast. The fact that myofibroblasts are now known to be key players in many pathologies makes understanding their functions, origin and the regulation of their differentiation important to enable them to be regulated in normal physiology and targeted in fibrosis, scarring and cancer.
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“Furthermore, during tissue repair, growth factors are induced by tissue injury and inflammation including CCN2/CTGF and CCN1/CYR61 that have respectively a stimulatory and antagonist effect on myofibroblasts proliferation and differentiation and on the resolution phase of the inflammatory state [24,25].”
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Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800
Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
TGF-β signaling and the fibrotic response
Leask, A., & Abraham, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1273rev · Cited by 2,319
Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,269
Self-citationPericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
The extracellular matrix modulates the hallmarks of cancer
Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,098
Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,952
Evidence that fibroblasts derive from epithelium during tissue fibrosis
Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809
Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754
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Cancer-associated fibroblasts in the single-cell era
Lavie, D., Ben‐Shmuel, A., Erez, N., & Scherz‐Shouval, R. (2022) · Nature Cancer · doi:10.1038/s43018-022-00411-z · Cited by 656
The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling
Shinde, A. V., Humeres, C. D., & Frangogiannis, N. G. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.006 · Cited by 602
Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., Wood, O., Machado, M., Lopez, M.-A., Ganesan, A.-P., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3158 · Cited by 411
Marconi, G. D., Fonticoli, L., Rajan, T. S., Pierdomenico, S. D., Trubiani, O., Pizzicannella, J., & Diomede, F. (2021) · Cells · doi:10.3390/cells10071587 · Cited by 449
Skeletal muscle fibrosis: an overview
Mahdy, M. A. A. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2955-2 · Cited by 320
Metadata
- Authors
- Darby, I. A., Zakuan, N., Billet, F., & Desmoulière, A.
- Affiliations
- RMIT University (AU)
- Maintenance Myélinique et Neuropathies Périphériques (FR)
- Corresponding author
- Darby, Ian A.
- Desmoulière, Alexis
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2015-12-17
- Volume
- 73
- Issue
- 6
- Pages
- 1145-1157
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11108523
- OpenAlex
- W2200832510
- Cited by
- 328
- References
- 143
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 42 · 2023: 22 · 2022: 26 · 2021: 30 · 2020: 48 · 2019: 25 · 2018: 36 · 2017: 30 · 2016: 8
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Figshare (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- myofibroblasts, tissue repair, fibrosis, alpha-smooth muscle actin, extracellular matrix synthesis, skin wound healing, cancer-associated fibroblasts, stromal cells, fibroblast differentiation, apoptosis, scar formation, liver fibrosis, renal fibrosis, pulmonary fibrosis, tumor stroma
- MeSH terms
- Animals, Cicatrix, Humans, Neoplasms, Wound Healing, Myofibroblasts
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