Modulation of Kv7 channels and excitability in the brain

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Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

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Hyperexcitable arousal circuits drive sleep instability during aging

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Potassium Channel Gain of Function in Epilepsy: An Unresolved Paradox

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Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits

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Cholinergic modulation of striatal microcircuits

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Ultrastructural anatomy of nodes of Ranvier in the peripheral nervous system as revealed by STED microscopy

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Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy

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Characteristics of KCNQ 2 variants causing either benign neonatal epilepsy or developmental and epileptic encephalopathy

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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

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Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle

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Voltage- and calcium-gated ion channels of neurons in the vertebrate retina

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XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits

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M‐type K+ channels in peripheral nociceptive pathways

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Age-related hearing loss pertaining to potassium ion channels in the cochlea and auditory pathway

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Human amyotrophic lateral sclerosis excitability phenotype screen: Target discovery and validation

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Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate

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Prevention of brain damage after traumatic brain injury by pharmacological enhancement of KCNQ (Kv7, “M-type”) K + currents in neurons

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The M-current works in tandem with the persistent sodium current to set the speed of locomotion

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Intellectual Disability and Potassium Channelopathies: A Systematic Review

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Differential contributions of Ca2+‐activated K+ channels and Na+/K+‐ATPases to the generation of the slow afterhyperpolarization in CA1 pyramidal cells

Tiwari, M. N., Mohan, S., Biala, Y., & Yaari, Y. (2018) · Hippocampus · doi:10.1002/hipo.22836 · Cited by 44

Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

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Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases

Marosi, M., Arman, P., Aceto, G., D’Ascenzo, M., & Laezza, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084413 · Cited by 43

Regulatory effect of general anesthetics on activity of potassium channels

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Flexible Stoichiometry: Implications for KCNQ2- and KCNQ3-Associated Neurodevelopmental Disorders

Springer, K., Varghese, N., & Tzingounis, A. V. (2021) · Developmental Neuroscience · doi:10.1159/000515495 · Cited by 36

The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons

Sahu, G., & Turner, R. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.759707 · Cited by 39

Kv7 Channels and Excitability Disorders

Jones, F., Gamper, N., & Gao, H. (2021) · Handbook of Experimental Pharmacology · doi:10.1007/164_2021_457 · Cited by 38

KCNQ2/3/5 channels in dorsal root ganglion neurons can be therapeutic targets of neuropathic pain in diabetic rats

Yu, T., Li, L., Liu, H., Li, H., Liu, Z., & Li, Z. (2018) · Molecular Pain · doi:10.1177/1744806918793229 · Cited by 38

Chemical modulation of Kv7 potassium channels

Borgini, M., Mondal, P., Liu, R., & Wipf, P. (2021) · RSC Medicinal Chemistry · doi:10.1039/d0md00328j · Cited by 37

Pharmacological Manipulation of Kv7 Channels as a New Therapeutic Tool for Multiple Brain Disorders

Vigil, F. A., Carver, C. M., & Shapiro, M. S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00688 · Cited by 36

The Potential of KCNQ Potassium Channel Openers as Novel Antidepressants

Costi, S., Han, M., & Murrough, J. W. (2022) · CNS Drugs · doi:10.1007/s40263-021-00885-y · Cited by 37

RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via M-like Current Activation and Contributes to Binge Eating Behavior

Kania, A., Szlaga, A., Sambak, P., Guguła, A., Błasiak, E., Bonaventura, M. V. M. D., Hossain, M. A., Cifani, C., Hess, G., Gundlach, A. L., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2895-19.2020 · Cited by 35

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

De La Rossa, A., Laporte, M. H., Astori, S., Marissal, T., Montessuit, S., Sheshadri, P., Ramos-Fernández, E., Mendez, P., Khani, A., Quairiaux, C., et al. (2022) · eLife · doi:10.7554/elife.72595 · Cited by 38

KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3

Soh, H., Springer, K., Doci, K., Balsbaugh, J. L., & Tzingounis, A. V. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2117640119 · Cited by 33

Gq-coupled muscarinic receptor enhancement of KCNQ2/3 channels and activation of TRPC channels in multimodal control of excitability in dentate gyrus granule cells

Carver, C. M., & Shapiro, M. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1781-18.2018 · Cited by 32

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M‐Type Voltage‐Gated Potassium Channels

Abdullaeva, O. S., Sahalianov, I. Y., Ejneby, M. S., Jakešová, M., Zozoulenko, I. V., Liin, S. I., & Głowacki, E. D. (2021) · Advanced Science · doi:10.1002/advs.202103132 · Cited by 32

Attenuating M‐current suppression in vivo by a mutantKcnq2gene knock‐in reduces seizure burden and prevents status epilepticus–induced neuronal death and epileptogenesis

Greene, D. L., Kosenko, A., & Hoshi, N. (2018) · Epilepsia · doi:10.1111/epi.14541 · Cited by 34

Spontaneous seizure and memory loss in mice expressing an epileptic encephalopathy variant in the calmodulin-binding domain of K v 7.2

Kim, E. C., Zhang, J., Tang, A. Y., Bolton, E. C., Rhodes, J. S., Christian, C. A., & Chung, H. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021265118 · Cited by 35

The Dopamine System: Insights between Kidney and Brain

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Protein kinase CK2 and ion channels (Review)

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Location, location, location: the organization and roles of potassium channels in mammalian motoneurons

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PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel

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Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons

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Role of KCNQ potassium channels in stress-induced deficit of working memory

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NRG1, PIP4K2A, and HTR2C as Potential Candidate Biomarker Genes for Several Clinical Subphenotypes of Depression and Bipolar Disorder

Levchenko, А., Vyalova, N. M., Nurgaliev, T., Pozhidaev, I. V., Simutkin, G. G., Bokhan, N. A., & Ivanova, S. А. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00936 · Cited by 25

Assembly and Function of the Juxtaparanodal Kv1 Complex in Health and Disease

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Differential Regulation of PI(4,5)P2 Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin

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Metabotropic Modulation of Potassium Channels During Synaptic Plasticity

Fernández‐Fernández, D., & Lamas, J. A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.025 · Cited by 22

Regulation of Hippocampal Gamma Oscillations by Modulation of Intrinsic Neuronal Excitability

Klemz, A., Wildner, F., Tütüncü, E., & Gerevich, Z. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.778022 · Cited by 22

Time‐limited alterations in cortical activity of a knock‐in mouse model of KCNQ2 ‐related developmental and epileptic encephalopathy

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Electrophysiological characterization of the M-current in rat hypoglossal motoneurons

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The Kv7 Channel and Cardiovascular Risk Factors

Fosmo, A. L., & Skraastad, Ø. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00075 · Cited by 21

Functional up‐regulation of the M‐current by retigabine contrasts hyperexcitability and excitotoxicity on rat hypoglossal motoneurons

Ghezzi, F., Monni, L., & Nistri, A. (2018) · The Journal of Physiology · doi:10.1113/jp275906 · Cited by 23

The novel dual-mechanism Kv7 potassium channel/TSPO receptor activator GRT-X is more effective than the Kv7 channel opener retigabine in the 6-Hz refractory seizure mouse model

Bloms-Funke, P., Bankstahl, M., Bankstahl, J., Kneip, C., Schröder, W., & Löscher, W. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108884 · Cited by 19

In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders

Grupe, M., Bentzen, B. H., Benned-Jensen, T., Nielsen, V., Frederiksen, K., Jensen, H. S., Jacobsen, A.-M., Skibsbye, L., Sams, A. G., Grunnet, M., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173440 · Cited by 19

Sex Differences in Biophysical Signatures across Molecularly Defined Medial Amygdala Neuronal Subpopulations

Matos, H. Y., Hernandez‐Pineda, D., Charpentier, C. M., Rusk, A., Corbin, J. G., & Jones, K. S. (2020) · eNeuro · doi:10.1523/eneuro.0035-20.2020 · Cited by 19

M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy

Hoshi, N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00513 · Cited by 19

Ligand modulation of KCNQ-encoded (KV7) potassium channels in the heart and nervous system

Naffaa, M. M., & Al-Ewaidat, O. A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174278 · Cited by 18

Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels

Edmond, M. A., Hinojo-Perez, A., Wu, X., Rodriguez, M. E. P., & Barro-Soria, R. (2022) · eLife · doi:10.7554/elife.77030 · Cited by 16

An epilepsy-causing mutation leads to co-translational misfolding of the Kv7.2 channel

Urrutia, J., Aguado, A., Gomis‐Pérez, C., Muguruza‐Montero, A., Ballesteros, Ó. R., Zhang, J., Núñez, E., Malo, C., Chung, H. J., Leonardo, A., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-01040-1 · Cited by 16

Ethanol Elevates Excitability of Superior Cervical Ganglion Neurons by Inhibiting Kv7 Channels in a Cell Type-Specific and PI(4,5)P2-Dependent Manner

Kim, K.-W., Kim, K.-T., Lee, H., & Suh, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184419 · Cited by 19

Spinal neuron-glial crosstalk and ion channel dysregulation in diabetic neuropathic pain

Wu, J., Hu, H., & Li, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1480534 · Cited by 18

Pregabalin can interact synergistically with Kv7 channel openers to exert antinociception in mice

Huang, C.-N., Chen, Y., Xiao, X., Zhou, H., Zhu, J., Qin, H.-M., Jiang, X., Li, Z., Zhuang, T., & Zhang, G. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175870 · Cited by 15

Identification of potassium channel proteins Kv7.2/7.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1

Bartolomé‐Martín, D., Ibáñez, I., Piniella, D., Martínez‐Blanco, E., Pelaz, S. G., & Zafra, F. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.011 · Cited by 15

KCNQ3 is the principal target of retigabine in CA1 and subicular excitatory neurons

Varghese, N., Lauritano, A., Taglialatela, M., & Tzingounis, A. V. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00564.2020 · Cited by 14

Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain

Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13

A new K+channel-independent mechanism is involved in the antioxidant effect of XE-991 in an in vitro model of glucose metabolism impairment: implications for Alzheimer’s disease

Piccirillo, S., Preziuso, A., Amoroso, S., Serfilippi, T., Miceli, F., Magi, S., & Lariccia, V. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01187-y · Cited by 13

Antagonism of the Muscarinic Acetylcholine Type 1 Receptor Enhances Mitochondrial Membrane Potential and Expression of Respiratory Chain Components via AMPK in Human Neuroblastoma SH-SY5Y Cells and Primary Neurons

Naznin, F., Waise, T. M. Z., & Fernyhough, P. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03003-1 · Cited by 14

SGK1.1 reduces Kainic acid-induced seizure severity and leads to rapid termination of seizures

Armas-Capote, N., Maglio, L. E., Pérez-Atencio, L., Martin-Batista, E., Reboreda, A., Barios, J. A., Hernandez, G., Alvarez de la Rosa, D., Lamas, J. A., Barrio, L. C., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhz302 · Cited by 12

Characterization of the Inhibitory Effect of Gastrodigenin and Gastrodin on M-type K+ Currents in Pituitary Cells and Hippocampal Neurons

Yang, C.-S., Lai, M., Liu, P., Lo, Y., Huang, C., & Wu, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010117 · Cited by 12

Intracellular zinc protects Kv7 K+ channels from Ca2+/calmodulin-mediated inhibition

Yang, X., Chen, D., Zhang, S., Shi, S., Zong, R. L., Gao, Y., Guan, B., Gamper, N. L., & Gao, H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102819 · Cited by 12

Functional responses of the hippocampus to hyperexcitability depend on directed, neuron‐specific KCNQ2 K+ channel plasticity

Carver, C. M., Hastings, S. D., Cook, M. E., & Shapiro, M. S. (2019) · Hippocampus · doi:10.1002/hipo.23163 · Cited by 12

Azetukalner, a Novel KV7 Potassium Channel Opener, in Adults With Major Depressive Disorder: A Randomized Clinical Trial

Butterfield, N. N., Luzon Rosenblut, C., Fava, M., Correll, C. U., Rothschild, A. J., Murrough, J. W., Mathew, S. J., Beatch, G. N., Grayson, C., Harden, C., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.14278 · Cited by 11

Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens

Aceto, G., Nardella, L., Nanni, S., Pecci, V., Bertozzi, A., Nutarelli, S., Viscomi, M. T., Colussi, C., D’Ascenzo, M., & Grassi, C. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05260-w · Cited by 13

Excitatory effect of bradykinin on intrinsic neurons of the rat heart

Arichi, S., Sasaki‐Hamada, S., Kadoya, Y., Ogata, M., & Ishibashi, H. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.04.002 · Cited by 12

KCNQ2- and KCNQ3-Associated Epilepsy

Weckhuysen, S., & George, A. L. (2022) · Cambridge University Press eBooks · doi:10.1017/9781009278270 · Cited by 12

Voltage vs. Ligand I: Structural basis of the intrinsic flexibility of S3 segment and its significance in ion channel activation

Balleza, D., Rosas, M. E., & Romero‐Romero, S. (2019) · Channels · doi:10.1080/19336950.2019.1674242 · Cited by 11

In Vivo Attenuation of M-Current Suppression Impairs Consolidation of Object Recognition Memory

Kosenko, A., Moftakhar, S., Wood, M. A., & Hoshi, N. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0348-20.2020 · Cited by 11

Cannabidiol counters the effects of a dominant-negative pathogenic Kv7.2 variant

Zhan, X., Drummond-Main, C., Greening, D., Yao, J., Chen, S. W. R., Appendino, J. P., Au, P. Y. B., & Turner, R. W. (2022) · iScience · doi:10.1016/j.isci.2022.105092 · Cited by 10

Interim analysis of the long‐term efficacy and safety of azetukalner in an ongoing open‐label extension study following a phase 2b clinical trial (X‐ TOLE ) in adults with focal epilepsy

French, J. A., Porter, R. J., Perucca, E., Brodie, M. J., Rogawski, M. A., Harden, C. L., Qian, J., Luzon, C., Kenney, C., Beatch, G. N., et al. (2025) · Epilepsia Open · doi:10.1002/epi4.70015 · Cited by 10

High Efficacy by GAL-021: A Known Intravenous Peripheral Chemoreceptor Modulator that Suppresses BKCa-Channel Activity and Inhibits IK(M) or Ih

Lu, T., Gao, Z.-H., Li, S.-W., & Wu, S. (2020) · Biomolecules · doi:10.3390/biom10020188 · Cited by 10

Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal ForebrainEx Vivo

Hou, B., Varghese, N., Soh, H., Santaniello, S., & Tzingounis, A. V. (2021) · eNeuro · doi:10.1523/eneuro.0024-21.2021 · Cited by 10

M current regulates firing mode and spike reliability in a collision-detecting neuron

Dewell, R. B., & Gabbiani, F. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00363.2018 · Cited by 11

Kv7/M channel dysfunction produces hyperexcitability in hippocampal CA1 pyramidal cells of Fmr1 knockout mice

Luque, M. A., Morcuende, S., Torres, B., & Herrero, L. (2024) · The Journal of Physiology · doi:10.1113/jp285244 · Cited by 9

A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels

Renigunta, V., Xhaferri, N., Shaikh, I. G., Schlegel, J. G., Bisen, R., Sanvido, I., Kalpachidou, T., Kummer, K. K., Oliver, D., Leitner, M. G., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05312-1 · Cited by 9

Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia

Morris, L. S., Costi, S., Hameed, S., Collins, K. A., Stern, E. R., Chowdhury, A., Morel, C., Salas, R., Iosifescu, D. V., Han, M., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02957-7 · Cited by 9

The anticonvulsant and neuroprotective effects of kir2.3 activation in PTZ-induced seizures and the kainic acid model of TLE

Zhang, L., Sun, W., Xu, L., Wang, Y., Zhu, G., Wu, X., Wang, Y., & Hong, Z. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.106167 · Cited by 9

Developmental age and biological sex influence muscarinic receptor function and neuron morphology within layer VI of the medial prefrontal cortex

Patel, A., Codeluppi-Arrowsmith, S. A., Ervin, K. S. J., St‐Denis, M., Choleris, E., & Bailey, C. D. C. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab406 · Cited by 11

General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates

Liu, S., Guo, P., Wang, K., Zhang, S.-Y., Li, Y., Shen, J., Mei, L., Ye, Y., Zhang, Q., & Yang, H. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c02115 · Cited by 8

Analgesic Action of Acetaminophen via Kv7 Channels

Stampf, J., Ciotu, C. I., Heber, S., Boehm, S., Fischer, M. J. M., & Salzer, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010650 · Cited by 8

Lack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutants

Alaimo, A., Etxeberría, A., Gómez-Posada, J. C., Gomis‐Pérez, C., Fernández‐Orth, J., Malo, C., & Villarroel, Á. (2018) · Channels · doi:10.1080/19336950.2018.1511512 · Cited by 8

Remodeling of Kv7.1 and Kv7.5 Expression in Vascular Tumors

Serrano‐Novillo, C., Oliveras, A., Ferreres, J. C., Condom, E., & Felipe, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176019 · Cited by 8

Voltage-Gated Ion Channel Compensatory Effect in DEE: Implications for Future Therapies

Shabani, K., Krupp, J., Lemesre, E., Lévy, N., & Tran, H. (2024) · Cells · doi:10.3390/cells13211763 · Cited by 8

Cortical projection neurons as a therapeutic target in multiple sclerosis

Beutel, T., Dzimiera, J., Kapell, H., Engelhardt, M., Gass, A., & Schirmer, L. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1842358 · Cited by 7

Homeostatic regulation of extracellular signal-regulated kinase 1/2 activity and axonal Kv7.3 expression by prolonged blockade of hippocampal neuronal activity

Baculis, B. C., Kesavan, H., Weiss, A. C., Kim, E. H., Tracy, G., Ouyang, W. O., Tsai, N., & Chung, H. J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.838419 · Cited by 7

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

Kandel, M. B., Zhuang, G. Z., Goins, W. F., Marzulli, M., Zhang, M., Glorioso, J. C., Kang, Y., Levitt, A. E., Kwok, W., Levitt, R. C., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1398839 · Cited by 9

Current insight into the role of voltage-gated potassiumion channel 7 (Kv7) channels: an emerging therapy target against epilepsy

Diao, Y., Tian, Y., Han, S. K., Zhang, N., Li, J., & Yin, Y. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000175 · Cited by 7

Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels

Sato, A., Arichi, S., Kojima, F., Hayashi, T., Ohba, T., Cheung, D. L., Eto, K., Narushima, M., Murakoshi, H., Maruo, Y., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173536 · Cited by 7

Fluorescence Fluctuation Spectroscopy enables quantification of potassium channel subunit dynamics and stoichiometry

Tedeschi, G., Scipioni, L., Papanikolaou, M., Abbott, G. W., & Digman, M. A. (2021) · Scientific Reports · doi:10.1038/s41598-021-90002-2 · Cited by 7

The Kv7 channel opener Retigabine reduces neuropathology and alleviates behavioral deficits in APP/PS1 transgenic mice

Zhuang, D., yu, N., Shuo, H., Zhang, X., & Ju, C. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115137 · Cited by 6

The paracetamol metabolite N‐acetyl‐4‐benzoquinoneimine (NAPQI) prevents modulation of KV7 channels via G‐protein coupled receptors by interference with PIP2 and Ca2+ sensitivity

Losgott, T., Kudlacek, O., Yang, J., Schicker, K. W., Boehm, S., & Salzer, I. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17419 · Cited by 7

Kv7 channels as pharmacological targets for central nervous system diseases

Miceli, F., Soldovieri, M. V., Barrese, V., & Taglialatela, M. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100153 · Cited by 1

Mutations in Kv7.5 Channels Associated with Intellectual Disability or Epileptic Encephalopathy

Lehman, A., Thouta, S., Mancini, G. M. S., van Slegtenhorst, M., Naidu, S., Desai, S., McWalter, K. M., Person, R., Mwenifumbo, J. C., Salvarinova, R., et al. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2017.11.702

Potassium channels Kv7 family –a new targetfor the treatment of neurodegenerative disorders

Tuleukhanov, S. T. (2025) · Astana Medical Journal · doi:10.54500/2790-1203-2025-4-125-amj007

Current insight into the role of voltage-gated potassiumion channel 7 (Kv7) channels: an emerging therapy target against epilepsy

Diao, Y., Tian, Y., Han, S. K., Zhang, N., Li, J., & Yin, Y. (2017) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000175 · Cited by 7

Axo-Somatic and Apical Dendritic Kv7/M Channels Differentially Regulate the Intrinsic Excitability of Adult Rat CA1 Pyramidal Cells

Yue, C., & Yaari, Y. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01333.2005 · Cited by 156