Cited by 452Redox biology and oxidative stressCancer and biochemical researchAntioxidant Activity and Oxidative Stress

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The multifaceted role of reactive oxygen species in tumorigenesis

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Kirtonia, Anuradha, Sethi, Gautam, Garg, Manoj·2020·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-020-03536-5PMC PMC11105050

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Abstract

Redox homeostasis is an essential requirement of the biological systems for performing various normal cellular functions including cellular growth, differentiation, senescence, survival and aging in humans. The changes in the basal levels of reactive oxygen species (ROS) are detrimental to cells and often lead to several disease conditions including cardiovascular, neurological, diabetes and cancer. During the last two decades, substantial research has been done which clearly suggests that ROS are essential for the initiation, progression, angiogenesis as well as metastasis of cancer in several ways. During the last two decades, the potential of dysregulated ROS to enhance tumor formation through the activation of various oncogenic signaling pathways, DNA mutations, immune escape, tumor microenvironment, metastasis, angiogenesis and extension of telomere has been discovered. At present, surgery followed by chemotherapy and/or radiotherapy is the major therapeutic modality for treating patients with either early or advanced stages of cancer. However, the majority of patients relapse or did not respond to initial treatment. One of the reasons for recurrence/relapse is the altered levels of ROS in tumor cells as well as in cancer-initiating stem cells. One of the critical issues is targeting the intracellular/extracellular ROS for significant antitumor response and relapse-free survival. Indeed, a large number of FDA-approved anticancer drugs are efficient to eliminate cancer cells and drug resistance by increasing ROS production. Thus, the modulation of oxidative stress response might represent a potential approach to eradicate cancer in combination with FDA-approved chemotherapies, radiotherapies as well as immunotherapies.

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Background
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Peer Review #2 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.2)"
(2023) · PeerJ · doi:10.7287/peerj.14784v0.2/reviews/2
Peer Review #1 of "A novel gene signature related to oxidative stress predicts the prognosis in clear cell renal cell carcinoma (v0.1)"
(2023) · PeerJ · doi:10.7287/peerj.14784v0.1/reviews/1

Authors: Kirtonia, A., Sethi, G., & Garg, M.
Affiliations: Amity University (IN)
National University of Singapore (SG)
Corresponding author: Sethi, Gautam
Garg, Manoj
ORCID: Kirtonia, Anuradha
Sethi, Gautam
Garg, Manoj
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2020-05-01
Volume: 77
Issue: 22
Pages: 4459-4483
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-020-03536-5
PMC: PMC11105050
OpenAlex: W3022746266
Cited by: 452
References: 257
Citations by year: 2026: 33 · 2025: 45 · 2024: 90 · 2023: 72 · 2022: 106 · 2021: 80 · 2020: 26
FWCI: 6.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Department of Biotechnology , Ministry of Science and Technology
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: reactive oxygen species, carcinogenesis, redox homeostasis, oxidative stress, metastasis, angiogenesis, oncogenic signaling, DNA mutations, tumor microenvironment, cancer stem cells, drug resistance, anticancer agents, immunotherapy, radiotherapy, chemotherapy
MeSH terms: Animals, Humans, Neoplasm Recurrence, Local, Neoplasms, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Carcinogenesis

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The multifaceted role of reactive oxygen species in tumorigenesis

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