The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Modulation of Kv7 channels and excitability in the brain
Open accessAbstract
Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons. We will discuss various factors that have been shown to drastically alter the activity of this channel such as protein and phospholipid interactions, phosphorylation, calcium, and numerous neurotransmitters. Kv7 channels locate to key areas for the control of action potential initiation and propagation. Moreover, we will explore the dynamic surface expression of the channel modulated by neurotransmitters and neural activity. We will also focus on known principle functions of neural Kv7 channels: control of resting membrane potential and spiking threshold, setting the firing frequency, afterhyperpolarization after burst firing, theta resonance, and transient hyperexcitability from neurotransmitter-induced suppression of the M-current. Finally, we will discuss the contribution of altered Kv7 activity to pathologies such as epilepsy and cognitive deficits.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Theta oscillations in the hippocampus
Buzsáki, G. (2002) · Neuron · doi:10.1016/s0896-6273(02)00586-x · Cited by 3,332
Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel
Sanguinetti, M. C., Curran, M. E., Zou, A., Shen, J., Specter, P. S., Atkinson, D. L., & Keating, M. T. (1996) · Nature · doi:10.1038/384080a0 · Cited by 1,765
Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone
Brown, D. A., & Adams, P. R. (1980) · Nature · doi:10.1038/283673a0 · Cited by 1,447
KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M-Channel
Wang, H. (1998) · Science · doi:10.1126/science.282.5395.1890 · Cited by 1,294
A Potassium Channel Mutation in Neonatal Human Epilepsy
Biervert, C., Schroeder, B. C., Kubisch, C., Berkovic, S. F., Propping, P., Jentsch, T. J., & Steinlein, O. K. (1998) · Science · doi:10.1126/science.279.5349.403 · Cited by 1,073
AKAP signalling complexes: focal points in space and time
Wong, W., & Scott, J. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1527 · Cited by 1,073
Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,046
The physiology and pharmacology of hippocampal formation theta rhythms
Bland, B. H. (1986) · Progress in Neurobiology · doi:10.1016/0301-0082(86)90019-5 · Cited by 1,039
Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001
The other side of the engram: experience-driven changes in neuronal intrinsic excitability
Zhang, W., & Linden, D. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1248 · Cited by 889
Cited by
Sorted by citations
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels
Alexander, S. P. H., Mathie, A. A., Peters, J. A., Veale, E. L., Striessnig, J., Kelly, E., Armstrong, J. F., Faccenda, E., Harding, S. D., Davies, J. A., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16178 · Cited by 204
Hyperexcitable arousal circuits drive sleep instability during aging
Li, S., Damonte, V. M., Chen, C., Wang, G. X., Kebschull, J. M., Yamaguchi, H., Bian, W.-J., Purmann, C., Pattni, R., Urban, A. E., et al. (2022) · Science · doi:10.1126/science.abh3021 · Cited by 203
Potassium Channel Gain of Function in Epilepsy: An Unresolved Paradox
Niday, Z., & Tzingounis, A. V. (2018) · The Neuroscientist · doi:10.1177/1073858418763752 · Cited by 156
Sonoda, T., Lee, S. K., Birnbaumer, L., & Schmidt, T. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.032 · Cited by 137
Cholinergic modulation of striatal microcircuits
Abudukeyoumu, N., Hernández-Flores, T., Garcia-Munoz, M., & Arbuthnott, G. W. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13949 · Cited by 144
Metadata
- Authors
- Greene, D. L., & Hoshi, N.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Hoshi, Naoto
- ORCID
- Hoshi, Naoto
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-09-19
- Volume
- 74
- Issue
- 3
- Pages
- 495-508
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC5243414
- OpenAlex
- W2521115404
- Cited by
- 177
- References
- 169
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 16 · 2023: 17 · 2022: 30 · 2021: 22 · 2020: 24 · 2019: 14 · 2018: 11 · 2017: 7 · 2016: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS067288)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- Kv7 channels, M-current, neuronal excitability, voltage-gated potassium channels, protein-lipid interactions, phosphorylation, calcium regulation, neurotransmitter modulation, action potential generation, resting membrane potential, afterhyperpolarization, epilepsy, cognitive impairment, brain
- MeSH terms
- Action Potentials, Animals, Brain, Calcium, Calmodulin, Epilepsy, Humans, Membrane Potentials, Neurons, Signal Transduction, GTP-Binding Protein alpha Subunits, Gq-G11, KCNQ Potassium Channels, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
