Cited by 179Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

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Modulation of Kv7 channels and excitability in the brain

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Greene, Derek L., Hoshi, Naoto·2017·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-016-2359-yPMC PMC5243414

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Abstract

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known as the M-current. Due to its particular characteristics, Kv7 channels show pronounced control over the excitability of neurons. We will discuss various factors that have been shown to drastically alter the activity of this channel such as protein and phospholipid interactions, phosphorylation, calcium, and numerous neurotransmitters. Kv7 channels locate to key areas for the control of action potential initiation and propagation. Moreover, we will explore the dynamic surface expression of the channel modulated by neurotransmitters and neural activity. We will also focus on known principle functions of neural Kv7 channels: control of resting membrane potential and spiking threshold, setting the firing frequency, afterhyperpolarization after burst firing, theta resonance, and transient hyperexcitability from neurotransmitter-induced suppression of the M-current. Finally, we will discuss the contribution of altered Kv7 activity to pathologies such as epilepsy and cognitive deficits.

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Authors: Greene, D. L., & Hoshi, N.
Affiliations: University of California, Irvine (US)
Corresponding author: Hoshi, Naoto
ORCID: Hoshi, Naoto
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2016-09-19
Volume: 74
Issue: 3
Pages: 495-508
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-016-2359-y
PMC: PMC5243414
OpenAlex: W2521115404
Cited by: 177
References: 169
Citations by year: 2026: 12 · 2025: 21 · 2024: 16 · 2023: 17 · 2022: 30 · 2021: 22 · 2020: 24 · 2019: 14 · 2018: 11 · 2017: 7 · 2016: 3
FWCI: 1.05
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS067288)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: Kv7 channels, M-current, neuronal excitability, voltage-gated potassium channels, protein-lipid interactions, phosphorylation, calcium regulation, neurotransmitter modulation, action potential generation, resting membrane potential, afterhyperpolarization, epilepsy, cognitive impairment, brain
MeSH terms: Action Potentials, Animals, Brain, Calcium, Calmodulin, Epilepsy, Humans, Membrane Potentials, Neurons, Signal Transduction, GTP-Binding Protein alpha Subunits, Gq-G11, KCNQ Potassium Channels, Cognitive Dysfunction

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Modulation of Kv7 channels and excitability in the brain

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