The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
The multifaceted role of reactive oxygen species in tumorigenesis
Open accessAbstract
Redox homeostasis is an essential requirement of the biological systems for performing various normal cellular functions including cellular growth, differentiation, senescence, survival and aging in humans. The changes in the basal levels of reactive oxygen species (ROS) are detrimental to cells and often lead to several disease conditions including cardiovascular, neurological, diabetes and cancer. During the last two decades, substantial research has been done which clearly suggests that ROS are essential for the initiation, progression, angiogenesis as well as metastasis of cancer in several ways. During the last two decades, the potential of dysregulated ROS to enhance tumor formation through the activation of various oncogenic signaling pathways, DNA mutations, immune escape, tumor microenvironment, metastasis, angiogenesis and extension of telomere has been discovered. At present, surgery followed by chemotherapy and/or radiotherapy is the major therapeutic modality for treating patients with either early or advanced stages of cancer. However, the majority of patients relapse or did not respond to initial treatment. One of the reasons for recurrence/relapse is the altered levels of ROS in tumor cells as well as in cancer-initiating stem cells. One of the critical issues is targeting the intracellular/extracellular ROS for significant antitumor response and relapse-free survival. Indeed, a large number of FDA-approved anticancer drugs are efficient to eliminate cancer cells and drug resistance by increasing ROS production. Thus, the modulation of oxidative stress response might represent a potential approach to eradicate cancer in combination with FDA-approved chemotherapies, radiotherapies as well as immunotherapies.
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“ROS play an essential role in carcinogenesis, affecting multiple biological processes, including genomic instability, cell growth, angiogenesis, inflammation, metabolic reprogramming, metastatization, and resistance to apoptosis [77].”
From Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma (2023) · cites this paper as [77]
In the citing paper
“Elevated levels of intracellular ROS are known to be one of the reasons for genomic instability and, hence, carcinogenesis [29].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [29]
In the citing paper
“ROS are known to play a multifaced, opposing role in cancer, by favoring cancer onset at low doses on the one hand, and killing tumors at high doses on the other hand [29,55].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [29]
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2 retracted
Garg, M., Kanojia, D., Mayakonda, A., Ganesan, T. S., Sadhanandhan, B., Suresh, S., Sneha, S., Nagare, R. P., SAID, J. W., Doan, N., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10325-x · Cited by 48
Self-citationRetractedKanojia, D., Garg, M., Martinez, J., Anand, M. T., Luty, S. B., Doan, N., SAID, J. W., Forscher, C. A., Tyner, J. W., & Koeffler, H. P. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0540-x · Cited by 30
Self-citationRetractedBray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109
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Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
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Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
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Xie, Y., Hou, W., Song, X., Yu, Y., Huang, J., Sun, X., Kang, R., & Tang, D. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2015.158 · Cited by 3,727
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Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2024) · eLife · doi:10.7554/elife.94988.1.sa4
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Cheng, X., Zhang, X., Hong, T., Yang, L., Tu, C., Yang, S., & An, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4532655/v1
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Qian, W., Jin, S., Suo, R., Li, Y., Ling, H., Li, S., Zhu, L., Deng, K., Sun, W., Wei, Y., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4873460
Zhou, Q., Yang, Y., Tang, G., Yang, Y., Fang, Y., Miao, Y., Hang, Y., Zhou, M., Hu, C., & Li, Z. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70304
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Qian, W., Jin, S., Suo, R., Li, Y., Ling, H., Li, S., Zhu, L., Deng, K., Sun, W., Wei, Y., et al. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c05488
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Yadav, S., Singh, J., Kumar, R., Sonkar, A. B., Kumar, A., Kumar, D., Shrivastava, N. K., Ansari, M. N., Saeedan, A. S., Aldossary, S. A., et al. (2025) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2025.100163
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Zhu, Y., Lei, C., Jiang, Q., Yu, Q., & Qiu, L. (2022) · Figshare · doi:10.6084/m9.figshare.20381856
Yoneda, J., Nishikawa, S., & Kurihara, S. (2021) · Figshare · doi:10.6084/m9.figshare.17284233
Zhu, Y., Lei, C., Jiang, Q., Yu, Q., & Qiu, L. (2022) · Figshare · doi:10.6084/m9.figshare.20381859
Wang, L., Zhao, S., Wang, Y., Liu, J., & Wang, X. (2024) · Figshare · doi:10.6084/m9.figshare.25649379
Xi, Y., Shen, Y., Wu, D., Zhang, J., Lin, C., Wang, L., Yu, C., Yu, B., & Shen, W. (2022) · Figshare · doi:10.6084/m9.figshare.20326413
Lu, C. L., Fang, Z., Che, L., Lin, Y., Xu, S. Y., Zhuo, Y., Hua, L., Jiang, X. M., Sun, M. M., Liu, G. M., et al. (2026) · animal · doi:10.1016/j.animal.2026.101756
SathishKumar, M., Palani, B., Jayakodi, S., & Shanmugam, R. (2026) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2026v19i1.57176
Li, Y. R., Kandyba, E. E., Halliwill, K. D., Delrosario, R., Tran, Q., Bayani, N., Wu, D., Mirzoeva, O. K., Reeves, M. M., Islam, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577147
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Theivendren, P., Panneerselvam, S., Swaminathan, J., Murugesan, V., Pradeep, K., Bhat, M. J., Zarfishan, A., Chidambaram, K., & Kiruthiga, N. (2026) · Regional Studies in Marine Science · doi:10.1016/j.rsma.2026.104935
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Zhou, L., Che, H., Jiang, H., Yin, L., Jiang, Y., Zhang, Y., Liang, H., Yu, R., Zhang, X., & Liu, X. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012120
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Alexandre, H. M. D. S., de Santana, P. V. S., Marques, K. K. G., Júnior, A. R. D. A., de Souza, R. R. M., Silva, A. L. E., Pontes, A. H. D. O., Duarte, S. S., Tavares, J. F., Agra, M. D. F., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9382393/v1
Fiallos, E., Cociancic, P., Esteban, J., Muñoz-Antolí, C., & Toledo, R. (2026) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0014294
Liu, W., Dai, G., Liao, G., Ouyang, P., Huang, J., & Xu, M. (2026) · Discover Oncology · doi:10.1007/s12672-026-05203-w
“The distinct metabolic profiles of cancer cells, particularly regarding ROS production and lipid/iron metabolism, may render them more susceptible to this cell death pathway [21].”
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Bu, Q., Wang, Z., (27728), Q. W., Qi, X., Lin, S., Liu, S., & Zhang, Y. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08865-0
Wan, Y., Shi, J. H., Fei, Y., 黄方柱, Lu, Z., Liaqat, K., Han, C., & Huang, T. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.179245
Dai, Y., & Ding, W. (2026) · Molecular Diversity · doi:10.1007/s11030-026-11707-y
Carrero, Y. N., & Mosquera, J. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1922814
“Moderating ROS levels are of great importance for cell survival, proliferation, differentiation and migration, facts that give ROS a crucial role in the context of cancer (76, 77).”
Pastrana-Peralta, P., Domínguez-Gómez, G., Romo‐Pérez, A., Chávez-Blanco, A. D., González‐Fierro, A., García-Carrancá, A. M., Gutiérrez-Delgado, F., Correa‐Basurto, J., Cortes-Algara, A., & Dueñas‐González, A. (2026) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2026.2749634
Zhang, Y., Wang, Q., Zhao, L., 钟儒刚, Sun, G., & Lin, N. (2026) · Molecules · doi:10.3390/molecules31203789
“Moreover, elevated ROS levels are characteristic of both solid tumors and hematological malignancies [4].”
Peroxidase-mimicking Nanozymes for redox monitoring and regulation in Cancer Theranostics
Ezeaniekwe, C., Logan, N., Liu, X., & Cao, C. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115981
Bridging phytochemistry and oncology: flavonoids as next-generation anticancer therapeutics
Goyal, V., Chauhan, A., Dhiman, S., Dora, C. P., Kumar, M., & Awasthi, A. (2026) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgag117
Metadata
- Authors
- Kirtonia, A., Sethi, G., & Garg, M.
- Affiliations
- Amity University (IN)
- National University of Singapore (SG)
- Corresponding author
- Sethi, Gautam
- Garg, Manoj
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2020-05-01
- Volume
- 77
- Issue
- 22
- Pages
- 4459-4483
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11105050
- OpenAlex
- W3022746266
- Cited by
- 452
- References
- 257
- Citations by year
- 2026: 33 · 2025: 45 · 2024: 90 · 2023: 72 · 2022: 106 · 2021: 80 · 2020: 26
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Biotechnology , Ministry of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- reactive oxygen species, carcinogenesis, redox homeostasis, oxidative stress, metastasis, angiogenesis, oncogenic signaling, DNA mutations, tumor microenvironment, cancer stem cells, drug resistance, anticancer agents, immunotherapy, radiotherapy, chemotherapy
- MeSH terms
- Animals, Humans, Neoplasm Recurrence, Local, Neoplasms, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Carcinogenesis
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