The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Regulated cell death and adaptive stress responses
Open accessAbstract
Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“On the other hand, RCD can originate from perturbations of the intracellular or extracellular microenvironment, when such perturbations are too intense or prolonged for adaptative responses to cope with stress and restore cellular homeostasis [5].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [5]
In the citing paper
“However, while adaptative stress responses operate at the cellular level (which—by extension—promotes the maintenance of homeostasis at the level of organism or colony), RCD directly operates at the level of the organism or colony in spite of cellular homeostasis [5].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [5]
In the citing paper
“RCD relies on a dedicated molecular machinery, implying that it can be modulated (i.e., delayed or accelerated) by pharmacological or genetic interventions [5, 17].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Self-citationClassification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
Self-citationProtein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
Harding, H. P., Zhang, Y., & Ron, D. (1999) · Nature · doi:10.1038/16729 · Cited by 3,310
Immunogenic Cell Death in Cancer Therapy
Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303
Self-citationImmunogenic cell death and DAMPs in cancer therapy
Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
Self-citation
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Self-citationImmunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Self-citationTong, X., Tang, R., Xiao, M., Xu, J., Wang, W., Zhang, B., Liu, J., Yu, X., & Shi, S. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01392-3 · Cited by 883
Linking cellular stress responses to systemic homeostasis
Galluzzi, L., Yamazaki, T., & Kroemer, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0068-0 · Cited by 556
Self-citationFerroptosis Mechanisms Involved in Neurodegenerative Diseases
Reichert, C. O., de Freitas, F. A., Sampaio‐Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 431
GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury
Shi, H., Gao, Y., Dong, Z., Yang, J., Gao, R., Li, X., Zhang, S., Ma, L., Sun, X., Wang, Z., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.318629 · Cited by 345
Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics
Garg, A. D., More, S., Rufo, N., Meçe, O., Sassano, M. L., Agostinis, P., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1386829 · Cited by 288
Self-citationThe STING1 network regulates autophagy and cell death
Zhang, R., Kang, R., & Tang, D. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00613-4 · Cited by 266
Autophagy in the eye: Development, degeneration, and aging
Boya, P., Esteban‐Martínez, L., Serrano‐Puebla, A., Gómez‐Sintes, R., & Villarejo‐Zori, B. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.08.001 · Cited by 236
Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology
Vanmeerbeek, I., Sprooten, J., Ruysscher, D. D., Tejpar, S., Vandenberghe, P., Fucikova, J. P., Špíšek, R., Zitvogel, L., Kroemer, G., Galluzzi, L., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2019.1703449 · Cited by 231
Self-citationMitochondrial Permeability Transition: New Findings and Persisting Uncertainties
Izzo, V., Bravo-San Pedro, J. M., Sica, V., Kroemer, G., & Galluzzi, L. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.04.006 · Cited by 205
Self-citationAutophagy and Ferroptosis—What Is the Connection?
Kang, R., & Tang, D. (2017) · Current Pathobiology Reports · doi:10.1007/s40139-017-0139-5 · Cited by 186
Mazure, N. M. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.03.002 · Cited by 166
The ‘stress’ concept in microalgal biology—homeostasis, acclimation and adaptation
Borowitzka, M. A. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1399-0 · Cited by 152
Berberine as a potential autophagy modulator
Mohammadinejad, R., Ahmadi, Z., Tavakol, S., & Ashrafizadeh, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28325 · Cited by 132
Long, K., Gu, L., Li, L., Zhang, Z., Li, E., Zhang, Y., He, L., Pan, F., Guo, Z., & Hu, Z. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03804-7 · Cited by 132
The ribotoxic stress response drives UV-mediated cell death
Sinha, N. K., McKenney, C. D., Yeow, Z. Y., Li, J. J., Nam, K. H., Yaron, T. M., Johnson, J. L., Huntsman, E. M., Cantley, L. C., Ordureau, A., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.018 · Cited by 142
Zhai, J., Gu, X., Liu, Y., Hu, Y., Jiang, Y., & Zhang, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152934 · Cited by 131
Molecular Interactions Between Reactive Oxygen Species and Autophagy in Kidney Disease
Kaushal, G. P., Chandrashekar, K., & Juncos, L. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153791 · Cited by 130
Mechanisms of Regulated Cell Death: Current Perspectives
Santagostino, S. F., Assenmacher, C., Tarrant, J. C., Adedeji, A. O., & Radaelli, E. (2021) · Veterinary Pathology · doi:10.1177/03009858211005537 · Cited by 137
Rodriguez, A., Nakhle, J., Griessinger, E., & Vignais, M. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1445906 · Cited by 120
Autophagy Function and Regulation in Kidney Disease
Kaushal, G. P., Chandrashekar, K., Juncos, L. A., & Shah, S. V. (2020) · Biomolecules · doi:10.3390/biom10010100 · Cited by 112
Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review
Pandurangan, A. K., Divya, T., Kumar, K., Dineshbabu, V., Velavan, B., & Sudhandiran, G. (2018) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v10.i9.244 · Cited by 108
Gielecińska, A., Kciuk, M., Yahya, E. B., Ainane, T., Mujwar, S., & Kontek, R. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189024 · Cited by 110
Sperm freezing damage: the role of regulated cell death
Hai, E., Li, B., Zhang, J., & Zhang, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02013-3 · Cited by 110
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy
Xu, W., Guan, G., Yue, R., Dong, Z., Lei, L., Kang, H., & Song, G. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00546 · Cited by 99
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment
Cao, Z., Tian, K., Ran, Y., Zhou, H., Zhou, L., Ding, Y., & Tang, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1506426 · Cited by 101
Immune recognition of irradiated cancer cells
Wennerberg, E., Vanpouille‐Box, C., Bornstein, S., Yamazaki, T., Demaria, S., & Galluzzi, L. (2017) · Immunological Reviews · doi:10.1111/imr.12568 · Cited by 88
Self-citationFerroptosis is associated with oxygen-glucose deprivation/reoxygenation-induced Sertoli cell death
Li, L., Yu, H., Zhao, Y., Wang, H., Zhao, X., Jiang, Y., & Gao, F. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3469 · Cited by 90
Regulated Necrosis in Pulmonary Disease. A Focus on Necroptosis and Ferroptosis
Minagawa, S., Yoshida, M., Araya, J., Hara, H., Imai, H., & Kuwano, K. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0337tr · Cited by 89
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
Pagán, A. J., Lee, L. J., Edwards-Hicks, J., Moens, C. B., Tobin, D. M., Busch‐Nentwich, E. M., Pearce, E. L., & Ramakrishnan, L. (2022) · Cell · doi:10.1016/j.cell.2022.08.018 · Cited by 84
Lee, W., Probst, S., Santoyo-Sánchez, M. P., Al-Hamdani, W., Diebels, I., von Sivers, J.-K., Kerek, E. M., Prenner, E. J., & Thévenod, F. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1942-9 · Cited by 76
Immune oncology, immune responsiveness and the theory of everything
Turan, T., Kannan, D., Patel, M. R., Barnes, J. M., Tanlimco, S. G., Lu, R. O., Halliwill, K. D., Kongpachith, S., Kline, D. E., Hendrickx, W., et al. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0355-5 · Cited by 76
Senescence and Apoptosis During in vitro Embryo Development in a Bovine Model
Ramos‐Ibeas, P., Gimeno, I., Cañón-Beltrán, K., Gutiérrez‐Adán, A., Rizos, D. V., & Gómez, E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.619902 · Cited by 74
Dhaouadi, N., Vitto, V. A. M., Pinton, P., Galluzzi, L., & Marchi, S. (2023) · Cell Calcium · doi:10.1016/j.ceca.2023.102759 · Cited by 72
Self-citationFerroptosis and Its Potential Role in the Nervous System Diseases
Zhou, Y., Lin, W., Rao, T., Zheng, J., Zhang, T., Zhang, M., & Lin, Z. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s351799 · Cited by 70
Cell death pathologies: targeting death pathways and the immune system for cancer therapy
Pentimalli, F., Grelli, S., Daniele, N. D., Melino, G., & Amelio, I. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0052-x · Cited by 69
Mitochondria and the Brain: Bioenergetics and Beyond
Belenguer, P., Duarte, J. M. N., Schuck, P. F., & Ferreira, G. C. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00061-7 · Cited by 69
The effects of autophagy on vascular endothelial cells induced by airborne PM2.5
Zhou, Z., Shao, T., Qin, M., Miao, X., Chang, Y., Sheng, W., Wu, F., & Yu, Y. (2018) · Journal of Environmental Sciences · doi:10.1016/j.jes.2017.05.019 · Cited by 64
BCL2L13: physiological and pathological meanings
Meng, F., Sun, N., Liu, D., Jia, J., Xiao, J., & Dai, H. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03702-9 · Cited by 63
Types of Cell Death from a Molecular Perspective
Hajibabaie, F., Abedpoor, N., & Mohamadynejad, P. (2023) · Biology · doi:10.3390/biology12111426 · Cited by 69
Sung, Y.-J., Kao, T., Kuo, C., Fan, C., Cheng, A. N., Fang, W., Chou, H.-Y., Lo, Y.-K., Chen, C., Jiang, S. S., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0730-7 · Cited by 60
C-ferroptosis is an iron-dependent form of regulated cell death in cyanobacteria
Aguilera, A., Berdun, F., Bartoli, C. G., Steelheart, C., Alegre, M. L., Bayır, H., Tyurina, Y. Y., Kagan, V. E., Salerno, G. L., Pagnussat, G. C., et al. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.201911005 · Cited by 58
Vaiserman, A. M., Cuttler, J. M., & Socol, Y. (2021) · Biogerontology · doi:10.1007/s10522-020-09908-5 · Cited by 63
Recent advances in the effect of adipose tissue inflammation on insulin resistance
Yan, K. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111229 · Cited by 64
Sansone, C., Bruno, A., Piscitelli, C., Baci, D., Fontana, A., Brunet, C., Noonan, D. M., & Albini, A. (2021) · Cells · doi:10.3390/cells10020231 · Cited by 55
Wrzesinski, K., & Fey, S. J. (2018) · Bioengineering · doi:10.3390/bioengineering5010022 · Cited by 55
Mesenchymal stem/stromal cell function in modulating cell death
Naji, A., Favier, B., Deschaseaux, F., Rouas‐Freiss, N., Eitoku, M., & Suganuma, N. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1158-4 · Cited by 55
SUMO and cellular adaptive mechanisms
Ryu, H., Ahn, S., & Hochstrasser, M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0457-2 · Cited by 52
Multifaceted Roles of Mitochondrial Components and Metabolites in Metabolic Diseases and Cancer
Nakhle, J., Rodriguez, A., & Vignais, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124405 · Cited by 52
Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer
Westaby, D., Jiménez‐Vacas, J. M., Padilha, A., Varkaris, A. S., Balk, S. P., Bono, J. S. D., & Sharp, A. (2021) · Cancers · doi:10.3390/cancers14010051 · Cited by 56
Cancer cell death: Cell-autonomous and immunogenic dimensions
Galluzzi, L., Kepp, O., Zitvogel, L., Tang, D., & Kroemer, G. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.12.005 · Cited by 59
Self-citationPashootan, P., Saadati, F., Fahimi, H., Rahmati, M., Strippoli, R., Zarrabi, A., Cordani, M., & Moosavi, M. A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123622 · Cited by 53
Bejoy, J., Yuan, X., Song, L., Hua, T., Jeske, R., Sart, S., Sang, Q. A., & Li, Y. (2019) · Stem Cells International · doi:10.1155/2019/2382534 · Cited by 52
Wu, L., Xian, X., Tan, Z., Dong, F., Xu, G., Zhang, M., & Zhang, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03245-7 · Cited by 51
Stearoyl-CoA desaturase-1 and adaptive stress signaling
Koeberle, A., Loeser, K., & Thürmer, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.009 · Cited by 47
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis
Thal, D. R., Gawor, K., & Moonen, S. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02722-0 · Cited by 50
Zhou, D. R., Eid, R., Miller, K. A., Boucher, É. L., Mandato, C. A., & Greenwood, M. T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.01.016 · Cited by 43
Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease
Hu, Y., Cai, Z., & He, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411701 · Cited by 42
Stress and Protists: No life without stress
Slaveykova, V. I., Sonntag, B., & Gutiérrez, J. C. (2016) · European Journal of Protistology · doi:10.1016/j.ejop.2016.06.001 · Cited by 42
Uribe, P., Meriño, J., Matus, C. E., Schulz, M., Zambrano, F., Villegas, J., Conejeros, I., Taubert, A., Hermosilla, C. R., & Sánchez, R. (2022) · Human Reproduction · doi:10.1093/humrep/deac021 · Cited by 42
Venom peptides in cancer therapy: An updated review on cellular and molecular aspects
Mirzaei, S., Fekri, H. S., Hashemi, F., Hushmandi, K., Mohammadinejad, R., Ashrafizadeh, M., Zarrabi, A., & Garg, M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105327 · Cited by 42
Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment
de Souza, I., Ramalho, M. C. C., Guedes, C. B., Osawa, I. Y. A., Monteiro, L. K. S., Gomes, L. R., & Rocha, C. R. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136879 · Cited by 42
Association between radiation-induced cell death and clinically relevant radioresistance
Kuwahara, Y., Tomita, K., Urushihara, Y., Sato, T., Kurimasa, A., & Fukumoto, M. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1728-z · Cited by 41
The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders
Rimessi, A., Patergnani, S., Morciano, G., Carinci, M., Leo, S., & Pinton, P. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339473 · Cited by 41
Rotenone induced neurodegeneration is mediated via cytoskeleton degradation and necroptosis
Roy, T., Chatterjee, A., & Swarnakar, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119417 · Cited by 37
Qiao, J., Chen, Y., Mi, Y., Jin, H., Huang, T., Liu, L., Gong, L., Wang, L., Wang, Q., & Zou, Z. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.05.069 · Cited by 37
Luo, M., Zeng, Q., Jiang, K., Zhao, Y., Long, Z., Du, Y., Wang, K., & He, G. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.01.007 · Cited by 39
Yang, Y.-C., Jiang, Q., Yang, K., Wang, L., Sethi, G., & Ma, Z. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01799-6 · Cited by 36
Emerging regulatory mechanisms in cardiovascular disease: Ferroptosis
Jin, S., Wang, H., Zhang, X., Song, M., Liu, B., & Sun, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116457 · Cited by 35
Diosgenin a steroidal compound: An emerging way to cancer management
Arya, P., & Kumar, P. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.14005 · Cited by 38
Sepsis-Induced Endothelial Dysfunction: Permeability and Regulated Cell Death
Zhang, W., Jiang, L., Tong, X., He, H., Zheng, Y., & Xia, Z. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s479926 · Cited by 36
Sécher, T., Bodier‐Montagutelli, E., Parent, C., Bouvart, L., Cortès, M., Ferreira, M., MacLoughlin, R. J., Ilango, G., Schmid, O., Respaud, R., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030671 · Cited by 34
Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer
D’Amico, M., & Amicis, F. D. (2024) · Cells · doi:10.3390/cells13131083 · Cited by 34
Stress is an agonist for the induction of programmed cell death: A review
Zhou, D. R., Eid, R., Boucher, É. L., Miller, K. A., Mandato, C. A., & Greenwood, M. T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.12.001 · Cited by 32
Soto‐Mercado, V., Mendivil‐Perez, M., Jiménez-Del-Río, M., Fox, J. E., & Velez‐Pardo, C. (2020) · Leukemia Research · doi:10.1016/j.leukres.2020.106389 · Cited by 32
Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
Ryu, H., López‐Giráldez, F., Knight, J., Hwang, S. S., Renner, C., Kreft, S. G., & Hochstrasser, M. (2018) · Nature Communications · doi:10.1038/s41467-018-07836-0 · Cited by 29
Unravelling oncosis: morphological and molecular insights into a unique cell death pathway
Guo, J., Yang, W.-T., Mai, F., Liang, J., Luo, J., Zhou, M., Yu, D., Wang, Y., & Li, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1450998 · Cited by 33
The Contribution of Necroptosis in Neurodegenerative Diseases
Shao, L., Yu, S., Ji, W., Li, H., & Gao, Y. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2249-1 · Cited by 30
Novel Insight into Ferroptosis in Kidney Diseases
Liu, Y., Liu, Y., Zhou, S., Feng, Q., Lu, Y., Liu, D., & Liu, Z. (2023) · American Journal of Nephrology · doi:10.1159/000530882 · Cited by 27
Kowalski, S., Karska, J., Łapińska, Z., Hetnał, B., Saczko, J., & Kulbacka, J. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30413 · Cited by 27
Ohshima, Y., Takata, N., Suzuki‐Karasaki, M., Yoshida, Y., Tokuhashi, Y., & Suzuki‐Karasaki, Y. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4096 · Cited by 27
Noh, M. R., & Padanilam, B. J. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00275.2023 · Cited by 27
Immunogenic cell death as interplay between physical anticancer modalities and immunotherapy
Engelen, Y., Demuynck, R., Ramon, J., Breckpot, K., Smedt, S. C. D., Lajoinie, G., Braeckmans, K., Krysko, D. V., & Lentacker, I. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113721 · Cited by 26
Sreenivasan, K., Ianni, A., Künne, C., Strilić, B., Günther, S., Perdiguero, E., Krüger, M., Spuler, S., Offermanns, S., Arco, P. G., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107652 · Cited by 26
Renal hypoxia–HIF–PHD–EPO signaling in transition metal nephrotoxicity: friend or foe?
Thévenod, F., Schreiber, T., & Lee, W. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03285-3 · Cited by 27
Hosseinkhani, S., Amandadi, M., Ghanavatian, P., Zarein, F., Ataei, F., Nikkhah, M., & Vandenabeele, P. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00743j · Cited by 25
Tokunaga, T., Ando, T., Suzuki‐Karasaki, M., Ito, T., Onoe‐Takahashi, A., Ochiai, T., Soma, M., & Suzuki‐Karasaki, Y. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4251 · Cited by 23
Villegas, J., Uribe, P., Cabrillana, M. E., Fornés, M. W., Treulen, F., Boguen, R. E., Isachenko, V., Isachenko, E., & Sánchez, R. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_29_18 · Cited by 24
Alternative approaches to overcome chemoresistance to apoptosis in cancer
Balaji, S., Terrero, D., Tiwari, A. K., Ashby, C. R., & Raman, D. (2021) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2021.01.005 · Cited by 24
Zhang, J., Zhu, X., Xue, J., Liu, X., Zheng, X. L., Chang, Y., Liu, K., Huang, X., & Zhang, X. (2018) · Functional & Integrative Genomics · doi:10.1007/s10142-018-0591-2 · Cited by 22
Bencze, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010362 · Cited by 20
Condemned or Not to Die? Gene Polymorphisms Associated With Cell Death in Pemphigus Foliaceus
Bumiller‐Bini, V., Cipolla, G. A., Spadoni, M. B., Augusto, D. G., Petzl‐Erler, M. L., Beltrame, M. H., & Boldt, A. B. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02416 · Cited by 21
The crosstalk between ferroptosis and autophagy in cancer
Lv, X., Wang, B., Dong, M., Wang, W., Tang, W., Qin, J., Gao, Y., & Wei, Y. (2023) · Autoimmunity · doi:10.1080/08916934.2023.2289362 · Cited by 18
Mansour, H., Mohamed, A., Khattab, M., & El-Khatib, A. S. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114069 · Cited by 14
The role of pyroptosis in heart failure and related traditional chinese medicine treatments
Qin, J., Yang, Q., Wang, Y., Shi, M., Zhao, X., & Zhou, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1377359 · Cited by 16
Żyła, J., Kabacik, S., O’Brien, G., Wakil, S. M., Al-Harbi, N., Kaprio, J. A., Badie, C., Polańska, J., & Alsbeih, G. (2019) · Functional & Integrative Genomics · doi:10.1007/s10142-019-00658-3 · Cited by 15
Markelic, M. B., Stančić, A., Saksida, T., Grigorov, I., Mićanović, D., Veličković, K., Martinović, V., Savic, N., Gudelj, A., & Otašević, V. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1227498 · Cited by 14
Luo, M., Luan, X., Yang, C., Chen, X., Yuan, S., Cao, Y., Zhang, J., Xie, J., Luo, Q., Chen, L., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1397863 · Cited by 14
Engelen, Y., Krysko, D. V., Efimova, I., Breckpot, K., Versluis, M., Smedt, S. C. D., Lajoinie, G., & Lentacker, I. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.09.016 · Cited by 14
Metadata
- Authors
- Galluzzi, L., Bravo-San Pedro, J. M., Kepp, O., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Karolinska University Hospital (SE)
- Corresponding author
- Galluzzi, Lorenzo
- Kroemer, Guido
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-04-05
- Volume
- 73
- Issue
- 11-12
- Pages
- 2405-2410
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11108439
- OpenAlex
- W2331898099
- Cited by
- 177
- References
- 53
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 26 · 2023: 26 · 2022: 18 · 2021: 16 · 2020: 17 · 2019: 13 · 2018: 23 · 2017: 11 · 2016: 5
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- regulated cell death, adaptive stress response, cellular homeostasis
- MeSH terms
- Autophagy, Eukaryotic Cells, Homeostasis, Mitochondria, Necrosis, Stress, Physiological, Signal Transduction, Apoptosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
