Cited by 502MicroRNA in disease regulationPlant Molecular Biology ResearchCancer-related molecular mechanisms research

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

Open access

Pu, Mengfan, Chen, Jing, Tao, Zhouteng, Miao, Lingling, Qi, Xinming, Wang, Yizheng, Ren, Jin·2019·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-018-2940-7PMC PMC11105547

Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3' UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-018-2940-7

Cites

82 of 82 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
The nuclear RNase III Drosha initiates microRNA processing
Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., et al. (2003) · Nature · doi:10.1038/nature01957 · Cited by 5,294
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 5,018
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,556
MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing
Grimson, A., Farh, K. K.-H., Johnston, W. K., Garrett-Engele, P., Lim, L. P., & Bartel, D. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.017 · Cited by 3,766
The Transcriptional Landscape of the Mammalian Genome
Carninci, P., Kasukawa, T., Katayama, S., Gough, J., Frith, M. C., Maeda, N., Oyama, R., Ravasi, T., Lenhard, B., Wells, C. A., et al. (2005) · Science · doi:10.1126/science.1112014 · Cited by 3,492
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint
Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003) · Genes & Development · doi:10.1101/gad.1158803 · Cited by 3,020

Show all 82 references

Sorted by citations

Items 301–400 of 502

Confined Gel-Electromembrane Extraction of Oligonucleotides
Liu, C., Liu, J., Liu, Q., Zhu, Q., Wang, H., Fang, X., Zhang, W., Liu, Z., & Huang, C. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c02239 · Cited by 4
Unraveling Effects of miRNAs Associated with APR Leaf Rust Resistance Genes in Hybrid Forms of Common Wheat (Triticum aestivum L.)
Spychała, J., Noweiska, A., Tomkowiak, A., Bobrowska, R., Szewczyk, K., & Kwiatek, M. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020665 · Cited by 4
Regulatory network identified by pulmonary transcriptome and proteome profiling reveals extensive change of tumor-related genes in microRNA-21 knockout mice
Luan, G., Wang, M., Yuan, J., Bu, X., Song, J. K., Wang, C., & Zhang, L. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-03967-6 · Cited by 4
Circulating biomarkers of response to immunotherapy and immune-related adverse events
Garrison, Z. R., Hornick, N. I., Cheng, J. B., & Kulkarni, R. P. (2022) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2130688 · Cited by 4
The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II
Pidíková, P., Chovancová, B., Mravec, B., & Herichová, I. (2022) · General Physiology and Biophysics · doi:10.4149/gpb_2022033 · Cited by 4
pPe Op inhibits HGC-27 cell proliferation, migration and invasion by upregulating miR-30b-5p and down-regulating the Rac1/Cdc42 pathway
Xu, W., Fu, Z., Xu, Y., Cheung, M. H., Chen, Y., Lin, M., Wen, H., Lv, H., Liang, C., Lou, J.-S., et al. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022193 · Cited by 4
Hsa_circ_0001944 enhanced GSPT1 expression via sponging miR ‐498 to promote proliferation and invasion of gastric cancer
Liu, R., Han, X., Gao, S., Yang, C. G., & Zhang, J. (2023) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24810 · Cited by 4
The Biological Processes of Ferroptosis Involved in Pathogenesis of COVID-19 and Core Ferroptoic Genes Related With the Occurrence and Severity of This Disease
Zhang, Z., Pang, T., Qi, M., & Sun, G. (2023) · Evolutionary Bioinformatics · doi:10.1177/11769343231153293 · Cited by 4
Circular RNA CircSATB2 facilitates osteosarcoma progression through regulating the miR-661/FUS-mediated mRNA of ZNFX1
Wang, Z., She, D., Liu, L., Hua, X., Zhu, H., Yu, L., Wang, H., Zhu, Y., Fan, G., Wang, Y., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110977 · Cited by 3
Self-citation
Upregulation of miRNA-1228-3p alleviates TGF-β-induced fibrosis in renal tubular epithelial cells.
Shen, H., He, Q., Dong, Y., Shao, L., Liu, Y., & Gong, J. (2020) · PubMed · doi:10.14670/hh-18-242 · Cited by 4
Prognostic Value of Long Noncoding RNA SNHG11 in Patients with Prostate Cancer
Li, Y., Pan, B., Guo, X., Meng, X., & Tian, X. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1745-8952 · Cited by 4
Integrated Analysis of Transcriptome, microRNAs, and Chromatin Accessibility Revealed Potential Early B-Cell Factor1-Regulated Transcriptional Networks during the Early Development of Fetal Brown Adipose Tissues in Rabbits
Du, K., Shi, Y., Bai, X., Chen, L., Sun, W., Chen, S., Wang, J., Jia, X., & Lai, S. (2022) · Cells · doi:10.3390/cells11172675 · Cited by 4
Differentially deregulated microRNAs contribute to ultraviolet radiation-induced photocarcinogenesis through immunomodulation: An-analysis of microRNAs expression profilingPreprint
Agarwal, A., Kansal, V., Farooqi, H., Singh, V. K., & Prasad, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529976 · Cited by 4
miRNAs in ovarian disorders: Small but strong cast
Tafazoli, P., Rad, H. M., Mashayekhi, M., Siadat, S. F., & Fathi, R. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155709 · Cited by 3
MicroRNA, MicroRNA-lncRNA and MicroRNA-Circular RNA axes, and exosomal MicroRNAs: driving exercise-induced cardioprotection in heart failure
Li, Y., Wang, J., Ma, D., & He, J. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1767057 · Cited by 3
Serum‐Based miRNA Panel as Diagnostic Biomarkers for Hepatitis C Virus‐Induced Hepatocellular Carcinoma: A Cross‐Sectional Study
Alzahrani, B., Ishaq, Y., Khan, Q. F., Shah, T. A., Shazly, G. A., Bourhia, M., & Ikram, A. (2026) · Health Science Reports · doi:10.1002/hsr2.72377 · Cited by 3
MiRNA/mRNA network topology in hepatitis virus B-related liver cirrhosis reveals miR-20a-5p/340-5p as hubs initiating fibrosis
Yao, H., Li, P., Xin, J., Liang, X., Jiang, J., Shi, D., Li, J., Hassan, H. M., Chen, X., & Li, . (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01390-x · Cited by 4
Identification of key genes and regulatory networks involved in the Comorbidity of atrial fibrillation and chronic obstructive pulmonary disease
Xiong, S., Liu, Q., Zhou, S., & Xiao, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22430 · Cited by 3
Integrated mRNA and miRNA analysis reveals the regulatory network of oxidative stress and inflammation in Coilia nasus brains during air exposure and salinity mitigation
Gao, J. L., Mang, Q., Liu, Y., Sun, Y., & Xu, G. (2024) · BMC Genomics · doi:10.1186/s12864-024-10327-w · Cited by 3
CheRRI—Accurate classification of the biological relevance of putative RNA–RNA interaction sites
Müller, T., Mautner, S., Videm, P., Eggenhofer, F., Raden, M., & Backofen, R. (2024) · GigaScience · doi:10.1093/gigascience/giae022 · Cited by 3
Heparin Differentially Regulates the Expression of Specific miRNAs in Mesenchymal Stromal Cells
Oeller, M., Schally, T., Zimmermann, G., Lauth, W., Schallmoser, K., Rohde, E., & Laner‐Plamberger, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312589 · Cited by 3
CircRBM33 competitively binds miR-15a-5p to mediate EZH1 expression to ameliorate sepsis-induced acute lung injury
Lin, J., Wei, Q., & Fang, Z. (2024) · Clinics · doi:10.1016/j.clinsp.2024.100550 · Cited by 3
Porcine reproductive and respiratory syndrome virus downregulates the circ-107191/miR-34c/RAD54L axis to promote testicular cell apoptosis via impaired homologous recombination repair
Huang, B., You, D., Liu, B., Lai, S., Ai, Y., Huang, J., Zhou, Y., Ge, L., Zeng, X., Xu, Z., et al. (2025) · Theriogenology · doi:10.1016/j.theriogenology.2025.117606 · Cited by 3
What Is the Transcriptome and How It Is Evaluated
Assis, A. F., de Oliveira, E. H. D., Donate, P. B., Giuliatti, S., Nguyen, C., & Passos, G. A. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-87821-4_1 · Cited by 5
Stochastic P-Bifurcation in a Delayed Myc/E2F/miR-17-92 Network
Han, Z., Wang, Q., Wu, H., & Hu, Z. (2022) · International Journal of Bifurcation and Chaos · doi:10.1142/s0218127422501590 · Cited by 3
A Small‐Molecule Probe with a Dual Function of miRNA Inhibition and Target identification
Wang, W., Deng, J., Zhang, Y., & Li, J. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202202013 · Cited by 3
MiR-654-3p targets SRC to suppress tumor growth in non-small cell lung cancer
Pang, M., Jiang, Y., Huang, Y., Ren, B., He, L., & Li, J. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.4.25 · Cited by 3
Recent Advances in PGPRs and Their Application in Imparting Biotic and Abiotic Stress Tolerance in Plants
Joshi, B., Jena, S. N., Joshi, S. R., & Bhau, B. S. (2023) · Springer eBooks · doi:10.1007/978-981-99-2816-3_15 · Cited by 3
Genome-wide analysis of non-coding RNA reveals the role of a novel miR319c for tuber dormancy release process in potato
Liu, S., Yang, J., Zhang, N., & Si, H. (2024) · Horticulture Research · doi:10.1093/hr/uhae303 · Cited by 3
Hairpin reporter facilitated single Cas13a test for amplification-free highly sensitive detection of miRNA-424
AL-Dulaiei, M. Z. A. A., Ma, T., Long, J., Yu, Y., Li, Y., & Yang, X. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.113768 · Cited by 3
miR-551b is Associated with the Poor Prognosis and Malignant Development of Papillary Thyroid Cancer Through Regulating ERBB4
Wang, J., & Liu, H. (2022) · Hormone and Metabolic Research · doi:10.1055/a-1735-3318 · Cited by 3
Deacetylated-poly-N-acetylglucosamine-folic Acid as a Nanocarrier for Delivering miR-196a Inhibitor to Anticancer Activity
Hao, Y., & Li, X. (2022) · Balkan Medical Journal · doi:10.4274/balkanmedj.galenos.2021.2021-8-62 · Cited by 3
LncRNA TP73-AS1 Exacerbates the Non-Small-Cell Lung Cancer (NSCLC) Process via Regulating miR-125a-3p-Mediated ACTN4
Tong, Y., Feng, Z.-M., Li, Y., Yan, C., He, W., & Chen, X. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4098271 · Cited by 3
isomiRs-specific differential expression is the rule, not the exception: Are we missing hundreds of species in microRNA analysis?Preprint
Schmauch, E., Laitinen, P., Turunen, T. A., Väänänen, M., Malm, T., Kellis, M., Kaikkonen, M. U., & Linna-Kuosmanen, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.15.472814 · Cited by 3
MiR-4291 stabilized the vulnerable atherosclerotic plaques by degrading the MAPK1/ERK2 in ApoE-/- mice
Jin, Y., Lu, J., Liu, F., Yang, X., Chen, F., & Zhang, J. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-5241 · Cited by 3
Hairpin self-assembly powered by exonuclease III for highly sensitive and cross-validated miRNA-155 detection
Ji, J., Xu, J., Wang, S., Wang, Q., & Li, H. (2024) · Analytical Methods · doi:10.1039/d4ay01135j · Cited by 2
Networks of pre-diagnostic circulating RNA in testicular germ cell tumour
Burton, J. A., Rounge, T. B., Haugen, T. B., & Wojewodzic, M. W. (2025) · Scientific Reports · doi:10.1038/s41598-024-84484-z · Cited by 2
Predictive value of microRNA-122 in obesity and metabolic syndrome
Abdelhafez, A. H. T. M., Fattah, W. M. A., Seliem, N., & Mohamed, E. F. (2024) · Al-Azhar Assiut Medical Journal · doi:10.4103/azmj.azmj_38_24 · Cited by 2
MicroRNA as a Potential Biomarker for Amyotrophic Lateral Sclerosis (ALS)
Nogueira-Machado, J. A., Albanaz, A. T. S., & Rocha-Silva, F. (2025) · Sclerosis · doi:10.3390/sclerosis3020016 · Cited by 2
LncRNA EBLN3P/microRNA-323a-3p/EphA1 axis affects the biological function of hepatocellular carcinoma cells
Li, M., Cheng, Y., Qiu, F., Mu, X., Zhai, P., Li, Z., Liu, Q., & Li, Q. (2025) · Discover Oncology · doi:10.1007/s12672-025-02902-8 · Cited by 2
MicroRNAs in cardiovascular disease
Sessa, F. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.11.001 · Cited by 2
Ascosphaeraapis LncRNA6140 promotes the infection of honeybee larvae through the milR5658-x–ATPase axis
Qiu, J., Wu, T., zhou, S., Fan, N., Gan, G., Liu, Z., Fu, Z., Guo, R., & Chen, D. (2026) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2026.104591 · Cited by 2
A comprehensive review on the role of protein tyrosine phosphatases in gastric cancer development and progression
Clerici, S. P., Oliveira, P. F. D. S., Akagi, E. M., Cordeiro, H. G., Azevedo-Martins, J. M., Faria, A. V. D. S., & Ferreira‐Halder, C. V. (2021) · Biological Chemistry · doi:10.1515/hsz-2020-0355 · Cited by 2
Role of microRNAs in the process of metformin treating multiple diseases
Ma, N., Chen, J., & Ren, J. (2021) · Frigid Zone Medicine · doi:10.2478/fzm-2021-0009 · Cited by 2
Self-citation
A comprehensive evaluation of circ_0065214/ miR-188-3p/GPNMB axis in breast cancer
Wu, X., Zhao, Y.-X., Xu, S.-L., Wang, L., Mao, J., Wang, B., & Yang, H. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.111019 · Cited by 2
Differential expression of miRNAs revealed by small RNA sequencing in traumatic tracheal stenosis
Li, W., Wei, J., Huang, P., Wei, Y., Chang, L., & Liu, G. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2023.1291488 · Cited by 2
Critical Roles of Micro-RNAs in the Pathogenesis and Immunoregulation of Leishmania Infection
Verma, C., Huston, R. H., Wharton, A. R., Fultz, R., Zidan, S., Volpedo, G., & Satoskar, A. R. (2023) · Springer eBooks · doi:10.1007/978-981-99-6999-9_9 · Cited by 2
Circ_0015382 Regulates the miR-942-5p/NDRG1 Axis to Suppress Trophoblast Cell Functions
Wu, H., & Zhao, L. (2024) · Reproductive Sciences · doi:10.1007/s43032-024-01685-7 · Cited by 2
In-Depth Analysis of miRNA Binding Sites Reveals the Complex Response of Uterine Epithelium to miR-26a-5p and miR-125b-5p During Early Pregnancy
Myszczyński, K., Szuszkiewicz, J., Krawczynski, K., Sikora, M., Romaniewicz, M., Guzewska, M. M., Zabielski, P., & Kaczmarek, M. M. (2024) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2024.100879 · Cited by 2
Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications
Hashemi, M., Fard, A. A., Pakshad, B., Asheghabadi, P. S., Hosseinkhani, A., Hosseini, A. S., Moradi, P., Niye, M. M., Najafi, G., Farahzadi, M., et al. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.11.006 · Cited by 3
Prediction of ncRNA-Disease Association Based on Correntropy Induced Loss Matrix Factorization Model
Li, P., Qian, Y., Xu, J., Ding, Y., & Guo, F. (2025) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbbio.2025.3574189 · Cited by 2
The aro-miR166b/c-ArHDZ22 module regulates reproductive development in Anoectochilus roxburghii
Yan, X., Xing, B., Jin, K., Wan, S., Zheng, Y., Shao, Q., Lu, C., & Zhao, C. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.121651 · Cited by 2
MicroRNAs: Crucial Players in the Differentiation of Human Pluripotent and Multipotent Stem Cells into Functional Hepatocyte-Like Cells
Wu, L., Farzaneh, M., Xu, H., Yuan, G., Liang, X., Liu, X., Li, Z., & Chen, N. (2021) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x16666211006102039 · Cited by 2
Long Non-coding RNA LINC01426 Contributes to the Malignant Behaviors of NSCLC Via Acting As a Sponge for miR-143-3p
Liu, W., Si, P., Fang, H., Ning, G., Chen, L., & Huang, Y. (2022) · Biochemical Genetics · doi:10.1007/s10528-022-10234-3 · Cited by 2
Identifying Hub Genes and miRNA-mRNA Regulatory Networks in Mice Infected with H1N1 Influenza Virus
Li, M., He, Q., & Chen, L. (2023) · Disease Markers · doi:10.1155/2023/2291051 · Cited by 2
Interplay of miRNA-TF-Gene Through a Novel Six-node Feed-forward Loop Identified Inflammatory Genes as Key Regulators in Type-2 Diabetes
S, G. S., Keshav, T. R., Hariharapura, R. C., & Fayaz, S. M. (2023) · Current Bioinformatics · doi:10.2174/1574893618666230731164002 · Cited by 2
MicroRNA‐145‐5p suppresses cell proliferation, migration, and invasion in upper tract urothelial carcinoma by targeting 5‐aminoimidazole‐4‐carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Luo, H., Lee, Y., Chang, Y., Hsu, W., Wu, Y., Jhan, J., Lin, H., Wu, Y., Ke, H., & Liu, H. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30449 · Cited by 1
miRNA-TF-gene regulatory network in metabolite differentiation of stem and root parts in Ephedra sinica Stapf
Jiang, S., & Cui, J. (2025) · Plant Growth Regulation · doi:10.1007/s10725-025-01286-7 · Cited by 1
miR-28-5p targeted Rap1b attenuates splenic inflammation infiltration in immune thrombocytopenia
Yu, R., Cen, L., Wu, X., Liu, H., Zhai, X., & Bin, Q. (2025) · Platelets · doi:10.1080/09537104.2025.2487756 · Cited by 1
Both a Growth‐Defence Trade‐Off and a Leaf N: P Stoichiometric Imbalance Can Account For Ectomycorrhizal Hyphae Inhibited Non‐Host Plant Growth
Wang, Y., Wei, X. L., Zhan, J., Yuan, J., Zheng, G., Zhou, W., He, X., & Yu, F. (2025) · Plant Cell & Environment · doi:10.1111/pce.15564 · Cited by 1
Self-citation
Melatonin Promotes Osteogenic Differentiation of Rat Adipose‐Derived Stem Cells via the p38/ MAPK Signaling Pathway
Meng, S., Han, S., Kong, M., Liu, Z., Lin, A., Qu, C., Li, L., Ma, X., & Wang, Y. (2025) · The FASEB Journal · doi:10.1096/fj.202403193rr · Cited by 1
Self-citation
MiRNA-211 Dysregulation contributes to the pathogenesis of digestive tract cancers: Mechanistic and clinical implications
Mohammadi, Y., Babaeenezhad, E., & Yarahmadi, S. (2025) · Gene · doi:10.1016/j.gene.2025.149596 · Cited by 1
miR-320-3p regulates apelin and TGF-β/SMAD3 signaling in hypobaric hypoxia exposed rats to induce skeletal muscle atrophy
Mondal, S., Srivastava, S., Srivastava, S., Rathor, R., & Suryakumar, G. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01100-y · Cited by 1
Transcription Dynamics and DNA Methylation Responses to Growth Modification
Christensen, K. A., Collette, É., Perley, D. S., Sakhrani, D., Muttray, A. F., Leggatt, R. A., Biagi, C. A., Koop, B. F., & Devlin, R. H. (2025) · Marine Biotechnology · doi:10.1007/s10126-025-10476-3 · Cited by 1
Computational interference of gene regulatory networks on the growth and development of millets
Panigrahi, L. L., Mishra, G., Swain, D., & Rout, G. R. (2025) · Plant Gene · doi:10.1016/j.plgene.2025.100531 · Cited by 1
miR-7002-5p targets caspase-1 to suppress the inflammatory response of macrophages induced by Streptococcus equi subsp. zooepidemicus
Xie, H., Deng, J., Yu, J., Li, S., Wang, Y., Li, Y., Huang, Y., Sun, Q., Liao, J., Deng, Z., et al. (2025) · Archives of Microbiology · doi:10.1007/s00203-025-04412-1 · Cited by 1
Self-citation
Plant MicroRNAs: Recent Advances in Their Roles Under Stress Conditions
Nayak, J., Pattnaik, S., Dweh, T. J., Kayastha, S., Sahoo, J. P., Mahapatra, M., & Pradhan, M. (2025) · CABI climate change series. · doi:10.1079/9781800626102.0025 · Cited by 1
Tetrastichus brontispae exploits host‐derived On‐ miR ‐281‐3p to suppress the phenoloxidase pathway and facilitate its development
Zhang, H.-J., Liao, G., Yin, J., Xu, J., Hou, Y., & Tang, B. (2025) · Pest Management Science · doi:10.1002/ps.70124 · Cited by 1
The role of miR-1303 in colon cancer and its possible molecular mechanism based on bioinformatics
Cheng, Q., & Fu, H. (2025) · Nucleosides Nucleotides & Nucleic Acids · doi:10.1080/15257770.2025.2560352 · Cited by 1
Dynamic microRNA Responses Contribute to Phenotypic Plasticity and Stress Memory in Invasive Species
Du, Z. (2025) · Molecular Ecology · doi:10.1111/mec.70160 · Cited by 1
MicroRNA miR-iab-8 modulates the diapause of Ostrinia furnacalis larvae by targeting the circadian clock gene cycle and affecting the ecdysone signaling pathway
Ma, H., Liu, Y., Cao, S., Tian, X., Chen, Y., Gao, S., & Feng, Y. (2025) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2025.104911 · Cited by 1
Potential Regulatory Role of miR-15b, miR-99b, and miR-181a of the Shikonin-Induced MAPK/ERK Apoptotic Signaling Pathway in Renal Carcinoma
Vass, A., Király, J., Szabó, E., Shree, N., Ramos, D., Choudhury, M., Fodor, P., Szegedi, K., Halmos, G., & Szabó, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13122898 · Cited by 1
Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions
Kapoor, R., Bellani, D., Patil, R., Bose, D., Pola, M., Singh, P. A., Mishra, M., & Shome, D. (2025) · ADMET & DMPK · doi:10.5599/admet.3030 · Cited by 1
Molecular crosstalk between herbal phytochemicals and microRNAs in electronic cigarette vapor: Implications for respiratory health
Situmorang, P. C., Helen, H., ILYAS, S., Pangestu, P. S., Wibowo, S., Berliani, K., Nugraha, A. P., & Pasaribu, K. M. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107120 · Cited by 1
MicroRNAs as potential biomarkers and future therapeutic targets in thrombosis: From molecular mechanisms to clinical implications
Shen, Z., Dong, X., & Liu, L. (2026) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2026.107464 · Cited by 1
Deregulation of Synaptic Plasticity-Related MicroRNAs After Repetitive Transcranial Magnetic Stimulation in Alzheimer’s Disease
Casciati, A., Colantoni, E., Camera, F., Fratini, E., Casula, E. P., Mencarelli, L., Lorenzo, F. D., Bonnı̀, S., Koch, G., Tanno, B., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05620-y · Cited by 1
A functionally differentiated DNA tetrahedron-based cascaded cyclic catalytic amplification assay for detecting miR-21 in prostate cancer
Guo, T., Zuo, C., Bai, P., & Hu, L. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.127782 · Cited by 1
The Role of MicroRNAs in Treg‐Derived Extracellular Vesicles: A Narrative Review Focusing on Immune‐Related Diseases
Gao, Y., Zhou, J., Mao, Y., Yuan, M., Yimin, R., & Zhang, F. B. (2026) · Journal of Immunology Research · doi:10.1155/jimr/6798693 · Cited by 1
Clinical significance of circulatory microRNA-183_5p and 3651 in serum as novel potential diagnostic marker for gallbladder cancer
Verma, D., Lohani, N., Kumar, J., Nayyar, V., Gupta, P., & Chauhan, S. S. (2026) · Indian Journal of Gastroenterology · doi:10.1007/s12664-026-01967-9 · Cited by 1
LncRNA7503 decreases peach (Prunus persica) branch number and angle by inducing pre-miR395a degradation and reducing bioactive BR content
Wang, X., Xie, H., Pei, W., Shen, R., Zhang, Y., Zhang, J., Lian, X., Zhang, H., Zheng, X., Hou, N., et al. (2026) · Molecular Horticulture · doi:10.1186/s43897-025-00215-6 · Cited by 1
Cell line–dependent effects of β‑estradiol and testosterone on aurora kinases, GATA3, and associated miRNAs in hepatocellular carcinoma models HepG2 and Huh‑7
Rezaei, T., Abidi, M., Mohammadi, Y., Farzam, F., & Bahreini, E. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04376-2 · Cited by 1
Retracted: Long non‐coding RNA TP73‐AS1 facilitates progression and radioresistance in lung cancer cells by the miR‐216a‐5p / CUL4B axis with exosome involvement
Qiu, H., Zhang, L., Yi, T., Yang, K. G., Gong, Y. Q., & Xie, C. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13602 · Cited by 1
Retracted
LONG NON-CODING RNAS AS REGULATORS OF PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES OF THE CARDIOVASCULAR SYSTEM
Khetsuriani, M., & Dosenko, V. (2020) · Fìzìologìčnij žurnal · doi:10.15407/fz66.04.072 · Cited by 1
Circular RNA circ_0001421 contributes to colony formation, migration, invasion and glycolysis of non-small cell lung cancer via the miR-409-3p/TMEM14A axis
Xu, Y., Liu, L., Zou, C., Zeng, J., & Feng, R. (2021) · Archives of Medical Science · doi:10.5114/aoms/120369 · Cited by 1
Network construction revealed that gestational diabetes mellitus may lead to congenital heart disease via potential lncRNAs-miRNAs regulating PPARγ
Baharlooie, M., Peymani, M., Nasr‐Esfahani, M. H., & Ghaedi, K. (2022) · Human Gene · doi:10.1016/j.humgen.2022.201062 · Cited by 1
MicroRNA-322-5p promotes lipopolysaccharide-induced acute kidney injury mouse models and mouse primary proximal renal tubular epithelial cell injury by regulating T-box transcription factor 21/mitogen-activated protein kinase/extracellular signal-related kinase axis
Ji, X., Liu, X., Li, X., Du, X., & Li, F. (2023) · Nefrología (English Edition) · doi:10.1016/j.nefro.2023.01.009 · Cited by 4
The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p
Lee, D. H., Bae, W. H., Ha, H., Kim, W. R., Park, E. G., Lee, Y. J., Kim, J. M., Shin, H. J., & Kim, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-55332-x · Cited by 1
MicroRNA-30e-3p regulates the inflammatory response by targeting the gimap8 gene in Ctenopharyngodon idella kidney (CIK) cells
Xie, L., Du, B., Yu, H., Gui, L., Qiu, J., Yuan, L., Shen, Y., Xu, X., & Li, J. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109524 · Cited by 1
MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma progression in rats
Vaghf, A., Sadegh, M., Khansarinejad, B., & Mondanizadeh, M. (2024) · Gene · doi:10.1016/j.gene.2024.148858 · Cited by 1
REMR: Identification of RNA Editing-mediated MiRNA Regulation in Cancers
Zhou, X., Liu, H., Hou, F., Zheng, Z.-Q., Cao, X., Wang, Q., & Jiang, W. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.09.011 · Cited by 1
Redefining the role of autophagy in diabetic vascular diseases
An, Y., & Ren, J. T. (2024) · Exploration of Medicine · doi:10.37349/emed.2024.00249 · Cited by 1
Self-citation
Scientific investigation of non-coding RNAs in mitochondrial epigenetic and aging disorders: Current nanoengineered approaches for their therapeutic improvement.
Patange, V., Ahirwar, K., Tripathi, T., Tripathi, P., & Shukla, R. (2024) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2024.101979
Potential Involvement of miR-144 in the Regulation of Hair Follicle Development and Cycle Through Interaction with Lhx2
Zhou, G., Wang, X., Chen, Y., & Kang, D. (2024) · Genes · doi:10.3390/genes15111454 · Cited by 1
LEF1 influences diabetic retinopathy and retinal pigment epithelial cell ferroptosis via the miR-495-3p/GRP78 axis through lnc-MGC
Luo, Y.-Y., Ba, X.-Y., Wang, L., Zhang, Y.-P., Xu, H., Chen, P.-Q., Zhang, L.-B., Han, J. Z., & Luo, H. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i3.92003 · Cited by 1
Role of the microRNA in Prediction of the Breast Cancer
Kheiry, M., & Maleki, F. (2025) · Journal of Basic Research in Medical Sciences · doi:10.61186/jbrms.12.2.11 · Cited by 1
Noncoding RNAs and Heart Failure
Luo, B., Zeng, X., Liu, P., & Hua Zhu, C. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1671-9_12 · Cited by 1
Fluorescent Mitoxantrone Hydrochloride Nanoparticles Inhibit the Malignant Behavior of Giant Cell Tumor of Bone via miR-125b/PTH1R Axis
Su, B., Yuan, Y., Zhang, J., Li, Y., & Zhang, Q. (2020) · Journal of Nanomaterials · doi:10.1155/2020/2391412 · Cited by 1
Advances of microRNAs in regulating mitochondrial function: new potential application in NAFLD treatment
Yu, C., Chen, J., & Ren, J. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07503-0 · Cited by 1
Self-citation
Relationship of Noncoding RNA and Swine Viruses
Fang, M., Hu, W., & Deng, Z. (2022) · Intervirology · doi:10.1159/000527298 · Cited by 1
MICRORNA-122 AS A BIOMARKER ASSOCIATED WITH OXIDATIVE STRESS IN PATIENTS SUFFERING FROM METABOLIC DISEASES
Reda, R. S., & Jabbar, N. K. (2024) · Military Medical Science Letters · doi:10.31482/mmsl.2023.020 · Cited by 1

Authors: Pu, M., Chen, J., Tao, Z., Miao, L., Qi, X., Wang, Y., & Ren, J.
Affiliations: Chinese Academy of Sciences (CN)
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
Corresponding author: Ren, Jin
ORCID: Pu, Mengfan
Chen, Jing
Tao, Zhouteng
Miao, Lingling
Qi, Xinming
Wang, Yizheng
Ren, Jin
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2018-10-29
Volume: 76
Issue: 3
Pages: 441-451
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-018-2940-7
PMC: PMC11105547
OpenAlex: W2899058989
Cited by: 500
References: 82
Citations by year: 2026: 48 · 2025: 59 · 2024: 83 · 2023: 73 · 2022: 91 · 2021: 77 · 2020: 53 · 2019: 14
FWCI: 3.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: microRNA, microRNA target regulation, transcriptional regulation, post-transcriptional regulation, 3' UTR binding, miRNA seed region, gene silencing, gene activation, regulatory networks, gene expression modulation
MeSH terms: Gene Expression Regulation, Humans, Protein Processing, Post-Translational, Transcriptional Activation, Drug Delivery Systems, Gene Silencing, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks