Cited by 502MicroRNA in disease regulationPlant Molecular Biology ResearchCancer-related molecular mechanisms research

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Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

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Pu, Mengfan, Chen, Jing, Tao, Zhouteng, Miao, Lingling, Qi, Xinming, Wang, Yizheng, Ren, Jin·2019·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-018-2940-7PMC PMC11105547

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Abstract

MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3' UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.

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Untitled work
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Additional file 5 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 4 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 2 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 6 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 2 of MiR-149-3p promotes the cisplatin resistance and EMT in ovarian cancer through downregulating TIMP2 and CDKN1A
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Additional file 7 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 2 of miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer
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Additional file 8 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 1 of Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
da Silva Rosa, P. M., Bridi, A., de Ávila Ferronato, G., Prado, C. M., Bastos, N. M., Sangalli, J. R., Meirelles, F. V., Perecin, F., & da Silveira, J. (2024) · Figshare · doi:10.6084/m9.figshare.26694729
Additional file 4 of Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
da Silva Rosa, P. M., Bridi, A., de Ávila Ferronato, G., Prado, C. M., Bastos, N. M., Sangalli, J. R., Meirelles, F. V., Perecin, F., & da Silveira, J. (2024) · Figshare · doi:10.6084/m9.figshare.26694738
Additional file 1 of MiR-149-3p promotes the cisplatin resistance and EMT in ovarian cancer through downregulating TIMP2 and CDKN1A
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Additional file 1 of miR-3065-3p promotes stemness and metastasis by targeting CRLF1 in colorectal cancer
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Additional file 2 of Corpus luteum presence in the bovine ovary increase intrafollicular progesterone concentration: consequences in follicular cells gene expression and follicular fluid small extracellular vesicles miRNA contents
da Silva Rosa, P. M., Bridi, A., de Ávila Ferronato, G., Prado, C. M., Bastos, N. M., Sangalli, J. R., Meirelles, F. V., Perecin, F., & da Silveira, J. (2024) · Figshare · doi:10.6084/m9.figshare.26694732
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Additional file 1 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Additional file 3 of HIF1α-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression
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Authors: Pu, M., Chen, J., Tao, Z., Miao, L., Qi, X., Wang, Y., & Ren, J.
Affiliations: Chinese Academy of Sciences (CN)
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
Corresponding author: Ren, Jin
ORCID: Pu, Mengfan
Chen, Jing
Tao, Zhouteng
Miao, Lingling
Qi, Xinming
Wang, Yizheng
Ren, Jin
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2018-10-29
Volume: 76
Issue: 3
Pages: 441-451
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-018-2940-7
PMC: PMC11105547
OpenAlex: W2899058989
Cited by: 500
References: 82
Citations by year: 2026: 48 · 2025: 59 · 2024: 83 · 2023: 73 · 2022: 91 · 2021: 77 · 2020: 53 · 2019: 14
FWCI: 3.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: microRNA, microRNA target regulation, transcriptional regulation, post-transcriptional regulation, 3' UTR binding, miRNA seed region, gene silencing, gene activation, regulatory networks, gene expression modulation
MeSH terms: Gene Expression Regulation, Humans, Protein Processing, Post-Translational, Transcriptional Activation, Drug Delivery Systems, Gene Silencing, MicroRNAs

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Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

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